Details for: NIP7

Gene ID: 51388

Symbol: NIP7

Ensembl ID: ENSG00000132603

Description: nucleolar pre-rRNA processing protein NIP7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 103.1211
    Cell Significance Index: -16.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.0663
    Cell Significance Index: -16.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.5285
    Cell Significance Index: -18.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.1316
    Cell Significance Index: -20.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.9475
    Cell Significance Index: -18.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6024
    Cell Significance Index: -20.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.8906
    Cell Significance Index: -15.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3522
    Cell Significance Index: -21.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0762
    Cell Significance Index: -12.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5903
    Cell Significance Index: 157.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5685
    Cell Significance Index: 255.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1286
    Cell Significance Index: 1019.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0884
    Cell Significance Index: 70.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9898
    Cell Significance Index: 70.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7826
    Cell Significance Index: 13.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7675
    Cell Significance Index: 20.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6624
    Cell Significance Index: 77.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6102
    Cell Significance Index: 17.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6076
    Cell Significance Index: 42.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5961
    Cell Significance Index: 263.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5948
    Cell Significance Index: 8.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5831
    Cell Significance Index: 71.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5400
    Cell Significance Index: 5.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4828
    Cell Significance Index: 56.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4724
    Cell Significance Index: 61.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4693
    Cell Significance Index: 22.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4469
    Cell Significance Index: 11.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4462
    Cell Significance Index: 243.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4453
    Cell Significance Index: 23.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3993
    Cell Significance Index: 54.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3947
    Cell Significance Index: 29.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3454
    Cell Significance Index: 9.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3451
    Cell Significance Index: 3.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3085
    Cell Significance Index: 58.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2933
    Cell Significance Index: 52.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2884
    Cell Significance Index: 13.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2246
    Cell Significance Index: 6.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2070
    Cell Significance Index: 41.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1994
    Cell Significance Index: 4.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1980
    Cell Significance Index: 6.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1938
    Cell Significance Index: 5.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1811
    Cell Significance Index: 3.7900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1571
    Cell Significance Index: 1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1565
    Cell Significance Index: 4.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1554
    Cell Significance Index: 4.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1163
    Cell Significance Index: 23.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1147
    Cell Significance Index: 5.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0676
    Cell Significance Index: 8.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0295
    Cell Significance Index: 1.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0201
    Cell Significance Index: 7.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0151
    Cell Significance Index: 0.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0125
    Cell Significance Index: 8.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0120
    Cell Significance Index: -22.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0147
    Cell Significance Index: -22.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0221
    Cell Significance Index: -14.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0248
    Cell Significance Index: -18.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0255
    Cell Significance Index: -2.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0337
    Cell Significance Index: -0.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0347
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0431
    Cell Significance Index: -26.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0436
    Cell Significance Index: -19.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0507
    Cell Significance Index: -8.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0512
    Cell Significance Index: -14.7400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0738
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0993
    Cell Significance Index: -14.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1054
    Cell Significance Index: -12.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1097
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1106
    Cell Significance Index: -23.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1250
    Cell Significance Index: -0.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2019
    Cell Significance Index: -21.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2055
    Cell Significance Index: -6.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2064
    Cell Significance Index: -5.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2143
    Cell Significance Index: -16.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2214
    Cell Significance Index: -16.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2299
    Cell Significance Index: -12.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2505
    Cell Significance Index: -16.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2597
    Cell Significance Index: -15.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2703
    Cell Significance Index: -16.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2809
    Cell Significance Index: -15.7600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2814
    Cell Significance Index: -2.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3070
    Cell Significance Index: -15.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3125
    Cell Significance Index: -3.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3367
    Cell Significance Index: -7.7800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3378
    Cell Significance Index: -4.7400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3643
    Cell Significance Index: -5.0600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3812
    Cell Significance Index: -3.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3976
    Cell Significance Index: -20.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4034
    Cell Significance Index: -14.8100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.4073
    Cell Significance Index: -3.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4081
    Cell Significance Index: -18.0500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.4096
    Cell Significance Index: -2.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4110
    Cell Significance Index: -3.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NIP7 is a 60S ribosome subunit biogenesis protein that belongs to the nucleolar pre-rRNA processing protein family. It is a nucleolar protein that localizes to the nucleolus and cytosol, where it participates in the processing of large subunit precursors (LSPs) and 60S ribosomal subunits. NIP7 exhibits a unique structure, consisting of two domains: a nucleolar domain and a cytosolic domain. The nucleolar domain is responsible for interacting with pre-rRNA, while the cytosolic domain mediates interactions with ribosomal proteins. **Pathways and Functions:** NIP7's primary function is to participate in the major pathway of rRNA processing in the nucleolus and cytosol. This process involves the maturation of pre-rRNA into mature rRNA, which is essential for ribosome assembly and function. NIP7's role in this pathway is to facilitate the processing of LSPs and 60S ribosomal subunits, ensuring the proper assembly and maturation of ribosomes. Additionally, NIP7 has been implicated in the regulation of cell growth, differentiation, and survival, highlighting its importance in various cellular processes. **Clinical Significance:** Dysregulation of NIP7 has been implicated in several human diseases, including hematological malignancies, such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Overexpression of NIP7 has been observed in AML cells, where it contributes to the development and progression of the disease. Furthermore, NIP7 has been identified as a potential biomarker for the diagnosis and monitoring of AML. Its dysregulation has also been linked to other diseases, including autoimmune disorders and cancer. Understanding the role of NIP7 in human diseases has significant implications for the development of novel therapeutic strategies and diagnostic tools. **Conclusion:** In conclusion, NIP7 is a crucial nucleolar pre-rRNA processing protein that plays a pivotal role in the major pathway of rRNA processing in the nucleolus and cytosol. Its dysregulation has been implicated in various human diseases, including hematological malignancies, autoimmune disorders, and cancer. Further research is necessary to elucidate the molecular mechanisms underlying NIP7's role in human diseases and to explore its potential as a therapeutic target and diagnostic biomarker.

Genular Protein ID: 28701651

Symbol: NIP7_HUMAN

Name: 60S ribosome subunit biogenesis protein NIP7 homolog

UniProtKB Accession Codes:

Q9Y221 B2RD04 Q9NZZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 14660641

Title: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.

PubMed ID: 14660641

DOI: 10.1074/jbc.m305935200

PubMed ID: 17643419

Title: The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels.

PubMed ID: 17643419

DOI: 10.1016/j.yexcr.2007.06.024

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22195017

Title: The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing.

PubMed ID: 22195017

DOI: 10.1371/journal.pone.0029174

PubMed ID: 15522784

Title: Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells.

PubMed ID: 15522784

DOI: 10.1016/j.jsb.2004.06.010

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 180
  • Mass: 20463
  • Checksum: FC6CFB2250AA4FC9
  • Sequence:
    • MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEK IMKLAANISG 
DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWIK PGAEQSFLYG NHVLKSGLGR 
ITENTSQYQG VVVYSMADIP LGFGVAAKST QDCRKVDPMA IVVFHQADIG EYVRHEETLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.