Details for: RWDD1

Gene ID: 51389

Symbol: RWDD1

Ensembl ID: ENSG00000111832

Description: RWD domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 439.8078
    Cell Significance Index: -68.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.1333
    Cell Significance Index: -59.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 209.8325
    Cell Significance Index: -86.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 172.9212
    Cell Significance Index: -81.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 171.3447
    Cell Significance Index: -69.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 153.5425
    Cell Significance Index: -78.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 122.0526
    Cell Significance Index: -81.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 73.8523
    Cell Significance Index: -70.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.6057
    Cell Significance Index: -77.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4341
    Cell Significance Index: -54.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.1847
    Cell Significance Index: -79.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.8357
    Cell Significance Index: -51.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1807
    Cell Significance Index: 148.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3008
    Cell Significance Index: 315.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0814
    Cell Significance Index: 109.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0474
    Cell Significance Index: 144.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9014
    Cell Significance Index: 233.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8949
    Cell Significance Index: 837.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7417
    Cell Significance Index: 81.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7091
    Cell Significance Index: 46.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6219
    Cell Significance Index: 292.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5650
    Cell Significance Index: 116.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5070
    Cell Significance Index: 17.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4895
    Cell Significance Index: 31.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2181
    Cell Significance Index: 665.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2143
    Cell Significance Index: 31.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2057
    Cell Significance Index: 205.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1943
    Cell Significance Index: 194.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1476
    Cell Significance Index: 147.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1034
    Cell Significance Index: 142.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0787
    Cell Significance Index: 69.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0775
    Cell Significance Index: 127.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0201
    Cell Significance Index: 29.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9083
    Cell Significance Index: 57.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5494
    Cell Significance Index: 110.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5348
    Cell Significance Index: 482.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4886
    Cell Significance Index: 16.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4403
    Cell Significance Index: 4.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3597
    Cell Significance Index: 3.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3500
    Cell Significance Index: 6.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3407
    Cell Significance Index: 9.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3162
    Cell Significance Index: 31.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3047
    Cell Significance Index: 15.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2970
    Cell Significance Index: 15.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1823
    Cell Significance Index: 34.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1673
    Cell Significance Index: 4.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1668
    Cell Significance Index: 115.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1637
    Cell Significance Index: 58.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1059
    Cell Significance Index: 80.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0572
    Cell Significance Index: 41.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0469
    Cell Significance Index: 9.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0314
    Cell Significance Index: 0.5300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0283
    Cell Significance Index: 0.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0142
    Cell Significance Index: 0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0173
    Cell Significance Index: -0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0386
    Cell Significance Index: -71.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0407
    Cell Significance Index: -25.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0427
    Cell Significance Index: -4.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0446
    Cell Significance Index: -68.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0530
    Cell Significance Index: -72.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0704
    Cell Significance Index: -44.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0918
    Cell Significance Index: -51.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1322
    Cell Significance Index: -59.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1546
    Cell Significance Index: -32.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1547
    Cell Significance Index: -2.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2122
    Cell Significance Index: -61.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2142
    Cell Significance Index: -24.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3484
    Cell Significance Index: -26.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3577
    Cell Significance Index: -40.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3775
    Cell Significance Index: -54.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4281
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4363
    Cell Significance Index: -49.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4741
    Cell Significance Index: -16.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4819
    Cell Significance Index: -12.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5466
    Cell Significance Index: -7.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5501
    Cell Significance Index: -33.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6131
    Cell Significance Index: -34.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6167
    Cell Significance Index: -48.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6208
    Cell Significance Index: -7.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6978
    Cell Significance Index: -19.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7393
    Cell Significance Index: -76.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7580
    Cell Significance Index: -4.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8583
    Cell Significance Index: -27.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8892
    Cell Significance Index: -61.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8901
    Cell Significance Index: -40.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9096
    Cell Significance Index: -24.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9440
    Cell Significance Index: -63.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9550
    Cell Significance Index: -13.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9825
    Cell Significance Index: -20.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0822
    Cell Significance Index: -9.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1497
    Cell Significance Index: -70.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1877
    Cell Significance Index: -29.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2257
    Cell Significance Index: -21.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3081
    Cell Significance Index: -35.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3092
    Cell Significance Index: -57.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.3431
    Cell Significance Index: -55.0300
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.3634
    Cell Significance Index: -8.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4127
    Cell Significance Index: -24.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RWDD1 is characterized by its RWD domain, a protein-protein interaction motif that plays a crucial role in protein-protein interactions, protein binding, and post-translational modifications. The gene's expression is widespread, with significant levels detected in hematopoietic oligopotent progenitor cells, embryonic stem cells, and various types of immune cells, including CD8-alpha-beta-positive alpha-beta intraepithelial T cells and peripheral blood mononuclear cells. RWDD1's expression in smooth muscle fibers of the ileum and mucosal type mast cells further highlights its diverse cellular localization. **Pathways and Functions:** RWDD1 is implicated in various cellular pathways, including: 1. **Androgen receptor signaling pathway:** RWDD1 is a positive regulator of androgen receptor activity, suggesting its role in androgen-mediated gene expression. 2. **Cellular response to oxidative stress:** RWDD1's expression in various cell types indicates its involvement in protecting cells against oxidative damage. 3. **Cytoplasmic translation:** RWDD1's localization to the cytoplasm suggests its role in regulating protein synthesis and translation. 4. **Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation:** RWDD1's involvement in these post-translational modifications highlights its potential role in protein regulation and signaling. **Clinical Significance:** RWDD1's expression in various immune cells and tissues implies its involvement in immune function and disease. Potential clinical applications of RWDD1 include: 1. **Immunotherapy:** RWDD1's role in androgen receptor signaling and immune cell regulation makes it a potential target for immunotherapeutic interventions. 2. **Oxidative stress disorders:** RWDD1's expression in various cell types suggests its potential involvement in oxidative stress-related disorders, such as cancer and neurodegenerative diseases. 3. **Protein modification disorders:** RWDD1's role in post-translational modifications highlights its potential involvement in protein modification disorders, such as protein quality control and degradation. In conclusion, RWDD1 is a multifaceted gene with widespread expression and involvement in various cellular pathways. Further research is necessary to fully elucidate RWDD1's functions and clinical significance, but its potential applications in immunotherapy, oxidative stress disorders, and protein modification disorders make it an exciting area of investigation.

Genular Protein ID: 4219215165

Symbol: RWDD1_HUMAN

Name: RWD domain-containing protein 1

UniProtKB Accession Codes:

Q9H446 A8K3W2 A8MT24 Q9Y313 Q9Y6B3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 243
  • Mass: 27940
  • Checksum: A7AABD457136B4DA
  • Sequence:
    • MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT TLKFTYSEKY 
PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT 
RREEEKKQKE KEAEEAEKQL FHGTPVTIEN FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK 
LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD 
SAD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.