RWDD1 | ENSG00000111832 | NCBI 51389

Details for: RWDD1

Gene ID: 51389

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RWDD1

Ensembl ID: ENSG00000111832

Description: RWD domain containing 1

Cell Significance Landscape

Display Count:

Associated with

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Protein hydroxylation
(R-HSA-9629569)
Androgen receptor signaling pathway
(GO:0030521)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to testosterone stimulus
(GO:0071394)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Positive regulation of androgen receptor activity
(GO:2000825)
Protein binding
(GO:0005515)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

keratinocyte CL0000312

CSI 53

rCSI 44.43%

PRS 12.63
megakaryocyte-erythroid progenitor cell CL0000050

CSI 51.19

rCSI 46.23%

PRS 9.33
pancreatic acinar cell CL0002064

CSI 48.89

rCSI 64.98%

PRS 11.51
common dendritic progenitor CL0001029

CSI 45.17

rCSI 56.69%

PRS 13.45
hematopoietic stem cell CL0000037

CSI 37.72

rCSI 25.07%

PRS 12.59
fraction A pre-pro B cell CL0002045

CSI 33.29

rCSI 38.11%

PRS 21.65
OFF-bipolar cell CL0000750

CSI 29.46

rCSI 40.27%

PRS 17.67
retinal cone cell CL0000573

CSI 27.99

rCSI 45.04%

PRS 8.12
intestinal epithelial cell CL0002563

CSI 27.83

rCSI 29.09%

PRS 11.14
common myeloid progenitor CL0000049

CSI 26.98

rCSI 21.82%

PRS 10.42
microcirculation associated smooth muscle cell CL0008035

CSI 26.21

rCSI 75.87%

PRS 11.93
granulocyte monocyte progenitor cell CL0000557

CSI 25.81

rCSI 22.34%

PRS 11.75
pancreatic A cell CL0000171

CSI 25.67

rCSI 26.89%

PRS 11.26
stem cell CL0000034

CSI 25.26

rCSI 24.36%

PRS 7.05
pancreatic D cell CL0000173

CSI 22.84

rCSI 22.46%

PRS 11.49
stromal cell of ovary CL0002132

CSI 21.69

rCSI 59.59%

PRS 17.5
transit amplifying cell of colon CL0009011

CSI 21.62

rCSI 25.4%

PRS 12.51
promyelocyte CL0000836

CSI 21.29

rCSI 30.71%

PRS 14.69
perivascular cell CL4033054

CSI 20.96

rCSI 28.66%

PRS 11.99
amacrine cell CL0000561

CSI 20.84

rCSI 60.41%

PRS 8.46
type B pancreatic cell CL0000169

CSI 19.86

rCSI 43.97%

PRS 9.81
extravillous trophoblast CL0008036

CSI 18.67

rCSI 23.09%

PRS 9.27
plasmablast CL0000980

CSI 17.2

rCSI 13.53%

PRS 12.51
early lymphoid progenitor CL0000936

CSI 17.01

rCSI 14.94%

PRS 11.86
mammary gland epithelial cell CL0002327

CSI 15.07

rCSI 52.86%

PRS 19.1
pancreatic PP cell CL0002275

CSI 14.73

rCSI 58.65%

PRS 18.53
peripheral nervous system neuron CL2000032

CSI 14.21

rCSI 19.36%

PRS 9.43
forebrain radial glial cell CL0013000

CSI 14.11

rCSI 45.28%

PRS 15.46
double-positive, alpha-beta thymocyte CL0000809

CSI 13.95

rCSI 14.21%

PRS 15.05
large pre-B-II cell CL0000957

CSI 13.84

rCSI 39.51%

PRS 18.33
pancreatic ductal cell CL0002079

CSI 13.76

rCSI 26.75%

PRS 10.76
primitive red blood cell CL0002355

CSI 12.52

rCSI 67.57%

PRS 19.9
pancreatic stellate cell CL0002410

CSI 12.37

rCSI 71.99%

PRS 15.86
retina horizontal cell CL0000745

CSI 12.16

rCSI 18.54%

PRS 9.9
myeloid lineage restricted progenitor cell CL0000839

CSI 11.89

rCSI 61.41%

PRS 20.83
promonocyte CL0000559

CSI 10.88

rCSI 18.64%

PRS 14.12
enteric smooth muscle cell CL0002504

CSI 9.8

rCSI 13.99%

PRS 11.9
endothelial cell of placenta CL0009092

CSI 9.01

rCSI 44.42%

PRS 14.33
Cajal-Retzius cell CL0000695

CSI 8.9

rCSI 69.7%

PRS 23.15
paneth cell CL0000510

CSI 8.63

rCSI 12.74%

PRS 16.59
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 8.3

rCSI 14.66%

PRS 6.17
activated type II NK T cell CL0000931

CSI 7.87

rCSI 8.86%

PRS 16.93
mesodermal cell CL0000222

CSI 7.58

rCSI 9.1%

PRS 10.44
mucous neck cell CL0000651

CSI 6.92

rCSI 9.97%

PRS 17
regular atrial cardiac myocyte CL0002129

CSI 6.42

rCSI 20.65%

PRS 11.72
cerebral cortex GABAergic interneuron CL0010011

CSI 6.26

rCSI 18.47%

PRS 13.02
fallopian tube secretory epithelial cell CL4030006

CSI 6.25

rCSI 6.02%

PRS 10.9
peptic cell CL0000155

CSI 6.05

rCSI 59.53%

PRS 31.84
thymocyte CL0000893

CSI 5.65

rCSI 20.09%

PRS 33.02
transitional stage B cell CL0000818

CSI 5.37

rCSI 17.58%

PRS 30.37
transit amplifying cell CL0009010

CSI 4.97

rCSI 7.6%

PRS 17.15
mucus secreting cell CL0000319

CSI 4.86

rCSI 7.73%

PRS 13.69
intestinal crypt stem cell of colon CL0009043

CSI 4.85

rCSI 36.39%

PRS 19.58
helper T cell CL0000912

CSI 4.8

rCSI 6.78%

PRS 14.92
plasmacytoid dendritic cell, human CL0001058

CSI 4.73

rCSI 3.3%

PRS 11.09
epithelial cell of lung CL0000082

CSI 4.72

rCSI 3.91%

PRS 9.97
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 4.67

rCSI 5.39%

PRS 9.34
double negative thymocyte CL0002489

CSI 4.43

rCSI 3.08%

PRS 12.33
skin fibroblast CL0002620

CSI 4.37

rCSI 3.77%

PRS 17.18
colon goblet cell CL0009039

CSI 4.3

rCSI 10.23%

PRS 15.88
naive T cell CL0000898

CSI 4.28

rCSI 2.98%

PRS 15.01
tracheal goblet cell CL1000329

CSI 4.18

rCSI 9.13%

PRS 21.36
club cell CL0000158

CSI 4.14

rCSI 6.07%

PRS 12.34
neuroblast (sensu Vertebrata) CL0000031

CSI 4.13

rCSI 5.3%

PRS 10.29
ON-bipolar cell CL0000749

CSI 4.09

rCSI 6.08%

PRS 13.01
enteroendocrine cell of colon CL0009042

CSI 4.09

rCSI 19.15%

PRS 28.48
bronchiolar smooth muscle cell CL4033017

CSI 3.97

rCSI 59.54%

PRS 33.6
ventricular cardiac muscle cell CL2000046

CSI 3.95

rCSI 13.54%

PRS 41.99
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 3.93

rCSI 5.4%

PRS 21.95
VIP GABAergic cortical interneuron CL4023016

CSI 3.88

rCSI 4.64%

PRS 6.1
neural crest cell CL0011012

CSI 3.86

rCSI 3.05%

PRS 7.27
lung secretory cell CL1000272

CSI 3.75

rCSI 9.29%

PRS 9.73
plasma cell CL0000786

CSI 3.7

rCSI 4.85%

PRS 46.94
multi-ciliated epithelial cell CL0005012

CSI 3.67

rCSI 3.66%

PRS 9.05
retinal rod cell CL0000604

CSI 3.66

rCSI 6.44%

PRS 10.64
acinar cell CL0000622

CSI 3.63

rCSI 5.32%

PRS 13.86
colon epithelial cell CL0011108

CSI 3.61

rCSI 3.78%

PRS 9.82
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.54

rCSI 2.84%

PRS 19.14
acinar cell of salivary gland CL0002623

CSI 3.49

rCSI 81.39%

PRS 18.57
bronchus fibroblast of lung CL2000093

CSI 3.49

rCSI 2.83%

PRS 11.18
melanocyte CL0000148

CSI 3.48

rCSI 2.57%

PRS 9.47
hair follicular keratinocyte CL2000092

CSI 3.38

rCSI 58.82%

PRS 41.95
pancreatic epsilon cell CL0005019

CSI 3.38

rCSI 15.76%

PRS 25.59
transit amplifying cell of small intestine CL0009012

CSI 3.34

rCSI 14.66%

PRS 19.75
stromal cell CL0000499

CSI 3.32

rCSI 9.34%

PRS 15.15
common lymphoid progenitor CL0000051

CSI 3.29

rCSI 4.4%

PRS 20.13
colon macrophage CL0009038

CSI 3.23

rCSI 14.94%

PRS 22.24
interstitial cell of Cajal CL0002088

CSI 3.15

rCSI 4.02%

PRS 12.27
vein endothelial cell of respiratory system CL4033008

CSI 3.12

rCSI 21.45%

PRS 20.73
group 2 innate lymphoid cell CL0001069

CSI 2.94

rCSI 15.93%

PRS 35.4
luminal epithelial cell of mammary gland CL0002326

CSI 2.94

rCSI 5.34%

PRS 16.13
tendon cell CL0000388

CSI 2.86

rCSI 7.44%

PRS 29.71
endothelial cell of uterus CL0009095

CSI 2.86

rCSI 20.9%

PRS 28.96
epithelial cell CL0000066

CSI 2.81

rCSI 4.32%

PRS 15.08
kidney epithelial cell CL0002518

CSI 2.8

rCSI 5.34%

PRS 25.04
type L enteroendocrine cell CL0002279

CSI 2.69

rCSI 5.05%

PRS 20.87
BEST4+ enteroycte CL4030026

CSI 2.68

rCSI 3.33%

PRS 11.16
CD14-low, CD16-positive monocyte CL0002396

CSI 2.67

rCSI 2.06%

PRS 9.55
midzonal region hepatocyte CL0019028

CSI 2.65

rCSI 6.22%

PRS 16.71
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 2.61

rCSI 11.85%

PRS 37.2

lung interstitial macrophage CL4033043

CSI -10.2

rCSI -23.0%

PRS 22.4%
centrilobular region hepatocyte CL0019029

CSI -8.5

rCSI -22.0%

PRS 17.5%
neural progenitor cell CL0011020

CSI -6.2

rCSI -27.4%

PRS 10.4%
intrahepatic cholangiocyte CL0002538

CSI -4.1

rCSI -9.8%

PRS 19.5%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -3.7

rCSI -11.5%

PRS 7.1%
astrocyte of the cerebral cortex CL0002605

CSI -3.3

rCSI -7.5%

PRS 6.5%
skeletal muscle satellite cell CL0000594

CSI -1.8

rCSI -5.4%

PRS 35.5%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -1.7

rCSI -1.6%

PRS 16.0%
regular ventricular cardiac myocyte CL0002131

CSI -1.3

rCSI -8.0%

PRS 8.4%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -1.2

rCSI -4.3%

PRS 5.7%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI -1.1

rCSI -2.9%

PRS 9.8%
sncg GABAergic cortical interneuron CL4023015

CSI -1.0

rCSI -1.6%

PRS 6.9%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -0.8

rCSI -4.7%

PRS 6.5%
choroid plexus epithelial cell CL0000706

CSI -0.8

rCSI -1.3%

PRS 8.2%
lung neuroendocrine cell CL1000223

CSI -0.5

rCSI -0.7%

PRS 12.1%
late pro-B cell CL0002048

CSI -0.4

rCSI -1.0%

PRS 31.6%
kidney connecting tubule epithelial cell CL1000768

CSI -0.3

rCSI -0.7%

PRS 8.1%
pulmonary alveolar type 1 cell CL0002062

CSI -0.2

rCSI -1.3%

PRS 14.3%
near-projecting glutamatergic cortical neuron CL4023012

CSI -0.1

rCSI -0.2%

PRS 6.3%
GABAergic amacrine cell CL4030027

CSI 0.0

rCSI 0.0%

PRS 9.9%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.3%

PRS 15.5%
cerebellar granule cell CL0001031

CSI 0.1

rCSI 0.1%

PRS 9.9%
megakaryocyte CL0000556

CSI 0.1

rCSI 0.3%

PRS 19.0%
memory T cell CL0000813

CSI 0.1

rCSI 0.2%

PRS 23.7%
OFF midget ganglion cell CL4033047

CSI 0.1

rCSI 2.5%

PRS 9.3%
renal alpha-intercalated cell CL0005011

CSI 0.1

rCSI 0.2%

PRS 14.1%
osteoblast CL0000062

CSI 0.1

rCSI 3.2%

PRS 69.2%
parietal cell CL0000162

CSI 0.1

rCSI 1.1%

PRS 54.6%
deuterosomal cell CL4033044

CSI 0.1

rCSI 0.5%

PRS 17.9%
odontoblast CL0000060

CSI 0.1

rCSI 3.1%

PRS 48.1%
lung microvascular endothelial cell CL2000016

CSI 0.1

rCSI 2.7%

PRS 34.4%
ON midget ganglion cell CL4033046

CSI 0.2

rCSI 3.0%

PRS 8.5%
epithelial cell of nephron CL1000449

CSI 0.2

rCSI 1.5%

PRS 44.4%
ON parasol ganglion cell CL4033052

CSI 0.2

rCSI 2.2%

PRS 7.4%
slow muscle cell CL0000189

CSI 0.2

rCSI 2.2%

PRS 51.7%
chondrocyte CL0000138

CSI 0.2

rCSI 0.3%

PRS 9.1%
GABAergic neuron CL0000617

CSI 0.2

rCSI 0.6%

PRS 7.7%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.2

rCSI 0.3%

PRS 9.9%
uterine smooth muscle cell CL0002601

CSI 0.2

rCSI 1.3%

PRS 59.2%
myelocyte CL0002193

CSI 0.2

rCSI 1.3%

PRS 33.9%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.2

rCSI 0.3%

PRS 18.3%
renal beta-intercalated cell CL0002201

CSI 0.3

rCSI 0.6%

PRS 13.0%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.3

rCSI 2.9%

PRS 40.5%
P/D1 enteroendocrine cell CL0002268

CSI 0.3

rCSI 1.4%

PRS 26.4%
retinal bipolar neuron CL0000748

CSI 0.3

rCSI 0.5%

PRS 7.7%
type EC enteroendocrine cell CL0000577

CSI 0.3

rCSI 1.0%

PRS 17.3%
lung macrophage CL1001603

CSI 0.3

rCSI 0.6%

PRS 12.0%
endocardial cell CL0002350

CSI 0.3

rCSI 1.4%

PRS 14.2%
endothelial cell of venule CL1000414

CSI 0.3

rCSI 2.8%

PRS 44.7%
tissue-resident macrophage CL0000864

CSI 0.3

rCSI 1.5%

PRS 23.4%
renal intercalated cell CL0005010

CSI 0.3

rCSI 2.8%

PRS 68.1%
IgM plasma cell CL0000986

CSI 0.3

rCSI 1.4%

PRS 49.1%
L6b glutamatergic cortical neuron CL4023038

CSI 0.3

rCSI 1.0%

PRS 6.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.3

rCSI 0.8%

PRS 6.0%
blood vessel endothelial cell CL0000071

CSI 0.4

rCSI 0.7%

PRS 10.5%
dendritic cell, human CL0001056

CSI 0.4

rCSI 0.5%

PRS 12.3%
intraepithelial lymphocyte CL0002496

CSI 0.4

rCSI 1.0%

PRS 43.8%
placental villous trophoblast CL2000060

CSI 0.4

rCSI 0.6%

PRS 9.9%
myoepithelial cell CL0000185

CSI 0.4

rCSI 0.9%

PRS 13.1%
mature alpha-beta T cell CL0000791

CSI 0.4

rCSI 1.4%

PRS 18.1%
sst GABAergic cortical interneuron CL4023017

CSI 0.4

rCSI 0.5%

PRS 6.5%
serous secreting cell CL0000313

CSI 0.4

rCSI 1.9%

PRS 44.1%
antibody secreting cell CL0000946

CSI 0.4

rCSI 1.7%

PRS 42.5%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.4

rCSI 2.0%

PRS 13.7%
vasa recta ascending limb cell CL1001131

CSI 0.4

rCSI 1.9%

PRS 39.9%
blood vessel smooth muscle cell CL0019018

CSI 0.4

rCSI 3.4%

PRS 11.0%
skeletal muscle satellite stem cell CL0008011

CSI 0.5

rCSI 2.0%

PRS 31.6%
eye photoreceptor cell CL0000287

CSI 0.5

rCSI 5.0%

PRS 28.2%
Kupffer cell CL0000091

CSI 0.5

rCSI 1.0%

PRS 10.2%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.5

rCSI 1.1%

PRS 16.8%
mesenchymal stem cell of adipose tissue CL0002570

CSI 0.5

rCSI 2.7%

PRS 32.3%
glial cell CL0000125

CSI 0.5

rCSI 1.9%

PRS 11.0%
syncytiotrophoblast cell CL0000525

CSI 0.5

rCSI 1.5%

PRS 20.7%
fibroblast of breast CL4006000

CSI 0.5

rCSI 2.2%

PRS 27.8%
CD14-positive, CD16-positive monocyte CL0002397

CSI 0.5

rCSI 0.7%

PRS 14.8%
pulmonary ionocyte CL0017000

CSI 0.5

rCSI 0.7%

PRS 13.3%
germinal center B cell CL0000844

CSI 0.5

rCSI 1.6%

PRS 26.5%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.5

rCSI 2.1%

PRS 17.4%
ependymal cell CL0000065

CSI 0.5

rCSI 1.1%

PRS 4.4%
IgG plasma cell CL0000985

CSI 0.6

rCSI 0.7%

PRS 18.2%
neuroendocrine cell CL0000165

CSI 0.6

rCSI 2.2%

PRS 22.1%
Bergmann glial cell CL0000644

CSI 0.6

rCSI 0.8%

PRS 11.0%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.6

rCSI 1.0%

PRS 6.2%
intestinal tuft cell CL0019032

CSI 0.6

rCSI 0.9%

PRS 12.1%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.6

rCSI 1.4%

PRS 11.1%
primordial germ cell CL0000670

CSI 0.6

rCSI 3.0%

PRS 58.2%
Hofbauer cell CL3000001

CSI 0.6

rCSI 1.2%

PRS 13.1%
natural T-regulatory cell CL0000903

CSI 0.6

rCSI 1.2%

PRS 29.0%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.6

rCSI 0.8%

PRS 14.3%
granulocyte CL0000094

CSI 0.6

rCSI 1.0%

PRS 13.3%
vasa recta descending limb cell CL1001285

CSI 0.6

rCSI 5.1%

PRS 43.3%
Langerhans cell CL0000453

CSI 0.6

rCSI 1.0%

PRS 18.4%
alveolar type 1 fibroblast cell CL4028004

CSI 0.7

rCSI 0.7%

PRS 12.2%
respiratory hillock cell CL4030023

CSI 0.7

rCSI 1.2%

PRS 18.0%
T-helper 17 cell CL0000899

CSI 0.7

rCSI 0.5%

PRS 18.6%
glutamatergic neuron CL0000679

CSI 0.7

rCSI 1.4%

PRS 10.9%
small intestine goblet cell CL1000495

CSI 0.7

rCSI 1.5%

PRS 14.2%
mononuclear phagocyte CL0000113

CSI 0.7

rCSI 1.5%

PRS 11.6%
pulmonary artery endothelial cell CL1001568

CSI 0.7

rCSI 0.9%

PRS 16.2%
regulatory T cell CL0000815

CSI 0.7

rCSI 0.8%

PRS 32.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RWDD1](/details-gene/51389) encodes RWD domain-containing protein 1, a protein primarily located in the [cytosol (GO:0005829)](https://www.ebi.ac.uk/QuickGO/term/GO:0005829). Functional annotations strongly suggest its involvement in protein metabolism, specifically in processes like [post-translational protein modification (R-HSA-597592)](https://reactome.org/content/detail/R-HSA-597592) and [protein hydroxylation (R-HSA-9629569)](https://reactome.org/content/detail/R-HSA-9629569). It is also implicated in the [androgen receptor signaling pathway (GO:0030521)](https://www.ebi.ac.uk/QuickGO/term/GO:0030521). **Overall**, expression data reveals that [RWDD1](/details-gene/51389) has the highest significance in a diverse array of cell types, including epithelial cells like [keratinocyte](/details-cell/CL0000312), various hematopoietic progenitors such as [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), and metabolically active endocrine cells like the [pancreatic acinar cell](/details-cell/CL0002064). This broad but distinct expression pattern points towards a fundamental role in cellular protein management and hormone signaling across multiple tissues. ## Cellular Roles and Expression Landscape The expression profile of [RWDD1](/details-gene/51389) indicates a significant role in highly proliferative or metabolically active cell populations, particularly those involved in tissue maintenance and development. Its highest significance is observed in [keratinocyte](/details-cell/CL0000312) (CSI: 53.00), suggesting a key function in epidermal biology. Furthermore, [RWDD1](/details-gene/51389) is a prominent marker across multiple stages of hematopoiesis, with high significance in [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), [common dendritic progenitor](/details-cell/CL0001029), [hematopoietic stem cell](/details-cell/CL0000037), and [common myeloid progenitor](/details-cell/CL0000049). This pattern suggests a potential role in regulating the differentiation or maintenance of these progenitor populations. High significance is also noted in secretory cells of the pancreas, including [pancreatic acinar cell](/details-cell/CL0002064) and [pancreatic A cell](/details-cell/CL0000171), which aligns with its annotated function in protein metabolism. Conversely, [RWDD1](/details-gene/51389) shows low to negative significance in many terminally differentiated cell types. This is particularly evident in the nervous system, with low expression in various neuronal subtypes like [chandelier pvalb GABAergic cortical interneuron](/details-cell/CL4023036) and glial cells such as [astrocyte of the cerebral cortex](/details-cell/CL0002605). It is also notably low in mature immune cells like the [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) and structural cells like the [regular ventricular cardiac myocyte](/details-cell/CL0002131). This lack of expression in highly specialized, post-mitotic cells further sharpens its profile as a gene primarily active in progenitor, stem, and high-turnover cell populations. ## Pathways and Molecular Function The molecular functions of [RWDD1](/details-gene/51389) are centered around protein lifecycle management. Its annotation for [protein binding (GO:0005515)](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) is consistent with its structural RWD domain. Its involvement in Reactome pathways such as [Metabolism of proteins (R-HSA-392499)](https://reactome.org/content/detail/R-HSA-392499) and [Post-translational protein modification (R-HSA-597592)](https://reactome.org/content/detail/R-HSA-597592) suggests it acts as a component or regulator within the cellular machinery that modifies and processes newly synthesized or existing proteins. A particularly notable function is its role in hormone signaling, specifically the [androgen receptor signaling pathway (GO:0030521)](https://www.ebi.ac.uk/QuickGO/term/GO:0030521), where it is annotated as a positive regulator of androgen receptor activity ([GO:2000825](https://www.ebi.ac.uk/QuickGO/term/GO:2000825)). This function provides a potential mechanistic link to its high expression in [keratinocyte](/details-cell/CL0000312)s, as skin is a key androgen-responsive organ. The gene's involvement in the [cellular response to oxidative stress (GO:0034599)](https://www.ebi.ac.uk/QuickGO/term/GO:0034599) further suggests it may play a role in protecting cells with high metabolic activity from damage. ## Research Directions The expression and functional data for [RWDD1](/details-gene/51389) provide a basis for several testable hypotheses regarding its specific biological roles. 1. **Hypothesis 1:** Given its role in positively regulating androgen receptor activity and its high expression in [keratinocyte](/details-cell/CL0000312)s, [RWDD1](/details-gene/51389) is a critical co-factor for androgen-mediated gene expression in the skin, influencing processes such as hair follicle cycling, sebaceous gland function, or wound healing. 2. **Hypothesis 2:** The high significance of [RWDD1](/details-gene/51389) in multiple hematopoietic progenitor populations, contrasted with its low significance in mature immune cells, suggests that its expression is essential for maintaining pluripotency or guiding early lineage commitment, and that its downregulation is a prerequisite for terminal hematopoietic differentiation. **Experimental Approach for Hypothesis 2:** To investigate the role of [RWDD1](/details-gene/51389) in hematopoiesis, one could utilize a CRISPR-Cas9 system to knock out the gene in primary human CD34+ [hematopoietic stem cell](/details-cell/CL0000037)s. These modified stem cells, along with wild-type controls, would be cultured in vitro under conditions that promote differentiation into various lineages (e.g., myeloid, erythroid, lymphoid). The resulting cell populations could be analyzed using colony-forming unit (CFU) assays to quantify progenitor activity and multi-parameter flow cytometry to assess the efficiency of differentiation into mature cell types. A skewed lineage output or a failure to properly differentiate in the knockout group would provide strong evidence for the gene's essential role in this process. **Therapeutic Potential:** The broad expression of [RWDD1](/details-gene/51389) in essential cell types like stem cells and epithelial cells suggests that systemic inhibition could lead to significant off-target toxicity. However, its specific function as a positive regulator of the androgen receptor could make it a context-specific therapeutic target. In androgen-dependent pathologies, such as certain types of prostate cancer, where androgen receptor signaling is pathologically amplified, targeted inhibition of [RWDD1](/details-gene/51389) could offer a strategy to suppress oncogenic signaling. This would likely require a highly specific small molecule inhibitor or a targeted delivery system to mitigate side effects in other androgen-responsive tissues.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RWD domain-containing protein 1

Genular Protein ID: 4219215165

Symbol: RWDD1_HUMAN

Name: RWD domain-containing protein 1

UniProtKB Accession Codes:

Q9H446 A8K3W2 A8MT24 Q9Y313 Q9Y6B3

Database IDs:

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 243
Mass: 27940
Checksum: A7AABD457136B4DA
Sequence:

MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT TLKFTYSEKY 
PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT 
RREEEKKQKE KEAEEAEKQL FHGTPVTIEN FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK 
LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD 
SAD

Details for: RWDD1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. PubMed ID: 10810093

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569