Details for: WDR83OS

Gene ID: 51398

Symbol: WDR83OS

Ensembl ID: ENSG00000105583

Description: WD repeat domain 83 opposite strand

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 392.6832
    Cell Significance Index: -61.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 221.1175
    Cell Significance Index: -56.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 193.9324
    Cell Significance Index: -79.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 164.4700
    Cell Significance Index: -77.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 153.1731
    Cell Significance Index: -78.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 116.1959
    Cell Significance Index: -77.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.1367
    Cell Significance Index: -71.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.5696
    Cell Significance Index: -66.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5918
    Cell Significance Index: -77.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5315
    Cell Significance Index: -33.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 10.5688
    Cell Significance Index: 1231.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 8.6850
    Cell Significance Index: 184.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.1332
    Cell Significance Index: 40.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.0766
    Cell Significance Index: 65.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.4596
    Cell Significance Index: 27.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5423
    Cell Significance Index: 81.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.4090
    Cell Significance Index: 254.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.4003
    Cell Significance Index: 89.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3132
    Cell Significance Index: 454.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.0937
    Cell Significance Index: 57.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.9221
    Cell Significance Index: 85.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.8970
    Cell Significance Index: 1582.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8723
    Cell Significance Index: 26.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7596
    Cell Significance Index: 31.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6978
    Cell Significance Index: 486.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6943
    Cell Significance Index: 126.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6698
    Cell Significance Index: 328.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4112
    Cell Significance Index: 50.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3024
    Cell Significance Index: 297.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2204
    Cell Significance Index: 261.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1997
    Cell Significance Index: 76.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9474
    Cell Significance Index: 137.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8544
    Cell Significance Index: 819.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7415
    Cell Significance Index: 49.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.6804
    Cell Significance Index: 29.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4525
    Cell Significance Index: 186.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4294
    Cell Significance Index: 15.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0383
    Cell Significance Index: 66.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8734
    Cell Significance Index: 86.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5698
    Cell Significance Index: 108.4400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.5651
    Cell Significance Index: 3.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5556
    Cell Significance Index: 29.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4771
    Cell Significance Index: 137.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4436
    Cell Significance Index: 30.6800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.4130
    Cell Significance Index: 2.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3061
    Cell Significance Index: 231.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1899
    Cell Significance Index: 38.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1565
    Cell Significance Index: 4.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1307
    Cell Significance Index: 96.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1283
    Cell Significance Index: 94.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0309
    Cell Significance Index: 5.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0297
    Cell Significance Index: 0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0114
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0140
    Cell Significance Index: -8.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0356
    Cell Significance Index: -12.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0508
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0711
    Cell Significance Index: -11.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0844
    Cell Significance Index: -47.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1315
    Cell Significance Index: -27.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2024
    Cell Significance Index: -10.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2368
    Cell Significance Index: -9.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3712
    Cell Significance Index: -73.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3782
    Cell Significance Index: -13.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3961
    Cell Significance Index: -10.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4133
    Cell Significance Index: -47.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5539
    Cell Significance Index: -63.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6141
    Cell Significance Index: -34.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6296
    Cell Significance Index: -13.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6403
    Cell Significance Index: -50.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6885
    Cell Significance Index: -4.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7652
    Cell Significance Index: -47.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7955
    Cell Significance Index: -25.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9159
    Cell Significance Index: -70.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9760
    Cell Significance Index: -44.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0484
    Cell Significance Index: -29.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0667
    Cell Significance Index: -65.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0691
    Cell Significance Index: -16.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1370
    Cell Significance Index: -71.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1920
    Cell Significance Index: -12.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2558
    Cell Significance Index: -32.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.4361
    Cell Significance Index: -66.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4529
    Cell Significance Index: -38.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.4741
    Cell Significance Index: -40.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.4983
    Cell Significance Index: -77.8300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.6048
    Cell Significance Index: -13.4800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.7122
    Cell Significance Index: -35.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.7205
    Cell Significance Index: -10.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7490
    Cell Significance Index: -64.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7790
    Cell Significance Index: -78.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9515
    Cell Significance Index: -57.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.9922
    Cell Significance Index: -69.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.0373
    Cell Significance Index: -66.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0683
    Cell Significance Index: -35.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.0794
    Cell Significance Index: -78.7400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -2.1001
    Cell Significance Index: -5.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.1004
    Cell Significance Index: -66.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -2.5102
    Cell Significance Index: -62.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.5319
    Cell Significance Index: -80.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -2.5783
    Cell Significance Index: -50.4100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.6242
    Cell Significance Index: -53.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The WDR83OS gene encodes a protein containing a WD repeat domain 83 opposite strand, which is a conserved structural motif found in numerous proteins involved in protein-protein interactions, protein folding, and cell signaling. The WD repeat domain is characterized by a conserved sequence of 40-60 amino acids, which forms a beta-sheet structure that can interact with other proteins. The opposite strand of this domain is thought to play a crucial role in the protein's function, although the exact mechanisms are not well understood. **Pathways and Functions:** The WDR83OS gene is involved in various cellular pathways, including: 1. **Endoplasmic reticulum membrane**: The protein encoded by WDR83OS interacts with the endoplasmic reticulum (ER) membrane, facilitating the translocation of multi-pass transmembrane proteins into the ER. 2. **Protein binding**: The WD repeat domain 83 opposite strand interacts with other proteins, influencing protein-protein interactions and modulating cellular signaling pathways. 3. **Protein folding**: The protein encoded by WDR83OS acts as a chaperone, assisting in the proper folding of proteins and preventing protein misfolding. 4. **Protein folding chaperone complex**: WDR83OS interacts with other chaperones to form a complex that regulates protein folding and quality control. **Significantly Expressed Cells:** The WDR83OS gene is expressed in various cell types, including: 1. **Polychromatophilic erythroblast**: A stage of erythrocyte development characterized by the accumulation of hemoglobin. 2. **Hematopoietic oligopotent progenitor cell**: A precursor cell that gives rise to multiple hematopoietic lineages. 3. **Embryonic stem cell**: A pluripotent cell that can differentiate into various cell types. 4. **Smooth muscle fiber of ileum**: A muscle layer in the ileum, a part of the small intestine. 5. **Peripheral blood mononuclear cell**: A type of immune cell that includes lymphocytes and monocytes. 6. **Ileal goblet cell**: A cell type found in the ileum, responsible for producing mucus. 7. **Orthochromatic erythroblast**: A stage of erythrocyte development characterized by the accumulation of hemoglobin. 8. **CD8-positive, alpha-beta regulatory T cell**: A subset of T cells that regulate immune responses. 9. **Stromal cell of bone marrow**: A cell type found in the bone marrow, responsible for supporting hematopoiesis. 10. **CD8-alpha-beta-positive, alpha-beta intraepithelial T cell**: A subset of T cells found in epithelial tissues. **Clinical Significance:** The WDR83OS gene has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the WDR83OS gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: The protein encoded by WDR83OS has been implicated in cancer development and progression, particularly in hematological malignancies. 3. **Neurological disorders**: WDR83OS has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the WDR83OS gene plays a crucial role in various cellular processes, including protein folding, translocation, and regulation. Its expression in multiple cell types and its involvement in various diseases highlight the importance of this gene in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the functions of WDR83OS and its role in human disease.

Genular Protein ID: 3590475739

Symbol: ASTER_HUMAN

Name: WD repeat domain 83 opposite strand

UniProtKB Accession Codes:

Q9Y284 B2R4T8 Q9BVI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12475939

Title: Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein.

PubMed ID: 12475939

DOI: 10.1091/mbc.e02-04-0198

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 32814900

Title: An intramembrane chaperone complex facilitates membrane protein biogenesis.

PubMed ID: 32814900

DOI: 10.1038/s41586-020-2624-y

PubMed ID: 36261522

Title: Substrate-driven assembly of a translocon for multipass membrane proteins.

PubMed ID: 36261522

DOI: 10.1038/s41586-022-05330-8

Sequence Information:

  • Length: 106
  • Mass: 12068
  • Checksum: 7D2BDDAF9279071B
  • Sequence:
    • MSTNNMSDPR RPNKVLRYKP PPSECNPALD DPTPDYMNLL GMIFSMCGLM LKLKWCAWVA 
VYCSFISFAN SRSSEDTKQM MSSFMLSISA VVMSYLQNPQ PMTPPW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.