Details for: YTHDF2

Gene ID: 51441

Symbol: YTHDF2

Ensembl ID: ENSG00000198492

Description: YTH N6-methyladenosine RNA binding protein F2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 439.2935
    Cell Significance Index: -68.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 249.5630
    Cell Significance Index: -63.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 157.2049
    Cell Significance Index: -74.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 142.8283
    Cell Significance Index: -58.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.0046
    Cell Significance Index: -68.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 110.4136
    Cell Significance Index: -74.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.2207
    Cell Significance Index: -58.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 60.3509
    Cell Significance Index: -74.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.3229
    Cell Significance Index: -59.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.1077
    Cell Significance Index: -75.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.0236
    Cell Significance Index: -36.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5919
    Cell Significance Index: -25.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.8400
    Cell Significance Index: 98.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9373
    Cell Significance Index: 51.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7384
    Cell Significance Index: 189.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4052
    Cell Significance Index: 99.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3494
    Cell Significance Index: 36.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1112
    Cell Significance Index: 23.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0989
    Cell Significance Index: 135.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0926
    Cell Significance Index: 483.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0795
    Cell Significance Index: 589.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0417
    Cell Significance Index: 77.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9973
    Cell Significance Index: 179.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9509
    Cell Significance Index: 190.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9298
    Cell Significance Index: 184.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9105
    Cell Significance Index: 42.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9082
    Cell Significance Index: 42.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8577
    Cell Significance Index: 110.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8533
    Cell Significance Index: 117.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6954
    Cell Significance Index: 7.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6942
    Cell Significance Index: 19.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6263
    Cell Significance Index: 40.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6043
    Cell Significance Index: 27.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4893
    Cell Significance Index: 62.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4224
    Cell Significance Index: 68.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4112
    Cell Significance Index: 21.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3958
    Cell Significance Index: 141.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3814
    Cell Significance Index: 44.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3346
    Cell Significance Index: 9.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2655
    Cell Significance Index: 6.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2031
    Cell Significance Index: 20.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1925
    Cell Significance Index: 32.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1724
    Cell Significance Index: 155.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1626
    Cell Significance Index: 8.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1453
    Cell Significance Index: 100.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0256
    Cell Significance Index: 4.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0191
    Cell Significance Index: 1.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0076
    Cell Significance Index: 14.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0224
    Cell Significance Index: -16.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0299
    Cell Significance Index: -18.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0321
    Cell Significance Index: -24.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0379
    Cell Significance Index: -69.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0428
    Cell Significance Index: -65.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0443
    Cell Significance Index: -27.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0572
    Cell Significance Index: -77.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0840
    Cell Significance Index: -47.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0867
    Cell Significance Index: -39.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0914
    Cell Significance Index: -1.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0935
    Cell Significance Index: -5.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0941
    Cell Significance Index: -9.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1277
    Cell Significance Index: -18.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1451
    Cell Significance Index: -5.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1768
    Cell Significance Index: -3.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1793
    Cell Significance Index: -20.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1986
    Cell Significance Index: -22.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1987
    Cell Significance Index: -41.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2036
    Cell Significance Index: -6.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2125
    Cell Significance Index: -61.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2454
    Cell Significance Index: -18.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2871
    Cell Significance Index: -17.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3802
    Cell Significance Index: -43.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4495
    Cell Significance Index: -13.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4682
    Cell Significance Index: -11.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4767
    Cell Significance Index: -25.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5669
    Cell Significance Index: -7.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5876
    Cell Significance Index: -8.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6064
    Cell Significance Index: -10.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6415
    Cell Significance Index: -18.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6495
    Cell Significance Index: -16.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6826
    Cell Significance Index: -54.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6911
    Cell Significance Index: -71.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6960
    Cell Significance Index: -46.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8416
    Cell Significance Index: -5.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8450
    Cell Significance Index: -9.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0734
    Cell Significance Index: -65.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0803
    Cell Significance Index: -54.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1450
    Cell Significance Index: -50.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1818
    Cell Significance Index: -25.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.2888
    Cell Significance Index: -10.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2971
    Cell Significance Index: -34.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.2982
    Cell Significance Index: -11.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3398
    Cell Significance Index: -35.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3570
    Cell Significance Index: -39.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3601
    Cell Significance Index: -34.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3695
    Cell Significance Index: -20.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4110
    Cell Significance Index: -53.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4466
    Cell Significance Index: -24.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4906
    Cell Significance Index: -27.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5053
    Cell Significance Index: -29.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** YTHDF2 shares conserved structural and functional characteristics with other YTHDF family members, including: 1. **RNA-binding domain**: YTHDF2 possesses a characteristic RNA-binding domain, which enables it to interact with m6A-modified RNAs. 2. **N6-methyladenosine binding affinity**: YTHDF2 exhibits high affinity for m6A-modified RNAs, allowing it to regulate mRNA stability and translation. 3. **Diverse cellular expression**: YTHDF2 is expressed in a wide range of cell types, including hematopoietic stem cells, erythrocytes, and immune cells. 4. **Regulatory functions**: YTHDF2 is involved in various cellular processes, including mRNA stability, localization, translation, and stability. **Pathways and Functions** YTHDF2 participates in multiple signaling pathways and cellular processes, including: 1. **mRNA stability and localization**: YTHDF2 regulates mRNA stability and localization by binding to m6A-modified RNAs, influencing translation and protein synthesis. 2. **Hematopoiesis and immune response**: YTHDF2 is involved in the regulation of hematopoietic stem cell proliferation, differentiation, and immune response, highlighting its importance in hematopoiesis and immune system development. 3. **Cellular differentiation and development**: YTHDF2 regulates cellular differentiation and development by controlling the expression of key genes involved in these processes. 4. **Regulation of stress granules and P-bodies**: YTHDF2 interacts with stress granules and P-bodies, influencing mRNA stability and translation in response to cellular stress. **Clinical Significance** The dysregulation of YTHDF2 has been implicated in various diseases, including: 1. **Hematological disorders**: YTHDF2 expression and function may be disrupted in hematological disorders, such as leukemia and lymphoma. 2. **Immune system disorders**: Alterations in YTHDF2 expression and function have been linked to immune system disorders, including autoimmune diseases and immunodeficiency. 3. **Cancer development**: YTHDF2 may play a role in cancer development, as it influences cellular proliferation, differentiation, and survival. 4. **Neurological disorders**: YTHDF2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where m6A modification plays a critical role in disease progression. In conclusion, YTHDF2 is a critical component of the m6A RNA modification system, playing a pivotal role in regulating mRNA stability, localization, translation, and stability. Its dysregulation has been implicated in various diseases, highlighting the importance of YTHDF2 in maintaining cellular homeostasis and promoting healthy development.

Genular Protein ID: 2747210893

Symbol: YTHD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y5A9 A6NKG4 A8K966 B4E1G7 D3DPM8 Q5VSZ9 Q8TDH0 Q9BUJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22575960

Title: Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

PubMed ID: 22575960

DOI: 10.1038/nature11112

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24206186

Title: A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae.

PubMed ID: 24206186

DOI: 10.1042/bj20130862

PubMed ID: 24284625

Title: N-methyladenosine-dependent regulation of messenger RNA stability.

PubMed ID: 24284625

DOI: 10.1038/nature12730

PubMed ID: 26046440

Title: N(6)-methyladenosine modulates messenger RNA translation efficiency.

PubMed ID: 26046440

DOI: 10.1016/j.cell.2015.05.014

PubMed ID: 26318451

Title: structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins.

PubMed ID: 26318451

DOI: 10.1074/jbc.m115.680389

PubMed ID: 26458103

Title: Dynamic m(6)A mRNA methylation directs translational control of heat shock response.

PubMed ID: 26458103

DOI: 10.1038/nature15377

PubMed ID: 27558897

Title: YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.

PubMed ID: 27558897

DOI: 10.1038/ncomms12626

PubMed ID: 28106072

Title: YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.

PubMed ID: 28106072

DOI: 10.1038/cr.2017.15

PubMed ID: 30428350

Title: Circadian clock regulation of hepatic lipid metabolism by modulation of m6A mRNA methylation.

PubMed ID: 30428350

DOI: 10.1016/j.celrep.2018.10.068

PubMed ID: 30065315

Title: Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion.

PubMed ID: 30065315

DOI: 10.1038/s41422-018-0072-0

PubMed ID: 29109479

Title: Viral and cellular N6-methyladenosine and N6,2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.

PubMed ID: 29109479

DOI: 10.1038/s41564-017-0056-8

PubMed ID: 29447282

Title: Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.

PubMed ID: 29447282

DOI: 10.1371/journal.ppat.1006919

PubMed ID: 29659627

Title: N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection.

PubMed ID: 29659627

DOI: 10.1371/journal.ppat.1006995

PubMed ID: 31388144

Title: Multivalent m6A motifs promote phase separation of YTHDF proteins.

PubMed ID: 31388144

DOI: 10.1038/s41422-019-0210-3

PubMed ID: 30930054

Title: Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex.

PubMed ID: 30930054

DOI: 10.1016/j.molcel.2019.02.034

PubMed ID: 31292544

Title: m6A enhances the phase separation potential of mRNA.

PubMed ID: 31292544

DOI: 10.1038/s41586-019-1374-1

PubMed ID: 30559377

Title: m6A modification controls the innate immune response to infection by targeting type I interferons.

PubMed ID: 30559377

DOI: 10.1038/s41590-018-0275-z

PubMed ID: 31815440

Title: YTHDF2 binds to 5-methylcytosine in RNA and modulates the maturation of ribosomal RNA.

PubMed ID: 31815440

DOI: 10.1021/acs.analchem.9b04505

PubMed ID: 32492408

Title: A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA.

PubMed ID: 32492408

DOI: 10.1016/j.cell.2020.05.012

PubMed ID: 32451507

Title: m6A-binding YTHDF proteins promote stress granule formation.

PubMed ID: 32451507

DOI: 10.1038/s41589-020-0524-y

PubMed ID: 32267835

Title: YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.

PubMed ID: 32267835

DOI: 10.1371/journal.pbio.3000664

PubMed ID: 31642031

Title: Binding to m6A RNA promotes YTHDF2-mediated phase separation.

PubMed ID: 31642031

DOI: 10.1007/s13238-019-00660-2

PubMed ID: 32169943

Title: YTHDF2 destabilizes m6A-modified neural-specific RNAs to restrain differentiation in induced pluripotent stem cells.

PubMed ID: 32169943

DOI: 10.1261/rna.073502.119

PubMed ID: 25412658

Title: Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.

PubMed ID: 25412658

DOI: 10.1038/cr.2014.153

PubMed ID: 25412661

Title: Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine.

PubMed ID: 25412661

DOI: 10.1038/cr.2014.152

Sequence Information:

  • Length: 579
  • Mass: 62334
  • Checksum: BF3959B5561A464E
  • Sequence:
    • MSASSLLEQR PKGQGNKVQN GSVHQKDGLN DDDFEPYLSP QARPNNAYTA MSDSYLPSYY 
SPSIGFSYSL GEAAWSTGGD TAMPYLTSYG QLSNGEPHFL PDAMFGQPGA LGSTPFLGQH 
GFNFFPSGID FSAWGNNSSQ GQSTQSSGYS SNYAYAPSSL GGAMIDGQSA FANETLNKAP 
GMNTIDQGMA ALKLGSTEVA SNVPKVVGSA VGSGSITSNI VASNSLPPAT IAPPKPASWA 
DIASKPAKQQ PKLKTKNGIA GSSLPPPPIK HNMDIGTWDN KGPVAKAPSQ ALVQNIGQPT 
QGSPQPVGQQ ANNSPPVAQA SVGQQTQPLP PPPPQPAQLS VQQQAAQPTR WVAPRNRGSG 
FGHNGVDGNG VGQSQAGSGS TPSEPHPVLE KLRSINNYNP KDFDWNLKHG RVFIIKSYSE 
DDIHRSIKYN IWCSTEHGNK RLDAAYRSMN GKGPVYLLFS VNGSGHFCGV AEMKSAVDYN 
TCAGVWSQDK WKGRFDVRWI FVKDVPNSQL RHIRLENNEN KPVTNSRDTQ EVPLEKAKQV 
LKIIASYKHT TSIFDDFSHY EKRQEEEESV KKERQGRGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.