Details for: UBE2J1

Gene ID: 51465

Symbol: UBE2J1

Ensembl ID: ENSG00000198833

Description: ubiquitin conjugating enzyme E2 J1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 283.9367
    Cell Significance Index: -44.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 145.0856
    Cell Significance Index: -36.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 125.8898
    Cell Significance Index: -51.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 110.1273
    Cell Significance Index: -44.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 105.6505
    Cell Significance Index: -49.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.6603
    Cell Significance Index: -50.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 74.5728
    Cell Significance Index: -50.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.3007
    Cell Significance Index: -45.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.4888
    Cell Significance Index: -47.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.0819
    Cell Significance Index: -45.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2908
    Cell Significance Index: -48.5000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 12.1514
    Cell Significance Index: 28.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3778
    Cell Significance Index: -31.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2845
    Cell Significance Index: -20.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.9923
    Cell Significance Index: 470.8100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.4200
    Cell Significance Index: 17.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.3251
    Cell Significance Index: 378.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.9167
    Cell Significance Index: 51.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6666
    Cell Significance Index: 181.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5379
    Cell Significance Index: 99.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5241
    Cell Significance Index: 28.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3745
    Cell Significance Index: 36.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2652
    Cell Significance Index: 58.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8716
    Cell Significance Index: 786.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7963
    Cell Significance Index: 159.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7213
    Cell Significance Index: 71.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5914
    Cell Significance Index: 81.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5325
    Cell Significance Index: 68.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5312
    Cell Significance Index: 290.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5248
    Cell Significance Index: 11.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5172
    Cell Significance Index: 63.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4741
    Cell Significance Index: 94.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4667
    Cell Significance Index: 84.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4485
    Cell Significance Index: 31.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4432
    Cell Significance Index: 158.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4232
    Cell Significance Index: 31.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3653
    Cell Significance Index: 62.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3635
    Cell Significance Index: 10.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3618
    Cell Significance Index: 17.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3056
    Cell Significance Index: 13.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2602
    Cell Significance Index: 115.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1852
    Cell Significance Index: 23.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1828
    Cell Significance Index: 4.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1401
    Cell Significance Index: 26.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1258
    Cell Significance Index: 0.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0977
    Cell Significance Index: 67.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0913
    Cell Significance Index: 1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0281
    Cell Significance Index: 52.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0259
    Cell Significance Index: 1.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0251
    Cell Significance Index: 38.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0150
    Cell Significance Index: -9.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0154
    Cell Significance Index: -6.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0171
    Cell Significance Index: -31.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0188
    Cell Significance Index: -1.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0323
    Cell Significance Index: -23.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0356
    Cell Significance Index: -2.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0443
    Cell Significance Index: -2.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0509
    Cell Significance Index: -28.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0536
    Cell Significance Index: -3.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0738
    Cell Significance Index: -1.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0744
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1099
    Cell Significance Index: -23.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1157
    Cell Significance Index: -11.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1403
    Cell Significance Index: -40.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1498
    Cell Significance Index: -4.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1535
    Cell Significance Index: -17.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1709
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1723
    Cell Significance Index: -19.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1801
    Cell Significance Index: -4.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1864
    Cell Significance Index: -5.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1982
    Cell Significance Index: -28.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2000
    Cell Significance Index: -5.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2206
    Cell Significance Index: -25.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2249
    Cell Significance Index: -4.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2374
    Cell Significance Index: -15.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2536
    Cell Significance Index: -8.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2699
    Cell Significance Index: -5.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2804
    Cell Significance Index: -14.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3002
    Cell Significance Index: -13.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3163
    Cell Significance Index: -8.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3588
    Cell Significance Index: -9.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3793
    Cell Significance Index: -13.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3956
    Cell Significance Index: -14.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4305
    Cell Significance Index: -44.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4397
    Cell Significance Index: -27.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4645
    Cell Significance Index: -11.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4934
    Cell Significance Index: -9.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5199
    Cell Significance Index: -8.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5333
    Cell Significance Index: -12.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5479
    Cell Significance Index: -43.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6207
    Cell Significance Index: -38.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6306
    Cell Significance Index: -16.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6720
    Cell Significance Index: -11.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7725
    Cell Significance Index: -11.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7758
    Cell Significance Index: -11.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8019
    Cell Significance Index: -9.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBE2J1 is a member of the ubiquitin-conjugating enzyme family (E2s), which plays a pivotal role in the ubiquitination process. This process involves the attachment of ubiquitin proteins to target proteins, marking them for degradation by the proteasome or other cellular pathways. UBE2J1 is specifically involved in the regulation of protein degradation and the processing of antigens for presentation to the immune system. **Pathways and Functions:** UBE2J1 is involved in several key pathways, including: 1. **Adaptive Immune System:** UBE2J1 is essential for the proper functioning of the adaptive immune system, particularly in the processing and presentation of antigens to T-cells. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** UBE2J1 is involved in the ubiquitination of antigens, marking them for degradation by the proteasome. 3. **Erad Pathway:** UBE2J1 is also involved in the ERAD (Endoplasmic Reticulum-Associated Degradation) pathway, which is responsible for the degradation of misfolded or damaged proteins in the endoplasmic reticulum. 4. **Regulation of Macrophage Cytokine Production:** UBE2J1 has been shown to regulate the production of cytokines in macrophages, which is crucial for the modulation of the immune response. 5. **Regulation of Tumor Necrosis Factor Production:** UBE2J1 is also involved in the regulation of tumor necrosis factor production, which is essential for the control of inflammatory responses. **Significantly Expressed Cells:** UBE2J1 is expressed in a variety of cell types, including: 1. **Polychromatophilic Erythroblast:** UBE2J1 is expressed in erythroblasts, which are precursor cells to red blood cells. 2. **Hematopoietic Oligopotent Progenitor Cell:** UBE2J1 is expressed in hematopoietic stem cells, which have the ability to differentiate into multiple blood cell types. 3. **Mucosal Type Mast Cell:** UBE2J1 is expressed in mast cells, which play a crucial role in the regulation of the immune response. 4. **Spermatid Development:** UBE2J1 is involved in the regulation of spermatogenesis, which is the process by which sperm cells are produced. **Clinical Significance:** UBE2J1 has been implicated in various diseases, including: 1. **Immunodeficiency Disorders:** UBE2J1 mutations have been associated with immunodeficiency disorders, such as the X-linked immunodeficiency disorder, which is characterized by impaired T-cell function. 2. **Cancer:** UBE2J1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, where it may contribute to tumorigenesis. 3. **Autoimmune Diseases:** UBE2J1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to the regulation of immune responses. In conclusion, UBE2J1 is a crucial gene involved in various cellular processes, including immune regulation and protein degradation. Its expression patterns and clinical significance highlight its importance in maintaining immune homeostasis and preventing disease. Further research is necessary to fully elucidate the role of UBE2J1 in human health and disease.

Genular Protein ID: 4190343464

Symbol: UB2J1_HUMAN

Name: Ubiquitin-conjugating enzyme E2 J1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10708578

Title: Identification of a family of non-canonical ubiquitin-conjugating enzymes structurally related to yeast UBC6.

PubMed ID: 10708578

DOI: 10.1006/bbrc.2000.2302

PubMed ID: 12082160

Title: A role for mammalian Ubc6 homologues in ER-associated protein degradation.

PubMed ID: 12082160

DOI: 10.1242/jcs.115.14.3007

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22607976

Title: STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

PubMed ID: 22607976

DOI: 10.1016/j.molcel.2012.04.015

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24020373

Title: Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFalpha production.

PubMed ID: 24020373

DOI: 10.1042/bj20130755

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28827405

Title: Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD).

PubMed ID: 28827405

DOI: 10.1242/jcs.206847

PubMed ID: 28321712

Title: The role of ubiquitin-conjugating enzyme Ube2j1 phosphorylation and its degradation by proteasome during endoplasmic stress recovery.

PubMed ID: 28321712

DOI: 10.1007/s12079-017-0386-6

PubMed ID: 30157886

Title: Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.

PubMed ID: 30157886

DOI: 10.1186/s12985-018-1040-5

PubMed ID: 33472082

Title: The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway.

PubMed ID: 33472082

DOI: 10.1016/j.celrep.2020.108659

PubMed ID: 35831855

Title: The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.

PubMed ID: 35831855

DOI: 10.1186/s12915-022-01368-2

Sequence Information:

  • Length: 318
  • Mass: 35199
  • Checksum: CFF5FE00C2BBD39E
  • Sequence:
  • METRYNLKSP AVKRLMKEAA ELKDPTDHYH AQPLEDNLFE WHFTVRGPPD SDFDGGVYHG 
    RIVLPPEYPM KPPSIILLTA NGRFEVGKKI CLSISGHHPE TWQPSWSIRT ALLAIIGFMP 
    TKGEGAIGSL DYTPEERRAL AKKSQDFCCE GCGSAMKDVL LPLKSGSDSS QADQEAKELA 
    RQISFKAEVN SSGKTISESD LNHSFSLTDL QDDIPTTFQG ATASTSYGLQ NSSAASFHQP 
    TQPVAKNTSM SPRQRRAQQQ SQRRLSTSPD VIQGHQPRDN HTDHGGSAVL IVILTLALAA 
    LIFRRIYLAN EYIFDFEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.