Details for: NOP16

Gene ID: 51491

Symbol: NOP16

Ensembl ID: ENSG00000048162

Description: NOP16 nucleolar protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.3058
    Cell Significance Index: -13.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.2818
    Cell Significance Index: -12.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 43.3065
    Cell Significance Index: -17.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.6854
    Cell Significance Index: -17.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 25.9306
    Cell Significance Index: -17.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2527
    Cell Significance Index: -16.3400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 7.3974
    Cell Significance Index: 22.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2112
    Cell Significance Index: -13.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4247
    Cell Significance Index: -17.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6432
    Cell Significance Index: -11.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.6219
    Cell Significance Index: 259.3700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.1037
    Cell Significance Index: 37.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5077
    Cell Significance Index: 245.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4240
    Cell Significance Index: 85.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1635
    Cell Significance Index: 82.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0709
    Cell Significance Index: 138.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0471
    Cell Significance Index: 47.4600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.0192
    Cell Significance Index: 7.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9890
    Cell Significance Index: 26.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9502
    Cell Significance Index: 70.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8641
    Cell Significance Index: 24.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7460
    Cell Significance Index: 673.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6569
    Cell Significance Index: 76.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6457
    Cell Significance Index: 7.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6295
    Cell Significance Index: 278.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5657
    Cell Significance Index: 39.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5459
    Cell Significance Index: 28.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4832
    Cell Significance Index: 66.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4739
    Cell Significance Index: 13.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4532
    Cell Significance Index: 21.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4433
    Cell Significance Index: 52.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4236
    Cell Significance Index: 5.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4021
    Cell Significance Index: 11.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3689
    Cell Significance Index: 9.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3598
    Cell Significance Index: 196.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3589
    Cell Significance Index: 9.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3541
    Cell Significance Index: 63.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3479
    Cell Significance Index: 42.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3437
    Cell Significance Index: 5.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3182
    Cell Significance Index: 8.1800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2884
    Cell Significance Index: 1.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2566
    Cell Significance Index: 7.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2380
    Cell Significance Index: 45.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2367
    Cell Significance Index: 7.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2052
    Cell Significance Index: 5.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1883
    Cell Significance Index: 12.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1843
    Cell Significance Index: 4.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1810
    Cell Significance Index: 3.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1734
    Cell Significance Index: 1.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1483
    Cell Significance Index: 29.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1439
    Cell Significance Index: 5.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1390
    Cell Significance Index: 1.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1317
    Cell Significance Index: 6.1400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1036
    Cell Significance Index: 0.8700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0996
    Cell Significance Index: 1.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0892
    Cell Significance Index: 1.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0743
    Cell Significance Index: 1.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0606
    Cell Significance Index: 1.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0519
    Cell Significance Index: 10.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0502
    Cell Significance Index: 6.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0472
    Cell Significance Index: 1.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0459
    Cell Significance Index: 0.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0328
    Cell Significance Index: 24.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0061
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0029
    Cell Significance Index: 2.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0069
    Cell Significance Index: -0.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0078
    Cell Significance Index: -2.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0099
    Cell Significance Index: -18.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0108
    Cell Significance Index: -1.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0150
    Cell Significance Index: -20.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0153
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0245
    Cell Significance Index: -15.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0277
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0278
    Cell Significance Index: -15.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0289
    Cell Significance Index: -18.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0387
    Cell Significance Index: -17.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0464
    Cell Significance Index: -13.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0563
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0599
    Cell Significance Index: -6.8600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0764
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0942
    Cell Significance Index: -19.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1078
    Cell Significance Index: -8.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1089
    Cell Significance Index: -15.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1601
    Cell Significance Index: -10.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1693
    Cell Significance Index: -17.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1706
    Cell Significance Index: -2.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1915
    Cell Significance Index: -15.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2053
    Cell Significance Index: -10.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2071
    Cell Significance Index: -12.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2111
    Cell Significance Index: -2.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2112
    Cell Significance Index: -12.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2199
    Cell Significance Index: -12.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2231
    Cell Significance Index: -15.0000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2751
    Cell Significance Index: -1.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3464
    Cell Significance Index: -15.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3487
    Cell Significance Index: -12.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NOP16 is a nucleolar protein that plays a pivotal role in ribosomal biogenesis and RNA binding. Its structural characteristics, including a conserved domain, enable it to interact with ribosomal components and facilitate the assembly of ribosomal large subunits. The protein's ability to bind RNA is also noteworthy, as it may influence RNA processing, translation, and stability. **Pathways and Functions:** NOP16 is involved in several cellular pathways, including: 1. **Ribosomal large subunit biogenesis**: NOP16 is essential for the assembly and maturation of ribosomal large subunits, which are crucial for protein synthesis. 2. **RNA binding**: NOP16's RNA-binding capabilities may regulate RNA processing, translation, and stability, affecting gene expression and cellular function. 3. **Cell proliferation and differentiation**: The NOP16 gene is expressed in hematopoietic cells and stem cells, suggesting its involvement in cell proliferation, differentiation, and survival. 4. **Immune system development**: The expression of NOP16 in immune cells, such as CD8-alpha-beta-positive T cells and regulatory T cells, implies its role in immune system development and function. **Clinical Significance:** The NOP16 gene's involvement in cellular processes and immune system development makes it a potential target for therapeutic interventions in various diseases, including: 1. **Immunodeficiency disorders**: NOP16's role in immune cell development and function may be exploited to develop novel therapeutic strategies for immunodeficiency disorders. 2. **Cancer**: The expression of NOP16 in cancer cells, including hematopoietic malignancies, suggests its potential as a biomarker or therapeutic target. 3. **Neurological disorders**: NOP16's involvement in RNA binding and processing may also be relevant to neurological disorders, such as neurodegenerative diseases. In conclusion, the NOP16 gene is a complex protein with multiple functions, including ribosomal biogenesis, RNA binding, and immune system development. Further research is necessary to fully elucidate its role in cellular processes and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 2137614076

Symbol: NOP16_HUMAN

Name: Nucleolar protein 16

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 178
  • Mass: 21188
  • Checksum: D9139BE32DA81FC5
  • Sequence:
  • MPKAKGKTRR QKFGYSVNRK RLNRNARRKA APRIECSHIR HAWDHAKSVR QNLAEMGLAV 
    DPNRAVPLRK RKVKAMEVDI EERPKELVRK PYVLNDLEAE ASLPEKKGNT LSRDLIDYVR 
    YMVENHGEDY KAMARDEKNY YQDTPKQIRS KINVYKRFYP AEWQDFLDSL QKRKMEVE

Genular Protein ID: 150700809

Symbol: A0A0C4DGU5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 231
  • Mass: 26433
  • Checksum: 4FF96D43F7C80EE4
  • Sequence:
  • MPKAKGKTRR QKFGYSVNRK RLNRNARRKA APRIECSHIR HAWDHAKSVR QNLAEMGLAV 
    DPNRAVPLRK RKVKAMEVDI EERPKELVRK PYVLNDLEAE ASLPEKKGNT LSRDLIDYVR 
    YMVENHGEDY KSGKTSSILC RRGRWRWSDW FTSQLPQAEA SPGPVKLEPG CKARRCCVAP 
    EELARSHGIR RLHTHVHTPR SGEGTVLRGS NLYSSGGSRK SQNLLFSGWV M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.