Details for: NELFCD

Gene ID: 51497

Symbol: NELFCD

Ensembl ID: ENSG00000101158

Description: negative elongation factor complex member C/D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 187.2124
    Cell Significance Index: -29.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.2369
    Cell Significance Index: -29.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 98.4591
    Cell Significance Index: -40.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.7084
    Cell Significance Index: -37.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.0356
    Cell Significance Index: -30.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.4032
    Cell Significance Index: -35.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.5847
    Cell Significance Index: -31.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.9467
    Cell Significance Index: -35.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1797
    Cell Significance Index: -27.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4246
    Cell Significance Index: -37.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4167
    Cell Significance Index: -22.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0365
    Cell Significance Index: -15.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6539
    Cell Significance Index: 99.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5199
    Cell Significance Index: 165.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3657
    Cell Significance Index: 271.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3618
    Cell Significance Index: 18.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3495
    Cell Significance Index: 10.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3053
    Cell Significance Index: 14.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2656
    Cell Significance Index: 26.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1031
    Cell Significance Index: 179.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0882
    Cell Significance Index: 29.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0679
    Cell Significance Index: 37.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8830
    Cell Significance Index: 87.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8581
    Cell Significance Index: 23.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8147
    Cell Significance Index: 111.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7979
    Cell Significance Index: 720.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7806
    Cell Significance Index: 40.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7742
    Cell Significance Index: 49.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7320
    Cell Significance Index: 34.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7179
    Cell Significance Index: 37.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7138
    Cell Significance Index: 128.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7082
    Cell Significance Index: 18.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6595
    Cell Significance Index: 132.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6489
    Cell Significance Index: 79.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6208
    Cell Significance Index: 46.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5926
    Cell Significance Index: 76.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5677
    Cell Significance Index: 66.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5528
    Cell Significance Index: 301.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4740
    Cell Significance Index: 22.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4666
    Cell Significance Index: 12.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4411
    Cell Significance Index: 11.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4407
    Cell Significance Index: 56.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4315
    Cell Significance Index: 29.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4232
    Cell Significance Index: 26.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3719
    Cell Significance Index: 257.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3604
    Cell Significance Index: 10.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3561
    Cell Significance Index: 157.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3352
    Cell Significance Index: 120.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3266
    Cell Significance Index: 14.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3068
    Cell Significance Index: 2.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2908
    Cell Significance Index: 20.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2797
    Cell Significance Index: 53.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2569
    Cell Significance Index: 13.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1906
    Cell Significance Index: 11.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1401
    Cell Significance Index: 1.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1191
    Cell Significance Index: 1.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0670
    Cell Significance Index: 2.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0668
    Cell Significance Index: 3.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0507
    Cell Significance Index: 3.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0417
    Cell Significance Index: 64.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0339
    Cell Significance Index: 62.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0178
    Cell Significance Index: 33.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0075
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0047
    Cell Significance Index: 6.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0027
    Cell Significance Index: 0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0209
    Cell Significance Index: -15.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0215
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0331
    Cell Significance Index: -24.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0361
    Cell Significance Index: -16.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0412
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0493
    Cell Significance Index: -8.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0517
    Cell Significance Index: -5.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0634
    Cell Significance Index: -35.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0636
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0669
    Cell Significance Index: -41.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0691
    Cell Significance Index: -10.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1027
    Cell Significance Index: -29.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1033
    Cell Significance Index: -12.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1608
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1650
    Cell Significance Index: -18.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1922
    Cell Significance Index: -40.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2004
    Cell Significance Index: -5.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2107
    Cell Significance Index: -14.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2288
    Cell Significance Index: -2.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2575
    Cell Significance Index: -7.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3262
    Cell Significance Index: -33.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3591
    Cell Significance Index: -28.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4523
    Cell Significance Index: -10.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4843
    Cell Significance Index: -21.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5252
    Cell Significance Index: -15.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5400
    Cell Significance Index: -12.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5875
    Cell Significance Index: -36.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6153
    Cell Significance Index: -15.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6195
    Cell Significance Index: -23.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6633
    Cell Significance Index: -17.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7746
    Cell Significance Index: -8.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7815
    Cell Significance Index: -28.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7832
    Cell Significance Index: -17.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7884
    Cell Significance Index: -25.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** NELFCD is expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, embryonic stem cells, smooth muscle fibers of the ileum, mucosal type mast cells, peripheral blood mononuclear cells, ciliated cells of the bronchus, and orthochromatic erythroblasts. 2. **Protein Structure:** NELFCD is a component of the negative elongation factor complex (NEF-C), which is composed of multiple subunits, including NELFCD, NELF1, NELF2, and NELF3. 3. **Function:** NELFCD is involved in the regulation of transcription elongation by RNA polymerase II, particularly in the absence of the Tat protein. **Pathways and Functions:** 1. **HIV Transcription:** NELFCD plays a crucial role in the regulation of HIV transcription, particularly in the absence of the Tat protein. The NELFCD protein binds to the HIV long terminal repeat (LTR) and regulates the recruitment of RNA polymerase II to the transcription start site. 2. **Transcription Elongation:** NELFCD is involved in the regulation of transcription elongation by RNA polymerase II, particularly in the absence of the Tat protein. The NELFCD protein binds to the transcription elongation factor, promoting the recruitment of RNA polymerase II to the transcription start site. 3. **Tat-Mediated Transcription:** In the presence of the Tat protein, NELFCD is involved in the regulation of Tat-mediated transcription. The NELFCD protein binds to the Tat protein and regulates the recruitment of RNA polymerase II to the transcription start site. **Clinical Significance:** 1. **HIV Infection:** NELFCD has been implicated in the regulation of HIV transcription, particularly in the absence of the Tat protein. The NELFCD protein may play a crucial role in the development of HIV-induced immune suppression. 2. **Immunodeficiency:** NELFCD may play a role in the development of immunodeficiency diseases, such as HIV-associated immunodeficiency, by regulating the expression of genes involved in immune function. 3. **Cancer:** NELFCD may play a role in the development of cancer, particularly in the absence of the Tat protein. The NELFCD protein may regulate the expression of genes involved in cell growth and proliferation. In conclusion, NELFCD plays a crucial role in the regulation of HIV transcription, particularly in the absence of the Tat protein. Further studies are needed to fully understand the role of NELFCD in HIV infection and its clinical significance in immunodeficiency diseases and cancer.

Genular Protein ID: 3083677250

Symbol: NELFD_HUMAN

Name: Negative elongation factor C/D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11030415

Title: Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13.

PubMed ID: 11030415

DOI: 10.1007/s004390000344

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12612062

Title: Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.

PubMed ID: 12612062

DOI: 10.1128/mcb.23.6.1863-1873.2003

PubMed ID: 11952167

Title: Identification of TH1 as an interaction partner of A-Raf kinase.

PubMed ID: 11952167

DOI: 10.1023/a:1014437024129

PubMed ID: 10199401

Title: NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

PubMed ID: 10199401

DOI: 10.1016/s0092-8674(00)80713-8

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23884411

Title: Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.

PubMed ID: 23884411

DOI: 10.1074/jbc.m113.496489

PubMed ID: 27282391

Title: Architecture and RNA binding of the human negative elongation factor.

PubMed ID: 27282391

DOI: 10.7554/elife.14981

Sequence Information:

  • Length: 590
  • Mass: 66247
  • Checksum: 425437DC46DAF953
  • Sequence:
  • MAGAVPGAIM DEDYYGSAAE WGDEADGGQQ EDDSGEGEDD AEVQQECLHK FSTRDYIMEP 
    SIFNTLKRYF QAGGSPENVI QLLSENYTAV AQTVNLLAEW LIQTGVEPVQ VQETVENHLK 
    SLLIKHFDPR KADSIFTEEG ETPAWLEQMI AHTTWRDLFY KLAEAHPDCL MLNFTVKLIS 
    DAGYQGEITS VSTACQQLEV FSRVLRTSLA TILDGGEENL EKNLPEFAKM VCHGEHTYLF 
    AQAMMSVLAQ EEQGGSAVRR IAQEVQRFAQ EKGHDASQIT LALGTAASYP RACQALGAML 
    SKGALNPADI TVLFKMFTSM DPPPVELIRV PAFLDLFMQS LFKPGARINQ DHKHKYIHIL 
    AYAASVVETW KKNKRVSINK DELKSTSKAV ETVHNLCCNE NKGASELVAE LSTLYQCIRF 
    PVVAMGVLKW VDWTVSEPRY FQLQTDHTPV HLALLDEIST CHQLLHPQVL QLLVKLFETE 
    HSQLDVMEQL ELKKTLLDRM VHLLSRGYVL PVVSYIRKCL EKLDTDISLI RYFVTEVLDV 
    IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFIMVN

Genular Protein ID: 1918401876

Symbol: H0UI80_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 599
  • Mass: 67347
  • Checksum: A263C8E6262ABFBB
  • Sequence:
  • MRRARSREGM AGAVPGAIMD EDYYGSAAEW GDEADGGQQE DDSGEGEDDA EVQQECLHKF 
    STRDYIMEPS IFNTLKRYFQ AGGSPENVIQ LLSENYTAVA QTVNLLAEWL IQTGVEPVQV 
    QETVENHLKS LLIKHFDPRK ADSIFTEEGE TPAWLEQMIA HTTWRDLFYK LAEAHPDCLM 
    LNFTVKLISD AGYQGEITSV STACQQLEVF SRVLRTSLAT ILDGGEENLE KNLPEFAKMV 
    CHGEHTYLFA QAMMSVLAQE EQGGSAVRRI AQEVQRFAQE KGHDASQITL ALGTAASYPR 
    ACQALGAMLS KGALNPADIT VLFKMFTSMD PPPVELIRVP AFLDLFMQSL FKPGARINQD 
    HKHKYIHILA YAASVVETWK KNKRVSINKD ELKSTSKAVE TVHNLCCNEN KGASELVAEL 
    STLYQCIRFP VVAMGVLKWV DWTVSEPRYF QLQTDHTPVH LALLDEISTC HQLLHPQVLQ 
    LLVKLFETEH SQLDVMEQLE LKKTLLDRMV HLLSRGYVLP VVSYIRKCLE KLDTDISLIR 
    YFVTEVLDVI APPYTSDFVQ LFLPILENDS IAGTIKTEGE HDPVTEFIAH CKSNFIMVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.