Details for: NELFCD
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 187.2124
Cell Significance Index: -29.1200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 118.2369
Cell Significance Index: -29.9900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 98.4591
Cell Significance Index: -40.5600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 78.7084
Cell Significance Index: -37.1600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 76.0356
Cell Significance Index: -30.8900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 69.4032
Cell Significance Index: -35.7000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 32.5847
Cell Significance Index: -31.1100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 28.9467
Cell Significance Index: -35.6900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.1797
Cell Significance Index: -27.2700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.4246
Cell Significance Index: -37.1900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.4167
Cell Significance Index: -22.7800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.0365
Cell Significance Index: -15.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.6539
Cell Significance Index: 99.2900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5199
Cell Significance Index: 165.3200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3657
Cell Significance Index: 271.0200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3618
Cell Significance Index: 18.5800 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.3495
Cell Significance Index: 10.7800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.3053
Cell Significance Index: 14.1900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.2656
Cell Significance Index: 26.4900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1031
Cell Significance Index: 179.4100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.0882
Cell Significance Index: 29.6200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.0679
Cell Significance Index: 37.1100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8830
Cell Significance Index: 87.3500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.8581
Cell Significance Index: 23.9800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8147
Cell Significance Index: 111.8800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7979
Cell Significance Index: 720.4800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7806
Cell Significance Index: 40.5500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7742
Cell Significance Index: 49.9500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7320
Cell Significance Index: 34.4100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.7179
Cell Significance Index: 37.6900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7138
Cell Significance Index: 128.6800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7082
Cell Significance Index: 18.9100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6595
Cell Significance Index: 132.2900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6489
Cell Significance Index: 79.7900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6208
Cell Significance Index: 46.2700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.5926
Cell Significance Index: 76.5600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5677
Cell Significance Index: 66.9500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5528
Cell Significance Index: 301.8900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4740
Cell Significance Index: 22.1000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4666
Cell Significance Index: 12.4800 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4411
Cell Significance Index: 11.6000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4407
Cell Significance Index: 56.4900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4315
Cell Significance Index: 29.8400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4232
Cell Significance Index: 26.6700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3719
Cell Significance Index: 257.2300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3604
Cell Significance Index: 10.3900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3561
Cell Significance Index: 157.4200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3352
Cell Significance Index: 120.2400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3266
Cell Significance Index: 14.8100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3068
Cell Significance Index: 2.8300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2908
Cell Significance Index: 20.5700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2797
Cell Significance Index: 53.2200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2569
Cell Significance Index: 13.3800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1906
Cell Significance Index: 11.7200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1401
Cell Significance Index: 1.6700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.1191
Cell Significance Index: 1.0000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0670
Cell Significance Index: 2.3600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0668
Cell Significance Index: 3.7500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0507
Cell Significance Index: 3.8900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0417
Cell Significance Index: 64.1400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0339
Cell Significance Index: 62.4500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0178
Cell Significance Index: 33.4400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0075
Cell Significance Index: 0.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0047
Cell Significance Index: 6.4000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0027
Cell Significance Index: 0.0500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0020
Cell Significance Index: -1.4600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0209
Cell Significance Index: -15.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0215
Cell Significance Index: -13.6500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0331
Cell Significance Index: -24.5300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0361
Cell Significance Index: -16.3800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0412
Cell Significance Index: -1.2100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0493
Cell Significance Index: -8.4200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0517
Cell Significance Index: -5.2800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0634
Cell Significance Index: -35.7700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0636
Cell Significance Index: -1.0900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0669
Cell Significance Index: -41.8000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0691
Cell Significance Index: -10.0400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1027
Cell Significance Index: -29.5600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1033
Cell Significance Index: -12.0400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1608
Cell Significance Index: -5.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1650
Cell Significance Index: -18.9000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1922
Cell Significance Index: -40.4800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2004
Cell Significance Index: -5.1200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2107
Cell Significance Index: -14.1700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2288
Cell Significance Index: -2.9300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2575
Cell Significance Index: -7.3800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3262
Cell Significance Index: -33.9600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3591
Cell Significance Index: -28.4400 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4523
Cell Significance Index: -10.4500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4843
Cell Significance Index: -21.4200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5252
Cell Significance Index: -15.4700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5400
Cell Significance Index: -12.9500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5875
Cell Significance Index: -36.0200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6153
Cell Significance Index: -15.3800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6195
Cell Significance Index: -23.4600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6633
Cell Significance Index: -17.0500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.7746
Cell Significance Index: -8.8000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7815
Cell Significance Index: -28.6900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7832
Cell Significance Index: -17.1500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7884
Cell Significance Index: -25.1100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3083677250
Symbol: NELFD_HUMAN
Name: Negative elongation factor C/D
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11030415
Title: Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13.
PubMed ID: 11030415
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12612062
Title: Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
PubMed ID: 12612062
PubMed ID: 11952167
Title: Identification of TH1 as an interaction partner of A-Raf kinase.
PubMed ID: 11952167
PubMed ID: 10199401
Title: NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.
PubMed ID: 10199401
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23884411
Title: Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.
PubMed ID: 23884411
PubMed ID: 27282391
Title: Architecture and RNA binding of the human negative elongation factor.
PubMed ID: 27282391
DOI: 10.7554/elife.14981
Sequence Information:
- Length: 590
- Mass: 66247
- Checksum: 425437DC46DAF953
- Sequence:
MAGAVPGAIM DEDYYGSAAE WGDEADGGQQ EDDSGEGEDD AEVQQECLHK FSTRDYIMEP SIFNTLKRYF QAGGSPENVI QLLSENYTAV AQTVNLLAEW LIQTGVEPVQ VQETVENHLK SLLIKHFDPR KADSIFTEEG ETPAWLEQMI AHTTWRDLFY KLAEAHPDCL MLNFTVKLIS DAGYQGEITS VSTACQQLEV FSRVLRTSLA TILDGGEENL EKNLPEFAKM VCHGEHTYLF AQAMMSVLAQ EEQGGSAVRR IAQEVQRFAQ EKGHDASQIT LALGTAASYP RACQALGAML SKGALNPADI TVLFKMFTSM DPPPVELIRV PAFLDLFMQS LFKPGARINQ DHKHKYIHIL AYAASVVETW KKNKRVSINK DELKSTSKAV ETVHNLCCNE NKGASELVAE LSTLYQCIRF PVVAMGVLKW VDWTVSEPRY FQLQTDHTPV HLALLDEIST CHQLLHPQVL QLLVKLFETE HSQLDVMEQL ELKKTLLDRM VHLLSRGYVL PVVSYIRKCL EKLDTDISLI RYFVTEVLDV IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFIMVN
Genular Protein ID: 1918401876
Symbol: H0UI80_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 599
- Mass: 67347
- Checksum: A263C8E6262ABFBB
- Sequence:
MRRARSREGM AGAVPGAIMD EDYYGSAAEW GDEADGGQQE DDSGEGEDDA EVQQECLHKF STRDYIMEPS IFNTLKRYFQ AGGSPENVIQ LLSENYTAVA QTVNLLAEWL IQTGVEPVQV QETVENHLKS LLIKHFDPRK ADSIFTEEGE TPAWLEQMIA HTTWRDLFYK LAEAHPDCLM LNFTVKLISD AGYQGEITSV STACQQLEVF SRVLRTSLAT ILDGGEENLE KNLPEFAKMV CHGEHTYLFA QAMMSVLAQE EQGGSAVRRI AQEVQRFAQE KGHDASQITL ALGTAASYPR ACQALGAMLS KGALNPADIT VLFKMFTSMD PPPVELIRVP AFLDLFMQSL FKPGARINQD HKHKYIHILA YAASVVETWK KNKRVSINKD ELKSTSKAVE TVHNLCCNEN KGASELVAEL STLYQCIRFP VVAMGVLKWV DWTVSEPRYF QLQTDHTPVH LALLDEISTC HQLLHPQVLQ LLVKLFETEH SQLDVMEQLE LKKTLLDRMV HLLSRGYVLP VVSYIRKCLE KLDTDISLIR YFVTEVLDVI APPYTSDFVQ LFLPILENDS IAGTIKTEGE HDPVTEFIAH CKSNFIMVN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.