Details for: CHMP5

Gene ID: 51510

Symbol: CHMP5

Ensembl ID: ENSG00000086065

Description: charged multivesicular body protein 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 368.2852
    Cell Significance Index: -57.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 214.9080
    Cell Significance Index: -54.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 165.2152
    Cell Significance Index: -68.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 132.8045
    Cell Significance Index: -62.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.1269
    Cell Significance Index: -52.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.2164
    Cell Significance Index: -59.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 93.6184
    Cell Significance Index: -62.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.9941
    Cell Significance Index: -53.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.0829
    Cell Significance Index: -61.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.7161
    Cell Significance Index: -44.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.3708
    Cell Significance Index: -64.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.0922
    Cell Significance Index: -46.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3478
    Cell Significance Index: -18.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.6658
    Cell Significance Index: 160.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2240
    Cell Significance Index: 20.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1530
    Cell Significance Index: 1175.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0577
    Cell Significance Index: 56.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8195
    Cell Significance Index: 328.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8084
    Cell Significance Index: 93.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7181
    Cell Significance Index: 211.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5342
    Cell Significance Index: 196.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4786
    Cell Significance Index: 30.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4763
    Cell Significance Index: 202.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3679
    Cell Significance Index: 35.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3669
    Cell Significance Index: 71.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3628
    Cell Significance Index: 71.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2753
    Cell Significance Index: 95.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2036
    Cell Significance Index: 56.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1915
    Cell Significance Index: 21.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1334
    Cell Significance Index: 39.3900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1047
    Cell Significance Index: 8.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9644
    Cell Significance Index: 27.6500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9177
    Cell Significance Index: 9.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8918
    Cell Significance Index: 394.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7721
    Cell Significance Index: 48.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7508
    Cell Significance Index: 35.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7104
    Cell Significance Index: 8.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6652
    Cell Significance Index: 133.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5985
    Cell Significance Index: 15.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4687
    Cell Significance Index: 30.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4669
    Cell Significance Index: 33.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3917
    Cell Significance Index: 9.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3885
    Cell Significance Index: 11.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3672
    Cell Significance Index: 36.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3415
    Cell Significance Index: 44.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3279
    Cell Significance Index: 38.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3030
    Cell Significance Index: 1.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2708
    Cell Significance Index: 44.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2592
    Cell Significance Index: 51.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2218
    Cell Significance Index: 42.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2021
    Cell Significance Index: 72.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1913
    Cell Significance Index: 11.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1657
    Cell Significance Index: 28.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0322
    Cell Significance Index: 23.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0131
    Cell Significance Index: 9.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0108
    Cell Significance Index: -0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0124
    Cell Significance Index: -23.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0328
    Cell Significance Index: -20.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0365
    Cell Significance Index: -67.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0372
    Cell Significance Index: -3.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0379
    Cell Significance Index: -0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0430
    Cell Significance Index: -66.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0570
    Cell Significance Index: -77.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0595
    Cell Significance Index: -37.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0742
    Cell Significance Index: -41.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1113
    Cell Significance Index: -1.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1161
    Cell Significance Index: -52.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1255
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1308
    Cell Significance Index: -14.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1401
    Cell Significance Index: -29.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1743
    Cell Significance Index: -19.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1765
    Cell Significance Index: -50.7700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2303
    Cell Significance Index: -1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2718
    Cell Significance Index: -9.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2773
    Cell Significance Index: -7.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3335
    Cell Significance Index: -48.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3734
    Cell Significance Index: -43.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3953
    Cell Significance Index: -31.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4039
    Cell Significance Index: -2.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4470
    Cell Significance Index: -11.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4559
    Cell Significance Index: -6.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5729
    Cell Significance Index: -18.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5956
    Cell Significance Index: -27.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5994
    Cell Significance Index: -40.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6213
    Cell Significance Index: -64.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6347
    Cell Significance Index: -13.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6927
    Cell Significance Index: -38.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7090
    Cell Significance Index: -54.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7123
    Cell Significance Index: -20.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8421
    Cell Significance Index: -22.5300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9737
    Cell Significance Index: -6.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0145
    Cell Significance Index: -62.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0619
    Cell Significance Index: -8.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0871
    Cell Significance Index: -18.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0944
    Cell Significance Index: -14.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1644
    Cell Significance Index: -13.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2021
    Cell Significance Index: -53.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CHMP5 is a member of the ESCRT complex, which is responsible for the sorting and degradation of ubiquitinated proteins. The ESCRT machinery is composed of multiple subunits, including CHMP5, CHMP2, CHMP3, and CHMP4, which work together to form a complex that mediates the fission of multivesicular bodies (MVBs) and the degradation of proteins. CHMP5 has been shown to interact with various proteins, including ubiquitin ligases, ubiquitin receptors, and other ESCRT components, to regulate protein degradation and trafficking. **Pathways and Functions** CHMP5 is involved in various cellular processes, including: 1. **Autophagy**: CHMP5 plays a crucial role in the regulation of autophagy, a process by which cells degrade and recycle damaged or dysfunctional proteins and organelles. 2. **Viral Budding**: CHMP5 is essential for the budding of viruses, including HIV, from the plasma membrane. 3. **Protein Trafficking**: CHMP5 regulates the sorting and degradation of proteins in the endosomal system, including the recycling of receptors and the clearance of misfolded proteins. 4. **Endosomal Sorting**: CHMP5 mediates the sorting of proteins into MVBs, which are then degraded by lysosomes. **Clinical Significance** Dysregulation of CHMP5 has been implicated in various diseases, including: 1. **Infectious Diseases**: CHMP5 has been shown to play a critical role in the regulation of HIV budding and replication, making it a potential target for antiviral therapy. 2. **Cancer**: CHMP5 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been implicated in the regulation of tumor cell growth and survival. 3. **Neurodegenerative Disorders**: CHMP5 has been found to be associated with various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, and has been implicated in the regulation of protein degradation and clearance in the brain. In conclusion, CHMP5 is a multifunctional protein that plays a critical role in various cellular processes, including autophagy, viral budding, and protein trafficking. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the role of CHMP5 in normal and diseased states.

Genular Protein ID: 3664167283

Symbol: CHMP5_HUMAN

Name: Charged multivesicular body protein 5

UniProtKB Accession Codes:

Q9NZZ3 B2RD95 B4DIR6 Q5VXW2 Q96AV2 Q9HB68 Q9NYS4 Q9Y323

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 EvolutionaryTrace 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14519844

Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

PubMed ID: 14519844

DOI: 10.1073/pnas.2133846100

PubMed ID: 15644320

Title: The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.

PubMed ID: 15644320

DOI: 10.1074/jbc.m413734200

PubMed ID: 17853893

Title: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

PubMed ID: 17853893

DOI: 10.1038/sj.emboj.7601850

PubMed ID: 17261583

Title: Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.

PubMed ID: 17261583

DOI: 10.1074/jbc.m611635200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21543490

Title: Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.

PubMed ID: 21543490

DOI: 10.1128/jvi.02610-10

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27812135

Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

PubMed ID: 27812135

DOI: 10.1371/journal.pone.0165420

PubMed ID: 30061757

Title: Nepsilon-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function.

PubMed ID: 30061757

DOI: 10.1038/s41564-018-0215-6

PubMed ID: 22484091

Title: Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B.

PubMed ID: 22484091

DOI: 10.1016/j.str.2012.03.001

Sequence Information:

  • Length: 219
  • Mass: 24571
  • Checksum: C99695F66FD7E126
  • Sequence:
    • MNRLFGKAKP KAPPPSLTDC IGTVDSRAES IDKKISRLDA ELVKYKDQIK KMREGPAKNM 
VKQKALRVLK QKRMYEQQRD NLAQQSFNME QANYTIQSLK DTKTTVDAMK LGVKEMKKAY 
KQVKIDQIED LQDQLEDMME DANEIQEALS RSYGTPELDE DDLEAELDAL GDELLADEDS 
SYLDEAASAP AIPEGVPTDT KNKDGVLVDE FGLPQIPAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.