Details for: ARMCX3

Gene ID: 51566

Symbol: ARMCX3

Ensembl ID: ENSG00000102401

Description: armadillo repeat containing X-linked 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 302.8058
    Cell Significance Index: -47.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 169.4899
    Cell Significance Index: -42.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 122.2243
    Cell Significance Index: -50.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 112.7779
    Cell Significance Index: -53.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 105.6228
    Cell Significance Index: -42.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.5619
    Cell Significance Index: -49.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.6993
    Cell Significance Index: -53.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.4677
    Cell Significance Index: -43.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.8554
    Cell Significance Index: -49.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4627
    Cell Significance Index: -46.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.5771
    Cell Significance Index: -49.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6318
    Cell Significance Index: -32.6600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0815
    Cell Significance Index: -13.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4121
    Cell Significance Index: 65.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9250
    Cell Significance Index: 100.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6744
    Cell Significance Index: 78.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5969
    Cell Significance Index: 219.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5869
    Cell Significance Index: 12.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4958
    Cell Significance Index: 31.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3315
    Cell Significance Index: 144.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2720
    Cell Significance Index: 694.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1903
    Cell Significance Index: 193.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1539
    Cell Significance Index: 141.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0031
    Cell Significance Index: 64.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9000
    Cell Significance Index: 25.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8624
    Cell Significance Index: 155.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7588
    Cell Significance Index: 152.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7339
    Cell Significance Index: 54.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7337
    Cell Significance Index: 38.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7328
    Cell Significance Index: 93.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7139
    Cell Significance Index: 70.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7031
    Cell Significance Index: 133.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5567
    Cell Significance Index: 502.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4761
    Cell Significance Index: 22.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4636
    Cell Significance Index: 16.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4616
    Cell Significance Index: 20.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4295
    Cell Significance Index: 22.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3664
    Cell Significance Index: 47.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3352
    Cell Significance Index: 20.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3256
    Cell Significance Index: 116.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3190
    Cell Significance Index: 9.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3185
    Cell Significance Index: 63.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2787
    Cell Significance Index: 3.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2729
    Cell Significance Index: 120.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2284
    Cell Significance Index: 15.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1855
    Cell Significance Index: 31.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1726
    Cell Significance Index: 3.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1169
    Cell Significance Index: 2.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0924
    Cell Significance Index: 63.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0544
    Cell Significance Index: 102.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0302
    Cell Significance Index: 0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0190
    Cell Significance Index: 13.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0120
    Cell Significance Index: 18.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0029
    Cell Significance Index: 5.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0099
    Cell Significance Index: -6.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0207
    Cell Significance Index: -15.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0292
    Cell Significance Index: -18.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0471
    Cell Significance Index: -21.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0471
    Cell Significance Index: -4.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0483
    Cell Significance Index: -27.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0678
    Cell Significance Index: -8.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0853
    Cell Significance Index: -9.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1059
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1097
    Cell Significance Index: -23.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1661
    Cell Significance Index: -24.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1783
    Cell Significance Index: -51.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1872
    Cell Significance Index: -12.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2240
    Cell Significance Index: -26.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2428
    Cell Significance Index: -18.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2575
    Cell Significance Index: -29.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2699
    Cell Significance Index: -19.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2714
    Cell Significance Index: -5.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2796
    Cell Significance Index: -2.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3325
    Cell Significance Index: -18.6600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.3430
    Cell Significance Index: -2.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3495
    Cell Significance Index: -5.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3721
    Cell Significance Index: -10.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4130
    Cell Significance Index: -18.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4437
    Cell Significance Index: -46.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5151
    Cell Significance Index: -5.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5289
    Cell Significance Index: -16.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5323
    Cell Significance Index: -20.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5404
    Cell Significance Index: -42.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5677
    Cell Significance Index: -16.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5981
    Cell Significance Index: -14.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6086
    Cell Significance Index: -6.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6302
    Cell Significance Index: -10.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6363
    Cell Significance Index: -15.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6648
    Cell Significance Index: -41.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7564
    Cell Significance Index: -46.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7586
    Cell Significance Index: -9.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7907
    Cell Significance Index: -21.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7973
    Cell Significance Index: -23.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8267
    Cell Significance Index: -21.1200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.8566
    Cell Significance Index: -8.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8990
    Cell Significance Index: -26.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9525
    Cell Significance Index: -18.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARMCX3 is a gene that encodes for an Armadillo repeat-containing protein, which is characterized by its unique structural motif. This motif, comprising a series of Armadillo repeats, is thought to play a crucial role in protein-protein interactions and cellular localization. The gene's X-linked location suggests that it may be involved in sex-specific processes or cellular differentiation. **Pathways and Functions** ARMCX3 has been implicated in various cellular processes, including: 1. **Axonal Transport of Mitochondria**: ARMCX3 has been shown to interact with mitochondrial proteins, facilitating the transport of mitochondria along axons. This process is crucial for maintaining mitochondrial homeostasis and energy metabolism in neurons. 2. **Mitochondrial Organization**: ARMCX3 has been implicated in the regulation of mitochondrial morphology and dynamics, suggesting its role in maintaining mitochondrial function and cellular energy homeostasis. 3. **Signaling Pathways**: ARMCX3 has been shown to interact with various signaling molecules, including Rho GTPases and Miro GTPases, which are involved in regulating cellular processes such as cytoskeleton dynamics and mitochondrial transport. 4. **Protein Localization**: ARMCX3 has been shown to regulate the localization of proteins to specific cellular compartments, including the nucleus and mitochondria. **Clinical Significance** The clinical significance of ARMCX3 is an area of ongoing research. However, its involvement in various cellular processes suggests that dysregulation of this gene may contribute to the development of diseases such as: 1. **Neurodegenerative Disorders**: Dysregulation of ARMCX3 may contribute to the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by mitochondrial dysfunction and axonal degeneration. 2. **Immunological Disorders**: ARMCX3's role in regulating immune cell function and signaling pathways suggests that dysregulation of this gene may contribute to the development of immunological disorders, such as autoimmune diseases and cancer. 3. **Epithelial Disorders**: ARMCX3's involvement in regulating epithelial cell function and signaling pathways suggests that dysregulation of this gene may contribute to the development of epithelial disorders, such as cancer and inflammatory bowel disease. In conclusion, ARMCX3 is a gene with multifaceted roles in cellular processes, including axonal transport, mitochondrial organization, and signaling pathways. Further research is needed to fully elucidate the clinical significance of this gene and its potential contributions to various diseases.

Genular Protein ID: 1060659931

Symbol: ARMX3_HUMAN

Name: Armadillo repeat-containing X-linked protein 3

UniProtKB Accession Codes:

Q9UH62 Q53HC6 Q7LCF5 Q9NPE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11162520

Title: ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.

PubMed ID: 11162520

DOI: 10.1006/bbrc.2000.4125

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 379
  • Mass: 42501
  • Checksum: B715D7F83DF4DFB0
  • Sequence:
    • MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG DCSGARYNDW 
SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR ARRAVQKRAS PNSDDTVLSP 
QELQKVLCLV EMSEKPYILE AALIALGNNA AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK 
EKALIVLNNL SVNAENQRRL KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM 
LANSISDFFR LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE 
VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI ESHHDFLVKV 
KVGKFMAKLA EHMFPKSQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.