Details for: TAF9B

Gene ID: 51616

Symbol: TAF9B

Ensembl ID: ENSG00000187325

Description: TATA-box binding protein associated factor 9b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.3625
    Cell Significance Index: -12.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.0345
    Cell Significance Index: -11.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.0301
    Cell Significance Index: -14.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.6364
    Cell Significance Index: -12.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.6840
    Cell Significance Index: -12.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2088
    Cell Significance Index: -13.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1962
    Cell Significance Index: -13.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5732
    Cell Significance Index: -14.1000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.8090
    Cell Significance Index: 21.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2180
    Cell Significance Index: 25.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8560
    Cell Significance Index: 7.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8458
    Cell Significance Index: 763.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7475
    Cell Significance Index: 47.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6698
    Cell Significance Index: 72.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6492
    Cell Significance Index: 17.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6175
    Cell Significance Index: 100.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6085
    Cell Significance Index: 36.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3509
    Cell Significance Index: 18.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3450
    Cell Significance Index: 23.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3007
    Cell Significance Index: 15.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2322
    Cell Significance Index: 44.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2281
    Cell Significance Index: 2.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2026
    Cell Significance Index: 4.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1987
    Cell Significance Index: 6.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1953
    Cell Significance Index: 14.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1936
    Cell Significance Index: 26.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1928
    Cell Significance Index: 24.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1828
    Cell Significance Index: 36.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1823
    Cell Significance Index: 80.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1689
    Cell Significance Index: 16.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1684
    Cell Significance Index: 20.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1569
    Cell Significance Index: 11.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1405
    Cell Significance Index: 16.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1365
    Cell Significance Index: 1.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1309
    Cell Significance Index: 23.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1144
    Cell Significance Index: 5.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0898
    Cell Significance Index: 1.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0793
    Cell Significance Index: 2.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0774
    Cell Significance Index: 3.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0757
    Cell Significance Index: 41.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0735
    Cell Significance Index: 26.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0608
    Cell Significance Index: 7.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0579
    Cell Significance Index: 11.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0413
    Cell Significance Index: 63.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0352
    Cell Significance Index: 0.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0331
    Cell Significance Index: 22.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0257
    Cell Significance Index: 34.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0143
    Cell Significance Index: 26.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0081
    Cell Significance Index: 15.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0075
    Cell Significance Index: -0.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0086
    Cell Significance Index: -0.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0097
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -8.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0146
    Cell Significance Index: -6.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0158
    Cell Significance Index: -2.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0177
    Cell Significance Index: -1.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0254
    Cell Significance Index: -15.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0258
    Cell Significance Index: -0.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0303
    Cell Significance Index: -1.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0332
    Cell Significance Index: -0.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0350
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0388
    Cell Significance Index: -4.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0419
    Cell Significance Index: -2.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0457
    Cell Significance Index: -6.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0491
    Cell Significance Index: -14.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0547
    Cell Significance Index: -2.4800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0549
    Cell Significance Index: -0.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0639
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0719
    Cell Significance Index: -15.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0729
    Cell Significance Index: -1.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0737
    Cell Significance Index: -2.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0762
    Cell Significance Index: -2.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0823
    Cell Significance Index: -2.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1101
    Cell Significance Index: -1.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1144
    Cell Significance Index: -1.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1213
    Cell Significance Index: -5.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1239
    Cell Significance Index: -9.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1243
    Cell Significance Index: -12.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1260
    Cell Significance Index: -3.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1463
    Cell Significance Index: -11.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1871
    Cell Significance Index: -5.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1902
    Cell Significance Index: -4.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1905
    Cell Significance Index: -2.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1913
    Cell Significance Index: -11.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1981
    Cell Significance Index: -5.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2309
    Cell Significance Index: -5.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2356
    Cell Significance Index: -10.4200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2456
    Cell Significance Index: -1.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2752
    Cell Significance Index: -10.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2873
    Cell Significance Index: -8.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3032
    Cell Significance Index: -8.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3137
    Cell Significance Index: -8.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3149
    Cell Significance Index: -10.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3231
    Cell Significance Index: -11.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3237
    Cell Significance Index: -10.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3317
    Cell Significance Index: -4.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** 1. **Transcriptional regulation**: TAF9B is a key component of the TFIID complex, which regulates the initiation of transcription by RNA polymerase II. This process involves the binding of the TFIID complex to the TATA box, a DNA sequence that serves as a binding site for TBP and TAF9B. 2. **Interaction with RNA polymerase II**: TAF9B interacts with RNA polymerase II, facilitating the recruitment of the enzyme to the promoter region of target genes. This interaction is essential for the initiation of transcription. 3. **Disease association**: TAF9B has been implicated in various diseases, including cancer and HIV infection. Its dysregulation can lead to aberrant gene expression, contributing to disease pathogenesis. 4. **Cell type specificity**: TAF9B has been identified in various cell types, including hematopoietic cells, smooth muscle cells, and epithelial cells. Its expression patterns suggest a role in regulating gene expression in specific cell types. **Pathways and functions** 1. **Deubiquitination**: TAF9B has been shown to participate in deubiquitination, a process that regulates protein stability and function. 2. **Disease**: TAF9B has been implicated in various diseases, including cancer and HIV infection. Its dysregulation can lead to aberrant gene expression, contributing to disease pathogenesis. 3. **Transcriptional regulation**: TAF9B regulates gene expression through its interactions with RNA polymerase II and other transcription factors. 4. **HIV infection**: TAF9B has been shown to play a role in HIV transcription initiation, suggesting its involvement in the regulation of HIV gene expression. **Clinical significance** 1. **Cancer**: TAF9B has been implicated in various cancers, including leukemia and lymphoma. Its dysregulation can contribute to tumorigenesis and cancer progression. 2. **HIV infection**: TAF9B plays a role in HIV transcription initiation, suggesting its involvement in the regulation of HIV gene expression. 3. **Regulation of gene expression**: TAF9B regulates gene expression in various cell types, suggesting its potential as a therapeutic target in diseases characterized by aberrant gene expression. 4. **Immunological significance**: TAF9B has been identified in various immune cells, including T cells and dendritic cells, suggesting its involvement in immune regulation and response. In conclusion, TAF9B is a complex gene that plays a critical role in transcriptional regulation, disease association, and cell type specificity. Its dysregulation can contribute to various diseases, including cancer and HIV infection. Further research is needed to fully elucidate the functions and clinical significance of TAF9B.

Genular Protein ID: 4063255103

Symbol: TAF9B_HUMAN

Name: Transcription initiation factor TFIID subunit 9B

UniProtKB Accession Codes:

Q9HBM6 B2RUZ9 Q9Y2S3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15899866

Title: TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9.

PubMed ID: 15899866

DOI: 10.1128/mcb.25.11.4638-4649.2005

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 251
  • Mass: 27622
  • Checksum: EB3A1116F7E8BCA0
  • Sequence:
    • MESGKMAPPK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI LDDAKIYSSH 
AKKPNVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN QTPLPLIKPY AGPRLPPDRY 
CLTAPNYRLK SLIKKGPNQG RLVPRLSVGA VSSKPTTPTI ATPQTVSVPN KVATPMSVTS 
QRFTVQIPPS QSTPVKPVPA TTAVQNVLIN PSMIGPKNIL ITTNMVSSQN TANEANPLKR 
KHEDDDDNDI M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.