Details for: PDHB
Gene ID: 5162
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PDHB
Ensembl ID: ENSG00000168291
Description: pyruvate dehydrogenase E1 subunit beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 18.46rCSI 28.14%PRS 56.97
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CSI 17.31rCSI 22.2%PRS 65.49
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CSI 13.97rCSI 40.46%PRS 62.19
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CSI 12.69rCSI 19.61%PRS 58.8
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CSI 11.44rCSI 50.32%PRS 51.26
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CSI 9.37rCSI 13.29%PRS 56.89
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CSI 8.83rCSI 5.87%PRS 63.79
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CSI 8.41rCSI 12.69%PRS 64.82
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CSI 7.82rCSI 19.1%PRS 54.35
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CSI 7.65rCSI 17.36%PRS 64.79
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CSI 6.83rCSI 13.29%PRS 63.62
-
CSI 6.16rCSI 8.89%PRS 70.25
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CSI 6.15rCSI 17.64%PRS 80.43
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CSI 6.12rCSI 13.51%PRS 46.88
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CSI 6.11rCSI 35.02%PRS 69.92
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CSI 5.89rCSI 9.65%PRS 49.96
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CSI 5.77rCSI 12.89%PRS 68.47
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CSI 5.59rCSI 17.95%PRS 65.96
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CSI 5.47rCSI 14.44%PRS 69.63
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CSI 5.34rCSI 4.42%PRS 62.78
-
CSI 5.1rCSI 4.29%PRS 77.84
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CSI 4.96rCSI 6.32%PRS 67.34
-
CSI 4.64rCSI 3.45%PRS 74.13
-
CSI 4.62rCSI 3.58%PRS 62.36
-
CSI 4.54rCSI 28.37%PRS 52.6
-
CSI 4.42rCSI 6.04%PRS 66.7
-
CSI 4.4rCSI 7.12%PRS 57.35
-
CSI 4.33rCSI 14.06%PRS 61.34
-
CSI 4.31rCSI 4.46%PRS 66.23
-
CSI 4.26rCSI 5.08%PRS 80.27
-
CSI 4.22rCSI 4.52%PRS 59.99
-
CSI 3.99rCSI 3.19%PRS 81.17
-
CSI 3.97rCSI 7.14%PRS 53.7
-
CSI 3.94rCSI 6.75%PRS 69.56
-
CSI 3.93rCSI 2.73%PRS 71.76
-
CSI 3.89rCSI 3.62%PRS 61.19
-
CSI 3.53rCSI 14.07%PRS 73.64
-
CSI 3.41rCSI 2.6%PRS 73.66
-
CSI 3.33rCSI 5.88%PRS 41.58
-
CSI 3.32rCSI 4.6%PRS 61.86
-
CSI 3.31rCSI 14.71%PRS 60.16
-
CSI 3.15rCSI 3.04%PRS 60.87
-
CSI 3.14rCSI 3.29%PRS 57.14
-
CSI 3.14rCSI 2.47%PRS 67.4
-
CSI 3.13rCSI 2.82%PRS 57.47
-
CSI 3.12rCSI 2.74%PRS 66.21
-
CSI 2.96rCSI 3.33%PRS 77.04
-
CSI 2.95rCSI 3.92%PRS 67.21
-
CSI 2.88rCSI 2.49%PRS 66.32
-
CSI 2.86rCSI 6.3%PRS 73.49
-
CSI 2.85rCSI 2.98%PRS 60.93
-
CSI 2.82rCSI 8.32%PRS 63.86
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CSI 2.76rCSI 2.76%PRS 53.89
-
CSI 2.75rCSI 4.91%PRS 74.14
-
CSI 2.72rCSI 2.41%PRS 58.7
-
CSI 2.71rCSI 3.48%PRS 57.89
-
CSI 2.68rCSI 2.01%PRS 75.97
-
CSI 2.62rCSI 21.3%PRS 53.96
-
CSI 2.61rCSI 2.07%PRS 47.55
-
CSI 2.6rCSI 2.56%PRS 63.33
-
CSI 2.54rCSI 2.34%PRS 62.18
-
CSI 2.45rCSI 4.24%PRS 50.77
-
CSI 2.41rCSI 6.11%PRS 55.09
-
CSI 2.39rCSI 3.51%PRS 72.35
-
CSI 2.37rCSI 1.91%PRS 62.03
-
CSI 2.36rCSI 3.68%PRS 84.37
-
CSI 2.36rCSI 2.23%PRS 60.18
-
CSI 2.35rCSI 11.79%PRS 73.2
-
CSI 2.33rCSI 2.67%PRS 79.52
-
CSI 2.32rCSI 2.37%PRS 73.83
-
CSI 2.32rCSI 3.4%PRS 65.21
-
CSI 2.27rCSI 4.57%PRS 49.75
-
CSI 2.26rCSI 3.36%PRS 62.29
-
CSI 2.24rCSI 4.96%PRS 58.63
-
CSI 2.24rCSI 2.16%PRS 51.21
-
CSI 2.22rCSI 5.06%PRS 57.13
-
CSI 2.21rCSI 2.28%PRS 77.26
-
CSI 2.19rCSI 1.53%PRS 63.42
-
CSI 2.18rCSI 2.91%PRS 61.05
-
CSI 2.18rCSI 1.63%PRS 66.22
-
CSI 2.16rCSI 2.5%PRS 50.7
-
CSI 2.15rCSI 2.48%PRS 53.9
-
CSI 2.13rCSI 4.7%PRS 65.01
-
CSI 2.09rCSI 2.79%PRS 69.56
-
CSI 2.07rCSI 1.99%PRS 82.13
-
CSI 2.06rCSI 2.55%PRS 57.08
-
CSI 2.04rCSI 4.19%PRS 79.21
-
CSI 2.04rCSI 2.37%PRS 68.35
-
CSI 2.01rCSI 3.54%PRS 69.03
-
CSI 1.98rCSI 2.07%PRS 64.32
-
CSI 1.97rCSI 3.02%PRS 56.98
-
CSI 1.94rCSI 4.8%PRS 59.04
-
CSI 1.92rCSI 2.34%PRS 68.17
-
CSI 1.92rCSI 1.59%PRS 59.76
-
CSI 1.89rCSI 2.99%PRS 62.89
-
CSI 1.89rCSI 9.71%PRS 87.58
-
CSI 1.87rCSI 1.64%PRS 48.49
-
CSI 1.85rCSI 1.4%PRS 74.61
-
CSI 1.85rCSI 2.93%PRS 71.77
-
CSI 1.83rCSI 1.8%PRS 76.51
-
CSI 0.2rCSI 2.1%PRS 87.0%
-
CSI 0.2rCSI 1.3%PRS 70.3%
-
CSI 0.2rCSI 2.2%PRS 78.1%
-
CSI 0.3rCSI 3.1%PRS 75.8%
-
CSI 0.4rCSI 3.2%PRS 86.9%
-
CSI 0.4rCSI 3.1%PRS 72.5%
-
CSI 0.4rCSI 3.6%PRS 93.4%
-
CSI 0.5rCSI 3.2%PRS 75.3%
-
CSI 0.5rCSI 2.9%PRS 69.9%
-
CSI 0.5rCSI 3.9%PRS 77.0%
-
CSI 0.5rCSI 7.8%PRS 75.7%
-
CSI 0.5rCSI 0.9%PRS 42.5%
-
CSI 0.6rCSI 2.6%PRS 79.4%
-
CSI 0.6rCSI 2.9%PRS 82.2%
-
CSI 0.6rCSI 1.5%PRS 84.6%
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CSI 0.6rCSI 0.9%PRS 76.7%
-
CSI 0.7rCSI 2.3%PRS 69.9%
-
CSI 0.7rCSI 3.0%PRS 73.4%
-
CSI 0.8rCSI 2.2%PRS 72.5%
-
CSI 0.8rCSI 1.9%PRS 69.7%
-
CSI 0.8rCSI 2.6%PRS 44.1%
-
CSI 0.8rCSI 1.4%PRS 50.3%
-
CSI 0.9rCSI 4.5%PRS 89.1%
-
CSI 0.9rCSI 3.1%PRS 64.9%
-
CSI 0.9rCSI 3.7%PRS 76.8%
-
CSI 1.0rCSI 4.7%PRS 71.8%
-
CSI 1.0rCSI 4.3%PRS 73.3%
-
CSI 1.0rCSI 1.5%PRS 76.4%
-
CSI 1.0rCSI 2.0%PRS 78.3%
-
CSI 1.0rCSI 2.5%PRS 78.5%
-
CSI 1.1rCSI 3.9%PRS 80.3%
-
CSI 1.1rCSI 2.4%PRS 74.5%
-
CSI 1.1rCSI 1.6%PRS 67.8%
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CSI 1.2rCSI 3.7%PRS 59.1%
-
CSI 1.2rCSI 1.8%PRS 65.0%
-
CSI 1.2rCSI 1.3%PRS 71.2%
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CSI 1.2rCSI 1.8%PRS 74.3%
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CSI 1.2rCSI 1.5%PRS 72.7%
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CSI 1.2rCSI 2.2%PRS 59.8%
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CSI 1.3rCSI 1.6%PRS 74.4%
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CSI 1.3rCSI 1.1%PRS 65.7%
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CSI 1.3rCSI 2.1%PRS 64.6%
-
CSI 1.3rCSI 2.5%PRS 86.6%
-
CSI 1.3rCSI 4.6%PRS 89.7%
-
CSI 1.3rCSI 2.0%PRS 69.7%
-
CSI 1.3rCSI 1.6%PRS 63.0%
-
CSI 1.4rCSI 4.8%PRS 83.1%
-
CSI 1.4rCSI 9.2%PRS 78.6%
-
CSI 1.5rCSI 1.8%PRS 58.7%
-
CSI 1.5rCSI 2.1%PRS 56.9%
-
CSI 1.5rCSI 2.9%PRS 58.5%
-
CSI 1.5rCSI 1.2%PRS 61.2%
-
CSI 1.5rCSI 2.8%PRS 80.5%
-
CSI 1.5rCSI 1.9%PRS 71.2%
-
CSI 1.5rCSI 4.3%PRS 58.8%
-
CSI 1.5rCSI 2.1%PRS 59.4%
-
CSI 1.5rCSI 1.3%PRS 71.6%
-
CSI 1.6rCSI 2.1%PRS 80.4%
-
CSI 1.6rCSI 2.3%PRS 71.6%
-
CSI 1.6rCSI 1.3%PRS 82.1%
-
CSI 1.6rCSI 2.0%PRS 40.6%
-
CSI 1.6rCSI 8.7%PRS 73.4%
-
CSI 1.6rCSI 2.4%PRS 66.0%
-
CSI 1.6rCSI 49.0%PRS 80.5%
-
CSI 1.6rCSI 1.1%PRS 73.8%
-
CSI 1.7rCSI 2.1%PRS 43.7%
-
CSI 1.7rCSI 3.1%PRS 71.3%
-
CSI 1.7rCSI 2.3%PRS 52.5%
-
CSI 1.7rCSI 2.4%PRS 63.2%
-
CSI 1.7rCSI 2.4%PRS 62.5%
-
CSI 1.7rCSI 4.0%PRS 73.2%
-
CSI 1.8rCSI 1.4%PRS 61.1%
-
CSI 1.8rCSI 2.9%PRS 53.4%
-
CSI 1.8rCSI 3.4%PRS 76.1%
-
CSI 1.8rCSI 1.9%PRS 58.9%
-
CSI 1.8rCSI 1.8%PRS 76.5%
-
CSI 1.9rCSI 2.9%PRS 71.8%
-
CSI 1.9rCSI 1.4%PRS 74.6%
-
CSI 1.9rCSI 1.6%PRS 48.5%
-
CSI 1.9rCSI 9.7%PRS 87.6%
-
CSI 1.9rCSI 3.0%PRS 62.9%
-
CSI 1.9rCSI 1.6%PRS 59.8%
-
CSI 1.9rCSI 2.3%PRS 68.2%
-
CSI 1.9rCSI 4.8%PRS 59.0%
-
CSI 2.0rCSI 3.0%PRS 57.0%
-
CSI 2.0rCSI 2.1%PRS 64.3%
-
CSI 2.0rCSI 3.5%PRS 69.0%
-
CSI 2.0rCSI 2.4%PRS 68.4%
-
CSI 2.0rCSI 4.2%PRS 79.2%
-
CSI 2.1rCSI 2.6%PRS 57.1%
-
CSI 2.1rCSI 2.0%PRS 82.1%
-
CSI 2.1rCSI 2.8%PRS 69.6%
-
CSI 2.1rCSI 4.7%PRS 65.0%
-
CSI 2.2rCSI 2.5%PRS 53.9%
-
CSI 2.2rCSI 2.5%PRS 50.7%
-
CSI 2.2rCSI 1.6%PRS 66.2%
-
CSI 2.2rCSI 2.9%PRS 61.1%
-
CSI 2.2rCSI 1.5%PRS 63.4%
-
CSI 2.2rCSI 2.3%PRS 77.3%
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CSI 2.2rCSI 5.1%PRS 57.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2735085847
Symbol: ODPB_HUMAN
Name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2323578
Title: Cloning and cDNA sequence of the beta-subunit component of human pyruvate dehydrogenase complex.
PubMed ID: 2323578
PubMed ID: 1702713
Title: Isolation, characterization and chromosomal localization of cDNA clones for the E1 beta subunit of the pyruvate dehydrogenase complex.
PubMed ID: 1702713
PubMed ID: 2376596
Title: Characterization of two cDNA clones for pyruvate dehydrogenase E1 beta subunit and its regulation in tricarboxylic acid cycle-deficient fibroblast.
PubMed ID: 2376596
PubMed ID: 2377599
Title: Molecular cloning and characterization of human pyruvate dehydrogenase beta subunit gene.
PubMed ID: 2377599
PubMed ID: 3422424
Title: Cloning and sequencing of cDNAs encoding alpha and beta subunits of human pyruvate dehydrogenase.
PubMed ID: 3422424
DOI: 10.1073/pnas.85.1.41
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2829898
Title: Identification of a cDNA clone for the beta-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex.
PubMed ID: 2829898
PubMed ID: 7895732
Title: The human myocardial two-dimensional gel protein database: update 1994.
PubMed ID: 7895732
PubMed ID: 2295468
Title: Isolation of tryptic fragment of antigen from mitochondrial inner membrane proteins reacting with antimitochondrial antibody in sera of patients with primary biliary cirrhosis.
PubMed ID: 2295468
PubMed ID: 14638692
Title: Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
PubMed ID: 14638692
PubMed ID: 20160912
Title: Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.
PubMed ID: 20160912
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 12651851
Title: Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase.
PubMed ID: 12651851
PubMed ID: 17474719
Title: Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex.
PubMed ID: 17474719
DOI: 10.1021/bi700083z
PubMed ID: 19081061
Title: Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
PubMed ID: 19081061
PubMed ID: 29970614
Title: Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the alphaV138M variant of human pyruvate dehydrogenase.
PubMed ID: 29970614
PubMed ID: 15138885
Title: Mutations in the gene for the E1beta subunit: a novel cause of pyruvate dehydrogenase deficiency.
PubMed ID: 15138885
Sequence Information:
- Length: 359
- Mass: 39233
- Checksum: AB459B1259FBDBD3
- Sequence:
MAAVSGLVRR PLREVSGLLK RRFHWTAPAA LQVTVRDAIN QGMDEELERD EKVFLLGEEV AQYDGAYKVS RGLWKKYGDK RIIDTPISEM GFAGIAVGAA MAGLRPICEF MTFNFSMQAI DQVINSAAKT YYMSGGLQPV PIVFRGPNGA SAGVAAQHSQ CFAAWYGHCP GLKVVSPWNS EDAKGLIKSA IRDNNPVVVL ENELMYGVPF EFPPEAQSKD FLIPIGKAKI ERQGTHITVV SHSRPVGHCL EAAAVLSKEG VECEVINMRT IRPMDMETIE ASVMKTNHLV TVEGGWPQFG VGAEICARIM EGPAFNFLDA PAVRVTGADV PMPYAKILED NSIPQVKDII FAIKKTLNI