Details for: LUC7L2

Gene ID: 51631

Symbol: LUC7L2

Ensembl ID: ENSG00000146963

Description: LUC7 like 2, pre-mRNA splicing factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 362.4348
    Cell Significance Index: -56.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 238.8787
    Cell Significance Index: -60.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.8609
    Cell Significance Index: -67.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.8931
    Cell Significance Index: -62.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.1964
    Cell Significance Index: -61.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.1966
    Cell Significance Index: -55.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8386
    Cell Significance Index: -62.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8785
    Cell Significance Index: -21.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 5.5744
    Cell Significance Index: 139.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.7067
    Cell Significance Index: 431.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2998
    Cell Significance Index: 824.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0157
    Cell Significance Index: 113.1100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.6359
    Cell Significance Index: 20.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6167
    Cell Significance Index: 124.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4255
    Cell Significance Index: 87.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3225
    Cell Significance Index: 50.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3163
    Cell Significance Index: 237.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2417
    Cell Significance Index: 54.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1952
    Cell Significance Index: 146.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1436
    Cell Significance Index: 329.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1399
    Cell Significance Index: 123.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9859
    Cell Significance Index: 681.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9848
    Cell Significance Index: 28.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9363
    Cell Significance Index: 49.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9165
    Cell Significance Index: 21.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8734
    Cell Significance Index: 142.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8523
    Cell Significance Index: 23.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8009
    Cell Significance Index: 102.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7969
    Cell Significance Index: 109.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7694
    Cell Significance Index: 90.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5315
    Cell Significance Index: 290.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5227
    Cell Significance Index: 231.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5114
    Cell Significance Index: 17.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4720
    Cell Significance Index: 13.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4436
    Cell Significance Index: 20.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3318
    Cell Significance Index: 299.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3159
    Cell Significance Index: 4.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2639
    Cell Significance Index: 11.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1925
    Cell Significance Index: 4.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1906
    Cell Significance Index: 36.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1577
    Cell Significance Index: 10.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1397
    Cell Significance Index: 10.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0952
    Cell Significance Index: 6.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0862
    Cell Significance Index: 4.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0845
    Cell Significance Index: 2.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0650
    Cell Significance Index: 1.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0545
    Cell Significance Index: 7.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0445
    Cell Significance Index: 0.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0321
    Cell Significance Index: 1.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0285
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0061
    Cell Significance Index: 11.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0276
    Cell Significance Index: -50.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0344
    Cell Significance Index: -21.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0364
    Cell Significance Index: -26.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0375
    Cell Significance Index: -57.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0432
    Cell Significance Index: -2.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0434
    Cell Significance Index: -32.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0477
    Cell Significance Index: -9.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0518
    Cell Significance Index: -70.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0666
    Cell Significance Index: -4.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0700
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0717
    Cell Significance Index: -53.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0723
    Cell Significance Index: -2.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0964
    Cell Significance Index: -43.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0999
    Cell Significance Index: -10.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1005
    Cell Significance Index: -20.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1051
    Cell Significance Index: -59.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1147
    Cell Significance Index: -71.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1316
    Cell Significance Index: -13.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1746
    Cell Significance Index: -8.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1860
    Cell Significance Index: -31.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2154
    Cell Significance Index: -3.6100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2166
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2346
    Cell Significance Index: -4.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2567
    Cell Significance Index: -37.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3046
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3407
    Cell Significance Index: -71.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3843
    Cell Significance Index: -44.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4943
    Cell Significance Index: -11.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5012
    Cell Significance Index: -14.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5149
    Cell Significance Index: -16.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5289
    Cell Significance Index: -13.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5391
    Cell Significance Index: -15.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5787
    Cell Significance Index: -60.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6670
    Cell Significance Index: -4.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6817
    Cell Significance Index: -53.9900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8108
    Cell Significance Index: -10.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9087
    Cell Significance Index: -55.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0162
    Cell Significance Index: -25.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0467
    Cell Significance Index: -13.4100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.1037
    Cell Significance Index: -13.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2218
    Cell Significance Index: -26.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.3908
    Cell Significance Index: -14.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4018
    Cell Significance Index: -51.4600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.4189
    Cell Significance Index: -14.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4707
    Cell Significance Index: -48.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.4829
    Cell Significance Index: -26.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5001
    Cell Significance Index: -38.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5600
    Cell Significance Index: -54.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5988
    Cell Significance Index: -50.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Luc7L2 is a pre-mRNA splicing factor that binds to specific mRNA sequences, facilitating the recognition and processing of splice sites. This gene belongs to the Luc7-like family, which is characterized by its RNA-binding capabilities. The protein encoded by Luc7L2 (LC7L2_HUMAN) is a putative RNA-binding protein that interacts with other RNA-binding proteins to regulate mRNA processing. The expression of Luc7L2 is widespread, with significant levels detected in hematopoietic cells, immune cells, and epithelial cells, suggesting its involvement in various cellular processes. **Pathways and Functions:** The Luc7L2 gene is involved in several key pathways, including: 1. **Enzyme binding:** Luc7L2 interacts with various enzymes, such as U1 snRNP and U2-type pre-spliceosome, to regulate mRNA processing. 2. **mRNA binding:** Luc7L2 binds to specific mRNA sequences, facilitating the recognition and processing of splice sites. 3. **mRNA splice site recognition:** Luc7L2 recognizes and processes specific splice sites, influencing the production of functional proteins. 4. **Nuclear speck:** Luc7L2 is localized to nuclear specks, a type of nuclear structure involved in gene regulation. 5. **Protein binding:** Luc7L2 interacts with other proteins, such as RNA-binding proteins, to regulate mRNA processing. 6. **RNA binding:** Luc7L2 binds to RNA molecules, influencing their processing and regulation. 7. **U1 snRNP:** Luc7L2 interacts with U1 snRNP, a complex involved in mRNA splicing. 8. **U2-type pre-spliceosome:** Luc7L2 interacts with U2-type pre-spliceosome, a complex involved in mRNA splicing. **Clinical Significance:** The Luc7L2 gene has significant implications for our understanding of immunological processes and disease mechanisms. The expression of Luc7L2 in hematopoietic cells, immune cells, and epithelial cells suggests its involvement in various cellular processes, including immune response, cell differentiation, and tissue development. Aberrant expression of Luc7L2 has been implicated in several diseases, including cancer, autoimmune disorders, and infectious diseases. Further research is needed to fully elucidate the role of Luc7L2 in human disease and to explore its potential as a therapeutic target. In conclusion, the Luc7L2 gene is a crucial pre-mRNA splicing factor that plays a significant role in regulating gene expression. Its widespread expression in various cell types and involvement in multiple pathways highlight its potential significance in immunological processes and disease mechanisms. Further research is necessary to fully understand the role of Luc7L2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 829383536

Symbol: LC7L2_HUMAN

Name: Putative RNA-binding protein Luc7-like 2

UniProtKB Accession Codes:

Q9Y383 B7Z500 Q8IUP9 Q9NVL3 Q9NVN7 Q9UQN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19574390

Title: Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

PubMed ID: 19574390

DOI: 10.1126/science.1175865

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 392
  • Mass: 46514
  • Checksum: 1C559CCE0F23F693
  • Sequence:
    • MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS GTRMDLGECL 
KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR TEVAKKRLAE TQEEISAEVA 
AKAERVHELN EEIGKLLAKV EQLGAEGNVE ESQKVMDEVE KARAKKREAE EVYRNSMPAS 
SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN 
QERLKRREER EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR 
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR DRSSRDRSPR 
DRDRKDKKRS YESANGRSED RRSSEEREAG EI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.