Details for: PTRH2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 186.3124
Cell Significance Index: -28.9800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 113.7424
Cell Significance Index: -28.8500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 72.0237
Cell Significance Index: -29.6700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 65.7880
Cell Significance Index: -31.0600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 61.8943
Cell Significance Index: -25.1500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 26.4626
Cell Significance Index: -25.2700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.6156
Cell Significance Index: -30.3500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.5922
Cell Significance Index: -28.3800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.7901
Cell Significance Index: -30.7400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.9483
Cell Significance Index: -18.2700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.8325
Cell Significance Index: 181.2800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.4083
Cell Significance Index: 1271.6000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3179
Cell Significance Index: 261.5500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9514
Cell Significance Index: 12.9800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8599
Cell Significance Index: 24.6500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7913
Cell Significance Index: 21.1300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.7891
Cell Significance Index: 15.4000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6991
Cell Significance Index: 42.9700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6570
Cell Significance Index: 29.7800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6086
Cell Significance Index: 34.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5894
Cell Significance Index: 30.6200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5559
Cell Significance Index: 100.2100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5349
Cell Significance Index: 14.5600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4607
Cell Significance Index: 251.5800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4356
Cell Significance Index: 53.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3754
Cell Significance Index: 48.5000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3481
Cell Significance Index: 26.7100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3451
Cell Significance Index: 24.4100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3316
Cell Significance Index: 146.5900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3203
Cell Significance Index: 43.9800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3180
Cell Significance Index: 23.7000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3175
Cell Significance Index: 21.9600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3163
Cell Significance Index: 113.4500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2818
Cell Significance Index: 13.1400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2794
Cell Significance Index: 8.0500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2776
Cell Significance Index: 13.0500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2408
Cell Significance Index: 6.0200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.2393
Cell Significance Index: 5.7400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2288
Cell Significance Index: 10.1200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2285
Cell Significance Index: 4.9500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2159
Cell Significance Index: 8.1800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1871
Cell Significance Index: 129.4400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1525
Cell Significance Index: 29.0200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1008
Cell Significance Index: 2.7000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0959
Cell Significance Index: 2.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0718
Cell Significance Index: 97.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0717
Cell Significance Index: 110.3400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0633
Cell Significance Index: 116.7200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0529
Cell Significance Index: 1.8600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0515
Cell Significance Index: 96.9000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0413
Cell Significance Index: 0.3800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0381
Cell Significance Index: 0.2300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0233
Cell Significance Index: 0.4000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0125
Cell Significance Index: 2.5100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0103
Cell Significance Index: 0.6900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0076
Cell Significance Index: 0.9000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0059
Cell Significance Index: 1.0200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0047
Cell Significance Index: 2.9800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0025
Cell Significance Index: 0.3200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0100
Cell Significance Index: -4.5600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0210
Cell Significance Index: -15.9200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0252
Cell Significance Index: -18.4900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0273
Cell Significance Index: -4.4400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0312
Cell Significance Index: -23.1200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0374
Cell Significance Index: -5.4400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0431
Cell Significance Index: -4.4000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0466
Cell Significance Index: -26.2800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0538
Cell Significance Index: -33.5800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0848
Cell Significance Index: -24.3900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0902
Cell Significance Index: -10.5100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0949
Cell Significance Index: -3.0400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1280
Cell Significance Index: -14.6600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1327
Cell Significance Index: -6.9100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1475
Cell Significance Index: -9.3000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1531
Cell Significance Index: -32.2500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1535
Cell Significance Index: -3.2700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1855
Cell Significance Index: -11.9700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2206
Cell Significance Index: -5.6700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2440
Cell Significance Index: -1.9900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2557
Cell Significance Index: -26.6200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3134
Cell Significance Index: -8.2400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3214
Cell Significance Index: -9.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3399
Cell Significance Index: -26.9200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3681
Cell Significance Index: -6.1600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4026
Cell Significance Index: -24.6900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4166
Cell Significance Index: -8.7200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4299
Cell Significance Index: -22.5700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4518
Cell Significance Index: -6.6700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4810
Cell Significance Index: -6.9100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5073
Cell Significance Index: -12.9600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5174
Cell Significance Index: -8.7200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5689
Cell Significance Index: -19.7700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5713
Cell Significance Index: -12.5100 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.5746
Cell Significance Index: -7.1700 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5843
Cell Significance Index: -13.5000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6048
Cell Significance Index: -17.2600 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.6263
Cell Significance Index: -8.9000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6312
Cell Significance Index: -23.1700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.6316
Cell Significance Index: -15.4100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6325
Cell Significance Index: -6.5500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3738015126
Symbol: PTH2_HUMAN
Name: Peptidyl-tRNA hydrolase 2, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10810093
Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
PubMed ID: 10810093
DOI: 10.1101/gr.10.5.703
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15006356
Title: A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.
PubMed ID: 15006356
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25574476
Title: Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness.
PubMed ID: 25574476
DOI: 10.1002/acn3.149
PubMed ID: 25558065
Title: Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.
PubMed ID: 25558065
PubMed ID: 25621951
Title: USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
PubMed ID: 25621951
DOI: 10.1038/ncb3097
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27184847
Title: APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest.
PubMed ID: 27184847
PubMed ID: 14660562
Title: Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.
PubMed ID: 14660562
Sequence Information:
- Length: 179
- Mass: 19194
- Checksum: 11A0BA9ECF6B5E46
- Sequence:
MPSKSLVMEY LAHPSTLGLA VGVACGMCLG WSLRVCFGML PKSKTSKTHT DTESEASILG DSGEYKMILV VRNDLKMGKG KVAAQCSHAA VSAYKQIQRR NPEMLKQWEY CGQPKVVVKA PDEETLIALL AHAKMLGLTV SLIQDAGRTQ IAPGSQTVLG IGPGPADLID KVTGHLKLY
Genular Protein ID: 1037647765
Symbol: J3KQ48_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 180
- Mass: 19325
- Checksum: FCA0F7AA92E9EC8D
- Sequence:
MMPSKSLVME YLAHPSTLGL AVGVACGMCL GWSLRVCFGM LPKSKTSKTH TDTESEASIL GDSGEYKMIL VVRNDLKMGK GKVAAQCSHA AVSAYKQIQR RNPEMLKQWE YCGQPKVVVK APDEETLIAL LAHAKMLGLT VSLIQDAGRT QIAPGSQTVL GIGPGPADLI DKVTGHLKLY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.