Details for: WBP11

Gene ID: 51729

Symbol: WBP11

Ensembl ID: ENSG00000084463

Description: WW domain binding protein 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.9711
    Cell Significance Index: -32.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.7488
    Cell Significance Index: -35.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.7245
    Cell Significance Index: -37.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.2263
    Cell Significance Index: -43.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.6812
    Cell Significance Index: -42.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.8013
    Cell Significance Index: -38.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.3893
    Cell Significance Index: -41.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7480
    Cell Significance Index: -34.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7981
    Cell Significance Index: -42.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9953
    Cell Significance Index: -30.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3420
    Cell Significance Index: -13.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.8962
    Cell Significance Index: 454.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.8134
    Cell Significance Index: 457.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5452
    Cell Significance Index: 168.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3888
    Cell Significance Index: 39.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2513
    Cell Significance Index: 34.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1756
    Cell Significance Index: 144.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1548
    Cell Significance Index: 9.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0388
    Cell Significance Index: 187.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9818
    Cell Significance Index: 51.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9364
    Cell Significance Index: 128.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8555
    Cell Significance Index: 29.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7808
    Cell Significance Index: 426.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7350
    Cell Significance Index: 38.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7132
    Cell Significance Index: 141.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6703
    Cell Significance Index: 49.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6655
    Cell Significance Index: 294.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6587
    Cell Significance Index: 41.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6445
    Cell Significance Index: 17.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6125
    Cell Significance Index: 31.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6044
    Cell Significance Index: 121.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5850
    Cell Significance Index: 528.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5591
    Cell Significance Index: 26.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5579
    Cell Significance Index: 36.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5517
    Cell Significance Index: 65.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5383
    Cell Significance Index: 25.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5098
    Cell Significance Index: 13.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5069
    Cell Significance Index: 12.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4889
    Cell Significance Index: 63.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4880
    Cell Significance Index: 34.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3985
    Cell Significance Index: 27.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3984
    Cell Significance Index: 51.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3598
    Cell Significance Index: 16.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3440
    Cell Significance Index: 7.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3385
    Cell Significance Index: 3.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3210
    Cell Significance Index: 9.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2915
    Cell Significance Index: 104.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2622
    Cell Significance Index: 5.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2148
    Cell Significance Index: 2.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1991
    Cell Significance Index: 5.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1900
    Cell Significance Index: 10.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1517
    Cell Significance Index: 25.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1501
    Cell Significance Index: 14.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1221
    Cell Significance Index: 2.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0748
    Cell Significance Index: 140.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0193
    Cell Significance Index: 13.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0083
    Cell Significance Index: 5.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0064
    Cell Significance Index: 9.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0049
    Cell Significance Index: 3.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0049
    Cell Significance Index: 9.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0115
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0122
    Cell Significance Index: -0.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0152
    Cell Significance Index: -0.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0186
    Cell Significance Index: -3.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0235
    Cell Significance Index: -31.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0245
    Cell Significance Index: -15.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0282
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0304
    Cell Significance Index: -3.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0371
    Cell Significance Index: -5.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0394
    Cell Significance Index: -22.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0399
    Cell Significance Index: -2.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0414
    Cell Significance Index: -18.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0545
    Cell Significance Index: -5.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0981
    Cell Significance Index: -11.2400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1077
    Cell Significance Index: -0.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1275
    Cell Significance Index: -36.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1276
    Cell Significance Index: -9.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2211
    Cell Significance Index: -6.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2305
    Cell Significance Index: -6.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2398
    Cell Significance Index: -7.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2400
    Cell Significance Index: -6.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2518
    Cell Significance Index: -16.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2538
    Cell Significance Index: -4.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2580
    Cell Significance Index: -3.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3057
    Cell Significance Index: -6.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3566
    Cell Significance Index: -6.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3633
    Cell Significance Index: -37.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3766
    Cell Significance Index: -9.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3823
    Cell Significance Index: -30.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3848
    Cell Significance Index: -2.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4514
    Cell Significance Index: -19.9700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.5165
    Cell Significance Index: -2.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5308
    Cell Significance Index: -20.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6131
    Cell Significance Index: -37.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6507
    Cell Significance Index: -12.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7788
    Cell Significance Index: -22.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7793
    Cell Significance Index: -22.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WBP11 is a small, non-coding gene that encodes a protein with a WW domain, a characteristic motif involved in protein-protein interactions. The protein is primarily expressed in hematopoietic cells, including polychromatophilic erythroblasts, mucosal type mast cells, and hematopoietic oligopotent progenitor cells. Its expression pattern suggests a significant role in the development and maturation of immune cells. **Pathways and Functions:** WBP11 is implicated in several cellular pathways, including: 1. **mRNA Splicing:** WBP11 interacts with other proteins to facilitate the splicing of intron-containing pre-mRNAs, which is a critical step in gene expression. 2. **RNA Processing:** WBP11 is involved in the processing of rRNA, a process essential for ribosome biogenesis. 3. **Protein Binding:** The WW domain of WBP11 enables it to interact with various proteins, including Npw38, a protein involved in the regulation of immune responses. 4. **Single-stranded DNA Binding:** WBP11 has been shown to bind to single-stranded DNA, which suggests a potential role in DNA repair and replication. **Clinical Significance:** While WBP11's exact clinical significance remains unclear, its expression in various cell types and its involvement in key cellular pathways suggest potential implications in immunological disorders. For instance: 1. **Immunodeficiency Diseases:** Alterations in WBP11 expression or function could contribute to immunodeficiency diseases, such as those characterized by impaired T-cell development or function. 2. **Cancer:** WBP11's role in mRNA splicing and RNA processing may be disrupted in cancer cells, leading to altered gene expression and tumor development. 3. **Autoimmune Diseases:** WBP11's interaction with immune-related proteins may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. In conclusion, WBP11 is a complex gene with multiple roles in cellular processes. Further research is needed to fully elucidate its functions and clinical significance, but its involvement in key pathways and its expression in hematopoietic cells make it an intriguing target for future studies.

Genular Protein ID: 3357067450

Symbol: WBP11_HUMAN

Name: Npw38-binding protein

UniProtKB Accession Codes:

Q9Y2W2 Q96AY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10593949

Title: Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine.

PubMed ID: 10593949

DOI: 10.1074/jbc.274.51.36513

PubMed ID: 11375989

Title: A nuclear SH3 domain-binding protein that colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks.

PubMed ID: 11375989

DOI: 10.1074/jbc.m103142200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14640981

Title: SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.

PubMed ID: 14640981

DOI: 10.1042/bj20030950

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19592703

Title: Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21).

PubMed ID: 19592703

DOI: 10.1074/jbc.m109.024828

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20410308

Title: Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing.

PubMed ID: 20410308

DOI: 10.1074/jbc.m109.084525

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33276377

Title: Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice.

PubMed ID: 33276377

DOI: 10.1093/hmg/ddaa258

Sequence Information:

  • Length: 641
  • Mass: 69998
  • Checksum: C94F9687D132CE77
  • Sequence:
    • MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP KQIIRDMEKL 
DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN PDIYKELRKL EVEYEQKRAQ 
LSQYFDAVKN AQHVEVESIP LPDMPHAPSN ILIQDIPLPG AQPPSILKKT SAYGPPTRAV 
SILPLLGHGV PRLPPGRKPP GPPPGPPPPQ VVQMYGRKVG FALDLPPRRR DEDMLYSPEL 
AQRGHDDDVS STSEDDGYPE DMDQDKHDDS TDDSDTDKSD GESDGDEFVH RDNGERDNNE 
EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE EFSEDDDEDD 
SDDSEAEKQS QKQHKEESHS DGTSTASSQQ QAPPQSVPPS QIQAPPMPGP PPLGPPPAPP 
LRPPGPPTGL PPGPPPGAPP FLRPPGMPGL RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP 
GPPPRGPPPR LPPPAPPGIP PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPNL 
IQRPKADDTS AATIEKKATA TISAKPQITN PKAEITRFVP TALRVRRENK GATAAPQRKS 
EDDSAVPLAK AAPKSGPSVP VSVQTKDDVY EAFMKEMEGL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.