Details for: PFDN5

Gene ID: 5204

Symbol: PFDN5

Ensembl ID: ENSG00000123349

Description: prefoldin subunit 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.86
    Marker Score: 4,587
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.68
    Marker Score: 4,285
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.98
    Marker Score: 7,667
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.91
    Marker Score: 48,582
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.89
    Marker Score: 10,241
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.69
    Marker Score: 8,041
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.65
    Marker Score: 158,264
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.63
    Marker Score: 62,158
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.61
    Marker Score: 14,546
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.6
    Marker Score: 4,109
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 4.59
    Marker Score: 4,496
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.53
    Marker Score: 8,266
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.52
    Marker Score: 238,998
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.51
    Marker Score: 1,662
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.41
    Marker Score: 3,157
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.37
    Marker Score: 2,812
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.35
    Marker Score: 243,283
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.31
    Marker Score: 3,124
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.28
    Marker Score: 2,282
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.28
    Marker Score: 12,481
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.25
    Marker Score: 2,182
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.24
    Marker Score: 5,524
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.21
    Marker Score: 48,889
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.12
    Marker Score: 54,348
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.11
    Marker Score: 1,850
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.04
    Marker Score: 9,879
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.01
    Marker Score: 11,073
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.01
    Marker Score: 1,303
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.97
    Marker Score: 11,143
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.97
    Marker Score: 17,032
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.96
    Marker Score: 947
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.92
    Marker Score: 3,865
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.9
    Marker Score: 2,376
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.9
    Marker Score: 4,339
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.88
    Marker Score: 9,474
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.86
    Marker Score: 10,355
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.86
    Marker Score: 7,250
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.84
    Marker Score: 3,271
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.83
    Marker Score: 4,093
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.83
    Marker Score: 2,247
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.83
    Marker Score: 5,640
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.8
    Marker Score: 13,492
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.8
    Marker Score: 3,671
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.76
    Marker Score: 3,538
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.74
    Marker Score: 8,516
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.74
    Marker Score: 3,182
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.73
    Marker Score: 2,650
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.71
    Marker Score: 2,914
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.71
    Marker Score: 4,031
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.7
    Marker Score: 3,112
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.69
    Marker Score: 19,374
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.68
    Marker Score: 6,583
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.62
    Marker Score: 3,231
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.61
    Marker Score: 3,069
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.61
    Marker Score: 3,170
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.59
    Marker Score: 2,719
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.59
    Marker Score: 9,058
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.57
    Marker Score: 1,842
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.57
    Marker Score: 3,172
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.56
    Marker Score: 4,073
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.55
    Marker Score: 26,460
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.54
    Marker Score: 23,013
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.54
    Marker Score: 8,536
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.53
    Marker Score: 30,653
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.52
    Marker Score: 22,953
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.5
    Marker Score: 927
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.48
    Marker Score: 917
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.48
    Marker Score: 5,709
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.48
    Marker Score: 2,849
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.48
    Marker Score: 1,652
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.46
    Marker Score: 792
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.44
    Marker Score: 2,857
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.41
    Marker Score: 1,466
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.4
    Marker Score: 1,991
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.39
    Marker Score: 2,247
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.38
    Marker Score: 953
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.38
    Marker Score: 1,752
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.38
    Marker Score: 1,234
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.36
    Marker Score: 3,362
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.36
    Marker Score: 3,408
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.35
    Marker Score: 115,974
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.34
    Marker Score: 2,949
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.34
    Marker Score: 1,498
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.33
    Marker Score: 4,107
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.32
    Marker Score: 7,545
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.32
    Marker Score: 1,145
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.32
    Marker Score: 5,501
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.31
    Marker Score: 941
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.31
    Marker Score: 1,506
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.31
    Marker Score: 3,559
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.3
    Marker Score: 3,088
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.3
    Marker Score: 1,316
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.3
    Marker Score: 1,819
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.29
    Marker Score: 9,396
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.28
    Marker Score: 1,080
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.28
    Marker Score: 1,638
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.27
    Marker Score: 20,865
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.26
    Marker Score: 5,193
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.26
    Marker Score: 12,588
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.26
    Marker Score: 1,839

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PFDN5 is a subunit of the prefoldin complex, which is composed of seven subunits (α, β, γ, δ, ε, ζ, and η). PFDN5 is the fifth subunit of this complex and is characterized by its ability to bind to unfolded proteins and facilitate their folding into their native conformation. PFDN5 is also involved in the regulation of amyloid fibril formation, which is a hallmark of various neurodegenerative diseases. Its expression is negatively regulated by amyloid-beta, a key player in Alzheimer's disease, and it also modulates the canonical Wnt signaling pathway. **Pathways and Functions:** PFDN5 is involved in several key pathways that regulate protein homeostasis and cellular signaling: 1. **Chaperone-mediated protein folding:** PFDN5 facilitates the folding of newly synthesized proteins into their native conformation, ensuring proper protein function and preventing protein misfolding. 2. **Cooperation of prefoldin and tric/CCT in actin and tubulin folding:** PFDN5 interacts with the tric/CCT complex to facilitate the folding of actin and tubulin, which are essential components of the cytoskeleton. 3. **Negative regulation of amyloid fibril formation:** PFDN5 binds to amyloid-beta and prevents its aggregation, thereby reducing the formation of amyloid fibrils that contribute to neurodegenerative diseases. 4. **Negative regulation of canonical Wnt signaling pathway:** PFDN5 modulates the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation and differentiation. 5. **Regulation of DNA-templated transcription:** PFDN5 interacts with RNA polymerase II to regulate the transcription of genes involved in protein homeostasis. **Clinical Significance:** PFDN5 dysregulation has been implicated in various diseases, including: 1. **Alzheimer's disease:** PFDN5 expression is reduced in Alzheimer's disease, and its dysregulation contributes to amyloid-beta aggregation and neurodegeneration. 2. **Cancer:** PFDN5 expression is altered in various types of cancer, including breast, lung, and colon cancer, and its dysregulation contributes to tumor progression and metastasis. 3. **Neurodegenerative diseases:** PFDN5 dysregulation has been implicated in other neurodegenerative diseases, including Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). 4. **Retina development:** PFDN5 is essential for retina development in camera-type eye, and its dysregulation can lead to retinal degeneration. In conclusion, PFDN5 is a critical component of the prefoldin complex that plays a vital role in maintaining protein homeostasis and regulating various cellular signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of PFDN5 in maintaining cellular homeostasis and preventing disease. Further research is necessary to fully elucidate the mechanisms by which PFDN5 regulates protein homeostasis and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2753006483

Symbol: PFD5_HUMAN

Name: Prefoldin subunit 5

UniProtKB Accession Codes:

Q99471 A8K9A8 Q54AA8 Q9C083 Q9C084

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 6 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9792694

Title: MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.

PubMed ID: 9792694

DOI: 10.1074/jbc.273.45.29794

PubMed ID: 11567024

Title: MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer.

PubMed ID: 11567024

DOI: 10.1074/jbc.m106127200

PubMed ID: 16173081

Title: Distinct localizations and repression activities of MM-1 isoforms toward c-Myc.

PubMed ID: 16173081

DOI: 10.1002/jcb.20619

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 154
  • Mass: 17328
  • Checksum: 0DA1F3644548CB14
  • Sequence:
    • MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLNKSNEGK 
ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA 
LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA TAKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.