Details for: PFDN5

Gene ID: 5204

Symbol: PFDN5

Ensembl ID: ENSG00000123349

Description: prefoldin subunit 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 970.1358
    Cell Significance Index: -150.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 569.5792
    Cell Significance Index: -144.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 487.1493
    Cell Significance Index: -200.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 452.9151
    Cell Significance Index: -184.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 412.8800
    Cell Significance Index: -194.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 388.8914
    Cell Significance Index: -200.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 291.8980
    Cell Significance Index: -195.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 194.5340
    Cell Significance Index: -185.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 140.7431
    Cell Significance Index: -173.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 47.6289
    Cell Significance Index: -146.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.9352
    Cell Significance Index: -85.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.5559
    Cell Significance Index: -58.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 8.8921
    Cell Significance Index: 164.3500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.4093
    Cell Significance Index: 43.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.4010
    Cell Significance Index: 345.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.2434
    Cell Significance Index: 190.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.5890
    Cell Significance Index: 904.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 6.5696
    Cell Significance Index: 308.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.1356
    Cell Significance Index: 175.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.7867
    Cell Significance Index: 157.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.5747
    Cell Significance Index: 128.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.4990
    Cell Significance Index: 97.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.3705
    Cell Significance Index: 693.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.3698
    Cell Significance Index: 660.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.3581
    Cell Significance Index: 60.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.1504
    Cell Significance Index: 928.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.9541
    Cell Significance Index: 2705.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.7742
    Cell Significance Index: 355.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.4755
    Cell Significance Index: 93.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.4751
    Cell Significance Index: 316.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.4492
    Cell Significance Index: 1967.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.8895
    Cell Significance Index: 498.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.6504
    Cell Significance Index: 430.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5715
    Cell Significance Index: 230.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.9405
    Cell Significance Index: 86.3600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.3581
    Cell Significance Index: 35.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.2926
    Cell Significance Index: 29.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.1955
    Cell Significance Index: 115.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.1438
    Cell Significance Index: 366.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0266
    Cell Significance Index: 91.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7896
    Cell Significance Index: 16.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5551
    Cell Significance Index: 54.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2127
    Cell Significance Index: 32.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1872
    Cell Significance Index: 61.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9401
    Cell Significance Index: 10.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8668
    Cell Significance Index: 782.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5392
    Cell Significance Index: 408.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4829
    Cell Significance Index: 95.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4005
    Cell Significance Index: 293.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2680
    Cell Significance Index: 51.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2403
    Cell Significance Index: 48.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0980
    Cell Significance Index: 1.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0165
    Cell Significance Index: -1.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0389
    Cell Significance Index: -73.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0547
    Cell Significance Index: -1.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0704
    Cell Significance Index: -4.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0720
    Cell Significance Index: -53.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0865
    Cell Significance Index: -4.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1016
    Cell Significance Index: -187.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1206
    Cell Significance Index: -185.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1262
    Cell Significance Index: -78.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1594
    Cell Significance Index: -216.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1705
    Cell Significance Index: -61.1700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1759
    Cell Significance Index: -1.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2066
    Cell Significance Index: -20.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2167
    Cell Significance Index: -1.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2198
    Cell Significance Index: -139.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2219
    Cell Significance Index: -125.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3483
    Cell Significance Index: -14.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3809
    Cell Significance Index: -172.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3854
    Cell Significance Index: -81.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5615
    Cell Significance Index: -161.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8768
    Cell Significance Index: -69.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9774
    Cell Significance Index: -24.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0138
    Cell Significance Index: -29.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0521
    Cell Significance Index: -120.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0560
    Cell Significance Index: -153.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0917
    Cell Significance Index: -18.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1280
    Cell Significance Index: -131.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.6189
    Cell Significance Index: -184.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.8752
    Cell Significance Index: -195.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.9292
    Cell Significance Index: -61.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.9443
    Cell Significance Index: -68.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.2193
    Cell Significance Index: -115.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.2639
    Cell Significance Index: -127.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.3026
    Cell Significance Index: -138.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.3465
    Cell Significance Index: -35.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.4507
    Cell Significance Index: -188.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.5713
    Cell Significance Index: -55.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.6525
    Cell Significance Index: -36.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.0918
    Cell Significance Index: -18.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.1503
    Cell Significance Index: -193.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.6584
    Cell Significance Index: -43.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.9631
    Cell Significance Index: -116.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.0865
    Cell Significance Index: -180.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -4.1028
    Cell Significance Index: -102.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.1355
    Cell Significance Index: -70.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -4.5025
    Cell Significance Index: -37.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.5185
    Cell Significance Index: -165.8700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.6490
    Cell Significance Index: -25.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PFDN5 is a subunit of the prefoldin complex, which is composed of seven subunits (α, β, γ, δ, ε, ζ, and η). PFDN5 is the fifth subunit of this complex and is characterized by its ability to bind to unfolded proteins and facilitate their folding into their native conformation. PFDN5 is also involved in the regulation of amyloid fibril formation, which is a hallmark of various neurodegenerative diseases. Its expression is negatively regulated by amyloid-beta, a key player in Alzheimer's disease, and it also modulates the canonical Wnt signaling pathway. **Pathways and Functions:** PFDN5 is involved in several key pathways that regulate protein homeostasis and cellular signaling: 1. **Chaperone-mediated protein folding:** PFDN5 facilitates the folding of newly synthesized proteins into their native conformation, ensuring proper protein function and preventing protein misfolding. 2. **Cooperation of prefoldin and tric/CCT in actin and tubulin folding:** PFDN5 interacts with the tric/CCT complex to facilitate the folding of actin and tubulin, which are essential components of the cytoskeleton. 3. **Negative regulation of amyloid fibril formation:** PFDN5 binds to amyloid-beta and prevents its aggregation, thereby reducing the formation of amyloid fibrils that contribute to neurodegenerative diseases. 4. **Negative regulation of canonical Wnt signaling pathway:** PFDN5 modulates the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation and differentiation. 5. **Regulation of DNA-templated transcription:** PFDN5 interacts with RNA polymerase II to regulate the transcription of genes involved in protein homeostasis. **Clinical Significance:** PFDN5 dysregulation has been implicated in various diseases, including: 1. **Alzheimer's disease:** PFDN5 expression is reduced in Alzheimer's disease, and its dysregulation contributes to amyloid-beta aggregation and neurodegeneration. 2. **Cancer:** PFDN5 expression is altered in various types of cancer, including breast, lung, and colon cancer, and its dysregulation contributes to tumor progression and metastasis. 3. **Neurodegenerative diseases:** PFDN5 dysregulation has been implicated in other neurodegenerative diseases, including Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). 4. **Retina development:** PFDN5 is essential for retina development in camera-type eye, and its dysregulation can lead to retinal degeneration. In conclusion, PFDN5 is a critical component of the prefoldin complex that plays a vital role in maintaining protein homeostasis and regulating various cellular signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of PFDN5 in maintaining cellular homeostasis and preventing disease. Further research is necessary to fully elucidate the mechanisms by which PFDN5 regulates protein homeostasis and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2753006483

Symbol: PFD5_HUMAN

Name: Prefoldin subunit 5

UniProtKB Accession Codes:

Q99471 A8K9A8 Q54AA8 Q9C083 Q9C084

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 6 Ensembl 8 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9792694

Title: MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.

PubMed ID: 9792694

DOI: 10.1074/jbc.273.45.29794

PubMed ID: 11567024

Title: MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer.

PubMed ID: 11567024

DOI: 10.1074/jbc.m106127200

PubMed ID: 16173081

Title: Distinct localizations and repression activities of MM-1 isoforms toward c-Myc.

PubMed ID: 16173081

DOI: 10.1002/jcb.20619

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 154
  • Mass: 17328
  • Checksum: 0DA1F3644548CB14
  • Sequence:
    • MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLNKSNEGK 
ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA 
LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA TAKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.