Details for: PFDN5

Gene ID: 5204

Symbol: PFDN5

Ensembl ID: ENSG00000123349

Description: prefoldin subunit 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.86
    Marker Score: 4587
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.68
    Marker Score: 4285
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.98
    Marker Score: 7667
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.91
    Marker Score: 48582
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.89
    Marker Score: 10240.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.69
    Marker Score: 8041
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.65
    Marker Score: 158263.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.63
    Marker Score: 62158
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.61
    Marker Score: 14546
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.6
    Marker Score: 4109
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 4.59
    Marker Score: 4495.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.53
    Marker Score: 8266
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.52
    Marker Score: 238998
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.51
    Marker Score: 1662
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.41
    Marker Score: 3156.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.37
    Marker Score: 2812
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.35
    Marker Score: 243282.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.31
    Marker Score: 3124
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.28
    Marker Score: 2282
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.28
    Marker Score: 12481
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.25
    Marker Score: 2182
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.24
    Marker Score: 5524
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.21
    Marker Score: 48889
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.12
    Marker Score: 54348
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.11
    Marker Score: 1850
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.04
    Marker Score: 9879
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.01
    Marker Score: 11072.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.01
    Marker Score: 1302.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.97
    Marker Score: 11143
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.97
    Marker Score: 17032
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.96
    Marker Score: 947
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.92
    Marker Score: 3865
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.9
    Marker Score: 2376
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.9
    Marker Score: 4339
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.88
    Marker Score: 9474
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.86
    Marker Score: 10355
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.86
    Marker Score: 7250
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.84
    Marker Score: 3270.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.83
    Marker Score: 4093
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.83
    Marker Score: 2247
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.83
    Marker Score: 5640
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.8
    Marker Score: 13491.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.8
    Marker Score: 3671
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.76
    Marker Score: 3538
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.74
    Marker Score: 8515.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.74
    Marker Score: 3182
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.73
    Marker Score: 2650
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.71
    Marker Score: 2913.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.71
    Marker Score: 4031
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.7
    Marker Score: 3112
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.69
    Marker Score: 19374
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.68
    Marker Score: 6583
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.62
    Marker Score: 3230.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.61
    Marker Score: 3069
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.61
    Marker Score: 3170
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.59
    Marker Score: 2719
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.59
    Marker Score: 9058
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.57
    Marker Score: 1841.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.57
    Marker Score: 3172
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.56
    Marker Score: 4073
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.55
    Marker Score: 26460
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.54
    Marker Score: 23012.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.54
    Marker Score: 8536
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.53
    Marker Score: 30653
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.52
    Marker Score: 22953
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.5
    Marker Score: 927
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.48
    Marker Score: 917
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.48
    Marker Score: 5709
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.48
    Marker Score: 2849
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.48
    Marker Score: 1652
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.46
    Marker Score: 792
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.44
    Marker Score: 2856.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.41
    Marker Score: 1466
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.4
    Marker Score: 1991
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.39
    Marker Score: 2246.5
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.38
    Marker Score: 953
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.38
    Marker Score: 1752
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.38
    Marker Score: 1234
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.36
    Marker Score: 3362
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.36
    Marker Score: 3408
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.35
    Marker Score: 115974
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.34
    Marker Score: 2949
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.34
    Marker Score: 1498
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.33
    Marker Score: 4107
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.32
    Marker Score: 7545
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.32
    Marker Score: 1145
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.32
    Marker Score: 5501
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.31
    Marker Score: 941
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.31
    Marker Score: 1506
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.31
    Marker Score: 3559
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.3
    Marker Score: 3087.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.3
    Marker Score: 1316
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.3
    Marker Score: 1819
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.29
    Marker Score: 9396
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.28
    Marker Score: 1079.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.28
    Marker Score: 1638
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.27
    Marker Score: 20865
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.26
    Marker Score: 5193
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.26
    Marker Score: 12588
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.26
    Marker Score: 1839

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Other Information

**Key characteristics:** * PFDN5 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including thyroid follicular cell, cord blood hematopoietic stem cell, mesenchymal stem cell, mature T cell, CD38-negative naive B cell, naive thymus-derived CD4-positive, alpha-beta T cell, fibroblast of mammary gland, malignant cell, mature gamma-delta T cell, naive B cell. * It is a key regulator of amyloid-beta precursor protein folding. **Pathways and functions:** * PFDN5 is involved in the following pathways: * Amyloid-beta binding * Chaperone-mediated protein folding * Chaperonin-mediated protein folding * Cooperation of prefoldin and tric/cct in actin and tubulin folding * Metabolism of proteins * Negative regulation of amyloid fibril formation * Negative regulation of canonical wnt signaling pathway * Negative regulation of dna-templated transcription * It plays a role in the assembly of the Rna polymerase i assembly complex, the Rna polymerase ii core complex assembly, and the Rna polymerase iii assembly. * It also plays a role in the regulation of DNA-templated transcription. **Clinical significance:** * Mutations in PFDN5 have been linked to the development of amyloidosis, a progressive, fatal neurodegenerative disease characterized by the deposition of amyloid-beta plaques in the brain. * PFDN5 is a potential therapeutic target for amyloidosis.

Genular Protein ID: 2753006483

Symbol: PFD5_HUMAN

Name: Prefoldin subunit 5

UniProtKB Accession Codes:

Q99471 A8K9A8 Q54AA8 Q9C083 Q9C084

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 6 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9792694

Title: MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.

PubMed ID: 9792694

DOI: 10.1074/jbc.273.45.29794

PubMed ID: 11567024

Title: MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer.

PubMed ID: 11567024

DOI: 10.1074/jbc.m106127200

PubMed ID: 16173081

Title: Distinct localizations and repression activities of MM-1 isoforms toward c-Myc.

PubMed ID: 16173081

DOI: 10.1002/jcb.20619

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 154
  • Mass: 17328
  • Checksum: 0DA1F3644548CB14
  • Sequence:
    • MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLNKSNEGK 
ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA 
LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA TAKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.