Gene POLR2L - ENSG00000177700 | NCBI Gene ID: 5441

Details for: POLR2L

Gene ID: 5441

Symbol: POLR2L

Ensembl ID: ENSG00000177700

Description: RNA polymerase II, I and III subunit L

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Innate immune system
(R-HSA-168249)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii chain elongation
(R-HSA-73780)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase iii transcription termination
(R-HSA-73980)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Dna binding
(GO:0003677)
Rna polymerase i activity
(GO:0001054)
Rna polymerase ii activity
(GO:0001055)
Rna polymerase iii activity
(GO:0001056)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: secretory cell (CL0000151)
Fold Change: 3.78
Marker Score: 6899
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.7
Marker Score: 10216.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 3.69
Marker Score: 3614
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.59
Marker Score: 4323
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.58
Marker Score: 18819
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.55
Marker Score: 22621
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 3.48
Marker Score: 2458
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.47
Marker Score: 12335.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.47
Marker Score: 2713.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.45
Marker Score: 9235
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.38
Marker Score: 22046
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.38
Marker Score: 4400
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.36
Marker Score: 5167
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.34
Marker Score: 8164
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.28
Marker Score: 7484
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.25
Marker Score: 181901
Cell Name: blood cell (CL0000081)
Fold Change: 3.24
Marker Score: 37668
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.22
Marker Score: 3360.5
Cell Name: serous secreting cell (CL0000313)
Fold Change: 3.13
Marker Score: 1250.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.12
Marker Score: 4955
Cell Name: radial glial cell (CL0000681)
Fold Change: 3.1
Marker Score: 1144
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.08
Marker Score: 5105
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.07
Marker Score: 1058
Cell Name: mature T cell (CL0002419)
Fold Change: 3.05
Marker Score: 30172
Cell Name: pneumocyte (CL0000322)
Fold Change: 3.03
Marker Score: 4869.5
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.02
Marker Score: 23571
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.01
Marker Score: 7595
Cell Name: cell in vitro (CL0001034)
Fold Change: 3
Marker Score: 103956
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3
Marker Score: 3334.5
Cell Name: chondrocyte (CL0000138)
Fold Change: 3
Marker Score: 1350
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3
Marker Score: 6806
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3
Marker Score: 3202
Cell Name: reticular cell (CL0000432)
Fold Change: 2.97
Marker Score: 1084
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.96
Marker Score: 2636
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.92
Marker Score: 11259
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.91
Marker Score: 2951
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.91
Marker Score: 1693
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.91
Marker Score: 2066
Cell Name: enterocyte (CL0000584)
Fold Change: 2.85
Marker Score: 13682.5
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.83
Marker Score: 24590
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.83
Marker Score: 1892
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.82
Marker Score: 2405
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.82
Marker Score: 1766
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.8
Marker Score: 36901.5
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.79
Marker Score: 2671
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.77
Marker Score: 20590.5
Cell Name: decidual cell (CL2000002)
Fold Change: 2.76
Marker Score: 11899.5
Cell Name: supporting cell (CL0000630)
Fold Change: 2.75
Marker Score: 5164
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.74
Marker Score: 4494
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.74
Marker Score: 7988
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.73
Marker Score: 7155
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.73
Marker Score: 2148
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 2.72
Marker Score: 995
Cell Name: club cell (CL0000158)
Fold Change: 2.72
Marker Score: 3173
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.7
Marker Score: 1400
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.69
Marker Score: 910
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 2.69
Marker Score: 2028
Cell Name: malignant cell (CL0001064)
Fold Change: 2.68
Marker Score: 35987
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.67
Marker Score: 639
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.65
Marker Score: 5154
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.63
Marker Score: 5261
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.62
Marker Score: 3604
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.61
Marker Score: 22508.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.6
Marker Score: 29290.5
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.6
Marker Score: 2038.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.59
Marker Score: 2588
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.58
Marker Score: 819
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.58
Marker Score: 3652
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.58
Marker Score: 5378
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.57
Marker Score: 1372.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.56
Marker Score: 7175.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.55
Marker Score: 1212
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.55
Marker Score: 2708.5
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.55
Marker Score: 8059
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.55
Marker Score: 3692
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.54
Marker Score: 1307
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.53
Marker Score: 86205
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.52
Marker Score: 809
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.51
Marker Score: 2251
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.51
Marker Score: 564.5
Cell Name: paneth cell (CL0000510)
Fold Change: 2.5
Marker Score: 1743
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.5
Marker Score: 2686
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.5
Marker Score: 2412
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.49
Marker Score: 819
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.48
Marker Score: 1798
Cell Name: acinar cell (CL0000622)
Fold Change: 2.47
Marker Score: 1744
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.47
Marker Score: 1233
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.46
Marker Score: 3796
Cell Name: stromal cell (CL0000499)
Fold Change: 2.46
Marker Score: 2885.5
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.46
Marker Score: 2811
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 2.45
Marker Score: 1066
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 2.45
Marker Score: 645.5
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.45
Marker Score: 1112
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.44
Marker Score: 1203.5
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.43
Marker Score: 644
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.43
Marker Score: 4339
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.43
Marker Score: 905
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.43
Marker Score: 1044
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.43
Marker Score: 1133
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.43
Marker Score: 599

Hover over a box to see details here...

**Key Characteristics:** POLR2L is a large gene that encodes a subunit of the Pol II complex, which is composed of two catalytic subunits (Rpb1 and Rpb2) and several regulatory subunits. The Pol II complex is responsible for transcribing mRNA from DNA, and POLR2L is involved in various aspects of this process, including promoter recognition, transcription initiation, and elongation. POLR2L has been shown to interact with multiple proteins, including transcription factors, RNA-binding proteins, and chromatin remodeling complexes, to regulate gene expression. **Pathways and Functions:** POLR2L is involved in multiple cellular pathways, including: 1. **Gene expression**: POLR2L is essential for the transcription of mRNA from DNA, and its dysregulation can lead to changes in gene expression patterns, contributing to various diseases. 2. **Cell cycle regulation**: POLR2L is involved in the regulation of the cell cycle, particularly during the G2/M phase, and its dysregulation can lead to cell cycle dysregulation and cancer. 3. **DNA repair**: POLR2L has been shown to interact with DNA repair proteins, such as BRCA1 and BRCA2, to regulate DNA repair processes. 4. **Transcriptional regulation**: POLR2L is involved in the regulation of transcriptional programs, including those involved in development, differentiation, and response to environmental stimuli. 5. **Immune response**: POLR2L has been shown to interact with immune-related proteins, such as interferons and cytokines, to regulate immune responses. **Clinical Significance:** The POLR2L gene has been implicated in various clinical conditions, including: 1. **Cancer**: POLR2L has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: POLR2L has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Infectious diseases**: POLR2L has been shown to interact with HIV proteins, such as Tat, to regulate HIV transcription and replication. 4. **Developmental disorders**: POLR2L has been implicated in developmental disorders, including Down syndrome and intellectual disability. In conclusion, the POLR2L gene is a complex and multifaceted component of the RNA polymerase II complex, involved in multiple cellular pathways, including gene expression, cell cycle regulation, DNA repair, transcriptional regulation, and immune response. Its dysregulation has been implicated in various clinical conditions, including cancer, neurological disorders, infectious diseases, and developmental disorders. Further research is needed to fully understand the role of POLR2L in human disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Genular Protein ID: 2593595146

Symbol: RPAB5_HUMAN

Name: DNA-directed RNA polymerases I, II, and III subunit RPABC5

UniProtKB Accession Codes:

P62875 P52436 Q6FHX3

Database IDs:

Citations:

PubMed ID: 8524256

Title: Six human RNA polymerase subunits functionally substitute for their yeast counterparts.

PubMed ID: 8524256

DOI: 10.1128/mcb.15.12.6895

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7651387

Title: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae.

PubMed ID: 7651387

DOI: 10.1128/mcb.15.9.4702

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 16809778

Title: RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.

PubMed ID: 16809778

DOI: 10.1128/mcb.00230-06

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

Sequence Information:

Length: 67
Mass: 7645
Checksum: 9E8A72F667FE7EC5
Sequence:

MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL AHVDLIEKLL 
NYAPLEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: POLR2L

Associated with

Cells (max top 100)

Other Information

Six human RNA polymerase subunits functionally substitute for their yeast counterparts. PubMed ID: 8524256

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. PubMed ID: 7651387

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. PubMed ID: 16809778

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells. PubMed ID: 20413673

Initial characterization of the human central proteome. PubMed ID: 21269460

Structure of human RNA polymerase III. PubMed ID: 33335104

Structure of human RNA polymerase III elongation complex. PubMed ID: 33674783

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine. PubMed ID: 34675218

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. PubMed ID: 33558764

Structural insights into transcriptional regulation of human RNA polymerase III. PubMed ID: 33558766