POLR2L | ENSG00000177700 | NCBI 5441

Details for: POLR2L

Gene ID: 5441

Symbol: POLR2L

Ensembl ID: ENSG00000177700

Description: RNA polymerase II, I and III subunit L

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Innate immune system
(R-HSA-168249)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii chain elongation
(R-HSA-73780)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase iii transcription termination
(R-HSA-73980)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Dna binding
(GO:0003677)
Rna polymerase i activity
(GO:0001054)
Rna polymerase ii activity
(GO:0001055)
Rna polymerase iii activity
(GO:0001056)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 486.2251
Cell Significance Index: -75.6300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 358.0618
Cell Significance Index: -90.8200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 266.6965
Cell Significance Index: -109.8700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 231.1793
Cell Significance Index: -109.1500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 206.9558
Cell Significance Index: -106.4600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 163.3851
Cell Significance Index: -109.6400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 82.7767
Cell Significance Index: -102.0600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.9419
Cell Significance Index: -110.2600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 27.6026
Cell Significance Index: -84.7800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.3067
Cell Significance Index: -51.7200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 15.0234
Cell Significance Index: -32.8800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.3280
Cell Significance Index: 248.4200
Cell Name: kidney cell (CL1000497)
Fold Change: 4.9416
Cell Significance Index: 39.4600
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 4.2678
Cell Significance Index: 26.2700
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 4.1043
Cell Significance Index: 37.8000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.8637
Cell Significance Index: 181.5900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.7921
Cell Significance Index: 43.0800
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 3.7379
Cell Significance Index: 32.1200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.6659
Cell Significance Index: 450.7600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.5673
Cell Significance Index: 265.8700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.5077
Cell Significance Index: 632.3400
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.4661
Cell Significance Index: 1892.9100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.9879
Cell Significance Index: 211.3200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.9243
Cell Significance Index: 1292.8900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.8306
Cell Significance Index: 59.2500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.7763
Cell Significance Index: 49.0600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.7127
Cell Significance Index: 372.5300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.6389
Cell Significance Index: 311.2100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5967
Cell Significance Index: 70.6800
Cell Name: odontoblast (CL0000060)
Fold Change: 2.4705
Cell Significance Index: 316.7000
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.2875
Cell Significance Index: 60.1500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.0899
Cell Significance Index: 22.7200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.9163
Cell Significance Index: 51.2600
Cell Name: lactocyte (CL0002325)
Fold Change: 1.9062
Cell Significance Index: 246.2700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.6783
Cell Significance Index: 31.0200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5400
Cell Significance Index: 152.3400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.3735
Cell Significance Index: 234.5400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.3038
Cell Significance Index: 38.2900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.1631
Cell Significance Index: 880.3600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.0860
Cell Significance Index: 57.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7936
Cell Significance Index: 151.0300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7771
Cell Significance Index: 50.1400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7524
Cell Significance Index: 20.0900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7086
Cell Significance Index: 36.8100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6492
Cell Significance Index: 18.6100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6467
Cell Significance Index: 105.1800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.5555
Cell Significance Index: 159.8500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4757
Cell Significance Index: 13.7100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4659
Cell Significance Index: 92.4600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2498
Cell Significance Index: 183.1400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1512
Cell Significance Index: 2.5300
Cell Name: peg cell (CL4033014)
Fold Change: 0.1445
Cell Significance Index: 3.3400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0084
Cell Significance Index: 0.3800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0274
Cell Significance Index: -20.2900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0299
Cell Significance Index: -56.3300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0334
Cell Significance Index: -20.8600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0472
Cell Significance Index: -4.8300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0475
Cell Significance Index: -87.6000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0527
Cell Significance Index: -71.7000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0555
Cell Significance Index: -85.4400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1085
Cell Significance Index: -68.9000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1374
Cell Significance Index: -77.4700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1678
Cell Significance Index: -33.6700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1762
Cell Significance Index: -79.9900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1823
Cell Significance Index: -65.3800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2015
Cell Significance Index: -7.0800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2460
Cell Significance Index: -28.1800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2550
Cell Significance Index: -16.0700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2606
Cell Significance Index: -20.6400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2870
Cell Significance Index: -60.4600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3211
Cell Significance Index: -1.9400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4190
Cell Significance Index: -14.5600
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.4287
Cell Significance Index: -8.9400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4319
Cell Significance Index: -12.0700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5926
Cell Significance Index: -15.1400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6169
Cell Significance Index: -71.8900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6291
Cell Significance Index: -91.4500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7159
Cell Significance Index: -22.9300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8249
Cell Significance Index: -94.1600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8822
Cell Significance Index: -23.6400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.9184
Cell Significance Index: -12.5300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.9397
Cell Significance Index: -14.0800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0467
Cell Significance Index: -108.9900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1679
Cell Significance Index: -34.4000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.2205
Cell Significance Index: -93.6600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.2625
Cell Significance Index: -15.0500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.3858
Cell Significance Index: -85.1800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.4943
Cell Significance Index: -100.4800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.5202
Cell Significance Index: -32.3800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.6033
Cell Significance Index: -89.9700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.6183
Cell Significance Index: -99.2200
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.7346
Cell Significance Index: -14.5700
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.9977
Cell Significance Index: -20.6800
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.0610
Cell Significance Index: -35.5300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.1309
Cell Significance Index: -46.1700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -2.2844
Cell Significance Index: -29.2600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.5538
Cell Significance Index: -65.6500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.5868
Cell Significance Index: -94.9600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.6079
Cell Significance Index: -115.3600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -2.6800
Cell Significance Index: -109.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** POLR2L is a large gene that encodes a subunit of the Pol II complex, which is composed of two catalytic subunits (Rpb1 and Rpb2) and several regulatory subunits. The Pol II complex is responsible for transcribing mRNA from DNA, and POLR2L is involved in various aspects of this process, including promoter recognition, transcription initiation, and elongation. POLR2L has been shown to interact with multiple proteins, including transcription factors, RNA-binding proteins, and chromatin remodeling complexes, to regulate gene expression. **Pathways and Functions:** POLR2L is involved in multiple cellular pathways, including: 1. **Gene expression**: POLR2L is essential for the transcription of mRNA from DNA, and its dysregulation can lead to changes in gene expression patterns, contributing to various diseases. 2. **Cell cycle regulation**: POLR2L is involved in the regulation of the cell cycle, particularly during the G2/M phase, and its dysregulation can lead to cell cycle dysregulation and cancer. 3. **DNA repair**: POLR2L has been shown to interact with DNA repair proteins, such as BRCA1 and BRCA2, to regulate DNA repair processes. 4. **Transcriptional regulation**: POLR2L is involved in the regulation of transcriptional programs, including those involved in development, differentiation, and response to environmental stimuli. 5. **Immune response**: POLR2L has been shown to interact with immune-related proteins, such as interferons and cytokines, to regulate immune responses. **Clinical Significance:** The POLR2L gene has been implicated in various clinical conditions, including: 1. **Cancer**: POLR2L has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: POLR2L has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Infectious diseases**: POLR2L has been shown to interact with HIV proteins, such as Tat, to regulate HIV transcription and replication. 4. **Developmental disorders**: POLR2L has been implicated in developmental disorders, including Down syndrome and intellectual disability. In conclusion, the POLR2L gene is a complex and multifaceted component of the RNA polymerase II complex, involved in multiple cellular pathways, including gene expression, cell cycle regulation, DNA repair, transcriptional regulation, and immune response. Its dysregulation has been implicated in various clinical conditions, including cancer, neurological disorders, infectious diseases, and developmental disorders. Further research is needed to fully understand the role of POLR2L in human disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Genular Protein ID: 2593595146

Symbol: RPAB5_HUMAN

Name: DNA-directed RNA polymerases I, II, and III subunit RPABC5

UniProtKB Accession Codes:

P62875 P52436 Q6FHX3

Database IDs:

Citations:

PubMed ID: 8524256

Title: Six human RNA polymerase subunits functionally substitute for their yeast counterparts.

PubMed ID: 8524256

DOI: 10.1128/mcb.15.12.6895

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7651387

Title: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae.

PubMed ID: 7651387

DOI: 10.1128/mcb.15.9.4702

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 16809778

Title: RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.

PubMed ID: 16809778

DOI: 10.1128/mcb.00230-06

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 34671025

Title: Structure of the human RNA polymerase I elongation complex.

PubMed ID: 34671025

DOI: 10.1038/s41421-021-00335-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 34887565

Title: Cryo-EM structures of human RNA polymerase I.

PubMed ID: 34887565

DOI: 10.1038/s41594-021-00693-4

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

PubMed ID: 36271492

Title: The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.

PubMed ID: 36271492

DOI: 10.26508/lsa.202201568

Sequence Information:

Length: 67
Mass: 7645
Checksum: 9E8A72F667FE7EC5
Sequence:

MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL AHVDLIEKLL 
NYAPLEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLR2L

Associated with

Cells (max top 100)

Other Information

Six human RNA polymerase subunits functionally substitute for their yeast counterparts. PubMed ID: 8524256

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. PubMed ID: 7651387

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. PubMed ID: 16809778

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells. PubMed ID: 20413673

Initial characterization of the human central proteome. PubMed ID: 21269460

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. PubMed ID: 30190596

Structure of human RNA polymerase III. PubMed ID: 33335104

Structure of the human RNA polymerase I elongation complex. PubMed ID: 34671025

Structure of human RNA polymerase III elongation complex. PubMed ID: 33674783

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine. PubMed ID: 34675218

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. PubMed ID: 33558764

Cryo-EM structures of human RNA polymerase I. PubMed ID: 34887565

Structural insights into transcriptional regulation of human RNA polymerase III. PubMed ID: 33558766

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. PubMed ID: 36271492