POMC | ENSG00000115138 | NCBI 5443

Details for: POMC

Gene ID: 5443

Symbol: POMC

Ensembl ID: ENSG00000115138

Description: proopiomelanocortin

Associated with

Androgen biosynthesis
(R-HSA-193048)
Biological oxidations
(R-HSA-211859)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective acth causes obesity and pomcd
(R-HSA-5579031)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Endogenous sterols
(R-HSA-211976)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
G-protein activation
(R-HSA-202040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glucocorticoid biosynthesis
(R-HSA-194002)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroid hormones
(R-HSA-196071)
Metabolism of steroids
(R-HSA-8957322)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Opioid signalling
(R-HSA-111885)
Peptide hormone biosynthesis
(R-HSA-209952)
Peptide hormone metabolism
(R-HSA-2980736)
Peptide ligand-binding receptors
(R-HSA-375276)
Phase i - functionalization of compounds
(R-HSA-211945)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Calcium-mediated signaling
(GO:0019722)
Cell-cell signaling
(GO:0007267)
Cellular pigmentation
(GO:0033059)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Generation of precursor metabolites and energy
(GO:0006091)
Glucose homeostasis
(GO:0042593)
G protein-coupled receptor binding
(GO:0001664)
Hormone activity
(GO:0005179)
Killing of cells of another organism
(GO:0031640)
Modulation of process of another organism
(GO:0035821)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Neuropeptide signaling pathway
(GO:0007218)
Peroxisomal matrix
(GO:0005782)
Peroxisome
(GO:0005777)
Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106071)
Positive regulation of neutrophil mediated killing of fungus
(GO:0070965)
Positive regulation of oxytocin production
(GO:0140668)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of appetite
(GO:0032098)
Regulation of blood pressure
(GO:0008217)
Regulation of corticosterone secretion
(GO:2000852)
Regulation of glycogen metabolic process
(GO:0070873)
Response to melanocyte-stimulating hormone
(GO:1990680)
Secretory granule
(GO:0030141)
Secretory granule lumen
(GO:0034774)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Type 1 melanocortin receptor binding
(GO:0070996)
Type 3 melanocortin receptor binding
(GO:0031781)
Type 4 melanocortin receptor binding
(GO:0031782)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 19.4799
Cell Significance Index: -3.0300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 16.7164
Cell Significance Index: -4.2400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 15.8433
Cell Significance Index: -7.4800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 15.1540
Cell Significance Index: -7.8000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 5.1664
Cell Significance Index: -6.3700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 4.4032
Cell Significance Index: 95.4000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.9133
Cell Significance Index: -7.5500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.7974
Cell Significance Index: -4.8200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.7972
Cell Significance Index: -5.5200
Cell Name: kidney cell (CL1000497)
Fold Change: 1.7885
Cell Significance Index: 14.2800
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.7783
Cell Significance Index: 45.4300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.7318
Cell Significance Index: 46.4100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.5214
Cell Significance Index: 289.5400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.8628
Cell Significance Index: 18.3800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7310
Cell Significance Index: 72.3100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7181
Cell Significance Index: 116.7900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5719
Cell Significance Index: 516.3600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.5006
Cell Significance Index: 13.3900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4835
Cell Significance Index: 52.6000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4686
Cell Significance Index: 28.1300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2840
Cell Significance Index: 33.4900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2463
Cell Significance Index: 17.0300
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2213
Cell Significance Index: 5.8200
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.1765
Cell Significance Index: 1.4600
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.1427
Cell Significance Index: 0.9800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1307
Cell Significance Index: 8.4300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1142
Cell Significance Index: 2.3900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1081
Cell Significance Index: 14.8400
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1005
Cell Significance Index: 1.4100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0872
Cell Significance Index: 2.5600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0841
Cell Significance Index: 45.9400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0686
Cell Significance Index: 11.7200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0330
Cell Significance Index: 1.1600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0262
Cell Significance Index: 11.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0153
Cell Significance Index: 0.4400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0146
Cell Significance Index: 1.6700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0138
Cell Significance Index: 0.3500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0078
Cell Significance Index: 0.2700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0075
Cell Significance Index: 0.4700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0026
Cell Significance Index: -1.9900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0028
Cell Significance Index: -5.2800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0033
Cell Significance Index: -0.1500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0037
Cell Significance Index: -2.7200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0037
Cell Significance Index: -1.3300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0050
Cell Significance Index: -9.2500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0060
Cell Significance Index: -9.1800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0061
Cell Significance Index: -4.5200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0066
Cell Significance Index: -9.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0068
Cell Significance Index: -1.3700
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0100
Cell Significance Index: -1.9800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0100
Cell Significance Index: -5.6200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0103
Cell Significance Index: -6.5700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0124
Cell Significance Index: -0.2300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0124
Cell Significance Index: -1.5900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0132
Cell Significance Index: -8.2200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0147
Cell Significance Index: -2.6600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0153
Cell Significance Index: -0.2300
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.0160
Cell Significance Index: -0.1700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0164
Cell Significance Index: -7.4300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0184
Cell Significance Index: -5.2800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0258
Cell Significance Index: -0.3300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0260
Cell Significance Index: -3.3600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0281
Cell Significance Index: -2.8700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0294
Cell Significance Index: -2.1900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0320
Cell Significance Index: -0.5400
Cell Name: hepatic pit cell (CL2000054)
Fold Change: -0.0336
Cell Significance Index: -0.0900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0346
Cell Significance Index: -7.2800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0361
Cell Significance Index: -4.4400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0396
Cell Significance Index: -0.4300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0420
Cell Significance Index: -1.9600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0451
Cell Significance Index: -2.3700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0468
Cell Significance Index: -6.8100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0473
Cell Significance Index: -5.5100
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0482
Cell Significance Index: -0.4100
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0592
Cell Significance Index: -0.6100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0626
Cell Significance Index: -3.1600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0628
Cell Significance Index: -2.9500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0664
Cell Significance Index: -2.7200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0708
Cell Significance Index: -7.3700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0721
Cell Significance Index: -4.4200
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.0768
Cell Significance Index: -0.7700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0787
Cell Significance Index: -2.2000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0840
Cell Significance Index: -5.1600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0843
Cell Significance Index: -4.3800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0844
Cell Significance Index: -6.4800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0867
Cell Significance Index: -6.8700
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0935
Cell Significance Index: -1.3400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0990
Cell Significance Index: -3.1700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0999
Cell Significance Index: -1.4300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1032
Cell Significance Index: -6.9400
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1040
Cell Significance Index: -1.2400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1069
Cell Significance Index: -6.0000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1241
Cell Significance Index: -5.4000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1460
Cell Significance Index: -4.3000
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.1478
Cell Significance Index: -0.8400
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.1571
Cell Significance Index: -1.9900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1628
Cell Significance Index: -1.8500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1686
Cell Significance Index: -2.3000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1694
Cell Significance Index: -3.5200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1754
Cell Significance Index: -6.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Multifunctional precursor**: POMC is a multifunctional precursor protein that gives rise to several biologically active peptides, including ACTH, MSH, and beta-endorphin. 2. **Regulation of energy homeostasis**: POMC peptides, particularly MSH, play a crucial role in regulating energy homeostasis by modulating appetite, glucose metabolism, and lipolysis. 3. **Immune function**: POMC peptides, particularly ACTH, have immunomodulatory effects, influencing the production of cytokines and the activation of immune cells. 4. **Neuroendocrine regulation**: POMC peptides are released from the pituitary gland and hypothalamus, influencing the regulation of various physiological processes, including growth, development, and metabolism. 5. **Disease associations**: Defects in the POMC gene have been associated with various diseases, including Cushing's syndrome, acromegaly, and obesity. **Pathways and Functions** 1. **G-protein coupled receptor signaling**: POMC peptides act through G-protein coupled receptors (GPCRs), which activate downstream signaling pathways, influencing energy metabolism, immune response, and appetite regulation. 2. **Cytokine signaling**: POMC peptides, particularly ACTH, modulate cytokine production and immune cell activation, influencing the immune response. 3. **Neurotransmitter signaling**: POMC peptides interact with neurotransmitters, such as oxytocin and vasopressin, influencing social behavior, stress response, and appetite regulation. 4. **Metabolic regulation**: POMC peptides regulate energy metabolism by modulating glucose and lipid metabolism, influencing insulin sensitivity and glucose homeostasis. 5. **Hormone regulation**: POMC peptides regulate the production of other hormones, including cortisol, insulin, and growth hormone, influencing energy metabolism and growth. **Clinical Significance** 1. **Cushing's syndrome**: Defects in the POMC gene can lead to Cushing's syndrome, a disorder characterized by excess cortisol production, obesity, and glucose intolerance. 2. **Acromegaly**: POMC gene mutations can cause acromegaly, a disorder characterized by excess growth hormone production, leading to excessive growth and tissue hypertrophy. 3. **Obesity**: POMC gene defects have been associated with obesity, as alterations in energy metabolism and appetite regulation contribute to the development of obesity. 4. **Immune disorders**: POMC peptides play a crucial role in regulating immune function, and defects in the POMC gene have been associated with immune disorders, such as autoimmune diseases and immunodeficiency syndromes. In conclusion, the POMC gene is a critical regulator of various physiological processes, including energy homeostasis, metabolism, and immune function. Understanding the key characteristics, pathways, and functions of POMC can provide valuable insights into the development of novel therapeutic strategies for the treatment of diseases associated with POMC gene defects.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Pro-opiomelanocortin

Genular Protein ID: 384316156

Symbol: COLI_HUMAN

Name: Pro-opiomelanocortin

UniProtKB Accession Codes:

P01189 P78442 Q53T23 Q9UD39 Q9UD40

Database IDs:

Citations:

PubMed ID: 6274691

Title: Isolation and structural organization of the human corticotropin-beta-lipotropin precursor gene.

PubMed ID: 6274691

DOI: 10.1016/0014-5793(81)80952-0

PubMed ID: 6299668

Title: The human pro-opiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA.

PubMed ID: 6299668

DOI: 10.1089/dna.1.1982.1.133

PubMed ID: 6314261

Title: Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene.

PubMed ID: 6314261

DOI: 10.1093/nar/11.19.6847

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3606677

Title: Synthesis, cloning and primary structure of DNA complementary to mRNA for human pituitary pro-opiomelanocortin.

PubMed ID: 3606677

PubMed ID: 6254047

Title: Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide.

PubMed ID: 6254047

DOI: 10.1073/pnas.77.8.4890

PubMed ID: 6945581

Title: Complete amino acid sequence of a human pituitary glycopeptide: an important maturation product of pro-opiomelanocortin.

PubMed ID: 6945581

DOI: 10.1073/pnas.78.7.4236

PubMed ID: 6267033

Title: Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity.

PubMed ID: 6267033

DOI: 10.1016/s0021-9258(18)43375-3

PubMed ID: 6272808

Title: The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation.

PubMed ID: 6272808

DOI: 10.1016/s0006-291x(81)80190-8

PubMed ID: 4352834

Title: Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin.

PubMed ID: 4352834

DOI: 10.1042/bj1330011

PubMed ID: 14463577

Title: On the structure of human corticotropin (adrenocorticotropic hormone).

PubMed ID: 14463577

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 4334191

Title: Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone.

PubMed ID: 4334191

DOI: 10.1038/newbio235114b0

PubMed ID: 4338630

Title: Synthesis of the human adrenal cortex hormone (alpha-h-ACTH) with a revised amino-acid sequence.

PubMed ID: 4338630

DOI: 10.1002/hlca.19720550420

PubMed ID: 4347148

Title: Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method.

PubMed ID: 4347148

DOI: 10.1021/ja00785a049

PubMed ID: 1264228

Title: Primary structure of human beta-lipotropin.

PubMed ID: 1264228

DOI: 10.1038/260622a0

PubMed ID: 195688

Title: Primary structure and morphine-like activity of human beta-endorphin.

PubMed ID: 195688

DOI: 10.1139/o77-096

PubMed ID: 2424570

Title: Gamma-endorphin and schizophrenia: amino acid composition of gamma-endorphin and nucleotide sequence of gamma-endorphin cDNA from pituitary glands of schizophrenic patients.

PubMed ID: 2424570

DOI: 10.1016/0006-8993(86)90896-6

PubMed ID: 2839146

Title: Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary.

PubMed ID: 2839146

DOI: 10.1042/bj2500781

PubMed ID: 7828531

Title: Reduced expression of a naturally deleted form of human proopiomelanocortin complementary deoxyribonucleic acid after transfection into Chinese hamster ovary cells.

PubMed ID: 7828531

DOI: 10.1210/endo.136.1.7828531

PubMed ID: 9620771

Title: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans.

PubMed ID: 9620771

DOI: 10.1038/509

PubMed ID: 16046320

Title: Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study.

PubMed ID: 16046320

DOI: 10.2337/diabetes.54.8.2492

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 9768693

Title: Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.

PubMed ID: 9768693

DOI: 10.1210/jcem.83.10.5298

PubMed ID: 10193875

Title: Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity.

PubMed ID: 10193875

DOI: 10.1038/sj.ijo.0800814

PubMed ID: 11244459

Title: Molecular screening of the proopiomelanocortin (POMC) gene in Italian obese children: report of three new mutations.

PubMed ID: 11244459

DOI: 10.1038/sj.ijo.0801485

PubMed ID: 12165561

Title: A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

PubMed ID: 12165561

DOI: 10.1093/hmg/11.17.1997

Sequence Information:

Length: 267
Mass: 29424
Checksum: B927323474A67536
Sequence:

MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC KPDLSAETPM 
FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSSGSSGA GQKREDVSAG EDCGPLPEGG 
PEPRSDGAKP GPREGKRSYS MEHFRWGKPV GKKRRPVKVY PNGAEDESAE AFPLEFKREL 
TGQRLREGDG PDGPADDGAG AQADLEHSLL VAAEKKDEGP YRMEHFRWGS PPKDKRYGGF 
MTSEKSQTPL VTLFKNAIIK NAYKKGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POMC

Associated with

Cells (max top 100)

Other Information

Isolation and structural organization of the human corticotropin-beta-lipotropin precursor gene. PubMed ID: 6274691

The human pro-opiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA. PubMed ID: 6299668

Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene. PubMed ID: 6314261

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Synthesis, cloning and primary structure of DNA complementary to mRNA for human pituitary pro-opiomelanocortin. PubMed ID: 3606677

Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide. PubMed ID: 6254047

Complete amino acid sequence of a human pituitary glycopeptide: an important maturation product of pro-opiomelanocortin. PubMed ID: 6945581

Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity. PubMed ID: 6267033

The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation. PubMed ID: 6272808

Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin. PubMed ID: 4352834

On the structure of human corticotropin (adrenocorticotropic hormone). PubMed ID: 14463577

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone. PubMed ID: 4334191

Synthesis of the human adrenal cortex hormone (alpha-h-ACTH) with a revised amino-acid sequence. PubMed ID: 4338630

Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method. PubMed ID: 4347148

Primary structure of human beta-lipotropin. PubMed ID: 1264228

Primary structure and morphine-like activity of human beta-endorphin. PubMed ID: 195688

Gamma-endorphin and schizophrenia: amino acid composition of gamma-endorphin and nucleotide sequence of gamma-endorphin cDNA from pituitary glands of schizophrenic patients. PubMed ID: 2424570

Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary. PubMed ID: 2839146

Reduced expression of a naturally deleted form of human proopiomelanocortin complementary deoxyribonucleic acid after transfection into Chinese hamster ovary cells. PubMed ID: 7828531

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. PubMed ID: 9620771

Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. PubMed ID: 16046320

Phosphoproteomic analysis of the human pituitary. PubMed ID: 16807684

Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes. PubMed ID: 9768693

Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity. PubMed ID: 10193875

Molecular screening of the proopiomelanocortin (POMC) gene in Italian obese children: report of three new mutations. PubMed ID: 11244459

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. PubMed ID: 12165561