Details for: PPP2R5A

Gene ID: 5525

Symbol: PPP2R5A

Ensembl ID: ENSG00000066027

Description: protein phosphatase 2 regulatory subunit B'alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.2733
    Cell Significance Index: -37.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.7665
    Cell Significance Index: -37.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.0263
    Cell Significance Index: -37.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.3290
    Cell Significance Index: -41.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.6231
    Cell Significance Index: -34.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.7603
    Cell Significance Index: -38.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.6038
    Cell Significance Index: -41.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.7245
    Cell Significance Index: -35.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.7367
    Cell Significance Index: -39.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0134
    Cell Significance Index: -37.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6985
    Cell Significance Index: -32.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9847
    Cell Significance Index: -39.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8916
    Cell Significance Index: -19.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.7143
    Cell Significance Index: 193.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1937
    Cell Significance Index: 220.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0573
    Cell Significance Index: 356.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2902
    Cell Significance Index: 2067.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9605
    Cell Significance Index: 150.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6885
    Cell Significance Index: 183.6600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4288
    Cell Significance Index: 20.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3780
    Cell Significance Index: 38.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3578
    Cell Significance Index: 269.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8173
    Cell Significance Index: 20.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7897
    Cell Significance Index: 158.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7773
    Cell Significance Index: 19.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5604
    Cell Significance Index: 12.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5362
    Cell Significance Index: 25.0000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5329
    Cell Significance Index: 8.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4991
    Cell Significance Index: 6.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4534
    Cell Significance Index: 247.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4417
    Cell Significance Index: 28.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3878
    Cell Significance Index: 5.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3611
    Cell Significance Index: 65.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3368
    Cell Significance Index: 41.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3279
    Cell Significance Index: 117.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2501
    Cell Significance Index: 113.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2071
    Cell Significance Index: 91.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1933
    Cell Significance Index: 8.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1863
    Cell Significance Index: 31.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1846
    Cell Significance Index: 21.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1831
    Cell Significance Index: 126.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1662
    Cell Significance Index: 7.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1341
    Cell Significance Index: 0.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1301
    Cell Significance Index: 21.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1253
    Cell Significance Index: 3.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0957
    Cell Significance Index: 4.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0855
    Cell Significance Index: 11.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0702
    Cell Significance Index: 0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0630
    Cell Significance Index: 118.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0578
    Cell Significance Index: 4.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0385
    Cell Significance Index: 24.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0206
    Cell Significance Index: 38.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0201
    Cell Significance Index: 0.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0188
    Cell Significance Index: 28.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0075
    Cell Significance Index: 5.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0071
    Cell Significance Index: 1.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0163
    Cell Significance Index: -10.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0241
    Cell Significance Index: -0.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0452
    Cell Significance Index: -25.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0652
    Cell Significance Index: -7.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0661
    Cell Significance Index: -3.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0668
    Cell Significance Index: -8.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0816
    Cell Significance Index: -2.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0919
    Cell Significance Index: -3.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1065
    Cell Significance Index: -10.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1067
    Cell Significance Index: -22.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1146
    Cell Significance Index: -32.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1235
    Cell Significance Index: -12.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1347
    Cell Significance Index: -19.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1544
    Cell Significance Index: -19.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1591
    Cell Significance Index: -11.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1762
    Cell Significance Index: -6.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1800
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1824
    Cell Significance Index: -20.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1922
    Cell Significance Index: -6.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2160
    Cell Significance Index: -22.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3153
    Cell Significance Index: -19.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3529
    Cell Significance Index: -18.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3761
    Cell Significance Index: -29.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3852
    Cell Significance Index: -24.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3853
    Cell Significance Index: -9.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4132
    Cell Significance Index: -25.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4152
    Cell Significance Index: -27.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4201
    Cell Significance Index: -6.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4615
    Cell Significance Index: -6.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5011
    Cell Significance Index: -6.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5675
    Cell Significance Index: -28.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5929
    Cell Significance Index: -5.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6011
    Cell Significance Index: -11.1100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6214
    Cell Significance Index: -7.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6669
    Cell Significance Index: -11.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6956
    Cell Significance Index: -20.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7594
    Cell Significance Index: -26.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7785
    Cell Significance Index: -13.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8252
    Cell Significance Index: -13.8100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.8270
    Cell Significance Index: -11.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Regulatory Subunit of PP2A:** PPP2R5A is a regulatory subunit of PP2A, which is a serine/threonine phosphatase that dephosphorylates and regulates numerous downstream targets, including proteins involved in immune response, cell cycle, and signaling pathways. 2. **Multiple Tissue Expressions:** PPP2R5A is expressed in various tissues, including lung endothelial cells, ciliary muscle cells, epithelial cells of the lower respiratory tract, and renal alpha-intercalated cells, suggesting its involvement in multiple physiological processes. 3. **Cellular Localization:** PPP2R5A is primarily localized to the cytosol and nucleus, where it interacts with various signaling molecules and regulates their activity. **Pathways and Functions:** 1. **Adaptive Immune System:** PPP2R5A plays a crucial role in regulating T-cell activation and differentiation, influencing the adaptive immune response. 2. **Signal Amplification:** PPP2R5A is involved in signal amplification from kinetochores, which is essential for proper cell cycle progression and mitotic spindle formation. 3. **Antiviral Mechanism:** PPP2R5A has been implicated in the antiviral response, particularly in the regulation of interferon-stimulated genes. 4. **Cell Cycle Regulation:** PPP2R5A regulates cell cycle progression, particularly in the G2/M phase, by dephosphorylating and activating key cyclin-dependent kinases. 5. **Signaling Pathways:** PPP2R5A interacts with various signaling molecules, including MAPK, PI3K/AKT, and WNT/β-catenin pathways, regulating their activity and downstream effects. **Clinical Significance:** 1. **Immune-Related Disorders:** Alterations in PPP2R5A expression or function may contribute to immune-related disorders, such as autoimmune diseases, allergies, and immunodeficiencies. 2. **Cancer:** PPP2R5A has been implicated in cancer development and progression, particularly in the regulation of cell cycle and signaling pathways. 3. **Neurological Disorders:** PPP2R5A may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where disruptions in PP2A signaling have been observed. 4. **Infectious Diseases:** PPP2R5A has been shown to regulate antiviral responses, suggesting its potential as a therapeutic target for infectious diseases. In conclusion, PPP2R5A is a complex regulator of immune function and disease, with implications for various cellular processes, including cell cycle regulation, signaling pathways, and antiviral mechanisms. Further research is needed to fully elucidate the role of PPP2R5A in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 1015327147

Symbol: 2A5A_HUMAN

Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

UniProtKB Accession Codes:

Q15172 B2R6D2 B7Z7L2 D3DT99 Q2NL72 Q5VVB2 Q8TBI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 EMDB 2 Ensembl 2 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 23 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7592815

Title: Identification of a new family of protein phosphatase 2A regulatory subunits.

PubMed ID: 7592815

DOI: 10.1074/jbc.270.44.26123

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8694763

Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

PubMed ID: 8694763

DOI: 10.1042/bj3170187

PubMed ID: 8703017

Title: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.

PubMed ID: 8703017

DOI: 10.1074/jbc.271.36.22081

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 486
  • Mass: 56194
  • Checksum: D31407F7032A6D44
  • Sequence:
    • MSSSSPPAGA ASAAISASEK VDGFTRKSVR KAQRQKRSQG SSQFRSQGSQ AELHPLPQLK 
DATSNEQQEL FCQKLQQCCI LFDFMDSVSD LKSKEIKRAT LNELVEYVST NRGVIVESAY 
SDIVKMISAN IFRTLPPSDN PDFDPEEDEP TLEASWPHIQ LVYEFFLRFL ESPDFQPSIA 
KRYIDQKFVQ QLLELFDSED PRERDFLKTV LHRIYGKFLG LRAFIRKQIN NIFLRFIYET 
EHFNGVAELL EILGSIINGF ALPLKAEHKQ FLMKVLIPMH TAKGLALFHA QLAYCVVQFL 
EKDTTLTEPV IRGLLKFWPK TCSQKEVMFL GEIEEILDVI EPTQFKKIEE PLFKQISKCV 
SSSHFQVAER ALYFWNNEYI LSLIEENIDK ILPIMFASLY KISKEHWNPT IVALVYNVLK 
TLMEMNGKLF DDLTSSYKAE RQREKKKELE REELWKKLEE LKLKKALEKQ NSAYNMHSIL 
SNTSAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.