PPP2R5A | ENSG00000066027 | NCBI 5525

Details for: PPP2R5A

Gene ID: 5525

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PPP2R5A

Ensembl ID: ENSG00000066027

Description: protein phosphatase 2 regulatory subunit B'alpha

Cell Significance Landscape

Display Count:

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Negative regulation of mapk pathway
(R-HSA-5675221)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Pkr-mediated signaling
(R-HSA-9833482)
Platelet homeostasis
(R-HSA-418346)
Platelet sensitization by ldl
(R-HSA-432142)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)
Centrosome
(GO:0005813)
Chromosome, centromeric region
(GO:0000775)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Kinase binding
(GO:0019900)
M band
(GO:0031430)
Negative regulation of lipid kinase activity
(GO:0090219)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Nucleus
(GO:0005634)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein phosphatase activator activity
(GO:0072542)
Protein phosphatase regulator activity
(GO:0019888)
Protein phosphatase type 2a complex
(GO:0000159)
Signal transduction
(GO:0007165)
Z disc
(GO:0030018)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

adipocyte CL0000136

CSI 23.96

rCSI 30.77%

PRS 29.1
cardiac endothelial cell CL0010008

CSI 12.02

rCSI 48.49%

PRS 29.49
CD1c-positive myeloid dendritic cell CL0002399

CSI 11.24

rCSI 13.57%

PRS 36.65
lung ciliated cell CL1000271

CSI 8.31

rCSI 9.61%

PRS 23.14
keratinocyte CL0000312

CSI 8.04

rCSI 6.74%

PRS 35.56
CD4-positive helper T cell CL0000492

CSI 7.69

rCSI 5.82%

PRS 41.32
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 7.69

rCSI 9.31%

PRS 32.86
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 7.06

rCSI 18.26%

PRS 28.35
lung neuroendocrine cell CL1000223

CSI 6.17

rCSI 9.12%

PRS 34.74
epithelial cell of lung CL0000082

CSI 5.39

rCSI 4.47%

PRS 29.29
differentiation-committed oligodendrocyte precursor CL4023059

CSI 4.45

rCSI 8.09%

PRS 26.66
glioblast CL0000030

CSI 4.26

rCSI 6.79%

PRS 26.26
mucus secreting cell CL0000319

CSI 4.2

rCSI 6.67%

PRS 39.16
early lymphoid progenitor CL0000936

CSI 4.2

rCSI 3.69%

PRS 34.92
intermediate monocyte CL0002393

CSI 3.89

rCSI 5.86%

PRS 31.69
lung macrophage CL1001603

CSI 3.69

rCSI 8.24%

PRS 35.84
Mueller cell CL0000636

CSI 3.64

rCSI 8.31%

PRS 26.44
hematopoietic precursor cell CL0008001

CSI 3.55

rCSI 3.66%

PRS 46.6
fallopian tube secretory epithelial cell CL4030006

CSI 3.55

rCSI 3.42%

PRS 31.59
Bergmann glial cell CL0000644

CSI 3.43

rCSI 4.69%

PRS 29.59
cardiac muscle cell CL0000746

CSI 3.36

rCSI 4.82%

PRS 24.39
retinal cone cell CL0000573

CSI 3.27

rCSI 5.27%

PRS 23.82
pulmonary capillary endothelial cell CL4028001

CSI 3.26

rCSI 6.21%

PRS 46.18
fibroblast of cardiac tissue CL0002548

CSI 3.13

rCSI 15.02%

PRS 28.2
Schwann cell CL0002573

CSI 3.13

rCSI 8.91%

PRS 32.57
mature T cell CL0002419

CSI 3.09

rCSI 2.41%

PRS 44.43
double-positive, alpha-beta thymocyte CL0000809

CSI 3.09

rCSI 3.15%

PRS 42.35
CD14-positive monocyte CL0001054

CSI 3.03

rCSI 3.77%

PRS 40.99
CD4-positive, alpha-beta thymocyte CL0000810

CSI 2.86

rCSI 2.29%

PRS 50.48
hematopoietic multipotent progenitor cell CL0000837

CSI 2.86

rCSI 6.88%

PRS 46.21
myelocyte CL0002193

CSI 2.81

rCSI 18.49%

PRS 68.23
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.64

rCSI 6.88%

PRS 29.76
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.61

rCSI 1.54%

PRS 42.47
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 2.55

rCSI 7.85%

PRS 42.68
platelet CL0000233

CSI 2.53

rCSI 10.5%

PRS 43.36
cardiac neuron CL0010022

CSI 2.48

rCSI 7.95%

PRS 27.59
ionocyte CL0005006

CSI 2.35

rCSI 2.52%

PRS 28.64
double negative thymocyte CL0002489

CSI 2.34

rCSI 1.63%

PRS 36.99
elicited macrophage CL0000861

CSI 2.34

rCSI 2.15%

PRS 36.46
near-projecting glutamatergic cortical neuron CL4023012

CSI 2.3

rCSI 8.71%

PRS 20.05
parietal epithelial cell CL1000452

CSI 2.3

rCSI 6.15%

PRS 25.97
ciliated epithelial cell CL0000067

CSI 2.3

rCSI 2.02%

PRS 22.72
regular atrial cardiac myocyte CL0002129

CSI 2.3

rCSI 7.39%

PRS 31.49
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.28

rCSI 1.74%

PRS 39.97
pancreatic A cell CL0000171

CSI 2.26

rCSI 2.36%

PRS 32.59
perivascular cell CL4033054

CSI 2.18

rCSI 2.98%

PRS 34.49
retinal pigment epithelial cell CL0002586

CSI 2.16

rCSI 4.29%

PRS 31.37
goblet cell CL0000160

CSI 2.14

rCSI 2.02%

PRS 31.9
alveolar macrophage CL0000583

CSI 2.13

rCSI 3.52%

PRS 35.44
vascular associated smooth muscle cell CL0000359

CSI 2.13

rCSI 6.9%

PRS 35.09
brush cell of tracheobronchial tree CL0002075

CSI 2.12

rCSI 6.28%

PRS 40.79
mucosal invariant T cell CL0000940

CSI 2.11

rCSI 1.71%

PRS 42.48
endothelial cell of placenta CL0009092

CSI 2.09

rCSI 10.28%

PRS 40.35
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.08

rCSI 1.88%

PRS 28.1
precursor B cell CL0000817

CSI 2.06

rCSI 1.81%

PRS 39.38
mononuclear phagocyte CL0000113

CSI 2.05

rCSI 4.52%

PRS 34.41
duct epithelial cell CL0000068

CSI 2.04

rCSI 2.98%

PRS 32.76
epithelial cell of lower respiratory tract CL0002632

CSI 1.98

rCSI 1.54%

PRS 30.25
retinal rod cell CL0000604

CSI 1.97

rCSI 3.48%

PRS 29.9
vascular leptomeningeal cell CL4023051

CSI 1.93

rCSI 3.38%

PRS 24.6
pro-B cell CL0000826

CSI 1.91

rCSI 1.58%

PRS 31.23
endothelial cell of vascular tree CL0002139

CSI 1.9

rCSI 10.38%

PRS 39
CD4-positive, alpha-beta memory T cell CL0000897

CSI 1.9

rCSI 1.36%

PRS 41.27
type B pancreatic cell CL0000169

CSI 1.88

rCSI 4.16%

PRS 28.43
centrilobular region hepatocyte CL0019029

CSI 1.87

rCSI 4.89%

PRS 41.55
CD14-low, CD16-positive monocyte CL0002396

CSI 1.87

rCSI 1.44%

PRS 29.18
renal beta-intercalated cell CL0002201

CSI 1.87

rCSI 4.45%

PRS 33.84
blood vessel endothelial cell CL0000071

CSI 1.81

rCSI 3.76%

PRS 30.09
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.81

rCSI 7.05%

PRS 48.59
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.81

rCSI 10.63%

PRS 20.29
renal alpha-intercalated cell CL0005011

CSI 1.8

rCSI 2.4%

PRS 37.92
cerebral cortex endothelial cell CL1001602

CSI 1.79

rCSI 3.1%

PRS 23.78
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.79

rCSI 5.13%

PRS 45.02
neural crest cell CL0011012

CSI 1.79

rCSI 1.41%

PRS 21.5
alpha-beta T cell CL0000789

CSI 1.78

rCSI 2.08%

PRS 43.04
neutrophil CL0000775

CSI 1.77

rCSI 9.89%

PRS 46.01
chondrocyte CL0000138

CSI 1.76

rCSI 2.8%

PRS 26
myoepithelial cell CL0000185

CSI 1.76

rCSI 4.44%

PRS 37.5
lung endothelial cell CL1001567

CSI 1.75

rCSI 4.07%

PRS 58.83
promyelocyte CL0000836

CSI 1.75

rCSI 2.52%

PRS 40.21
choroid plexus epithelial cell CL0000706

CSI 1.74

rCSI 2.84%

PRS 24.07
H1 horizontal cell CL0004217

CSI 1.73

rCSI 6.83%

PRS 36.58
midzonal region hepatocyte CL0019028

CSI 1.72

rCSI 4.03%

PRS 40.86
intestinal crypt stem cell of colon CL0009043

CSI 1.71

rCSI 12.86%

PRS 50.94
pancreatic D cell CL0000173

CSI 1.7

rCSI 1.67%

PRS 32.88
Kupffer cell CL0000091

CSI 1.7

rCSI 3.89%

PRS 30.26
melanocyte CL0000148

CSI 1.7

rCSI 1.26%

PRS 26.5
sst GABAergic cortical interneuron CL4023017

CSI 1.68

rCSI 2.16%

PRS 19.94
fibroblast of lung CL0002553

CSI 1.66

rCSI 1.55%

PRS 30.72
macroglial cell CL0000126

CSI 1.66

rCSI 4.26%

PRS 36.19
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.61

rCSI 1.47%

PRS 44.47
small intestine goblet cell CL1000495

CSI 1.6

rCSI 3.51%

PRS 39.83
hepatic stellate cell CL0000632

CSI 1.6

rCSI 5.99%

PRS 26.07
multi-ciliated epithelial cell CL0005012

CSI 1.58

rCSI 1.58%

PRS 26.32
glial cell CL0000125

CSI 1.58

rCSI 6%

PRS 27.83
periportal region hepatocyte CL0019026

CSI 1.57

rCSI 6.12%

PRS 40.13
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.57

rCSI 1.06%

PRS 38.3
plasmacytoid dendritic cell, human CL0001058

CSI 1.56

rCSI 1.09%

PRS 32.34
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.55

rCSI 1.85%

PRS 49.41
rod bipolar cell CL0000751

CSI 1.54

rCSI 2.77%

PRS 25.83

cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.6%

PRS 42.7%
peptic cell CL0000155

CSI 0.1

rCSI 1.4%

PRS 61.1%
acinar cell of salivary gland CL0002623

CSI 0.2

rCSI 5.4%

PRS 52.7%
regular ventricular cardiac myocyte CL0002131

CSI 0.2

rCSI 1.5%

PRS 25.1%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.2

rCSI 2.6%

PRS 35.1%
amacrine cell CL0000561

CSI 0.3

rCSI 0.7%

PRS 24.6%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.3

rCSI 1.8%

PRS 57.3%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.3

rCSI 1.0%

PRS 21.9%
vein endothelial cell of respiratory system CL4033008

CSI 0.3

rCSI 2.3%

PRS 51.6%
podocyte CL0000653

CSI 0.3

rCSI 1.5%

PRS 29.6%
GABAergic amacrine cell CL4030027

CSI 0.4

rCSI 1.3%

PRS 26.3%
L6b glutamatergic cortical neuron CL4023038

CSI 0.4

rCSI 1.2%

PRS 20.2%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.6%

PRS 18.3%
enterocyte of epithelium of large intestine CL0002071

CSI 0.5

rCSI 2.3%

PRS 46.8%
H2 horizontal cell CL0004218

CSI 0.5

rCSI 2.4%

PRS 32.4%
basophil CL0000767

CSI 0.5

rCSI 1.0%

PRS 53.2%
myeloid dendritic cell CL0000782

CSI 0.5

rCSI 0.7%

PRS 44.9%
extravillous trophoblast CL0008036

CSI 0.5

rCSI 0.7%

PRS 27.3%
pancreatic acinar cell CL0002064

CSI 0.6

rCSI 0.7%

PRS 33.9%
transit amplifying cell of small intestine CL0009012

CSI 0.6

rCSI 2.5%

PRS 50.6%
mature alpha-beta T cell CL0000791

CSI 0.6

rCSI 2.2%

PRS 48.4%
cholangiocyte CL1000488

CSI 0.6

rCSI 3.6%

PRS 47.1%
respiratory basal cell CL0002633

CSI 0.6

rCSI 0.6%

PRS 35.8%
paneth cell of epithelium of small intestine CL1000343

CSI 0.6

rCSI 1.8%

PRS 45.0%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.7

rCSI 1.8%

PRS 39.0%
innate lymphoid cell CL0001065

CSI 0.7

rCSI 1.4%

PRS 40.5%
microcirculation associated smooth muscle cell CL0008035

CSI 0.7

rCSI 2.0%

PRS 33.7%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.7

rCSI 1.5%

PRS 48.0%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.8

rCSI 1.8%

PRS 18.8%
neural progenitor cell CL0011020

CSI 0.8

rCSI 3.3%

PRS 27.0%
colon goblet cell CL0009039

CSI 0.8

rCSI 1.8%

PRS 42.9%
sncg GABAergic cortical interneuron CL4023015

CSI 0.8

rCSI 1.2%

PRS 21.0%
pulmonary alveolar type 1 cell CL0002062

CSI 0.8

rCSI 4.4%

PRS 35.4%
pancreatic ductal cell CL0002079

CSI 0.8

rCSI 1.5%

PRS 31.8%
epithelial cell of proximal tubule CL0002306

CSI 0.8

rCSI 2.0%

PRS 29.1%
granulocyte monocyte progenitor cell CL0000557

CSI 0.8

rCSI 0.7%

PRS 34.1%
helper T cell CL0000912

CSI 0.9

rCSI 1.2%

PRS 40.6%
mature B cell CL0000785

CSI 0.9

rCSI 0.8%

PRS 38.1%
astrocyte of the cerebral cortex CL0002605

CSI 0.9

rCSI 2.0%

PRS 19.9%
luminal epithelial cell of mammary gland CL0002326

CSI 0.9

rCSI 1.6%

PRS 45.2%
promonocyte CL0000559

CSI 0.9

rCSI 1.5%

PRS 39.5%
endothelial cell of uterus CL0009095

CSI 0.9

rCSI 6.5%

PRS 62.0%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.9

rCSI 1.5%

PRS 19.2%
foveolar cell of stomach CL0002179

CSI 0.9

rCSI 2.0%

PRS 45.2%
retinal ganglion cell CL0000740

CSI 1.0

rCSI 2.2%

PRS 22.3%
kidney collecting duct intercalated cell CL1001432

CSI 1.0

rCSI 7.3%

PRS 42.3%
retina horizontal cell CL0000745

CSI 1.0

rCSI 1.6%

PRS 28.4%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.1

rCSI 1.4%

PRS 42.2%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.1

rCSI 5.3%

PRS 39.7%
lung secretory cell CL1000272

CSI 1.1

rCSI 2.6%

PRS 29.0%
intestine goblet cell CL0019031

CSI 1.1

rCSI 1.0%

PRS 30.5%
contractile cell CL0000183

CSI 1.1

rCSI 3.2%

PRS 29.7%
conjunctival epithelial cell CL1000432

CSI 1.1

rCSI 1.7%

PRS 31.1%
renal principal cell CL0005009

CSI 1.1

rCSI 2.9%

PRS 36.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.1

rCSI 1.9%

PRS 18.7%
respiratory suprabasal cell CL4033048

CSI 1.1

rCSI 1.4%

PRS 35.2%
alternatively activated macrophage CL0000890

CSI 1.1

rCSI 1.4%

PRS 43.5%
paneth cell CL0000510

CSI 1.1

rCSI 1.7%

PRS 45.9%
tracheobronchial smooth muscle cell CL0019019

CSI 1.1

rCSI 2.0%

PRS 38.4%
BEST4+ enteroycte CL4030026

CSI 1.1

rCSI 1.4%

PRS 32.8%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.2

rCSI 1.5%

PRS 18.1%
colon epithelial cell CL0011108

CSI 1.2

rCSI 1.3%

PRS 28.7%
glandular epithelial cell CL0000150

CSI 1.2

rCSI 3.2%

PRS 53.5%
pulmonary alveolar type 2 cell CL0002063

CSI 1.2

rCSI 1.9%

PRS 41.8%
Hofbauer cell CL3000001

CSI 1.2

rCSI 2.3%

PRS 38.8%
myeloid leukocyte CL0000766

CSI 1.2

rCSI 1.1%

PRS 31.9%
group 3 innate lymphoid cell CL0001071

CSI 1.2

rCSI 0.9%

PRS 33.0%
adventitial cell CL0002503

CSI 1.3

rCSI 3.0%

PRS 42.5%
alveolar adventitial fibroblast CL4028006

CSI 1.3

rCSI 2.0%

PRS 31.3%
VIP GABAergic cortical interneuron CL4023016

CSI 1.3

rCSI 1.5%

PRS 19.1%
transit amplifying cell of colon CL0009011

CSI 1.3

rCSI 1.6%

PRS 34.4%
enteroendocrine cell of small intestine CL0009006

CSI 1.4

rCSI 3.0%

PRS 44.3%
retinal bipolar neuron CL0000748

CSI 1.4

rCSI 2.5%

PRS 23.1%
intestinal epithelial cell CL0002563

CSI 1.4

rCSI 1.4%

PRS 31.3%
hepatocyte CL0000182

CSI 1.4

rCSI 2.5%

PRS 28.9%
epicardial adipocyte CL1000309

CSI 1.4

rCSI 4.5%

PRS 34.6%
acinar cell CL0000622

CSI 1.4

rCSI 2.1%

PRS 39.7%
keratocyte CL0002363

CSI 1.4

rCSI 3.4%

PRS 42.0%
direct pathway medium spiny neuron CL4023026

CSI 1.4

rCSI 34.1%

PRS 18.5%
tracheobronchial serous cell CL0019001

CSI 1.4

rCSI 6.2%

PRS 48.7%
stem cell CL0000034

CSI 1.4

rCSI 1.4%

PRS 23.4%
granulocyte CL0000094

CSI 1.4

rCSI 2.2%

PRS 38.7%
kidney connecting tubule epithelial cell CL1000768

CSI 1.4

rCSI 3.7%

PRS 23.9%
retinal blood vessel endothelial cell CL0002585

CSI 1.5

rCSI 2.3%

PRS 33.6%
renal interstitial pericyte CL1001318

CSI 1.5

rCSI 4.1%

PRS 28.8%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.5

rCSI 2.1%

PRS 28.6%
T-helper 17 cell CL0000899

CSI 1.5

rCSI 1.2%

PRS 50.8%
activated type II NK T cell CL0000931

CSI 1.5

rCSI 1.7%

PRS 45.8%
indirect pathway medium spiny neuron CL4023029

CSI 1.5

rCSI 36.1%

PRS 19.3%
intrahepatic cholangiocyte CL0002538

CSI 1.5

rCSI 3.6%

PRS 48.4%
rod bipolar cell CL0000751

CSI 1.5

rCSI 2.8%

PRS 25.8%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.6

rCSI 1.9%

PRS 49.4%
plasmacytoid dendritic cell, human CL0001058

CSI 1.6

rCSI 1.1%

PRS 32.3%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.6

rCSI 1.1%

PRS 38.3%
periportal region hepatocyte CL0019026

CSI 1.6

rCSI 6.1%

PRS 40.1%
glial cell CL0000125

CSI 1.6

rCSI 6.0%

PRS 27.8%
multi-ciliated epithelial cell CL0005012

CSI 1.6

rCSI 1.6%

PRS 26.3%
hepatic stellate cell CL0000632

CSI 1.6

rCSI 6.0%

PRS 26.1%
small intestine goblet cell CL1000495

CSI 1.6

rCSI 3.5%

PRS 39.8%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.6

rCSI 1.5%

PRS 44.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Node Color (Target Cell CSI, relative to current network):
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PPP2R5A](/details-gene/5525) encodes the protein phosphatase 2A (PP2A) regulatory subunit B'alpha, a member of the B56 family of regulatory subunits. As a key component of the PP2A holoenzyme, it plays a crucial role in directing the serine/threonine phosphatase activity towards specific substrates, thereby modulating a wide array of fundamental cellular processes. Its function is integral to [signal transduction](/details-go/GO:0007165), [protein dephosphorylation](/details-go/GO:0006470), and cell cycle control. Expression data reveals that **Overall**, [PPP2R5A](/details-gene/5525) is a significant gene in a diverse set of cell types, with a particularly high cell significance index (CSI) in [adipocytes](/details-cell/CL0000136), followed by [cardiac endothelial cells](/details-cell/CL0010008) and various immune cells, including [CD1c-positive myeloid dendritic cells](/details-cell/CL0002399). This broad but distinct expression pattern suggests its importance in both tissue-specific functions and ubiquitous cellular maintenance. Clinically, it is associated with an OMIM entry of [601643](https://omim.org/entry/601643). ## Cellular Roles and Expression Landscape The expression profile of [PPP2R5A](/details-gene/5525) highlights its role as a fundamental regulatory protein across multiple cellular lineages. **Overall**, the gene exhibits its highest significance in [adipocytes](/details-cell/CL0000136) (CSI: 23.96), suggesting a primary role in metabolic regulation and adipogenesis. Its strong presence is also noted in the vasculature, specifically in [cardiac endothelial cells](/details-cell/CL0010008) (CSI: 12.02). Furthermore, [PPP2R5A](/details-gene/5525) appears to be a key player in the immune system, with significant expression in antigen-presenting cells like [CD1c-positive myeloid dendritic cells](/details-cell/CL0002399) (CSI: 11.24) and in adaptive lymphocytes such as [CD4-positive helper T cells](/details-cell/CL0000492) (CSI: 7.69) and [CD8-positive, alpha-beta memory T cells](/details-cell/CL0001203) (CSI: 7.69). The gene's importance extends to various epithelial and specialized cell types, including [lung ciliated cells](/details-cell/CL1000271) (CSI: 8.31), [keratinocytes](/details-cell/CL0000312) (CSI: 8.04), and [kidney loop of Henle thin ascending limb epithelial cells](/details-cell/CL1001107) (CSI: 7.06). This widespread expression pattern is consistent with its function as a regulatory subunit of PP2A, a phosphatase involved in core cellular machinery. Its involvement in multiple distinct cell types suggests that [PPP2R5A](/details-gene/5525) helps tailor the broad activity of the PP2A catalytic subunit to the specific signaling contexts of each cellular environment. ## Pathways and Molecular Function [PPP2R5A](/details-gene/5525) functions as a protein phosphatase regulator, directing the dephosphorylation of specific substrates and influencing numerous signaling cascades. Its functional annotations reflect a central role in cellular control. **Molecular Function:** As a component of the [protein phosphatase type 2a complex](/details-go/GO:0000159), [PPP2R5A](/details-gene/5525) is involved in [phosphoprotein phosphatase activity](/details-go/GO:0004721) and exhibits [kinase binding](/details-go/GO:0019900) capabilities, enabling it to regulate signaling pathways by reversing kinase-mediated phosphorylation events. **Biological Processes and Pathways:** * **Cell Cycle Control:** The gene is deeply integrated into the regulation of the [cell cycle](/details-pathway/R-HSA-1640170), particularly mitosis. It is implicated in the [Mitotic spindle checkpoint](/details-pathway/R-HSA-69618) and the [Resolution of sister chromatid cohesion](/details-pathway/R-HSA-2500257), where it collaborates with other proteins to ensure proper chromosome segregation, as supported by studies on cohesin protection ([Link](https://doi.org/10.1038/nature04663)). * **Signal Transduction:** [PPP2R5A](/details-gene/5525) is a critical node in several major signaling pathways. It is involved in the [Signaling by wnt](/details-pathway/R-HSA-195721) pathway, specifically in the [Degradation of beta-catenin by the destruction complex](/details-pathway/R-HSA-195253). It also plays a negative regulatory role in growth factor signaling, including the [Raf/map kinase cascade](/details-pathway/R-HSA-5673001) and the PI3K/AKT network ([Negative regulation of the pi3k/akt network](/details-pathway/R-HSA-199418)). * **Immune Regulation:** Consistent with its expression in immune cells, [PPP2R5A](/details-gene/5525) is annotated in pathways of the [adaptive immune system](/details-pathway/R-HSA-1280218) and [cytokine signaling](/details-pathway/R-HSA-1280215). Its participation in [Costimulation by the cd28 family](/details-pathway/R-HSA-388841) and [Ctla4 inhibitory signaling](/details-pathway/R-HSA-389513) suggests it is involved in fine-tuning T-cell activation thresholds. ## Research Directions The widespread yet cell-type-specific significance of [PPP2R5A](/details-gene/5525) suggests it is a critical signaling hub. Future research should focus on dissecting its substrate specificity in different cellular contexts to understand how it executes its diverse biological functions. **Proposed Hypotheses:** 1. Given its exceptionally high CSI in [adipocytes](/details-cell/CL0000136) and its established role in negatively regulating PI3K/AKT and Wnt signaling, it is hypothesized that [PPP2R5A](/details-gene/5525) is a key gatekeeper of adipogenesis, dephosphorylating crucial factors to prevent premature or excessive lipid accumulation. 2. Based on its significance in T cells and its connection to CD28 and CTLA4 signaling pathways, we hypothesize that the [PPP2R5A](/details-gene/5525) subunit directs PP2A to specific substrates downstream of T-cell co-stimulatory and co-inhibitory receptors, thereby acting as a rheostat to control T-cell activation, tolerance, and exhaustion. **Experimental Approach:** To test the first hypothesis regarding its role in adipogenesis, a compelling experiment would involve the use of CRISPR-Cas9 to knock out [PPP2R5A](/details-gene/5525) in a human pre-adipocyte cell line. Following induction of differentiation, the cellular phenotype would be assessed by quantifying lipid droplet formation via Oil Red O staining and measuring the expression of key adipogenic transcription factors (e.g., PPARγ, C/EBPα) by qPCR and Western blot. Concurrently, quantitative phosphoproteomics on wild-type versus knockout cells at different time points of differentiation would identify the specific substrates of the [PPP2R5A](/details-gene/5525)-PP2A holoenzyme, potentially revealing novel regulatory nodes in metabolic signaling. **Therapeutic Potential:** As a regulatory subunit of a master phosphatase, [PPP2R5A](/details-gene/5525) represents a complex but potentially valuable therapeutic target. Its involvement in fundamental pathways like Wnt, MAPK, and PI3K/AKT, which are often dysregulated in cancer, makes it highly relevant. Direct inhibition of the PP2A complex is likely to be toxic due to its housekeeping functions. However, the regulatory nature of [PPP2R5A](/details-gene/5525) offers a more nuanced approach. Developing small molecules or biologics that specifically disrupt the interaction between [PPP2R5A](/details-gene/5525) and a particular oncogenic substrate, or that modulate its subcellular localization, could provide a more targeted therapeutic window. Such a strategy might involve activating its function in tumors where it serves to suppress oncogenic signaling or inhibiting its activity where it dephosphorylates and activates oncoproteins.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Genular Protein ID: 1015327147

Symbol: 2A5A_HUMAN

Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

UniProtKB Accession Codes:

Q15172 B2R6D2 B7Z7L2 D3DT99 Q2NL72 Q5VVB2 Q8TBI9

Database IDs:

Citations:

PubMed ID: 7592815

Title: Identification of a new family of protein phosphatase 2A regulatory subunits.

PubMed ID: 7592815

DOI: 10.1074/jbc.270.44.26123

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8694763

Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

PubMed ID: 8694763

DOI: 10.1042/bj3170187

PubMed ID: 8703017

Title: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.

PubMed ID: 8703017

DOI: 10.1074/jbc.271.36.22081

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 486
Mass: 56194
Checksum: D31407F7032A6D44
Sequence:

MSSSSPPAGA ASAAISASEK VDGFTRKSVR KAQRQKRSQG SSQFRSQGSQ AELHPLPQLK 
DATSNEQQEL FCQKLQQCCI LFDFMDSVSD LKSKEIKRAT LNELVEYVST NRGVIVESAY 
SDIVKMISAN IFRTLPPSDN PDFDPEEDEP TLEASWPHIQ LVYEFFLRFL ESPDFQPSIA 
KRYIDQKFVQ QLLELFDSED PRERDFLKTV LHRIYGKFLG LRAFIRKQIN NIFLRFIYET 
EHFNGVAELL EILGSIINGF ALPLKAEHKQ FLMKVLIPMH TAKGLALFHA QLAYCVVQFL 
EKDTTLTEPV IRGLLKFWPK TCSQKEVMFL GEIEEILDVI EPTQFKKIEE PLFKQISKCV 
SSSHFQVAER ALYFWNNEYI LSLIEENIDK ILPIMFASLY KISKEHWNPT IVALVYNVLK 
TLMEMNGKLF DDLTSSYKAE RQREKKKELE REELWKKLEE LKLKKALEKQ NSAYNMHSIL 
SNTSAE

Details for: PPP2R5A

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification of a new family of protein phosphatase 2A regulatory subunits. PubMed ID: 7592815

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. PubMed ID: 8694763

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. PubMed ID: 8703017

Shugoshin collaborates with protein phosphatase 2A to protect cohesin. PubMed ID: 16541025

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569