Details for: PRCP

Gene ID: 5547

Symbol: PRCP

Ensembl ID: ENSG00000137509

Description: prolylcarboxypeptidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.2657
    Cell Significance Index: -36.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.9499
    Cell Significance Index: -32.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.0559
    Cell Significance Index: -39.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.5861
    Cell Significance Index: -39.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.0107
    Cell Significance Index: -38.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.6404
    Cell Significance Index: -40.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.0306
    Cell Significance Index: -34.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.2363
    Cell Significance Index: -37.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.1623
    Cell Significance Index: -35.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4679
    Cell Significance Index: -22.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5640
    Cell Significance Index: -37.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.9575
    Cell Significance Index: 67.6800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.7789
    Cell Significance Index: 28.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.5353
    Cell Significance Index: 132.0600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.6419
    Cell Significance Index: 29.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2856
    Cell Significance Index: 209.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2418
    Cell Significance Index: 57.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1820
    Cell Significance Index: 61.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1248
    Cell Significance Index: 1015.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0803
    Cell Significance Index: 194.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9900
    Cell Significance Index: 198.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9819
    Cell Significance Index: 134.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9564
    Cell Significance Index: 117.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9507
    Cell Significance Index: 8.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9077
    Cell Significance Index: 11.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8250
    Cell Significance Index: 89.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7967
    Cell Significance Index: 47.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7545
    Cell Significance Index: 149.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6871
    Cell Significance Index: 12.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6630
    Cell Significance Index: 84.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6040
    Cell Significance Index: 16.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5924
    Cell Significance Index: 323.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5394
    Cell Significance Index: 102.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4258
    Cell Significance Index: 3.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3426
    Cell Significance Index: 23.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2823
    Cell Significance Index: 7.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2412
    Cell Significance Index: 106.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2286
    Cell Significance Index: 81.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1996
    Cell Significance Index: 138.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1865
    Cell Significance Index: 13.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1681
    Cell Significance Index: 16.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1128
    Cell Significance Index: 3.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1109
    Cell Significance Index: 0.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0884
    Cell Significance Index: 11.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0739
    Cell Significance Index: 12.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0701
    Cell Significance Index: 1.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0521
    Cell Significance Index: 1.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0471
    Cell Significance Index: 34.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0428
    Cell Significance Index: 1.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0361
    Cell Significance Index: 67.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0175
    Cell Significance Index: 0.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0088
    Cell Significance Index: 0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0099
    Cell Significance Index: -1.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0134
    Cell Significance Index: -24.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0185
    Cell Significance Index: -11.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0185
    Cell Significance Index: -28.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0224
    Cell Significance Index: -16.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0225
    Cell Significance Index: -1.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0252
    Cell Significance Index: -34.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0262
    Cell Significance Index: -16.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0337
    Cell Significance Index: -2.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0349
    Cell Significance Index: -26.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0350
    Cell Significance Index: -0.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0372
    Cell Significance Index: -16.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0382
    Cell Significance Index: -1.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0433
    Cell Significance Index: -24.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0558
    Cell Significance Index: -2.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0663
    Cell Significance Index: -3.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0739
    Cell Significance Index: -10.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0971
    Cell Significance Index: -20.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1017
    Cell Significance Index: -29.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1085
    Cell Significance Index: -12.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1247
    Cell Significance Index: -14.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1335
    Cell Significance Index: -15.3000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1494
    Cell Significance Index: -1.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1662
    Cell Significance Index: -7.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1921
    Cell Significance Index: -5.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2050
    Cell Significance Index: -5.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2188
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2562
    Cell Significance Index: -29.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2638
    Cell Significance Index: -17.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2706
    Cell Significance Index: -11.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2989
    Cell Significance Index: -11.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3105
    Cell Significance Index: -19.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3493
    Cell Significance Index: -36.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3515
    Cell Significance Index: -10.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3673
    Cell Significance Index: -23.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3849
    Cell Significance Index: -23.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4093
    Cell Significance Index: -13.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4328
    Cell Significance Index: -34.2800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4804
    Cell Significance Index: -3.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5255
    Cell Significance Index: -7.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5513
    Cell Significance Index: -27.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5686
    Cell Significance Index: -7.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5758
    Cell Significance Index: -16.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6072
    Cell Significance Index: -38.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6405
    Cell Significance Index: -12.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6589
    Cell Significance Index: -17.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6676
    Cell Significance Index: -17.0600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6939
    Cell Significance Index: -9.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PRCP is a lysosomal enzyme that exhibits carboxypeptidase activity, cleaving peptides at the C-terminus of proline residues. Its expression is widespread in various tissues, including endothelial cells, macrophages (Kupffer cells), and epithelial cells of the kidney and intestine. The enzyme's activity is regulated by its interaction with various cellular components, including the plasma membrane and intracellular organelles. One of the most striking aspects of PRCP is its ability to modulate immune responses. It has been implicated in the regulation of neutrophil degranulation, a critical step in the inflammatory response. Additionally, PRCP has been shown to inhibit the activity of various pro-inflammatory mediators, including cytokines and chemokines, thereby contributing to the resolution of inflammation. **Pathways and Functions** PRCP's involvement in multiple cellular processes can be attributed to its role in several key pathways: 1. **Angiogenesis**: PRCP has been shown to regulate the migration of endothelial cells, a critical step in the formation of new blood vessels. Its activity is essential for the development of tissues and organs. 2. **Wound Healing**: PRCP plays a crucial role in the regulation of inflammation and tissue repair after injury. Its activity helps to modulate the expression of pro-inflammatory mediators and promote the resolution of inflammation. 3. **Energy Homeostasis**: PRCP has been implicated in the regulation of glucose homeostasis, a critical aspect of maintaining energy balance in the body. 4. **Innate Immune System**: PRCP's role in regulating immune responses is critical in the context of innate immunity. Its activity helps to modulate the expression of pro-inflammatory mediators and promote the resolution of inflammation. **Clinical Significance** Dysregulation of PRCP has been implicated in various diseases, including: 1. **Inflammatory Disorders**: PRCP's role in regulating inflammation makes it a potential therapeutic target for the treatment of inflammatory disorders, such as rheumatoid arthritis and asthma. 2. **Cardiovascular Disease**: PRCP's involvement in angiogenesis and vascular remodeling makes it a potential therapeutic target for the treatment of cardiovascular disease. 3. **Diabetes**: PRCP's role in regulating glucose homeostasis makes it a potential therapeutic target for the treatment of diabetes. In conclusion, PRCP is a multifaceted enzyme that plays a critical role in various physiological and pathological processes. Its involvement in multiple cellular pathways, including angiogenesis, wound healing, and energy homeostasis, underscores its significance in maintaining tissue homeostasis and overall health. Further research is needed to fully elucidate the mechanisms by which PRCP regulates immune responses and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 4207208262

Symbol: PCP_HUMAN

Name: Lysosomal Pro-X carboxypeptidase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8344943

Title: Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families.

PubMed ID: 8344943

DOI: 10.1016/s0021-9258(19)85465-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28321

Title: Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney.

PubMed ID: 28321

DOI: 10.1016/s0021-9258(17)34557-x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20540760

Title: Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.

PubMed ID: 20540760

DOI: 10.1186/1472-6807-10-16

Sequence Information:

  • Length: 496
  • Mass: 55800
  • Checksum: FC5DD570D3D3AB4F
  • Sequence:
  • MGRRALLLLL LSFLAPWATI ALRPALRALG SLHLPTNPTS LPAVAKNYSV LYFQQKVDHF 
    GFNTVKTFNQ RYLVADKYWK KNGGSILFYT GNEGDIIWFC NNTGFMWDVA EELKAMLVFA 
    EHRYYGESLP FGDNSFKDSR HLNFLTSEQA LADFAELIKH LKRTIPGAEN QPVIAIGGSY 
    GGMLAAWFRM KYPHMVVGAL AASAPIWQFE DLVPCGVFMK IVTTDFRKSG PHCSESIHRS 
    WDAINRLSNT GSGLQWLTGA LHLCSPLTSQ DIQHLKDWIS ETWVNLAMVD YPYASNFLQP 
    LPAWPIKVVC QYLKNPNVSD SLLLQNIFQA LNVYYNYSGQ VKCLNISETA TSSLGTLGWS 
    YQACTEVVMP FCTNGVDDMF EPHSWNLKEL SDDCFQQWGV RPRPSWITTM YGGKNISSHT 
    NIVFSNGELD PWSGGGVTKD ITDTLVAVTI SEGAHHLDLR TKNALDPMSV LLARSLEVRH 
    MKNWIRDFYD SAGKQH

Genular Protein ID: 2438416983

Symbol: B7Z7Q6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 391
  • Mass: 43934
  • Checksum: 05850E302DA49AE4
  • Sequence:
  • MWDVAEELKA MLVFAEHRYY GESLPFGDNS FKDSRHLNFL TSEQALADFA ELIKHLKRTI 
    PGAENQPVIA IGGSYGGMLA AWFRMKYPHM VVGALAASAP IWQFEDLVPC GVFMKIVTTD 
    FRKSGPHCSE SIHRSWDAIN RLSNTGSGLQ WLTGALHLCS PLTSQDIQHL KDWISETWVN 
    LAMVDYPYAS NFLQPLPAWP IKVVCQYLKN PNVSDSLLLQ NIFQALNVYY NYSGQVKCLN 
    ISETATSSLG TLGWSYQACT EVVMPFCTNG VDDMFEPHSW NLKELSDDCF QQWGVRPRPS 
    WITTMYGGKN ISSHTNIVFS NGELDPWSGG GVTKDITDTL VAVTISEGAH HLDLRTKNAL 
    DPMSVLLARS LEVRHMKNWI RDFYDSAGKQ H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.