Details for: KLK7

Gene ID: 5650

Symbol: KLK7

Ensembl ID: ENSG00000169035

Description: kallikrein related peptidase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 10.2133
    Cell Significance Index: 174.5900
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 3.2315
    Cell Significance Index: 3.7200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.8496
    Cell Significance Index: 23.3700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.1212
    Cell Significance Index: 11.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0159
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.5453
    Cell Significance Index: 3.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3861
    Cell Significance Index: 49.8800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2707
    Cell Significance Index: 0.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1503
    Cell Significance Index: 66.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1045
    Cell Significance Index: 57.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0613
    Cell Significance Index: 1.7100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0612
    Cell Significance Index: 0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0287
    Cell Significance Index: 1.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0065
    Cell Significance Index: 1.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0091
    Cell Significance Index: -17.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0136
    Cell Significance Index: -8.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0142
    Cell Significance Index: -1.6600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0215
    Cell Significance Index: -0.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0220
    Cell Significance Index: -16.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0232
    Cell Significance Index: -1.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0270
    Cell Significance Index: -1.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0354
    Cell Significance Index: -12.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0432
    Cell Significance Index: -1.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0484
    Cell Significance Index: -8.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0502
    Cell Significance Index: -6.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0567
    Cell Significance Index: -16.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0592
    Cell Significance Index: -8.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0630
    Cell Significance Index: -12.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0637
    Cell Significance Index: -28.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0663
    Cell Significance Index: -4.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0714
    Cell Significance Index: -8.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1177
    Cell Significance Index: -13.4800
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1616
    Cell Significance Index: -1.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1742
    Cell Significance Index: -3.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1778
    Cell Significance Index: -9.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1929
    Cell Significance Index: -14.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2081
    Cell Significance Index: -13.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2112
    Cell Significance Index: -4.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2201
    Cell Significance Index: -7.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2261
    Cell Significance Index: -2.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2273
    Cell Significance Index: -5.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2342
    Cell Significance Index: -5.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2457
    Cell Significance Index: -15.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2570
    Cell Significance Index: -6.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2823
    Cell Significance Index: -5.9100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2964
    Cell Significance Index: -3.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3005
    Cell Significance Index: -9.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3056
    Cell Significance Index: -9.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3226
    Cell Significance Index: -19.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3357
    Cell Significance Index: -12.3300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3381
    Cell Significance Index: -3.8900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3452
    Cell Significance Index: -4.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3508
    Cell Significance Index: -10.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3587
    Cell Significance Index: -16.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3604
    Cell Significance Index: -5.3200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3629
    Cell Significance Index: -5.2900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.3652
    Cell Significance Index: -4.6800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3712
    Cell Significance Index: -5.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3774
    Cell Significance Index: -12.0200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3777
    Cell Significance Index: -3.2100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.4125
    Cell Significance Index: -4.8200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.4143
    Cell Significance Index: -5.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4267
    Cell Significance Index: -9.1200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4277
    Cell Significance Index: -5.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.4316
    Cell Significance Index: -5.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4464
    Cell Significance Index: -15.6400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.4564
    Cell Significance Index: -2.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4569
    Cell Significance Index: -6.0900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4590
    Cell Significance Index: -5.9300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4594
    Cell Significance Index: -7.4400
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.4627
    Cell Significance Index: -5.4900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.4924
    Cell Significance Index: -4.9600
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.4946
    Cell Significance Index: -4.7200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5084
    Cell Significance Index: -8.6400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.5101
    Cell Significance Index: -5.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5135
    Cell Significance Index: -13.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5234
    Cell Significance Index: -27.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5401
    Cell Significance Index: -7.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5651
    Cell Significance Index: -16.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5827
    Cell Significance Index: -8.4600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.5931
    Cell Significance Index: -5.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6188
    Cell Significance Index: -16.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6206
    Cell Significance Index: -13.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6434
    Cell Significance Index: -17.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6693
    Cell Significance Index: -12.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6867
    Cell Significance Index: -17.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7109
    Cell Significance Index: -13.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7125
    Cell Significance Index: -12.2100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.7140
    Cell Significance Index: -8.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7151
    Cell Significance Index: -17.1500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.7192
    Cell Significance Index: -5.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7199
    Cell Significance Index: -27.2600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7322
    Cell Significance Index: -8.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7399
    Cell Significance Index: -15.9900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.7630
    Cell Significance Index: -10.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7636
    Cell Significance Index: -15.3300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.7707
    Cell Significance Index: -8.8400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.7776
    Cell Significance Index: -9.3800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7799
    Cell Significance Index: -15.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KLK7 is a member of the kallikrein-related peptidase family, characterized by its ability to cleave peptides at the carboxyl side of arginine or lysine residues. The enzyme exhibits metalloendopeptidase activity, which allows it to degrade various substrates, including proteins and peptides. KLK7 is highly homologous to other kallikrein-related peptidases, such as KLK1 and KLK2, and shares similar substrate specificity. The enzyme's activity is regulated by its binding to the extracellular matrix, which modulates its proteolytic activity. **Pathways and Functions** KLK7 is involved in various biological processes, including: 1. **Epidermal development and differentiation**: KLK7 plays a crucial role in the development and maturation of epithelial cells, particularly in the skin and hair follicles. 2. **Extracellular matrix remodeling**: KLK7 degrades various components of the extracellular matrix, including collagen and elastin, which is essential for tissue remodeling and repair. 3. **Antibacterial peptide production**: KLK7 is involved in the regulation of antibacterial peptide production, which is essential for defending against bacterial infections. 4. **Cell migration and invasion**: KLK7 promotes cell migration and invasion by degrading components of the extracellular matrix, which is essential for tissue remodeling and cancer progression. **Clinical Significance** KLK7 has been implicated in various diseases and disorders, including: 1. **Cancer**: KLK7 is overexpressed in various types of cancer, including breast, prostate, and lung cancer, where it is involved in tumor progression and metastasis. 2. **Atherosclerosis**: KLK7 is involved in the degradation of extracellular matrix components, which is essential for atherosclerotic plaque formation and progression. 3. **Neurological disorders**: KLK7 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it is involved in neuroinflammation and neurodegeneration. 4. **Infectious diseases**: KLK7 has been shown to play a role in the regulation of antibacterial peptide production, which is essential for defending against bacterial infections. In conclusion, KLK7 is a serine-type peptidase enzyme that plays a crucial role in various physiological and pathological processes, including epidermal development and differentiation, extracellular matrix remodeling, antibacterial peptide production, and cell migration and invasion. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this enzyme in human health and disease.

Genular Protein ID: 4160931996

Symbol: KLK7_HUMAN

Name: Kallikrein-7

UniProtKB Accession Codes:

P49862 A8K0U5 Q8N5N9 Q8NFV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8034709

Title: Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.

PubMed ID: 8034709

DOI: 10.1016/s0021-9258(17)32185-3

PubMed ID: 10974542

Title: The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation.

PubMed ID: 10974542

DOI: 10.1016/s0378-1119(00)00280-8

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 11874483

Title: Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.

PubMed ID: 11874483

DOI: 10.1046/j.0022-202x.2001.01684.x

PubMed ID: 12738725

Title: Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.

PubMed ID: 12738725

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7794273

Title: Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme.

PubMed ID: 7794273

DOI: 10.1006/bbrc.1995.1853

PubMed ID: 23370777

Title: Vaspin inhibits kallikrein 7 by serpin mechanism.

PubMed ID: 23370777

DOI: 10.1007/s00018-013-1258-8

PubMed ID: 17909180

Title: Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.

PubMed ID: 17909180

DOI: 10.1073/pnas.0707811104

PubMed ID: 18329042

Title: Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6).

PubMed ID: 18329042

DOI: 10.1016/j.jmb.2008.01.089

Sequence Information:

  • Length: 253
  • Mass: 27525
  • Checksum: 2D68B6B15A76A668
  • Sequence:
    • MARSLLLPLQ ILLLSLALET AGEEAQGDKI IDGAPCARGS HPWQVALLSG NQLHCGGVLV 
NERWVLTAAH CKMNEYTVHL GSDTLGDRRA QRIKASKSFR HPGYSTQTHV NDLMLVKLNS 
QARLSSMVKK VRLPSRCEPP GTTCTVSGWG TTTSPDVTFP SDLMCVDVKL ISPQDCTKVY 
KDLLENSMLC AGIPDSKKNA CNGDSGGPLV CRGTLQGLVS WGTFPCGQPN DPGVYTQVCK 
FTKWINDTMK KHR

Genular Protein ID: 3227403073

Symbol: B4DHX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DHX9

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 140
  • Mass: 15217
  • Checksum: 2DD42803DA58FEA7
  • Sequence:
    • MLVKLNSQAR LSSMVKKVRL PSRCEPPGTT CTVSGWGTTT SPDVTFPSDL MCVDVKLISP 
QDCTKVYKDL LENSMLCAGI PDSKKNACNG DSGGPLVCRG TLQGLVSWGT FPCGQPNDPG 
VYTQVCKFTK WINDTMKKHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.