PSMC2 | ENSG00000161057 | NCBI 5701

Details for: PSMC2

Gene ID: 5701

Symbol: PSMC2

Ensembl ID: ENSG00000161057

Description: proteasome 26S subunit, ATPase 2

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 194.9272
Cell Significance Index: -30.3200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 133.7311
Cell Significance Index: -33.9200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 101.7362
Cell Significance Index: -41.9100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 92.4548
Cell Significance Index: -43.6500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 88.7123
Cell Significance Index: -36.0400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 79.7457
Cell Significance Index: -41.0200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 65.3183
Cell Significance Index: -43.8300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 38.2721
Cell Significance Index: -36.5400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 33.2129
Cell Significance Index: -40.9500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.8970
Cell Significance Index: -43.0000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.6202
Cell Significance Index: -28.4500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.6041
Cell Significance Index: -32.5700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.6926
Cell Significance Index: 1528.3300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1186
Cell Significance Index: 181.9300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9475
Cell Significance Index: 25.3000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9066
Cell Significance Index: 181.8600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7499
Cell Significance Index: 102.9800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.7360
Cell Significance Index: 25.5800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7337
Cell Significance Index: 324.4000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.7286
Cell Significance Index: 15.2500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.6697
Cell Significance Index: 17.9500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6676
Cell Significance Index: 132.4800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.6335
Cell Significance Index: 39.9300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6157
Cell Significance Index: 75.7100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5943
Cell Significance Index: 42.0300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5856
Cell Significance Index: 75.0700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5833
Cell Significance Index: 105.1600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.5711
Cell Significance Index: 9.5600
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5078
Cell Significance Index: 65.6000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4860
Cell Significance Index: 22.6600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4488
Cell Significance Index: 245.1000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4424
Cell Significance Index: 32.9700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4161
Cell Significance Index: 12.2200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4034
Cell Significance Index: 10.9800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3720
Cell Significance Index: 8.0600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3692
Cell Significance Index: 17.3500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3427
Cell Significance Index: 9.0100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3390
Cell Significance Index: 121.6000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3349
Cell Significance Index: 39.5000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3342
Cell Significance Index: 17.3600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3295
Cell Significance Index: 22.7900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2175
Cell Significance Index: 11.4200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2131
Cell Significance Index: 13.7500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1972
Cell Significance Index: 10.2700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1925
Cell Significance Index: 36.6300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1685
Cell Significance Index: 4.8600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1188
Cell Significance Index: 11.7500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1051
Cell Significance Index: 17.9500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0696
Cell Significance Index: 48.1200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0638
Cell Significance Index: 0.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0402
Cell Significance Index: 3.0900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0386
Cell Significance Index: 1.0800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0285
Cell Significance Index: 53.5800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0087
Cell Significance Index: 6.5700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0012
Cell Significance Index: -0.9000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0034
Cell Significance Index: -2.1500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0118
Cell Significance Index: -7.3700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0119
Cell Significance Index: -21.9200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0120
Cell Significance Index: -18.5500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0237
Cell Significance Index: -32.2300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0267
Cell Significance Index: -12.1400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0336
Cell Significance Index: -1.1800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0393
Cell Significance Index: -4.0100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0444
Cell Significance Index: -25.0300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0790
Cell Significance Index: -3.5800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0901
Cell Significance Index: -18.9800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1099
Cell Significance Index: -12.6000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1223
Cell Significance Index: -1.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1288
Cell Significance Index: -37.0700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1527
Cell Significance Index: -17.8000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1537
Cell Significance Index: -9.4500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1666
Cell Significance Index: -24.2200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1716
Cell Significance Index: -11.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1994
Cell Significance Index: -11.1900
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2070
Cell Significance Index: -5.0500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2105
Cell Significance Index: -24.0300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2173
Cell Significance Index: -6.2300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2521
Cell Significance Index: -4.3200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2584
Cell Significance Index: -6.6000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2944
Cell Significance Index: -5.7500
Cell Name: kidney cell (CL1000497)
Fold Change: -0.3119
Cell Significance Index: -2.4900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3550
Cell Significance Index: -7.5600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3725
Cell Significance Index: -11.9300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3801
Cell Significance Index: -30.1000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3906
Cell Significance Index: -10.0400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3973
Cell Significance Index: -41.3700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4489
Cell Significance Index: -6.1300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4678
Cell Significance Index: -20.6900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4746
Cell Significance Index: -4.3700
Cell Name: peg cell (CL4033014)
Fold Change: -0.5341
Cell Significance Index: -12.3400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5522
Cell Significance Index: -20.9100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5546
Cell Significance Index: -14.8400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7019
Cell Significance Index: -43.0300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7843
Cell Significance Index: -13.8600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8109
Cell Significance Index: -20.2700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.8386
Cell Significance Index: -15.5000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8471
Cell Significance Index: -24.9500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.8648
Cell Significance Index: -24.6800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8886
Cell Significance Index: -28.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit**: PSMC2 is a subunit of the 26S proteasome complex, which is responsible for the degradation of ubiquitinated proteins. 2. **ATPase activity**: PSMC2 possesses ATPase activity, which is necessary for the unfolding and translocation of protein substrates into the proteasome. 3. **Significant expression**: PSMC2 is significantly expressed in multiple cell types, including hematopoietic cells, neural cells, and trophoblasts. 4. **Involvement in cellular processes**: PSMC2 is involved in various cellular processes, including immune system regulation, apoptosis, and cell cycle progression. **Pathways and Functions** 1. **Adaptive immune system**: PSMC2 is involved in the regulation of the adaptive immune system, particularly in the processing and presentation of antigens to T-cells. 2. **Antigen processing and presentation**: PSMC2 is essential for the degradation of ubiquitinated proteins, which are then presented to T-cells via MHC class I molecules. 3. **Apoptosis**: PSMC2 plays a role in regulating apoptosis by degrading pro-apoptotic proteins, such as Bcl-2 family members. 4. **Cell cycle regulation**: PSMC2 is involved in the regulation of the cell cycle, particularly in the G2/M phase, by degrading proteins that inhibit cell cycle progression. 5. **Innate immune system**: PSMC2 is also involved in the regulation of the innate immune system, particularly in the processing and presentation of antigens to dendritic cells. **Clinical Significance** 1. **Autoimmune diseases**: Alterations in PSMC2 expression have been implicated in various autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: PSMC2 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 3. **Neurodegenerative diseases**: PSMC2 has been implicated in the regulation of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Infectious diseases**: PSMC2 is involved in the regulation of the immune response to infectious diseases, such as HIV and tuberculosis. In conclusion, the PSMC2 gene plays a crucial role in regulating various cellular processes, including the adaptive immune system, apoptosis, and cell cycle progression. Its dysregulation has been implicated in various diseases, including autoimmune diseases, cancer, and neurodegenerative diseases. Further research is needed to fully understand the mechanisms by which PSMC2 regulates cellular processes and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome regulatory subunit 7
B7Z571_HUMAN

Genular Protein ID: 3495332222

Symbol: PRS7_HUMAN

Name: 26S proteasome regulatory subunit 7

UniProtKB Accession Codes:

P35998 A4D0Q1 B7Z5E2 Q3LIA5 Q9UDI3

Database IDs:

Citations:

PubMed ID: 1377363

Title: New human gene encoding a positive modulator of HIV Tat-mediated transactivation.

PubMed ID: 1377363

DOI: 10.1038/357700a0

PubMed ID: 12880961

Title: Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.

PubMed ID: 12880961

DOI: 10.1016/s0304-3835(03)00085-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8500623

Title: Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease.

PubMed ID: 8500623

DOI: 10.1016/0014-5793(93)81356-5

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 9295362

Title: HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins.

PubMed ID: 9295362

DOI: 10.1074/jbc.272.38.24081

PubMed ID: 10409732

Title: Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins.

PubMed ID: 10409732

DOI: 10.1128/mcb.19.8.5417

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15340068

Title: Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.

PubMed ID: 15340068

DOI: 10.1128/mcb.24.18.8055-8068.2004

PubMed ID: 15831487

Title: Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.

PubMed ID: 15831487

DOI: 10.1128/mcb.25.9.3842-3853.2005

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22078707

Title: TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions.

PubMed ID: 22078707

DOI: 10.1186/1742-4690-8-93

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24811749

Title: Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

PubMed ID: 24811749

DOI: 10.1002/embj.201386906

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28539385

Title: Phosphatase UBLCP1 controls proteasome assembly.

PubMed ID: 28539385

DOI: 10.1098/rsob.170042

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 433
Mass: 48634
Checksum: 85FD95F6DF7A3E84
Sequence:

MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN 
ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK 
FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC 
KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV 
IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML 
ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR 
SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKIATEKDFL EAVNKVIKSY 
AKFSATPRYM TYN

Genular Protein ID: 3320242577

Symbol: B7Z571_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z571

Database IDs:

Sequence Information:

Length: 141
Mass: 15796
Checksum: E5167FDC01DDACCA
Sequence:

MPDYLGADQR KTKEDEKDDK PIRALDEGDI ASLKTYGQST YSRQIKQVED DIQQLLKKIN 
ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK 
FVVDLSDQVA PTDIEEGMRV G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMC2

Associated with

Cells (max top 100)

Other Information

New human gene encoding a positive modulator of HIV Tat-mediated transactivation. PubMed ID: 1377363

Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. PubMed ID: 12880961

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease. PubMed ID: 8500623

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins. PubMed ID: 9295362

Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. PubMed ID: 10409732

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. PubMed ID: 15340068

Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. PubMed ID: 15831487

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. PubMed ID: 22078707

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. PubMed ID: 24811749

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Phosphatase UBLCP1 controls proteasome assembly. PubMed ID: 28539385

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858