PSMC5 | ENSG00000087191 | NCBI 5705

Details for: PSMC5

Gene ID: 5705

Symbol: PSMC5

Ensembl ID: ENSG00000087191

Description: proteasome 26S subunit, ATPase 5

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 291.9408
Cell Significance Index: -45.4100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 175.7389
Cell Significance Index: -44.5800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 150.1405
Cell Significance Index: -61.8500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 129.8391
Cell Significance Index: -61.3000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 128.5885
Cell Significance Index: -52.2400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 115.4777
Cell Significance Index: -59.4000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 91.6959
Cell Significance Index: -61.5300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 55.7218
Cell Significance Index: -53.2000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 48.0471
Cell Significance Index: -59.2400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.8336
Cell Significance Index: -62.4800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.4129
Cell Significance Index: -47.3400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.3830
Cell Significance Index: -38.5300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.1788
Cell Significance Index: 63.9900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.0835
Cell Significance Index: 56.7100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.7156
Cell Significance Index: 80.6300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.6925
Cell Significance Index: 78.9100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.6082
Cell Significance Index: 84.4400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.5818
Cell Significance Index: 285.1400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4951
Cell Significance Index: 183.8300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.4616
Cell Significance Index: 646.2300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4473
Cell Significance Index: 198.7600
Cell Name: kidney cell (CL1000497)
Fold Change: 1.4428
Cell Significance Index: 11.5200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.3714
Cell Significance Index: 96.9900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3605
Cell Significance Index: 87.7700
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3558
Cell Significance Index: 740.4300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2337
Cell Significance Index: 42.8700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.1720
Cell Significance Index: 13.3200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.1625
Cell Significance Index: 86.6400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1294
Cell Significance Index: 23.6400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.1268
Cell Significance Index: 12.2500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0757
Cell Significance Index: 55.8800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.0284
Cell Significance Index: 9.4700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.9515
Cell Significance Index: 122.9300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9384
Cell Significance Index: 48.8800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9278
Cell Significance Index: 100.9200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9110
Cell Significance Index: 107.4400
Cell Name: peg cell (CL4033014)
Fold Change: 0.7663
Cell Significance Index: 17.7100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.7652
Cell Significance Index: 98.0900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5456
Cell Significance Index: 11.8200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5423
Cell Significance Index: 34.1800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4734
Cell Significance Index: 8.3700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4165
Cell Significance Index: 11.1200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4076
Cell Significance Index: 11.6900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3011
Cell Significance Index: 60.4100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2838
Cell Significance Index: 46.1600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2700
Cell Significance Index: 46.1000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2099
Cell Significance Index: 5.6200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2011
Cell Significance Index: 12.0800
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1784
Cell Significance Index: 4.6900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1530
Cell Significance Index: 29.1200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0991
Cell Significance Index: 2.8600
Cell Name: germ cell (CL0000586)
Fold Change: 0.0980
Cell Significance Index: 0.7400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0792
Cell Significance Index: 58.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0682
Cell Significance Index: 51.6200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0571
Cell Significance Index: 20.4900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0528
Cell Significance Index: 10.4800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0302
Cell Significance Index: 0.5100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0151
Cell Significance Index: 1.4900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0162
Cell Significance Index: -11.9900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0222
Cell Significance Index: -41.8800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0288
Cell Significance Index: -2.9400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0352
Cell Significance Index: -21.9800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0361
Cell Significance Index: -66.6000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0452
Cell Significance Index: -69.5500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0526
Cell Significance Index: -71.5700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0625
Cell Significance Index: -39.6700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0741
Cell Significance Index: -41.8200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1162
Cell Significance Index: -24.4700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1191
Cell Significance Index: -54.0400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1318
Cell Significance Index: -15.1000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1784
Cell Significance Index: -51.3400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2125
Cell Significance Index: -24.7700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2478
Cell Significance Index: -6.3300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2611
Cell Significance Index: -4.8300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2806
Cell Significance Index: -40.7900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3244
Cell Significance Index: -25.6900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3378
Cell Significance Index: -9.4400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4779
Cell Significance Index: -6.5200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5092
Cell Significance Index: -13.6500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5133
Cell Significance Index: -31.5500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5220
Cell Significance Index: -59.5900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5942
Cell Significance Index: -61.8700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6480
Cell Significance Index: -9.7100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.6877
Cell Significance Index: -31.1700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7010
Cell Significance Index: -14.9300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7148
Cell Significance Index: -12.2500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7404
Cell Significance Index: -56.8200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7659
Cell Significance Index: -51.5000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7903
Cell Significance Index: -44.3500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.7976
Cell Significance Index: -6.7000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8271
Cell Significance Index: -26.4900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.9038
Cell Significance Index: -37.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9935
Cell Significance Index: -60.9100
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.0545
Cell Significance Index: -12.5700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1499
Cell Significance Index: -33.8700
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.1766
Cell Significance Index: -12.1800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.2848
Cell Significance Index: -56.8300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.3484
Cell Significance Index: -49.5000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.4144
Cell Significance Index: -71.4800
Cell Name: Sertoli cell (CL0000216)
Fold Change: -1.4245
Cell Significance Index: -19.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PSMC5 is a 5 subunit component of the 26S proteasome, which is composed of two large subunits (α and β) and 14-20 smaller subunits (including PSMC5). The 26S proteasome is a multi-chambered complex that uses ATP hydrolysis to degrade proteins by proteolysis. PSMC5 is a regulatory subunit that interacts with other subunits to modulate the activity of the proteasome. **Pathways and Functions:** PSMC5 is involved in various cellular processes, including: 1. **Protein degradation:** PSMC5 plays a key role in degrading damaged or misfolded proteins, which helps maintain protein homeostasis and prevent protein aggregation. 2. **Cell cycle regulation:** The 26S proteasome, including PSMC5, regulates cell cycle progression by degrading proteins involved in cell cycle checkpoints and mitotic progression. 3. **Immune response:** PSMC5 is involved in the regulation of immune response by degrading proteins involved in antigen processing and presentation. 4. **Signaling pathways:** PSMC5 interacts with various signaling proteins, including those involved in Wnt, Hedgehog, and Notch signaling pathways. 5. **Cellular stress response:** PSMC5 helps regulate cellular responses to stress, including hypoxia, chemical stress, and viral infections. **Clinical Significance:** Dysregulation of PSMC5 has been implicated in various diseases, including: 1. **Cancer:** Alterations in PSMC5 expression have been observed in various cancers, including leukemia, lymphoma, and solid tumors. 2. **Autoimmune diseases:** PSMC5 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of the 26S proteasome contributes to immune dysfunction. 3. **Neurodegenerative diseases:** PSMC5 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where dysregulation of the 26S proteasome contributes to protein aggregation and neuronal death. 4. **Genetic disorders:** Mutations in PSMC5 have been associated with genetic disorders, such as cystic fibrosis and muscular dystrophy. In conclusion, PSMC5 is a critical component of the 26S proteasome, playing a central role in regulating protein turnover, cell cycle progression, and immune response. Dysregulation of PSMC5 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and immune function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome regulatory subunit 8

Genular Protein ID: 3712985231

Symbol: PRS8_HUMAN

Name: 26S proteasome regulatory subunit 8

UniProtKB Accession Codes:

P62195 A8K3Z3 A8K763 O35051 O43208 P47210 P52915 P52916

Database IDs:

Citations:

PubMed ID: 7729537

Title: cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p.

PubMed ID: 7729537

DOI: 10.1016/0014-5793(95)00304-r

PubMed ID: 7776974

Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

PubMed ID: 7776974

DOI: 10.1210/mend.9.2.7776974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 9295362

Title: HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins.

PubMed ID: 9295362

DOI: 10.1074/jbc.272.38.24081

PubMed ID: 10409732

Title: Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins.

PubMed ID: 10409732

DOI: 10.1128/mcb.19.8.5417

PubMed ID: 15831487

Title: Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.

PubMed ID: 15831487

DOI: 10.1128/mcb.25.9.3842-3853.2005

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22078707

Title: TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions.

PubMed ID: 22078707

DOI: 10.1186/1742-4690-8-93

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 406
Mass: 45626
Checksum: 29C6410C4A85A7F7
Sequence:

MALDGPEQME LEEGKAGSGL RQYYLSKIEE LQLIVNDKSQ NLRRLQAQRN ELNAKVRLLR 
EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD KNIDINDVTP NCRVALRNDS 
YTLHKILPNK VDPLVSLMMV EKVPDSTYEM IGGLDKQIKE IKEVIELPVK HPELFEALGI 
AQPKGVLLYG PPGTGKTLLA RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE 
HAPSIIFMDE IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI 
LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL MPGASGAEVK 
GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS IKKLWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMC5

Associated with

Cells (max top 100)

Other Information

cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p. PubMed ID: 7729537

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. PubMed ID: 7776974

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale concatenation cDNA sequencing. PubMed ID: 9110174

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins. PubMed ID: 9295362

Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. PubMed ID: 10409732

Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. PubMed ID: 15831487

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. PubMed ID: 22078707

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. PubMed ID: 23824326

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. PubMed ID: 25489052

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. PubMed ID: 26030138

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858