PSMD1 | ENSG00000173692 | NCBI 5707

Details for: PSMD1

Gene ID: 5707

Symbol: PSMD1

Ensembl ID: ENSG00000173692

Description: proteasome 26S subunit, non-ATPase 1

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 365.2314
Cell Significance Index: -56.8100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 248.0254
Cell Significance Index: -62.9100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 173.4687
Cell Significance Index: -71.4600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 146.8898
Cell Significance Index: -69.3500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 141.4006
Cell Significance Index: -57.4500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 125.8979
Cell Significance Index: -64.7600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 103.6031
Cell Significance Index: -69.5200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 60.4351
Cell Significance Index: -57.7000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 54.1524
Cell Significance Index: -66.7700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 23.4353
Cell Significance Index: -62.7800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.3857
Cell Significance Index: -68.6100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.3012
Cell Significance Index: -53.1400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.8818
Cell Significance Index: 103.6500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2367
Cell Significance Index: 448.6800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1318
Cell Significance Index: 423.0700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.0051
Cell Significance Index: 51.5400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3630
Cell Significance Index: 104.6000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3504
Cell Significance Index: 484.3600
Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.3418
Cell Significance Index: 32.7400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2341
Cell Significance Index: 134.2400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1772
Cell Significance Index: 70.6700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1219
Cell Significance Index: 137.9500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0594
Cell Significance Index: 190.9900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9887
Cell Significance Index: 683.8100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9491
Cell Significance Index: 27.3500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6827
Cell Significance Index: 38.3100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6824
Cell Significance Index: 372.6600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6767
Cell Significance Index: 14.6600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.6340
Cell Significance Index: 42.6300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6030
Cell Significance Index: 266.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5505
Cell Significance Index: 75.6000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5058
Cell Significance Index: 14.1400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4699
Cell Significance Index: 12.5900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4578
Cell Significance Index: 20.2500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4561
Cell Significance Index: 17.2700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3744
Cell Significance Index: 338.0800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3550
Cell Significance Index: 16.0900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3057
Cell Significance Index: 2.8200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2691
Cell Significance Index: 31.7400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2553
Cell Significance Index: 15.6900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.2220
Cell Significance Index: 3.7400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2022
Cell Significance Index: 10.5300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1890
Cell Significance Index: 9.8200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1471
Cell Significance Index: 276.9300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1328
Cell Significance Index: 6.2400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1173
Cell Significance Index: 74.4900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1097
Cell Significance Index: 20.8800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1086
Cell Significance Index: 13.9200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1049
Cell Significance Index: 7.4200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1027
Cell Significance Index: 3.6100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0987
Cell Significance Index: 3.4300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0935
Cell Significance Index: 42.4500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0924
Cell Significance Index: 125.6400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0809
Cell Significance Index: 124.6000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0716
Cell Significance Index: 132.0800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0669
Cell Significance Index: 1.9100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0577
Cell Significance Index: 2.6900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0242
Cell Significance Index: 4.1400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0147
Cell Significance Index: 2.4000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0008
Cell Significance Index: -0.0600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0186
Cell Significance Index: -13.8100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0285
Cell Significance Index: -20.9000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0470
Cell Significance Index: -35.5800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0514
Cell Significance Index: -0.8800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0668
Cell Significance Index: -41.7400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0671
Cell Significance Index: -8.6800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0699
Cell Significance Index: -4.5100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0846
Cell Significance Index: -47.7200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1250
Cell Significance Index: -12.7700
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1557
Cell Significance Index: -15.4000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1694
Cell Significance Index: -35.6700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1825
Cell Significance Index: -3.9000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1862
Cell Significance Index: -13.8800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2091
Cell Significance Index: -60.1500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2119
Cell Significance Index: -11.1300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2255
Cell Significance Index: -26.2800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2269
Cell Significance Index: -32.9800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3240
Cell Significance Index: -20.4200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3441
Cell Significance Index: -10.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3597
Cell Significance Index: -41.2100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4614
Cell Significance Index: -52.6700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4810
Cell Significance Index: -8.0500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5465
Cell Significance Index: -56.9100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5467
Cell Significance Index: -14.8800
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5651
Cell Significance Index: -11.0300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5749
Cell Significance Index: -16.4800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6108
Cell Significance Index: -16.0600
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.6208
Cell Significance Index: -7.7000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.6292
Cell Significance Index: -15.0900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6684
Cell Significance Index: -9.1200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6996
Cell Significance Index: -55.4100
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.7908
Cell Significance Index: -12.7600
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.8089
Cell Significance Index: -11.9400
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.8239
Cell Significance Index: -12.1600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.9159
Cell Significance Index: -19.0000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.9275
Cell Significance Index: -20.3100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9931
Cell Significance Index: -25.3700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0130
Cell Significance Index: -62.1100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.0200
Cell Significance Index: -14.6700
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.0538
Cell Significance Index: -13.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit**: PSMD1 is a non-ATPase regulatory subunit of the 26S proteasome, which is a large protein complex responsible for degrading ubiquitinated proteins. 2. **Ubiquitination**: PSMD1 is involved in the ubiquitination and degradation of proteins, facilitating protein quality control and cell cycle regulation. 3. **Antigen presentation**: The 26S proteasome complex, including PSMD1, plays a critical role in antigen presentation, where ubiquitinated proteins are degraded and presented to T-cells, activating an immune response. 4. **Cell cycle regulation**: PSMD1 is involved in cell cycle regulation, where the 26S proteasome complex degrades cyclin-dependent kinases and other proteins, controlling cell proliferation. **Pathways and Functions** 1. **Antigen processing and presentation**: PSMD1 is involved in the degradation of ubiquitinated proteins, which are then presented to T-cells, activating an immune response. 2. **Cell cycle regulation**: PSMD1 is involved in the degradation of cyclin-dependent kinases and other proteins, controlling cell proliferation. 3. **Neurodegeneration**: PSMD1 is highly expressed in neurons and is involved in neurodegeneration, where the 26S proteasome complex is implicated in the degradation of toxic proteins. 4. **Immune function**: PSMD1 is involved in immune function, where the 26S proteasome complex is critical for the degradation of ubiquitinated proteins, which are then presented to T-cells, activating an immune response. **Clinical Significance** 1. **Neurodegenerative diseases**: PSMD1 is implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where the 26S proteasome complex is involved in the degradation of toxic proteins. 2. **Immune disorders**: PSMD1 is involved in immune disorders, such as autoimmune diseases and cancer, where the 26S proteasome complex is critical for the degradation of ubiquitinated proteins, which are then presented to T-cells, activating an immune response. 3. **Cancer**: PSMD1 is overexpressed in various cancers, where the 26S proteasome complex is involved in the degradation of ubiquitinated proteins, facilitating cancer progression. 4. **Genetic disorders**: PSMD1 is involved in genetic disorders, such as hereditary spastic paraplegia, where mutations in the PSMD1 gene lead to impaired protein degradation, resulting in neurological symptoms. In conclusion, PSMD1 is a critical component of the 26S proteasome complex, involved in various cellular processes, including protein degradation, antigen presentation, and cell cycle regulation. Its dysregulation has been implicated in neurodegenerative diseases, immune disorders, cancer, and genetic disorders, highlighting its importance in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 1

Genular Protein ID: 2467044508

Symbol: PSMD1_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 1

UniProtKB Accession Codes:

Q99460 B8ZZH9 Q24JU0 Q53TI2 Q6GMU5 Q6P2P4 Q6PJM7 Q6PKG9 Q86VU1 Q8IV79

Database IDs:

Citations:

PubMed ID: 8816993

Title: cDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.

PubMed ID: 8816993

DOI: 10.1091/mbc.7.6.853

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 16990800

Title: A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.

PubMed ID: 16990800

DOI: 10.1038/sj.emboj.7601338

PubMed ID: 16906146

Title: Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.

PubMed ID: 16906146

DOI: 10.1038/ncb1460

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29804830

Title: ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules.

PubMed ID: 29804830

DOI: 10.1016/j.molcel.2018.04.021

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 953
Mass: 105836
Checksum: B8682146082D21FA
Sequence:

MITSAAGIIS LLDEDEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE DEGFRSRQFA 
ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI IAKCIDHYTK QCVENADLPE 
GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA IGIALETRRL DVFEKTILES NDVPGMLAYS 
LKLCMSLMQN KQFRNKVLRV LVKIYMNLEK PDFINVCQCL IFLDDPQAVS DILEKLVKED 
NLLMAYQICF DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGS EKDSDSMETE 
EKTSSAFVGK TPEASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL MILKNTKDAV 
RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA KFTATASLGV IHKGHEKEAL 
QLMATYLPKD TSPGSAYQEG GGLYALGLIH ANHGGDIIDY LLNQLKNASN DIVRHGGSLG 
LGLAAMGTAR QDVYDLLKTN LYQDDAVTGE AAGLALGLVM LGSKNAQAIE DMVGYAQETQ 
HEKILRGLAV GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR 
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY GAAMALGICC 
AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE ITCPKVNQFR QLYSKVINDK 
HDDVMAKFGA ILAQGILDAG GHNVTISLQS RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS 
LAYTPTCVIG LNKDLKMPKV QYKSNCKPST FAYPAPLEVP KEKEKEKVST AVLSITAKAK 
KKEKEKEKKE EEKMEVDEAE KKEEKEKKKE PEPNFQLLDN PARVMPAQLK VLTMPETCRY 
QPFKPLSIGG IIILKDTSED IEELVEPVAA HGPKIEEEEQ EPEPPEPFEY IDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMD1

Associated with

Cells (max top 100)

Other Information

cDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. PubMed ID: 8816993

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. PubMed ID: 16990800

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. PubMed ID: 16906146

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules. PubMed ID: 29804830

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858