Details for: PSMD4

Gene ID: 5710

Symbol: PSMD4

Ensembl ID: ENSG00000159352

Description: proteasome 26S subunit ubiquitin receptor, non-ATPase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 345.3015
    Cell Significance Index: -53.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 202.6467
    Cell Significance Index: -51.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 161.7985
    Cell Significance Index: -66.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 149.6433
    Cell Significance Index: -70.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 139.4191
    Cell Significance Index: -56.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.5503
    Cell Significance Index: -65.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 105.7342
    Cell Significance Index: -70.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.9847
    Cell Significance Index: -57.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.8696
    Cell Significance Index: -62.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.2780
    Cell Significance Index: -68.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5999
    Cell Significance Index: -41.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.1729
    Cell Significance Index: -40.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5365
    Cell Significance Index: -23.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8385
    Cell Significance Index: 1660.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6281
    Cell Significance Index: 42.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4842
    Cell Significance Index: 11.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3862
    Cell Significance Index: 757.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3816
    Cell Significance Index: 48.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3623
    Cell Significance Index: 187.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3321
    Cell Significance Index: 264.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2879
    Cell Significance Index: 34.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2654
    Cell Significance Index: 81.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2122
    Cell Significance Index: 218.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1614
    Cell Significance Index: 24.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1121
    Cell Significance Index: 12.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1023
    Cell Significance Index: 76.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0799
    Cell Significance Index: 31.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0544
    Cell Significance Index: 211.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0296
    Cell Significance Index: 455.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0151
    Cell Significance Index: 47.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0085
    Cell Significance Index: 47.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9837
    Cell Significance Index: 120.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9280
    Cell Significance Index: 118.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8991
    Cell Significance Index: 47.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8929
    Cell Significance Index: 115.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8803
    Cell Significance Index: 62.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8189
    Cell Significance Index: 96.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7352
    Cell Significance Index: 54.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6982
    Cell Significance Index: 19.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6474
    Cell Significance Index: 7.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4712
    Cell Significance Index: 76.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4059
    Cell Significance Index: 280.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3606
    Cell Significance Index: 129.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3513
    Cell Significance Index: 59.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3500
    Cell Significance Index: 10.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3167
    Cell Significance Index: 16.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2899
    Cell Significance Index: 15.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2261
    Cell Significance Index: 43.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1453
    Cell Significance Index: 2.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1049
    Cell Significance Index: 10.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0357
    Cell Significance Index: 1.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0073
    Cell Significance Index: 5.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0063
    Cell Significance Index: 0.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0127
    Cell Significance Index: -9.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0204
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0227
    Cell Significance Index: -14.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0247
    Cell Significance Index: -45.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0299
    Cell Significance Index: -46.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0375
    Cell Significance Index: -50.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0555
    Cell Significance Index: -35.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0773
    Cell Significance Index: -43.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0834
    Cell Significance Index: -2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0895
    Cell Significance Index: -40.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0991
    Cell Significance Index: -7.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1695
    Cell Significance Index: -35.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1790
    Cell Significance Index: -11.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1866
    Cell Significance Index: -53.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1888
    Cell Significance Index: -21.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2436
    Cell Significance Index: -4.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2458
    Cell Significance Index: -14.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2619
    Cell Significance Index: -16.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3013
    Cell Significance Index: -9.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3033
    Cell Significance Index: -6.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3072
    Cell Significance Index: -35.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3262
    Cell Significance Index: -47.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4190
    Cell Significance Index: -9.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4291
    Cell Significance Index: -6.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4638
    Cell Significance Index: -52.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5229
    Cell Significance Index: -4.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5606
    Cell Significance Index: -14.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6008
    Cell Significance Index: -40.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6191
    Cell Significance Index: -49.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6341
    Cell Significance Index: -66.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6569
    Cell Significance Index: -36.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8343
    Cell Significance Index: -23.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9275
    Cell Significance Index: -27.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9418
    Cell Significance Index: -12.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9802
    Cell Significance Index: -26.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0230
    Cell Significance Index: -62.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0247
    Cell Significance Index: -27.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0616
    Cell Significance Index: -46.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0829
    Cell Significance Index: -23.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2783
    Cell Significance Index: -31.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2786
    Cell Significance Index: -10.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2964
    Cell Significance Index: -49.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3065
    Cell Significance Index: -22.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PSMD4 is a non-ATPase regulatory subunit of the 26S proteasome, which is composed of two subunits: the 19S regulatory subunit (PSMD4) and the 20S catalytic subunit. The 19S regulatory subunit is responsible for the recognition and binding of ubiquitinated proteins to the proteasome, while the 20S catalytic subunit is responsible for the degradation of these proteins. PSMD4 is a ubiquitin receptor that recognizes and binds to ubiquitinated proteins, facilitating their degradation by the 20S catalytic subunit. **Pathways and Functions** PSMD4 is involved in various cellular processes, including: 1. **Antigen processing and presentation**: PSMD4 plays a crucial role in the processing and presentation of antigens to the immune system. It recognizes and binds to ubiquitinated antigens, facilitating their degradation and presentation to T-cells. 2. **Cell cycle regulation**: PSMD4 is involved in the regulation of the cell cycle, particularly during the G2/M phase. It recognizes and binds to ubiquitinated proteins that are involved in cell cycle progression, facilitating their degradation and preventing the progression of the cell cycle. 3. **Immune response**: PSMD4 is involved in the regulation of the immune response, particularly in the recognition and elimination of pathogens. It recognizes and binds to ubiquitinated pathogens, facilitating their degradation and presentation to T-cells. 4. **Protein degradation**: PSMD4 is involved in the degradation of proteins marked for destruction, including ubiquitinated proteins. It recognizes and binds to ubiquitinated proteins, facilitating their degradation by the 20S catalytic subunit. **Clinical Significance** Dysregulation of PSMD4 has been implicated in various diseases, including: 1. **Cancer**: PSMD4 is often overexpressed in cancer cells, leading to the degradation of tumor suppressor proteins and the promotion of tumorigenesis. 2. **Autoimmune diseases**: PSMD4 is involved in the regulation of the immune response, and dysregulation of PSMD4 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious diseases**: PSMD4 is involved in the recognition and elimination of pathogens, and dysregulation of PSMD4 has been implicated in infectious diseases, such as tuberculosis and HIV. 4. **Neurodegenerative diseases**: PSMD4 is involved in the regulation of protein degradation, and dysregulation of PSMD4 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, PSMD4 is a critical component of the ubiquitin-proteasome system, and dysregulation of PSMD4 has been implicated in various diseases. Further research is needed to fully understand the role of PSMD4 in maintaining cellular homeostasis and immune function.

Genular Protein ID: 4036863163

Symbol: PSMD4_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 4

UniProtKB Accession Codes:

P55036 D3DV16 Q5VWC5 Q9NS92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 EMDB 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 62 PDBsum 62 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 59 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7657640

Title: Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion.

PubMed ID: 7657640

DOI: 10.1074/jbc.270.35.20615

PubMed ID: 8641424

Title: Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease.

PubMed ID: 8641424

DOI: 10.1016/0014-5793(96)00101-9

PubMed ID: 10921894

Title: Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes.

PubMed ID: 10921894

DOI: 10.1093/emboj/19.15.4144

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3524692

Title: Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin.

PubMed ID: 3524692

DOI: 10.1016/0304-4165(86)90144-3

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 9488668

Title: Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a.

PubMed ID: 9488668

DOI: 10.1074/jbc.273.10.5461

PubMed ID: 11585840

Title: Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1.

PubMed ID: 11585840

DOI: 10.1074/jbc.m108636200

PubMed ID: 15147878

Title: Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.

PubMed ID: 15147878

DOI: 10.1016/j.febslet.2004.04.031

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15280365

Title: The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up.

PubMed ID: 15280365

DOI: 10.1074/jbc.m406284200

PubMed ID: 15340068

Title: Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.

PubMed ID: 15340068

DOI: 10.1128/mcb.24.18.8055-8068.2004

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22645313

Title: Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

PubMed ID: 22645313

DOI: 10.1128/mcb.00201-12

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29290612

Title: Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.

PubMed ID: 29290612

DOI: 10.1016/j.molcel.2017.11.035

PubMed ID: 12970176

Title: Structural determinants for the binding of ubiquitin-like domains to the proteasome.

PubMed ID: 12970176

DOI: 10.1093/emboj/cdg467

PubMed ID: 14585839

Title: Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B.

PubMed ID: 14585839

DOI: 10.1074/jbc.m309448200

PubMed ID: 15826667

Title: Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.

PubMed ID: 15826667

DOI: 10.1016/j.jmb.2005.03.007

PubMed ID: 19683493

Title: Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13.

PubMed ID: 19683493

DOI: 10.1016/j.molcel.2009.06.010

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

  • Length: 377
  • Mass: 40737
  • Checksum: EC712EC4DB1CE9AB
  • Sequence:
    • MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV 
LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN 
EKDLVKLAKR LKKEKVNVDI INFGEEEVNT EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA 
DALISSPILA GEGGAMLGLG ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA 
ASAAEAGIAT TGTEDSDDAL LKMTISQQEF GRTGLPDLSS MTEEEQIAYA MQMSLQGAEF 
GQAESADIDA SSAMDTSEPA KEEDDYDVMQ DPEFLQSVLE NLPGVDPNNE AIRNAMGSLA 
SQATKDGKKD KKEEDKK

Genular Protein ID: 2527560315

Symbol: Q5VWC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VWC4

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 380
  • Mass: 41079
  • Checksum: 349CEDC533705229
  • Sequence:
    • MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV 
LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN 
EKDLVKLAKR LKKEKVNVDI INFGEEEVNT EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA 
DALISSPILA GEGGAMLGLG ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA 
ASAAEAGIAT TGTEGERDSD DALLKMTISQ QEFGRTGLPD LSSMTEEEQI AYAMQMSLQG 
AEFGQAESAD IDASSAMDTS EPAKEEDDYD VMQDPEFLQS VLENLPGVDP NNEAIRNAMG 
SLASQATKDG KKDKKEEDKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.