Details for: PTGDR

Gene ID: 5729

Symbol: PTGDR

Ensembl ID: ENSG00000168229

Description: prostaglandin D2 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.7026
    Cell Significance Index: -6.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.9707
    Cell Significance Index: -6.0800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 13.9200
    Cell Significance Index: 37.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8907
    Cell Significance Index: -6.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.7403
    Cell Significance Index: 118.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.9539
    Cell Significance Index: 752.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2221
    Cell Significance Index: 197.5500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.0518
    Cell Significance Index: 32.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.7622
    Cell Significance Index: 37.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6425
    Cell Significance Index: -4.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8323
    Cell Significance Index: 49.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6745
    Cell Significance Index: 14.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6586
    Cell Significance Index: 107.1100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.6172
    Cell Significance Index: 1.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5895
    Cell Significance Index: 532.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5635
    Cell Significance Index: 25.5400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5517
    Cell Significance Index: 5.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3440
    Cell Significance Index: 23.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3010
    Cell Significance Index: 9.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2396
    Cell Significance Index: 23.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2085
    Cell Significance Index: 4.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1995
    Cell Significance Index: 10.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1085
    Cell Significance Index: 1.5600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: 0.1016
    Cell Significance Index: 1.3000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0762
    Cell Significance Index: 0.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0258
    Cell Significance Index: 9.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0115
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0099
    Cell Significance Index: 18.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0022
    Cell Significance Index: 1.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0019
    Cell Significance Index: 0.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0004
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0065
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0072
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0114
    Cell Significance Index: -6.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0118
    Cell Significance Index: -6.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0212
    Cell Significance Index: -0.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0246
    Cell Significance Index: -1.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0260
    Cell Significance Index: -5.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0272
    Cell Significance Index: -0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0280
    Cell Significance Index: -4.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0346
    Cell Significance Index: -6.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0350
    Cell Significance Index: -1.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0380
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0381
    Cell Significance Index: -6.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0412
    Cell Significance Index: -5.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0501
    Cell Significance Index: -6.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0528
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0546
    Cell Significance Index: -6.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0560
    Cell Significance Index: -7.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0578
    Cell Significance Index: -6.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0580
    Cell Significance Index: -6.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0597
    Cell Significance Index: -6.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0728
    Cell Significance Index: -5.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0756
    Cell Significance Index: -1.2000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0771
    Cell Significance Index: -0.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0781
    Cell Significance Index: -3.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0800
    Cell Significance Index: -0.8300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0809
    Cell Significance Index: -0.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0824
    Cell Significance Index: -6.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0912
    Cell Significance Index: -5.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0953
    Cell Significance Index: -6.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0961
    Cell Significance Index: -7.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1002
    Cell Significance Index: -2.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1049
    Cell Significance Index: -6.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1186
    Cell Significance Index: -5.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1212
    Cell Significance Index: -6.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1233
    Cell Significance Index: -6.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1397
    Cell Significance Index: -1.9000
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.1413
    Cell Significance Index: -1.0900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1448
    Cell Significance Index: -1.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1547
    Cell Significance Index: -5.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1548
    Cell Significance Index: -2.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1577
    Cell Significance Index: -2.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1765
    Cell Significance Index: -4.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1785
    Cell Significance Index: -3.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1793
    Cell Significance Index: -5.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1846
    Cell Significance Index: -5.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1911
    Cell Significance Index: -6.6400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1933
    Cell Significance Index: -2.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1964
    Cell Significance Index: -5.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1967
    Cell Significance Index: -7.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1990
    Cell Significance Index: -5.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2043
    Cell Significance Index: -2.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2077
    Cell Significance Index: -6.5700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2102
    Cell Significance Index: -3.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2135
    Cell Significance Index: -5.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2145
    Cell Significance Index: -6.1500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.2147
    Cell Significance Index: -2.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2200
    Cell Significance Index: -6.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2205
    Cell Significance Index: -3.2300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2230
    Cell Significance Index: -2.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** PTGDR belongs to the class A/1 rhodopsin-like receptor family, characterized by a seven-transmembrane domain structure. 2. **Agonist:** Prostaglandin D2 (PGD2) is the primary agonist that activates PTGDR, leading to downstream signaling events. 3. **Expression:** PTGDR is widely expressed in various cell types, including immune cells (e.g., T cells, NK cells), epithelial cells, and progenitor cells. 4. **Signaling:** PTGDR activates G-protein coupled signaling pathways, leading to changes in cell behavior, including proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Immune Response:** PTGDR modulates immune responses by regulating the function of immune cells, such as T cells and NK cells. It also influences the production of cytokines and chemokines, which are essential for immune cell recruitment and activation. 2. **Inflammation:** PTGDR is involved in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and the recruitment of immune cells to sites of inflammation. 3. **Cell Signaling:** PTGDR activates G-protein coupled signaling pathways, leading to changes in cell behavior, including proliferation, differentiation, and survival. 4. **Sleep Regulation:** PTGDR has been implicated in the regulation of sleep-wake cycles, with studies suggesting that PGD2 and PTGDR play a role in the modulation of sleep patterns. **Clinical Significance:** 1. **Autoimmune Diseases:** PTGDR has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it contributes to the regulation of immune responses and inflammation. 2. **Cancer:** PTGDR has been shown to play a role in cancer progression, including the regulation of tumor cell growth, invasion, and metastasis. 3. **Neurological Disorders:** PTGDR has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and schizophrenia, where it contributes to the regulation of immune responses and inflammation. 4. **Sleep Disorders:** PTGDR has been shown to play a role in the regulation of sleep-wake cycles, with studies suggesting that abnormalities in PTGDR expression or function may contribute to sleep disorders. **Conclusion:** In conclusion, PTGDR is a key player in immune response and beyond, with implications for various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms by which PTGDR regulates immune responses, inflammation, and cell signaling, as well as its clinical significance and potential applications.

Genular Protein ID: 1046861525

Symbol: PD2R_HUMAN

Name: Prostaglandin D2 receptor

UniProtKB Accession Codes:

Q13258 G3V5L3 Q13250 Q13251 Q1ZZ52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 8 Ensembl 2 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7642548

Title: Molecular cloning and characterization of the human prostanoid DP receptor.

PubMed ID: 7642548

DOI: 10.1074/jbc.270.32.18910

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6302737

Title: Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors.

PubMed ID: 6302737

DOI: 10.1016/0090-6980(83)90131-4

PubMed ID: 11082108

Title: Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand.

PubMed ID: 11082108

DOI: 10.1038/sj.bjp.0703686

PubMed ID: 15496624

Title: Role of prostanoid DP receptor variants in susceptibility to asthma.

PubMed ID: 15496624

DOI: 10.1056/nejmoa031785

Sequence Information:

  • Length: 359
  • Mass: 40271
  • Checksum: 098F89F08D0BE12A
  • Sequence:
    • MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS RRPLRPLPSV 
FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL DNSLCQAFAF FMSFFGLSST 
LQLLAMALEC WLSLGHPFFY RRHITLRLGA LVAPVVSAFS LAFCALPFMG FGKFVQYCPG 
TWCFIQMVHE EGSLSVLGYS VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT 
RDCAEPRADG REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS 
EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS NSTNMESSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.