Details for: RAB1A

Gene ID: 5861

Symbol: RAB1A

Ensembl ID: ENSG00000138069

Description: RAB1A, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 590.8249
    Cell Significance Index: -91.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 352.6211
    Cell Significance Index: -89.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 239.3023
    Cell Significance Index: -98.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 212.2753
    Cell Significance Index: -100.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 211.5655
    Cell Significance Index: -85.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 188.2247
    Cell Significance Index: -96.8200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 149.8758
    Cell Significance Index: -100.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 90.0242
    Cell Significance Index: -85.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.9404
    Cell Significance Index: -97.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.7602
    Cell Significance Index: -87.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.7929
    Cell Significance Index: -56.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.0909
    Cell Significance Index: -99.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.7537
    Cell Significance Index: -76.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.4495
    Cell Significance Index: 307.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.8732
    Cell Significance Index: 103.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4159
    Cell Significance Index: 479.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8051
    Cell Significance Index: 1629.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7570
    Cell Significance Index: 130.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7391
    Cell Significance Index: 348.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.6949
    Cell Significance Index: 28.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6310
    Cell Significance Index: 46.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5181
    Cell Significance Index: 273.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5030
    Cell Significance Index: 184.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4790
    Cell Significance Index: 203.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4645
    Cell Significance Index: 799.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4348
    Cell Significance Index: 66.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4141
    Cell Significance Index: 182.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4016
    Cell Significance Index: 38.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2424
    Cell Significance Index: 58.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2414
    Cell Significance Index: 65.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0443
    Cell Significance Index: 374.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0377
    Cell Significance Index: 79.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9887
    Cell Significance Index: 160.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9597
    Cell Significance Index: 18.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7904
    Cell Significance Index: 349.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7870
    Cell Significance Index: 48.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7082
    Cell Significance Index: 1333.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7013
    Cell Significance Index: 20.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6904
    Cell Significance Index: 88.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5875
    Cell Significance Index: 406.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5275
    Cell Significance Index: 27.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4601
    Cell Significance Index: 9.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4570
    Cell Significance Index: 86.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4135
    Cell Significance Index: 70.6000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.3690
    Cell Significance Index: 2.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3513
    Cell Significance Index: 223.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3475
    Cell Significance Index: 19.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2783
    Cell Significance Index: 9.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2727
    Cell Significance Index: 419.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2615
    Cell Significance Index: 11.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2166
    Cell Significance Index: 399.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1641
    Cell Significance Index: 74.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0850
    Cell Significance Index: 115.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0617
    Cell Significance Index: 46.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0078
    Cell Significance Index: 0.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0199
    Cell Significance Index: -1.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0597
    Cell Significance Index: -37.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0605
    Cell Significance Index: -1.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0820
    Cell Significance Index: -9.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0912
    Cell Significance Index: -9.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1110
    Cell Significance Index: -11.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1196
    Cell Significance Index: -67.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1454
    Cell Significance Index: -8.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2190
    Cell Significance Index: -46.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2599
    Cell Significance Index: -6.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2748
    Cell Significance Index: -39.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3059
    Cell Significance Index: -88.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4587
    Cell Significance Index: -7.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4846
    Cell Significance Index: -50.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4929
    Cell Significance Index: -56.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5555
    Cell Significance Index: -64.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5561
    Cell Significance Index: -63.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5578
    Cell Significance Index: -7.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5607
    Cell Significance Index: -37.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5956
    Cell Significance Index: -38.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6588
    Cell Significance Index: -14.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6667
    Cell Significance Index: -42.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7607
    Cell Significance Index: -7.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7659
    Cell Significance Index: -24.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7738
    Cell Significance Index: -4.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8562
    Cell Significance Index: -15.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8893
    Cell Significance Index: -23.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8975
    Cell Significance Index: -71.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9276
    Cell Significance Index: -41.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9861
    Cell Significance Index: -11.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9956
    Cell Significance Index: -14.7000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9957
    Cell Significance Index: -14.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2108
    Cell Significance Index: -45.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2396
    Cell Significance Index: -64.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2796
    Cell Significance Index: -23.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.2980
    Cell Significance Index: -31.1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.3076
    Cell Significance Index: -10.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3409
    Cell Significance Index: -33.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.4054
    Cell Significance Index: -32.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.4205
    Cell Significance Index: -34.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4272
    Cell Significance Index: -87.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.4292
    Cell Significance Index: -50.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB1A exhibits the following key characteristics: 1. **GTP-binding protein**: RAB1A is a small GTPase that binds GTP, which is hydrolyzed to GDP, regulating its activity. 2. **Ras superfamily member**: RAB1A is a member of the RAS oncogene family, which includes other small GTPases like RAB3A and RAB11A. 3. **Regulatory role in vesicle trafficking**: RAB1A regulates the activity of downstream effectors, influencing the dynamics of vesicle trafficking, endocytosis, and exocytosis. 4. **Cell cycle regulation**: RAB1A is involved in the regulation of the cell cycle, particularly in the G1/S and G2/M phases. 5. **Expression in various cell types**: RAB1A is expressed in a wide range of cell types, including epithelial, endothelial, and fibroblastic cells. **Pathways and Functions** RAB1A is involved in various cellular pathways and functions, including: 1. **Autophagosome assembly**: RAB1A regulates the formation of autophagosomes, which are involved in the degradation of cellular components. 2. **Autophagy**: RAB1A influences the autophagic process, which is essential for maintaining cellular homeostasis. 3. **Endocytosis**: RAB1A regulates the internalization of molecules and the formation of endosomes. 4. **Exocytosis**: RAB1A influences the secretion of molecules from cells. 5. **Cell migration**: RAB1A regulates the dynamics of cell migration, which is essential for tissue development and repair. 6. **Cilium assembly**: RAB1A is involved in the formation and maintenance of cilia, which are essential for sensory perception and signaling. 7. **Golgi apparatus organization**: RAB1A regulates the organization and function of the Golgi apparatus, which is essential for protein modification and secretion. **Clinical Significance** RAB1A dysregulation has been implicated in various diseases, including: 1. **Cancer**: RAB1A overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disorders**: RAB1A dysregulation has been implicated in cardiovascular disorders, including atherosclerosis and cardiac hypertrophy. 3. **Neurodegenerative diseases**: RAB1A has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Endothelial dysfunction**: RAB1A dysregulation has been observed in endothelial dysfunction, which is a hallmark of cardiovascular disease. In conclusion, RAB1A is a multifunctional protein that plays a crucial role in various cellular processes, including cell cycle regulation, cell migration, and protein transport. Its dysregulation has been implicated in various diseases, highlighting the importance of RAB1A as a potential therapeutic target.

Genular Protein ID: 2770779080

Symbol: RAB1A_HUMAN

Name: Ras-related protein Rab-1A

UniProtKB Accession Codes:

P62820 P11476 Q6FIE7 Q96N61 Q9Y3T2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 2 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2501306

Title: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

PubMed ID: 2501306

DOI: 10.1016/s0021-9258(18)63872-4

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1902553

Title: Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.

PubMed ID: 1902553

DOI: 10.1038/350715a0

PubMed ID: 7991565

Title: Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

PubMed ID: 7991565

DOI: 10.1073/pnas.91.25.11963

PubMed ID: 19603039

Title: Rab GTPases as coordinators of vesicle traffic.

PubMed ID: 19603039

DOI: 10.1038/nrm2728

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20861236

Title: Rab1 small GTP-binding protein regulates cell surface trafficking of the human calcium-sensing receptor.

PubMed ID: 20861236

DOI: 10.1210/en.2010-0422

PubMed ID: 20639577

Title: Regulation of integrin beta 1 recycling to lipid rafts by Rab1a to promote cell migration.

PubMed ID: 20639577

DOI: 10.1074/jbc.m110.141440

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21303926

Title: Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles.

PubMed ID: 21303926

DOI: 10.1242/jcs.079020

PubMed ID: 21822290

Title: Modulation of Rab GTPase function by a protein phosphocholine transferase.

PubMed ID: 21822290

DOI: 10.1038/nature10335

PubMed ID: 22158903

Title: Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination.

PubMed ID: 22158903

DOI: 10.1073/pnas.1114023109

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23815289

Title: Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy.

PubMed ID: 23815289

DOI: 10.3109/09687688.2013.818725

PubMed ID: 26209634

Title: Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.

PubMed ID: 26209634

DOI: 10.1074/jbc.m115.669242

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27334615

Title: The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.

PubMed ID: 27334615

DOI: 10.15252/embj.201694401

PubMed ID: 32504010

Title: Arginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium.

PubMed ID: 32504010

DOI: 10.1038/s42003-020-1005-2

PubMed ID: 32974215

Title: The Salmonella effector SseK3 targets small Rab GTPases.

PubMed ID: 32974215

DOI: 10.3389/fcimb.2020.00419

PubMed ID: 35343654

Title: RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13.

PubMed ID: 35343654

DOI: 10.1002/advs.202105391

PubMed ID: 19942850

Title: Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA.

PubMed ID: 19942850

DOI: 10.1038/emboj.2009.347

PubMed ID: 20176951

Title: Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.

PubMed ID: 20176951

DOI: 10.1073/pnas.0914231107

PubMed ID: 22939626

Title: Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.

PubMed ID: 22939626

DOI: 10.1016/j.cell.2012.06.050

PubMed ID: 22416225

Title: Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state.

PubMed ID: 22416225

DOI: 10.1371/journal.ppat.1002528

PubMed ID: 23588383

Title: Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP.

PubMed ID: 23588383

DOI: 10.1038/cr.2013.54

PubMed ID: 23821544

Title: The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.

PubMed ID: 23821544

DOI: 10.1074/jbc.m113.470625

Sequence Information:

  • Length: 205
  • Mass: 22678
  • Checksum: B2A8F4E3B0FB17D6
  • Sequence:
    • MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI RTIELDGKTI 
KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN NVKQWLQEID RYASENVNKL 
LVGNKCDLTT KKVVDYTTAK EFADSLGIPF LETSAKNATN VEQSFMTMAA EIKKRMGPGA 
TAGGAEKSNV KIQSTPVKQS GGGCC

Genular Protein ID: 2565596013

Symbol: B7Z8M7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8M7

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 173
  • Mass: 18990
  • Checksum: BE42EEBBD90985D2
  • Sequence:
    • MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI RTIELDGKTI 
KLQIESFNNV KQWLQEIDRY ASENVNKLLV GNKCDLTTKK VVDYTTAKEF ADSLGIPFLE 
TSAKNATNVE QSFMTMAAEI KKRMGPGATA GGAEKSNVKI QSTPVKQSGG GCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.