Details for: RABGGTB

Gene ID: 5876

Symbol: RABGGTB

Ensembl ID: ENSG00000137955

Description: Rab geranylgeranyltransferase subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.9857
    Cell Significance Index: -33.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 130.4193
    Cell Significance Index: -33.0800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.0843
    Cell Significance Index: -37.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.6223
    Cell Significance Index: -39.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.0262
    Cell Significance Index: -33.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.3800
    Cell Significance Index: -38.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.4965
    Cell Significance Index: -33.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.9849
    Cell Significance Index: -36.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2851
    Cell Significance Index: -32.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6932
    Cell Significance Index: -38.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7846
    Cell Significance Index: -23.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0437
    Cell Significance Index: -8.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.3648
    Cell Significance Index: 232.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8646
    Cell Significance Index: 53.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4743
    Cell Significance Index: 239.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2657
    Cell Significance Index: 13.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2366
    Cell Significance Index: 58.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0826
    Cell Significance Index: 14.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9903
    Cell Significance Index: 26.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8483
    Cell Significance Index: 463.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8418
    Cell Significance Index: 17.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7769
    Cell Significance Index: 40.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7598
    Cell Significance Index: 104.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7009
    Cell Significance Index: 82.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6925
    Cell Significance Index: 48.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6773
    Cell Significance Index: 31.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6390
    Cell Significance Index: 282.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6111
    Cell Significance Index: 16.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5916
    Cell Significance Index: 106.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5548
    Cell Significance Index: 68.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5386
    Cell Significance Index: 34.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5087
    Cell Significance Index: 100.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4666
    Cell Significance Index: 12.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4627
    Cell Significance Index: 13.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4508
    Cell Significance Index: 57.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4221
    Cell Significance Index: 84.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4158
    Cell Significance Index: 11.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3868
    Cell Significance Index: 38.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2984
    Cell Significance Index: 15.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2839
    Cell Significance Index: 36.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2777
    Cell Significance Index: 20.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2740
    Cell Significance Index: 46.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2014
    Cell Significance Index: 9.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1898
    Cell Significance Index: 171.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1811
    Cell Significance Index: 64.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1722
    Cell Significance Index: 32.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1462
    Cell Significance Index: 5.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1334
    Cell Significance Index: 10.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1204
    Cell Significance Index: 7.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1086
    Cell Significance Index: 3.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0771
    Cell Significance Index: 2.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0698
    Cell Significance Index: 48.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0131
    Cell Significance Index: 9.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0063
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0104
    Cell Significance Index: -19.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0128
    Cell Significance Index: -19.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0187
    Cell Significance Index: -11.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0226
    Cell Significance Index: -30.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0257
    Cell Significance Index: -16.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0309
    Cell Significance Index: -3.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0431
    Cell Significance Index: -24.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0433
    Cell Significance Index: -19.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0487
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0675
    Cell Significance Index: -14.2200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0714
    Cell Significance Index: -0.5700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0780
    Cell Significance Index: -0.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1022
    Cell Significance Index: -29.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1068
    Cell Significance Index: -12.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1071
    Cell Significance Index: -3.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1244
    Cell Significance Index: -4.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1470
    Cell Significance Index: -1.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1490
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1595
    Cell Significance Index: -18.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1596
    Cell Significance Index: -18.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1668
    Cell Significance Index: -24.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1869
    Cell Significance Index: -10.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2317
    Cell Significance Index: -14.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2454
    Cell Significance Index: -5.6700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2717
    Cell Significance Index: -3.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2828
    Cell Significance Index: -7.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3249
    Cell Significance Index: -6.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3278
    Cell Significance Index: -8.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3334
    Cell Significance Index: -17.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3372
    Cell Significance Index: -4.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3532
    Cell Significance Index: -36.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3567
    Cell Significance Index: -28.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3607
    Cell Significance Index: -24.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3967
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4394
    Cell Significance Index: -2.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5174
    Cell Significance Index: -26.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5391
    Cell Significance Index: -33.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5657
    Cell Significance Index: -10.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5763
    Cell Significance Index: -25.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6000
    Cell Significance Index: -14.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6315
    Cell Significance Index: -18.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6379
    Cell Significance Index: -9.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6573
    Cell Significance Index: -26.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RABGGTB is a subunit of the geranylgeranyltransferase complex, which is responsible for catalyzing the geranylgeranylation of RAB proteins. The gene is composed of 11 exons and spans approximately 12 kb of genomic DNA. RABGGTB is highly conserved across species, suggesting its essential role in maintaining cellular functions. The protein is a small, soluble protein that is localized to the cytosol and is involved in protein-protein interactions. **Pathways and Functions:** RABGGTB is involved in various cellular pathways, including: 1. **Protein Geranylgeranylation:** RABGGTB is essential for the geranylgeranylation of RAB proteins, which is a critical step in activating these small GTPases. 2. **Cell Signaling:** Geranylgeranylation of RAB proteins is involved in various cell signaling pathways, including those regulating cell growth, differentiation, and survival. 3. **Membrane Trafficking:** RAB proteins are involved in membrane trafficking, including vesicle formation, transport, and fusion. 4. **Cell Growth and Survival:** Geranylgeranylation of RAB proteins is involved in regulating cell growth and survival, including apoptosis and cell cycle progression. **Clinical Significance:** Dysregulation of RABGGTB has been implicated in various diseases, including: 1. **Cancer:** Overexpression of RABGGTB has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 2. **Neurodegenerative Diseases:** Geranylgeranylation of RAB proteins has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Infectious Diseases:** RABGGTB has been shown to play a role in the regulation of immune responses, including the activation of macrophages and neutrophils. In conclusion, RABGGTB is a critical gene involved in protein geranylgeranylation and cellular regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis. Further research is necessary to elucidate the mechanisms by which RABGGTB regulates cellular processes and to explore its therapeutic potential in disease prevention and treatment. **References:** * [Insert references to relevant studies on RABGGTB] Note: The references should be based on the actual research studies related to the gene RABGGTB.

Genular Protein ID: 2441225323

Symbol: PGTB2_HUMAN

Name: Geranylgeranyl transferase type-2 subunit beta

UniProtKB Accession Codes:

P53611 Q92697

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8706741

Title: Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II.

PubMed ID: 8706741

DOI: 10.1111/j.1432-1033.1996.0362u.x

PubMed ID: 8954794

Title: cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter.

PubMed ID: 8954794

DOI: 10.1006/geno.1996.0608

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11447212

Title: Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II.

PubMed ID: 11447212

DOI: 10.1074/jbc.m010400200

PubMed ID: 7991565

Title: Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

PubMed ID: 7991565

DOI: 10.1073/pnas.91.25.11963

PubMed ID: 18532927

Title: Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.

PubMed ID: 18532927

DOI: 10.1042/bj20080662

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

Sequence Information:

  • Length: 331
  • Mass: 36924
  • Checksum: 37A8A6329146C49B
  • Sequence:
    • MGTPQKDVII KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGI YWGLTVMDLM 
GQLHRMNREE ILAFIKSCQH ECGGISASIG HDPHLLYTLS AVQILTLYDS INVIDVNKVV 
EYVKGLQKED GSFAGDIWGE IDTRFSFCAV ATLALLGKLD AINVEKAIEF VLSCMNFDGG 
FGCRPGSESH AGQIYCCTGF LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC 
YSWWVLASLK IIGRLHWIDR EKLRNFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL 
LGEEQIKPVN PVFCMPEEVL QRVNVQPELV S

Genular Protein ID: 1466052018

Symbol: A8KAJ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8KAJ2

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 3 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 157
  • Mass: 17433
  • Checksum: 9B3830B475AE6C56
  • Sequence:
    • MNFDGGFGCG PGSESHAGQI YCCTGFLAIT SQLHQVNSDL LGWWLCERQL PSGGLNGRPE 
KLPDVCYSWW VLASLKIIGR LHWIDREKLR NFILACQDEE TGGFADRPGD MVDPFHTLFG 
IAGLSLLGEE QIKPVNPVFC MPEEVLQRVN VQPELVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.