Details for: RAD23A

Gene ID: 5886

Symbol: RAD23A

Ensembl ID: ENSG00000179262

Description: RAD23 homolog A, nucleotide excision repair protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 202.5679
    Cell Significance Index: -51.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 178.5664
    Cell Significance Index: -73.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 148.7008
    Cell Significance Index: -70.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 147.4190
    Cell Significance Index: -59.8900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.3661
    Cell Significance Index: -20.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.1213
    Cell Significance Index: -68.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 104.9816
    Cell Significance Index: -70.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.6925
    Cell Significance Index: -60.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.7272
    Cell Significance Index: -44.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.4202
    Cell Significance Index: -49.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.1133
    Cell Significance Index: -67.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9180
    Cell Significance Index: -45.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8739
    Cell Significance Index: -21.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 6.4644
    Cell Significance Index: 54.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.2037
    Cell Significance Index: 103.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9427
    Cell Significance Index: 52.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7243
    Cell Significance Index: 90.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6008
    Cell Significance Index: 219.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5620
    Cell Significance Index: 100.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4966
    Cell Significance Index: 16.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4663
    Cell Significance Index: 172.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4505
    Cell Significance Index: 42.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4445
    Cell Significance Index: 788.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4288
    Cell Significance Index: 257.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4194
    Cell Significance Index: 66.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3927
    Cell Significance Index: 171.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3713
    Cell Significance Index: 177.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3415
    Cell Significance Index: 28.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2398
    Cell Significance Index: 35.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2207
    Cell Significance Index: 156.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1758
    Cell Significance Index: 28.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1353
    Cell Significance Index: 84.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1204
    Cell Significance Index: 29.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0129
    Cell Significance Index: 71.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0117
    Cell Significance Index: 27.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0113
    Cell Significance Index: 447.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9817
    Cell Significance Index: 886.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9190
    Cell Significance Index: 10.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8814
    Cell Significance Index: 143.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8749
    Cell Significance Index: 45.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8502
    Cell Significance Index: 29.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7675
    Cell Significance Index: 34.7900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.7614
    Cell Significance Index: 12.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7105
    Cell Significance Index: 142.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7084
    Cell Significance Index: 36.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6496
    Cell Significance Index: 18.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6217
    Cell Significance Index: 13.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5374
    Cell Significance Index: 91.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4887
    Cell Significance Index: 4.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4265
    Cell Significance Index: 11.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3711
    Cell Significance Index: 9.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3051
    Cell Significance Index: 60.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3008
    Cell Significance Index: 18.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2990
    Cell Significance Index: 107.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2414
    Cell Significance Index: 4.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2076
    Cell Significance Index: 20.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2006
    Cell Significance Index: 4.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1552
    Cell Significance Index: 107.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1407
    Cell Significance Index: 26.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0694
    Cell Significance Index: 52.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0463
    Cell Significance Index: 0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0339
    Cell Significance Index: 1.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0171
    Cell Significance Index: 32.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0087
    Cell Significance Index: 0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0058
    Cell Significance Index: 4.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0148
    Cell Significance Index: -27.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0154
    Cell Significance Index: -1.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0197
    Cell Significance Index: -30.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0215
    Cell Significance Index: -15.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0266
    Cell Significance Index: -36.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0402
    Cell Significance Index: -25.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0595
    Cell Significance Index: -37.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0834
    Cell Significance Index: -47.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1041
    Cell Significance Index: -47.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1336
    Cell Significance Index: -28.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1504
    Cell Significance Index: -2.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1703
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1911
    Cell Significance Index: -21.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1974
    Cell Significance Index: -23.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2047
    Cell Significance Index: -58.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2057
    Cell Significance Index: -15.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2114
    Cell Significance Index: -2.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2390
    Cell Significance Index: -5.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2916
    Cell Significance Index: -9.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3164
    Cell Significance Index: -46.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3828
    Cell Significance Index: -26.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3903
    Cell Significance Index: -9.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4205
    Cell Significance Index: -5.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5245
    Cell Significance Index: -32.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5309
    Cell Significance Index: -60.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5506
    Cell Significance Index: -8.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5897
    Cell Significance Index: -15.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5942
    Cell Significance Index: -33.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6168
    Cell Significance Index: -64.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6342
    Cell Significance Index: -50.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6618
    Cell Significance Index: -9.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7494
    Cell Significance Index: -50.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8539
    Cell Significance Index: -52.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0100
    Cell Significance Index: -29.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0920
    Cell Significance Index: -28.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAD23A is a member of the RAD23 family of proteins, which are characterized by their ability to interact with ubiquitin-proteasome system (UPS) and ubiquitin-specific proteases (USPs). This interaction enables RAD23A to regulate the activity of USPs, which are involved in the degradation of damaged or misfolded proteins. RAD23A's ability to bind to ubiquitin and USPs also suggests its involvement in protein degradation pathways, including proteasomal ubiquitin-dependent protein catabolic process. **Pathways and Functions:** RAD23A is involved in several cellular pathways, including: 1. **Nucleotide Excision Repair (NER) pathway**: RAD23A plays a crucial role in the NER pathway, which is responsible for repairing DNA damage caused by environmental mutagens, such as UV radiation. This pathway involves the recognition of DNA damage, incision of damaged DNA, and subsequent repair of the damaged region. 2. **Deubiquitination**: RAD23A interacts with USPs, which are involved in the removal of ubiquitin from proteins, thereby regulating protein degradation. 3. **Protein degradation**: RAD23A's interaction with ubiquitin and USPs suggests its involvement in protein degradation pathways, including proteasomal ubiquitin-dependent protein catabolic process. 4. **Cell cycle regulation**: RAD23A's ability to regulate the activity of USPs suggests its involvement in cell cycle regulation, particularly in the positive regulation of the cell cycle. 5. **Viral genome replication**: RAD23A's interaction with USPs and its ability to regulate protein degradation suggest its involvement in viral genome replication. **Clinical Significance:** RAD23A's involvement in the NER pathway and protein degradation pathways highlights its significance in maintaining genome stability and preventing cancer. Abnormalities in RAD23A expression or function have been associated with various diseases, including: 1. **Cancer**: RAD23A's involvement in the NER pathway suggests its potential role in cancer prevention. Mutations or deletions in RAD23A have been associated with an increased risk of cancer. 2. **Neurodegenerative diseases**: RAD23A's interaction with USPs and its ability to regulate protein degradation suggest its potential role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: RAD23A's interaction with USPs and its ability to regulate protein degradation suggest its potential role in infectious diseases, such as viral infections. In conclusion, RAD23A is a crucial component of the NER pathway and protein degradation pathways, and its dysregulation has been associated with various diseases. Further research is needed to fully understand the role of RAD23A in human health and disease, and to explore its potential as a therapeutic target for cancer and other diseases.

Genular Protein ID: 2208021817

Symbol: RD23A_HUMAN

Name: UV excision repair protein RAD23 homolog A

UniProtKB Accession Codes:

P54725 K7ESE3 Q59EU8 Q5M7Z1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8168482

Title: Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

PubMed ID: 8168482

DOI: 10.1002/j.1460-2075.1994.tb06452.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9371639

Title: Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.

PubMed ID: 9371639

DOI: 10.1128/jvi.71.12.9732-9742.1997

PubMed ID: 9372924

Title: Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.

PubMed ID: 9372924

DOI: 10.1128/mcb.17.12.6924

PubMed ID: 10488153

Title: Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.

PubMed ID: 10488153

DOI: 10.1074/jbc.274.39.28019

PubMed ID: 10915768

Title: Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.

PubMed ID: 10915768

DOI: 10.1093/hmg/9.12.1795

PubMed ID: 14621999

Title: Ubiquitin recognition by the DNA repair protein hHR23a.

PubMed ID: 14621999

DOI: 10.1021/bi035391j

PubMed ID: 12643283

Title: Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains.

PubMed ID: 12643283

DOI: 10.1074/jbc.m212841200

PubMed ID: 15321727

Title: Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A.

PubMed ID: 15321727

DOI: 10.1016/j.jmb.2004.06.057

PubMed ID: 16712842

Title: Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.

PubMed ID: 16712842

DOI: 10.1016/j.febslet.2006.05.012

PubMed ID: 17098253

Title: Ubiquitin receptor proteins hHR23a and hPLIC2 interact.

PubMed ID: 17098253

DOI: 10.1016/j.jmb.2006.10.056

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18234089

Title: Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.

PubMed ID: 18234089

DOI: 10.1186/1471-2091-9-4

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20614012

Title: HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.

PubMed ID: 20614012

DOI: 10.1371/journal.pone.0011371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30455355

Title: Physiological and pathophysiological characteristics of ataxin-3 isoforms.

PubMed ID: 30455355

DOI: 10.1074/jbc.ra118.005801

PubMed ID: 9846873

Title: Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr.

PubMed ID: 9846873

DOI: 10.1038/4220

PubMed ID: 11087358

Title: Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr.

PubMed ID: 11087358

DOI: 10.1021/bi0017071

PubMed ID: 12079361

Title: Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions.

PubMed ID: 12079361

DOI: 10.1016/s0022-2836(02)00302-9

PubMed ID: 12970176

Title: Structural determinants for the binding of ubiquitin-like domains to the proteasome.

PubMed ID: 12970176

DOI: 10.1093/emboj/cdg467

PubMed ID: 14557549

Title: DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.

PubMed ID: 14557549

DOI: 10.1073/pnas.1634989100

PubMed ID: 15322280

Title: Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction.

PubMed ID: 15322280

DOI: 10.1110/ps.04824304

PubMed ID: 15949443

Title: Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.

PubMed ID: 15949443

DOI: 10.1016/j.molcel.2005.05.013

Sequence Information:

  • Length: 363
  • Mass: 39609
  • Checksum: C4E47E9313BB47B5
  • Sequence:
    • MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP 
IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE 
DKSPSEESAP TTSPESVSGS VPSSGSSGRE EDAASTLVTG SEYETMLTEI MSMGYERERV 
VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ 
FQNMRQVIQQ NPALLPALLQ QLGQENPQLL QQISRHQEQF IQMLNEPPGE LADISDVEGE 
VGAIGEEAPQ MNYIQVTPQE KEAIERLKAL GFPESLVIQA YFACEKNENL AANFLLSQNF 
DDE

Genular Protein ID: 1008661226

Symbol: A8K1J3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K1J3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 2 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 362
  • Mass: 39466
  • Checksum: 66898B6AFD8F6682
  • Sequence:
    • MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP 
IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE 
DKSPSEESAP TTSPESVSGS VPSSGSSGRG EDAASTLVTG SEYETMLTEI MSMGYERERV 
VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPATEAGENP LEFLRDQPQF 
QNMRQVIQQN PALLPALLQQ LGQENPQLLQ QISRHQEQFI QMLNEPPGEL ADISDVEGEV 
GAIGEEAPQM NYIQVTPQEK EAIERLKALG FPESLVIQAY FACEKNENLA ANFLLSQNFD 
DE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.