Details for: RAD51C

Gene ID: 5889

Symbol: RAD51C

Ensembl ID: ENSG00000108384

Description: RAD51 paralog C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.7845
    Cell Significance Index: -13.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.2812
    Cell Significance Index: -18.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.9992
    Cell Significance Index: -19.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.2547
    Cell Significance Index: -22.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.3670
    Cell Significance Index: -22.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.5189
    Cell Significance Index: -21.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6036
    Cell Significance Index: -17.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4497
    Cell Significance Index: -19.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8235
    Cell Significance Index: -22.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.0517
    Cell Significance Index: 43.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9821
    Cell Significance Index: 58.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9640
    Cell Significance Index: 193.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8315
    Cell Significance Index: 98.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8175
    Cell Significance Index: 132.9500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7801
    Cell Significance Index: 5.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6963
    Cell Significance Index: 9.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6486
    Cell Significance Index: 40.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6420
    Cell Significance Index: 74.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6205
    Cell Significance Index: 32.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5833
    Cell Significance Index: 4.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5625
    Cell Significance Index: 111.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5530
    Cell Significance Index: 14.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5413
    Cell Significance Index: 18.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4051
    Cell Significance Index: 10.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3801
    Cell Significance Index: 136.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3782
    Cell Significance Index: 26.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3611
    Cell Significance Index: 197.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3282
    Cell Significance Index: 17.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2973
    Cell Significance Index: 40.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2838
    Cell Significance Index: 51.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2707
    Cell Significance Index: 12.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2615
    Cell Significance Index: 32.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2392
    Cell Significance Index: 105.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2204
    Cell Significance Index: 28.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1852
    Cell Significance Index: 10.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1628
    Cell Significance Index: 4.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1191
    Cell Significance Index: 1.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1059
    Cell Significance Index: 2.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1056
    Cell Significance Index: 8.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1029
    Cell Significance Index: 7.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0955
    Cell Significance Index: 4.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0941
    Cell Significance Index: 7.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0900
    Cell Significance Index: 4.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0814
    Cell Significance Index: 5.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0802
    Cell Significance Index: 4.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0746
    Cell Significance Index: 2.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0678
    Cell Significance Index: 6.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0554
    Cell Significance Index: 1.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0432
    Cell Significance Index: 5.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0410
    Cell Significance Index: 37.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0367
    Cell Significance Index: 69.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0327
    Cell Significance Index: 0.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0240
    Cell Significance Index: 4.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0054
    Cell Significance Index: 9.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0038
    Cell Significance Index: 5.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0036
    Cell Significance Index: 0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0012
    Cell Significance Index: 0.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0005
    Cell Significance Index: 0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0085
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0259
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0270
    Cell Significance Index: -20.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0301
    Cell Significance Index: -0.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0308
    Cell Significance Index: -4.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0365
    Cell Significance Index: -20.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0369
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0371
    Cell Significance Index: -6.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0430
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0446
    Cell Significance Index: -27.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0683
    Cell Significance Index: -19.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0985
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1202
    Cell Significance Index: -25.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1204
    Cell Significance Index: -13.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1354
    Cell Significance Index: -3.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1405
    Cell Significance Index: -2.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1612
    Cell Significance Index: -4.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1827
    Cell Significance Index: -4.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1857
    Cell Significance Index: -1.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1887
    Cell Significance Index: -9.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1922
    Cell Significance Index: -2.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1928
    Cell Significance Index: -15.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2001
    Cell Significance Index: -20.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2544
    Cell Significance Index: -15.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2618
    Cell Significance Index: -11.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2954
    Cell Significance Index: -6.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3180
    Cell Significance Index: -12.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3443
    Cell Significance Index: -6.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3522
    Cell Significance Index: -5.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3598
    Cell Significance Index: -8.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3754
    Cell Significance Index: -8.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3769
    Cell Significance Index: -4.6800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3960
    Cell Significance Index: -5.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4038
    Cell Significance Index: -4.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4254
    Cell Significance Index: -6.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4258
    Cell Significance Index: -13.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4319
    Cell Significance Index: -14.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4482
    Cell Significance Index: -11.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4536
    Cell Significance Index: -13.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Homologous recombination repair (HRR) pathway:** RAD51C is a key player in the HRR pathway, which is responsible for repairing DSBs in DNA. 2. **DNA binding:** RAD51C binds to DNA, specifically to the Holliday junction intermediate, which is a structure formed during homologous recombination. 3. **Complex formation:** RAD51C forms a complex with RAD51, RAD51D, and XRCC2, which is essential for the resolution of DSBs. 4. **Meiosis-specific expression:** RAD51C is highly expressed in cells undergoing meiosis, particularly in oogonial cells, male germ cells, and primordial germ cells. 5. **Tissue-specific expression:** RAD51C is also expressed in other tissues, including erythroid progenitor cells, placental villous trophoblasts, and large pre-B-II cells. **Pathways and Functions:** 1. **Homologous recombination repair (HRR) pathway:** RAD51C is involved in the HRR pathway, which is responsible for repairing DSBs in DNA. 2. **DNA double-strand break repair:** RAD51C plays a crucial role in the resolution of DSBs through homologous recombination. 3. **Meiotic recombination:** RAD51C is essential for meiotic recombination, which is the process by which genetic material is exchanged between homologous chromosomes during meiosis. 4. **Telomere maintenance:** RAD51C is also involved in telomere maintenance via recombination, which is the process by which telomeres are lengthened and maintained. **Clinical Significance:** 1. **Breast cancer:** Mutations or alterations in RAD51C expression have been linked to breast cancer, particularly in cases where BRCA1 and BRCA2 mutations are present. 2. **Ovarian cancer:** RAD51C has also been implicated in ovarian cancer, particularly in cases where BRCA1 and BRCA2 mutations are present. 3. **Other conditions:** RAD51C has also been linked to other conditions, including Fanconi anemia, Bloom syndrome, and ataxia-telangiectasia. 4. **Immunological disorders:** RAD51C has also been implicated in immunological disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, RAD51C is a critical gene involved in the homologous recombination repair pathway, which plays a pivotal role in maintaining genome stability. Mutations or alterations in RAD51C expression have been linked to various diseases, including breast cancer, ovarian cancer, and other conditions related to DNA repair defects. Further research is needed to fully understand the role of RAD51C in human disease and to develop effective therapeutic strategies for targeting this gene.

Genular Protein ID: 2610961791

Symbol: RA51C_HUMAN

Name: DNA repair protein RAD51 homolog 3

UniProtKB Accession Codes:

O43502 O43503 Q3B783

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 4 Ensembl 2 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9469824

Title: Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.

PubMed ID: 9469824

DOI: 10.1093/nar/26.5.1179

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11751635

Title: Identification and purification of two distinct complexes containing the five RAD51 paralogs.

PubMed ID: 11751635

DOI: 10.1101/gad.947001

PubMed ID: 11751636

Title: Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.

PubMed ID: 11751636

DOI: 10.1101/gad.935501

PubMed ID: 11744692

Title: RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.

PubMed ID: 11744692

DOI: 10.1074/jbc.m108306200

PubMed ID: 11842112

Title: Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.

PubMed ID: 11842112

DOI: 10.1093/nar/30.4.1001

PubMed ID: 11842113

Title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.

PubMed ID: 11842113

DOI: 10.1093/nar/30.4.1009

PubMed ID: 12427746

Title: Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.

PubMed ID: 12427746

DOI: 10.1074/jbc.m211038200

PubMed ID: 12966089

Title: Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion.

PubMed ID: 12966089

DOI: 10.1074/jbc.m308621200

PubMed ID: 14704354

Title: Domain mapping of the Rad51 paralog protein complexes.

PubMed ID: 14704354

DOI: 10.1093/nar/gkg925

PubMed ID: 14716019

Title: RAD51C is required for Holliday junction processing in mammalian cells.

PubMed ID: 14716019

DOI: 10.1126/science.1093037

PubMed ID: 16215984

Title: Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.

PubMed ID: 16215984

DOI: 10.1002/jcb.20640

PubMed ID: 16395335

Title: Interplay between human DNA repair proteins at a unique double-strand break in vivo.

PubMed ID: 16395335

DOI: 10.1038/sj.emboj.7600914

PubMed ID: 19783859

Title: Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.

PubMed ID: 19783859

DOI: 10.1074/jbc.m109.024646

PubMed ID: 19451272

Title: RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.

PubMed ID: 19451272

DOI: 10.1083/jcb.200811079

PubMed ID: 20413593

Title: Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.

PubMed ID: 20413593

DOI: 10.1074/jbc.m109.099846

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21965664

Title: hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.

PubMed ID: 21965664

DOI: 10.1074/jbc.m111.271080

PubMed ID: 23108668

Title: The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.

PubMed ID: 23108668

DOI: 10.1242/jcs.114595

PubMed ID: 24005041

Title: Helq acts in parallel to Fancc to suppress replication-associated genome instability.

PubMed ID: 24005041

DOI: 10.1093/nar/gkt676

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23149936

Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.

PubMed ID: 23149936

DOI: 10.1128/mcb.00465-12

PubMed ID: 35849344

Title: LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms.

PubMed ID: 35849344

DOI: 10.1093/nar/gkac611

PubMed ID: 24141787

Title: Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.

PubMed ID: 24141787

DOI: 10.1038/onc.2013.421

PubMed ID: 20207730

Title: Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.

PubMed ID: 20207730

DOI: 10.1074/jbc.m109.074286

PubMed ID: 20400963

Title: Mutation of the RAD51C gene in a Fanconi anemia-like disorder.

PubMed ID: 20400963

DOI: 10.1038/ng.570

PubMed ID: 20400964

Title: Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.

PubMed ID: 20400964

DOI: 10.1038/ng.569

PubMed ID: 21990120

Title: Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.

PubMed ID: 21990120

DOI: 10.1002/humu.21625

Sequence Information:

  • Length: 376
  • Mass: 42190
  • Checksum: 3AAADD3C1C0851E0
  • Sequence:
    • MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET 
LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT 
TEICGAPGVG KTQLCMQLAV DVQIPECFGG VAGEAVFIDT EGSFMVDRVV DLATACIQHL 
QLIAEKHKGE EHRKALEDFT LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI 
VDGIAFPFRH DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA 
LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV VTSACSLQTE 
GSLSTRKRSR DPEEEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.