Details for: RAF1

Gene ID: 5894

Symbol: RAF1

Ensembl ID: ENSG00000132155

Description: Raf-1 proto-oncogene, serine/threonine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 344.6586
    Cell Significance Index: -53.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 213.0156
    Cell Significance Index: -54.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 123.7390
    Cell Significance Index: -58.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.5948
    Cell Significance Index: -48.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.0781
    Cell Significance Index: -54.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 87.0612
    Cell Significance Index: -58.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.6419
    Cell Significance Index: -48.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.7089
    Cell Significance Index: -57.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.0888
    Cell Significance Index: -53.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9636
    Cell Significance Index: -45.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.7895
    Cell Significance Index: -58.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.6526
    Cell Significance Index: -29.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.4413
    Cell Significance Index: 187.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1177
    Cell Significance Index: 420.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0474
    Cell Significance Index: 114.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0417
    Cell Significance Index: 237.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.8230
    Cell Significance Index: 46.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7613
    Cell Significance Index: 353.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5722
    Cell Significance Index: 21.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2170
    Cell Significance Index: 436.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1901
    Cell Significance Index: 73.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1823
    Cell Significance Index: 33.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0110
    Cell Significance Index: 699.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9741
    Cell Significance Index: 24.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7181
    Cell Significance Index: 71.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5991
    Cell Significance Index: 12.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5890
    Cell Significance Index: 72.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5470
    Cell Significance Index: 15.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5453
    Cell Significance Index: 98.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4900
    Cell Significance Index: 67.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4851
    Cell Significance Index: 11.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4820
    Cell Significance Index: 11.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4780
    Cell Significance Index: 9.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4060
    Cell Significance Index: 28.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3815
    Cell Significance Index: 173.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3807
    Cell Significance Index: 17.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3343
    Cell Significance Index: 22.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3027
    Cell Significance Index: 165.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2987
    Cell Significance Index: 4.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2552
    Cell Significance Index: 112.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2412
    Cell Significance Index: 45.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2165
    Cell Significance Index: 27.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2144
    Cell Significance Index: 403.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2096
    Cell Significance Index: 24.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1528
    Cell Significance Index: 97.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1168
    Cell Significance Index: 179.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1045
    Cell Significance Index: 1.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0890
    Cell Significance Index: 164.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0609
    Cell Significance Index: 10.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0531
    Cell Significance Index: 72.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0410
    Cell Significance Index: 36.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0398
    Cell Significance Index: 2.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0317
    Cell Significance Index: 2.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0131
    Cell Significance Index: 0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0072
    Cell Significance Index: 0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0121
    Cell Significance Index: -0.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0296
    Cell Significance Index: -3.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0342
    Cell Significance Index: -1.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0418
    Cell Significance Index: -30.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0501
    Cell Significance Index: -37.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0540
    Cell Significance Index: -39.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0613
    Cell Significance Index: -2.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0657
    Cell Significance Index: -0.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0699
    Cell Significance Index: -3.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0718
    Cell Significance Index: -1.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0829
    Cell Significance Index: -3.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0829
    Cell Significance Index: -13.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0971
    Cell Significance Index: -54.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1023
    Cell Significance Index: -63.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1074
    Cell Significance Index: -8.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1075
    Cell Significance Index: -5.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1299
    Cell Significance Index: -13.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1385
    Cell Significance Index: -7.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1767
    Cell Significance Index: -50.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1863
    Cell Significance Index: -5.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1870
    Cell Significance Index: -27.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1879
    Cell Significance Index: -4.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1933
    Cell Significance Index: -3.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2628
    Cell Significance Index: -5.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2827
    Cell Significance Index: -29.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2884
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2923
    Cell Significance Index: -61.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3459
    Cell Significance Index: -39.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4011
    Cell Significance Index: -28.3700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.5711
    Cell Significance Index: -9.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6062
    Cell Significance Index: -8.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6152
    Cell Significance Index: -48.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6896
    Cell Significance Index: -12.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7257
    Cell Significance Index: -15.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7536
    Cell Significance Index: -46.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7672
    Cell Significance Index: -9.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8414
    Cell Significance Index: -22.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8670
    Cell Significance Index: -27.7700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8698
    Cell Significance Index: -12.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8790
    Cell Significance Index: -22.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9098
    Cell Significance Index: -15.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9104
    Cell Significance Index: -25.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0752
    Cell Significance Index: -15.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0850
    Cell Significance Index: -31.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proto-oncogene**: RAF1 is a proto-oncogene, which means it has the potential to become oncogenic if mutated or overexpressed. 2. **Serine/threonine kinase**: RAF1 is a serine/threonine kinase, which means it specifically phosphorylates serine and threonine residues on its substrates. 3. **MAPK/ERK signaling pathway**: RAF1 is a key component of the MAPK/ERK signaling pathway, which regulates various cellular processes, including cell growth, differentiation, and immune response. **Pathways and Functions:** 1. **MAPK/ERK signaling pathway**: RAF1 acts as a kinase that phosphorylates and activates downstream targets, including MEK1/2 and ERK1/2, leading to a cascade of downstream effects. 2. **Apoptotic process**: RAF1 regulates the apoptotic process by phosphorylating and activating pro-apoptotic proteins, such as BAD and BAX. 3. **Immune system**: RAF1 plays a critical role in the immune system, particularly in the regulation of T-cell activation and cytokine production. 4. **Cell growth and differentiation**: RAF1 regulates cell growth and differentiation by phosphorylating and activating downstream targets, including transcription factors and signaling molecules. 5. **Neurotrophin signaling pathway**: RAF1 regulates the neurotrophin signaling pathway, which is involved in the development and maintenance of the nervous system. **Clinical Significance:** 1. **Cancer**: Mutations in RAF1 are commonly found in various cancers, including melanoma, colorectal cancer, and thyroid cancer. 2. **Immune-related disorders**: RAF1 mutations are associated with immune-related disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Neurological disorders**: RAF1 mutations are implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease**: RAF1 mutations are associated with cardiovascular disease, particularly in the context of atherosclerosis and cardiac hypertrophy. In conclusion, RAF1 is a critical regulator of signaling pathways and immune response, with implications for various diseases, including cancer, immune-related disorders, neurological disorders, and cardiovascular disease. Further research is needed to fully understand the mechanisms by which RAF1 regulates cellular processes and to develop targeted therapies for RAF1-related diseases.

Genular Protein ID: 1212440347

Symbol: RAF1_HUMAN

Name: Proto-oncogene c-RAF

UniProtKB Accession Codes:

P04049 B0LPH8 B2R5N3 Q15278 Q9UC20

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 15 CPTC 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 16 EMDB 13 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 51 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 52 PDBsum 52 PIR 2 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 17 RefSeq 3 Rhea 8 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3003687

Title: The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.

PubMed ID: 3003687

DOI: 10.1093/nar/14.2.1009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2993863

Title: Structure and biological activity of human homologs of the raf/mil oncogene.

PubMed ID: 2993863

DOI: 10.1128/mcb.5.6.1400-1407.1985

PubMed ID: 21917714

Title: Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.

PubMed ID: 21917714

DOI: 10.1126/scisignal.2001936

PubMed ID: 7477354

Title: Phosphorylation of Raf by ceramide-activated protein kinase.

PubMed ID: 7477354

DOI: 10.1038/378307a0

PubMed ID: 1886707

Title: An alternatively spliced c-mil/raf mRNA is predominantly expressed in chicken muscular tissues and conserved among vertebrate species.

PubMed ID: 1886707

PubMed ID: 8349614

Title: Identification of the major phosphorylation sites of the Raf-1 kinase.

PubMed ID: 8349614

DOI: 10.1016/s0021-9258(19)85336-x

PubMed ID: 9360956

Title: 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.

PubMed ID: 9360956

DOI: 10.1074/jbc.272.46.28882

PubMed ID: 9823899

Title: The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.

PubMed ID: 9823899

DOI: 10.1038/24184

PubMed ID: 10576742

Title: Phosphorylation and regulation of Raf by Akt (protein kinase B).

PubMed ID: 10576742

DOI: 10.1126/science.286.5445.1741

PubMed ID: 10801873

Title: Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.

PubMed ID: 10801873

DOI: 10.1074/jbc.m003259200

PubMed ID: 11447113

Title: Positive and negative regulation of Raf kinase activity and function by phosphorylation.

PubMed ID: 11447113

DOI: 10.1093/emboj/20.14.3716

PubMed ID: 11427728

Title: Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.

PubMed ID: 11427728

DOI: 10.1073/pnas.141224398

PubMed ID: 11719507

Title: Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity.

PubMed ID: 11719507

DOI: 10.1074/jbc.m106343200

PubMed ID: 11733498

Title: Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1.

PubMed ID: 11733498

DOI: 10.1074/jbc.m110000200

PubMed ID: 11756411

Title: Dephosphorylation of Ser-259 regulates Raf-1 membrane association.

PubMed ID: 11756411

DOI: 10.1074/jbc.m108733200

PubMed ID: 11784866

Title: The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

PubMed ID: 11784866

DOI: 10.1128/mcb.22.3.916-926.2001

PubMed ID: 12717443

Title: Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

PubMed ID: 12717443

DOI: 10.1038/ncb978

PubMed ID: 15047712

Title: LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway.

PubMed ID: 15047712

DOI: 10.1074/jbc.m314192200

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 15618521

Title: Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

PubMed ID: 15618521

DOI: 10.1126/science.1103233

PubMed ID: 15935327

Title: Raf-1 is a binding partner of DSCR1.

PubMed ID: 15935327

DOI: 10.1016/j.abb.2005.05.002

PubMed ID: 15943972

Title: Second nature: biological functions of the Raf-1 'kinase'.

PubMed ID: 15943972

DOI: 10.1016/j.febslet.2005.03.024

PubMed ID: 15849194

Title: p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.

PubMed ID: 15849194

DOI: 10.1074/jbc.m413374200

PubMed ID: 16093354

Title: Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.

PubMed ID: 16093354

DOI: 10.1091/mbc.e05-02-0090

PubMed ID: 16630891

Title: A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.

PubMed ID: 16630891

DOI: 10.1016/j.molcel.2006.03.027

PubMed ID: 16508002

Title: Regulation and role of Raf-1/B-Raf heterodimerization.

PubMed ID: 16508002

DOI: 10.1128/mcb.26.6.2262-2272.2006

PubMed ID: 16892053

Title: Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.

PubMed ID: 16892053

DOI: 10.1038/ncb1465

PubMed ID: 17218791

Title: Phosphatase and feedback regulation of Raf-1 signaling.

PubMed ID: 17218791

DOI: 10.4161/cc.6.1.3593

PubMed ID: 16924233

Title: Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug.

PubMed ID: 16924233

DOI: 10.1038/sj.onc.1209902

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18294816

Title: The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.

PubMed ID: 18294816

DOI: 10.1016/j.cellsig.2008.01.012

PubMed ID: 18465753

Title: p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.

PubMed ID: 18465753

DOI: 10.1002/jcb.21809

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19298812

Title: Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells.

PubMed ID: 19298812

DOI: 10.1016/j.yexcr.2009.03.004

PubMed ID: 19710016

Title: Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.

PubMed ID: 19710016

DOI: 10.1074/jbc.m109.043604

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20674547

Title: RAF protein-serine/threonine kinases: structure and regulation.

PubMed ID: 20674547

DOI: 10.1016/j.bbrc.2010.07.092

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21779496

Title: Raf family kinases: old dogs have learned new tricks.

PubMed ID: 21779496

DOI: 10.1177/1947601911407323

PubMed ID: 20956560

Title: Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation.

PubMed ID: 20956560

DOI: 10.1128/mcb.00648-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22886302

Title: FAM83B mediates EGFR- and RAS-driven oncogenic transformation.

PubMed ID: 22886302

DOI: 10.1172/jci60517

PubMed ID: 22538822

Title: Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.

PubMed ID: 22538822

DOI: 10.1073/pnas.1116573109

PubMed ID: 23327923

Title: MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.

PubMed ID: 23327923

DOI: 10.1182/blood-2011-10-385252

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23509299

Title: Phosphodiesterase-8A binds to and regulates Raf-1 kinase.

PubMed ID: 23509299

DOI: 10.1073/pnas.1303004110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 30368668

Title: Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.

PubMed ID: 30368668

DOI: 10.1007/s00439-018-1951-7

PubMed ID: 31024343

Title: A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway.

PubMed ID: 31024343

DOI: 10.3389/fphys.2019.00388

PubMed ID: 7791872

Title: The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.

PubMed ID: 7791872

DOI: 10.1038/375554a0

PubMed ID: 8756332

Title: Ras/Rap effector specificity determined by charge reversal.

PubMed ID: 8756332

DOI: 10.1038/nsb0896-723

PubMed ID: 7766599

Title: Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface.

PubMed ID: 7766599

DOI: 10.1021/bi00021a001

PubMed ID: 8710867

Title: The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.

PubMed ID: 8710867

DOI: 10.1073/pnas.93.16.8312

PubMed ID: 17603483

Title: Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.

PubMed ID: 17603483

DOI: 10.1038/ng2073

PubMed ID: 17603482

Title: Germline gain-of-function mutations in RAF1 cause Noonan syndrome.

PubMed ID: 17603482

DOI: 10.1038/ng2078

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 20683980

Title: Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations.

PubMed ID: 20683980

DOI: 10.1002/ajmg.a.33564

PubMed ID: 24777450

Title: RAF1 mutations in childhood-onset dilated cardiomyopathy.

PubMed ID: 24777450

DOI: 10.1038/ng.2963

Sequence Information:

  • Length: 648
  • Mass: 73052
  • Checksum: EF821B5349711BC3
  • Sequence:
    • MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV 
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS 
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 
PTMCVDWSNI RQLLLFPNST IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF 
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 
GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 
LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP 
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF

Genular Protein ID: 1725170034

Symbol: A0A0S2Z4L5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4L5

Database IDs:

ARBA 16 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 4 GO 10 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 8 SAM 1 SMART 3 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 615
  • Mass: 69513
  • Checksum: E5E5CCAD196D2F45
  • Sequence:
    • MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV 
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS 
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 
PTMCVDWSNI RQLFSQHRYS TPHAFTFNTS SPSSEGSLSQ RQRSTSTPNV HMVSTTLPVD 
SRMIEDAIRS HSESASPSAL SSSPNNLSPT GWSQPKTPVP AQRERAPVSG TQEKNKIRPR 
GQRDSSYYWE IEASEVMLST RIGSGSFGTV YKGKWHGDVA VKILKVVDPT PEQFQAFRNE 
VAVLRKTRHV NILLFMGYMT KDNLAIVTQW CEGSSLYKHL HVQETKFQMF QLIDIARQTA 
QGMDYLHAKN IIHRDMKSNN IFLHEGLTVK IGDFGLATVK SRWSGSQQVE QPTGSVLWMA 
PEVIRMQDNN PFSFQSDVYS YGIVLYELMT GELPYSHINN RDQIIFMVGR GYASPDLSKL 
YKNCPKAMKR LVADCVKKVK EERPLFPQIL SSIELLQHSL PKINRSASEP SLHRAAHTED 
INACTLTTSP RLPVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.