Details for: RBM4

Gene ID: 5936

Symbol: RBM4

Ensembl ID: ENSG00000173933

Description: RNA binding motif protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 229.3867
    Cell Significance Index: -35.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.8961
    Cell Significance Index: -32.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 98.1193
    Cell Significance Index: -40.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.8765
    Cell Significance Index: -39.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.1710
    Cell Significance Index: -40.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.9071
    Cell Significance Index: -39.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.4572
    Cell Significance Index: -36.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.6585
    Cell Significance Index: -38.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1963
    Cell Significance Index: -40.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4483
    Cell Significance Index: 242.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9560
    Cell Significance Index: 56.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7164
    Cell Significance Index: 46.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6491
    Cell Significance Index: 38.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4363
    Cell Significance Index: 176.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4043
    Cell Significance Index: 163.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3626
    Cell Significance Index: 273.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3067
    Cell Significance Index: 142.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2834
    Cell Significance Index: 231.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2814
    Cell Significance Index: 368.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1859
    Cell Significance Index: 16.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1699
    Cell Significance Index: 419.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9464
    Cell Significance Index: 8.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9371
    Cell Significance Index: 57.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9081
    Cell Significance Index: 116.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9010
    Cell Significance Index: 26.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9010
    Cell Significance Index: 18.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8960
    Cell Significance Index: 50.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8272
    Cell Significance Index: 53.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8010
    Cell Significance Index: 9.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7886
    Cell Significance Index: 128.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6759
    Cell Significance Index: 51.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6429
    Cell Significance Index: 44.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6402
    Cell Significance Index: 87.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5642
    Cell Significance Index: 66.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5640
    Cell Significance Index: 12.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5497
    Cell Significance Index: 28.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5325
    Cell Significance Index: 12.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4671
    Cell Significance Index: 16.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4670
    Cell Significance Index: 12.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4619
    Cell Significance Index: 252.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3958
    Cell Significance Index: 11.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3846
    Cell Significance Index: 17.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3672
    Cell Significance Index: 13.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3528
    Cell Significance Index: 15.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3227
    Cell Significance Index: 64.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3223
    Cell Significance Index: 290.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2775
    Cell Significance Index: 13.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2700
    Cell Significance Index: 6.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2636
    Cell Significance Index: 50.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2568
    Cell Significance Index: 113.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2280
    Cell Significance Index: 16.9900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2256
    Cell Significance Index: 3.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2148
    Cell Significance Index: 11.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1282
    Cell Significance Index: 3.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1084
    Cell Significance Index: 6.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0631
    Cell Significance Index: 118.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0589
    Cell Significance Index: 3.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0563
    Cell Significance Index: 0.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0537
    Cell Significance Index: 0.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0473
    Cell Significance Index: 6.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0385
    Cell Significance Index: 59.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0375
    Cell Significance Index: 0.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0268
    Cell Significance Index: 0.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0238
    Cell Significance Index: 43.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0193
    Cell Significance Index: 0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0152
    Cell Significance Index: 9.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0112
    Cell Significance Index: 15.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0075
    Cell Significance Index: 3.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0303
    Cell Significance Index: -22.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0312
    Cell Significance Index: -23.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0375
    Cell Significance Index: -27.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0557
    Cell Significance Index: -31.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0614
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0699
    Cell Significance Index: -43.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1231
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1314
    Cell Significance Index: -22.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1385
    Cell Significance Index: -14.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1490
    Cell Significance Index: -21.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1681
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1908
    Cell Significance Index: -40.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2018
    Cell Significance Index: -9.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2218
    Cell Significance Index: -1.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2333
    Cell Significance Index: -5.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2489
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2746
    Cell Significance Index: -31.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3004
    Cell Significance Index: -31.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3519
    Cell Significance Index: -17.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3975
    Cell Significance Index: -12.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4237
    Cell Significance Index: -8.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4813
    Cell Significance Index: -38.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5133
    Cell Significance Index: -31.4700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5841
    Cell Significance Index: -3.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5954
    Cell Significance Index: -16.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6282
    Cell Significance Index: -11.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6695
    Cell Significance Index: -21.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6933
    Cell Significance Index: -22.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7250
    Cell Significance Index: -20.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7641
    Cell Significance Index: -16.7300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.7962
    Cell Significance Index: -5.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8004
    Cell Significance Index: -21.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RBM4 is a member of the RNA-binding motif (RBM) family of proteins, which are known for their ability to bind to specific RNA sequences. RBM4 contains a characteristic RNA-binding domain (RBD) that allows it to interact with various RNA molecules, including messenger RNA (mRNA), microRNA (miRNA), and small nuclear RNA (snRNA). The protein is also known to be involved in the regulation of alternative splicing, where it acts as a scaffold for the assembly of spliceosome components. Additionally, RBM4 has been shown to regulate translational initiation and elongation, as well as the activity of the circadian clock. **Pathways and Functions** RBM4 is involved in several key signaling pathways, including: 1. **Cap-independent translational initiation**: RBM4 regulates the translation of mRNAs that do not require a 5' cap for translation. 2. **Circadian clock regulation**: RBM4 is involved in the regulation of the circadian clock, where it interacts with clock proteins to regulate the expression of clock-controlled genes. 3. **Insulin secretion**: RBM4 regulates the translation of insulin-related genes in pancreatic A cells. 4. **Cyclin binding**: RBM4 interacts with cyclins to regulate the cell cycle. 5. **Mirna-mediated gene silencing**: RBM4 can inhibit the translation of mRNAs that are targeted by miRNAs. **Clinical Significance** Dysregulation of RBM4 has been implicated in various diseases, including: 1. **Diabetes**: RBM4 has been shown to regulate insulin secretion in pancreatic A cells, making it a potential target for the treatment of diabetes. 2. **Cancer**: RBM4 has been implicated in the regulation of alternative splicing in cancer cells, where it can contribute to the development of resistance to chemotherapy. 3. **Neurological disorders**: RBM4 has been implicated in the regulation of the circadian clock, which is disrupted in various neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Immune disorders**: RBM4 has been shown to regulate the activity of immune cells, including T cells and macrophages, making it a potential target for the treatment of immune disorders. In conclusion, RBM4 is a multifunctional RNA-binding protein that plays a crucial role in various cellular processes, including translational regulation, alternative splicing, and circadian rhythm control. Its dysregulation has been implicated in various diseases, making it a potential target for the treatment of these disorders. Further research is needed to fully understand the mechanisms by which RBM4 regulates gene expression and to explore its potential as a therapeutic target.

Genular Protein ID: 4045551230

Symbol: RBM4_HUMAN

Name: RNA-binding protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9169144

Title: A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans.

PubMed ID: 9169144

DOI: 10.1006/geno.1997.4704

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12469345

Title: Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.

PubMed ID: 12469345

DOI: 10.1002/1615-9861(200212)2:12<1752::aid-prot1752>3.0.co;2-y

PubMed ID: 12628928

Title: A novel splicing regulator shares a nuclear import pathway with SR proteins.

PubMed ID: 12628928

DOI: 10.1093/emboj/cdg126

PubMed ID: 16260624

Title: Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.

PubMed ID: 16260624

DOI: 10.1128/mcb.25.22.10111-10121.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16907643

Title: Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties.

PubMed ID: 16907643

DOI: 10.1089/dna.2006.25.457

PubMed ID: 16934801

Title: WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.

PubMed ID: 16934801

DOI: 10.1016/j.yexcr.2006.07.008

PubMed ID: 16777844

Title: RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.

PubMed ID: 16777844

DOI: 10.1074/jbc.m603971200

PubMed ID: 17284590

Title: Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.

PubMed ID: 17284590

DOI: 10.1073/pnas.0611015104

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18708123

Title: The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.

PubMed ID: 18708123

DOI: 10.1016/j.neulet.2008.08.017

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19801630

Title: RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.

PubMed ID: 19801630

DOI: 10.1074/jbc.m109.032946

PubMed ID: 19561594

Title: Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.

PubMed ID: 19561594

DOI: 10.1038/nbt.1550

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21518792

Title: RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.

PubMed ID: 21518792

DOI: 10.1083/jcb.201007131

PubMed ID: 21343338

Title: RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.

PubMed ID: 21343338

DOI: 10.1128/mcb.01149-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 37548402

Title: Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators.

PubMed ID: 37548402

DOI: 10.1093/nar/gkad652

Sequence Information:

  • Length: 364
  • Mass: 40314
  • Checksum: 3EA1C80D4C9122A2
  • Sequence:
  • MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL 
    HGVNINVEAS KNKSKTSTKL HVGNISPTCT NKELRAKFEE YGPVIECDIV KDYAFVHMER 
    AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPIDRS 
    GRVADLTEQY NEQYGAVRTP YTMSYGDSLY YNNAYGALDA YYKRCRAARS YEAVAAAAAS 
    VYNYAEQTLS QLPQVQNTAM ASHLTSTSLD PYDRHLLPTS GAAATAAAAA AAAAAVTAAS 
    TSYYGRDRSP LRRATAPVPT VGEGYGYGHE SELSQASAAA RNSLYDMARY EREQYADRAR 
    YSAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.