Details for: RBM4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 229.3867
Cell Significance Index: -35.6800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 127.8961
Cell Significance Index: -32.4400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 98.1193
Cell Significance Index: -40.4200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 83.8765
Cell Significance Index: -39.6000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 78.1710
Cell Significance Index: -40.2100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.9071
Cell Significance Index: -39.3400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.4572
Cell Significance Index: -36.0500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.6585
Cell Significance Index: -38.8800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.1963
Cell Significance Index: -40.2400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.4483
Cell Significance Index: 242.1900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.9560
Cell Significance Index: 56.0700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.7164
Cell Significance Index: 46.7200 - Cell Name: peg cell (CL4033014)
Fold Change: 1.6491
Cell Significance Index: 38.1000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4363
Cell Significance Index: 176.6100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.4043
Cell Significance Index: 163.6500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3626
Cell Significance Index: 273.3400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3067
Cell Significance Index: 142.1300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2834
Cell Significance Index: 231.3600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.2814
Cell Significance Index: 368.7100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.1859
Cell Significance Index: 16.1800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1699
Cell Significance Index: 419.6400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9464
Cell Significance Index: 8.7200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.9371
Cell Significance Index: 57.6000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.9081
Cell Significance Index: 116.4100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9010
Cell Significance Index: 26.4600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.9010
Cell Significance Index: 18.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8960
Cell Significance Index: 50.2800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8272
Cell Significance Index: 53.3700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.8010
Cell Significance Index: 9.9400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7886
Cell Significance Index: 128.2600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6759
Cell Significance Index: 51.8700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6429
Cell Significance Index: 44.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6402
Cell Significance Index: 87.9200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5642
Cell Significance Index: 66.5400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5640
Cell Significance Index: 12.2200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.5497
Cell Significance Index: 28.8600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.5325
Cell Significance Index: 12.7700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4671
Cell Significance Index: 16.2300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4670
Cell Significance Index: 12.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4619
Cell Significance Index: 252.2500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3958
Cell Significance Index: 11.4100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3846
Cell Significance Index: 17.0100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3672
Cell Significance Index: 13.9100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3528
Cell Significance Index: 15.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3227
Cell Significance Index: 64.0400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3223
Cell Significance Index: 290.9900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2775
Cell Significance Index: 13.0400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2700
Cell Significance Index: 6.9400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2636
Cell Significance Index: 50.1600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2568
Cell Significance Index: 113.5500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2280
Cell Significance Index: 16.9900 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.2256
Cell Significance Index: 3.6200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2148
Cell Significance Index: 11.1600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1282
Cell Significance Index: 3.3700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1084
Cell Significance Index: 6.8400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0631
Cell Significance Index: 118.7200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0589
Cell Significance Index: 3.9600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0563
Cell Significance Index: 0.6400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0537
Cell Significance Index: 0.6400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0473
Cell Significance Index: 6.1200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0385
Cell Significance Index: 59.3100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0375
Cell Significance Index: 0.4800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0268
Cell Significance Index: 0.9400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0238
Cell Significance Index: 43.8600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0193
Cell Significance Index: 0.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0152
Cell Significance Index: 9.6600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0112
Cell Significance Index: 15.2600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0075
Cell Significance Index: 3.4000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0303
Cell Significance Index: -22.4100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0312
Cell Significance Index: -23.6400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0375
Cell Significance Index: -27.5100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0557
Cell Significance Index: -31.4400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0614
Cell Significance Index: -4.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0699
Cell Significance Index: -43.6600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1231
Cell Significance Index: -2.0600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1314
Cell Significance Index: -22.4300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1385
Cell Significance Index: -14.1500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1490
Cell Significance Index: -21.6600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1681
Cell Significance Index: -4.5100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1908
Cell Significance Index: -40.1800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2018
Cell Significance Index: -9.4100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2218
Cell Significance Index: -1.3400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2333
Cell Significance Index: -5.9600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2489
Cell Significance Index: -5.3000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2746
Cell Significance Index: -31.4600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3004
Cell Significance Index: -31.2800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3519
Cell Significance Index: -17.7800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3975
Cell Significance Index: -12.7300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4237
Cell Significance Index: -8.7900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4813
Cell Significance Index: -38.1200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5133
Cell Significance Index: -31.4700 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.5841
Cell Significance Index: -3.8000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5954
Cell Significance Index: -16.6400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6282
Cell Significance Index: -11.6100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6695
Cell Significance Index: -21.9200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6933
Cell Significance Index: -22.0800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7250
Cell Significance Index: -20.6900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7641
Cell Significance Index: -16.7300 - Cell Name: glioblast (CL0000030)
Fold Change: -0.7962
Cell Significance Index: -5.0000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8004
Cell Significance Index: -21.4100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4045551230
Symbol: RBM4_HUMAN
Name: RNA-binding protein 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9169144
Title: A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans.
PubMed ID: 9169144
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12469345
Title: Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.
PubMed ID: 12469345
DOI: 10.1002/1615-9861(200212)2:12<1752::aid-prot1752>3.0.co;2-y
PubMed ID: 12628928
Title: A novel splicing regulator shares a nuclear import pathway with SR proteins.
PubMed ID: 12628928
DOI: 10.1093/emboj/cdg126
PubMed ID: 16260624
Title: Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.
PubMed ID: 16260624
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16907643
Title: Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties.
PubMed ID: 16907643
PubMed ID: 16934801
Title: WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.
PubMed ID: 16934801
PubMed ID: 16777844
Title: RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.
PubMed ID: 16777844
PubMed ID: 17284590
Title: Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.
PubMed ID: 17284590
PubMed ID: 17932509
Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
PubMed ID: 17932509
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18708123
Title: The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.
PubMed ID: 18708123
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19801630
Title: RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.
PubMed ID: 19801630
PubMed ID: 19561594
Title: Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.
PubMed ID: 19561594
DOI: 10.1038/nbt.1550
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21518792
Title: RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.
PubMed ID: 21518792
PubMed ID: 21343338
Title: RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.
PubMed ID: 21343338
DOI: 10.1128/mcb.01149-10
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 37548402
Title: Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators.
PubMed ID: 37548402
DOI: 10.1093/nar/gkad652
Sequence Information:
- Length: 364
- Mass: 40314
- Checksum: 3EA1C80D4C9122A2
- Sequence:
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL HGVNINVEAS KNKSKTSTKL HVGNISPTCT NKELRAKFEE YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPIDRS GRVADLTEQY NEQYGAVRTP YTMSYGDSLY YNNAYGALDA YYKRCRAARS YEAVAAAAAS VYNYAEQTLS QLPQVQNTAM ASHLTSTSLD PYDRHLLPTS GAAATAAAAA AAAAAVTAAS TSYYGRDRSP LRRATAPVPT VGEGYGYGHE SELSQASAAA RNSLYDMARY EREQYADRAR YSAF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.