Details for: RELB

Gene ID: 5971

Symbol: RELB

Ensembl ID: ENSG00000104856

Description: RELB proto-oncogene, NF-kB subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.7652
    Cell Significance Index: -18.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.8582
    Cell Significance Index: -18.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.4822
    Cell Significance Index: -19.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.5101
    Cell Significance Index: -20.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.6505
    Cell Significance Index: -20.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3939
    Cell Significance Index: -18.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0963
    Cell Significance Index: -19.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8124
    Cell Significance Index: -18.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6069
    Cell Significance Index: -14.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9203
    Cell Significance Index: -8.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.5890
    Cell Significance Index: 102.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.0268
    Cell Significance Index: 48.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2237
    Cell Significance Index: 39.3000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.0747
    Cell Significance Index: 14.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5600
    Cell Significance Index: 107.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1757
    Cell Significance Index: 138.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0177
    Cell Significance Index: 75.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9173
    Cell Significance Index: 118.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8949
    Cell Significance Index: 16.5400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8274
    Cell Significance Index: 13.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7956
    Cell Significance Index: 47.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7907
    Cell Significance Index: 17.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7249
    Cell Significance Index: 78.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6225
    Cell Significance Index: 101.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5288
    Cell Significance Index: 15.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5102
    Cell Significance Index: 23.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3678
    Cell Significance Index: 200.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3604
    Cell Significance Index: 9.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3360
    Cell Significance Index: 8.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3149
    Cell Significance Index: 16.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2750
    Cell Significance Index: 248.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2435
    Cell Significance Index: 48.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2239
    Cell Significance Index: 10.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2131
    Cell Significance Index: 3.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2121
    Cell Significance Index: 2.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2119
    Cell Significance Index: 20.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2105
    Cell Significance Index: 93.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1553
    Cell Significance Index: 19.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1306
    Cell Significance Index: 3.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1299
    Cell Significance Index: 23.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1184
    Cell Significance Index: 4.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1077
    Cell Significance Index: 14.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0900
    Cell Significance Index: 17.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0722
    Cell Significance Index: 14.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0712
    Cell Significance Index: 0.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0654
    Cell Significance Index: 1.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0553
    Cell Significance Index: 38.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0401
    Cell Significance Index: 1.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0324
    Cell Significance Index: 2.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0188
    Cell Significance Index: 35.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0111
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0034
    Cell Significance Index: 0.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0068
    Cell Significance Index: -10.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0137
    Cell Significance Index: -1.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0150
    Cell Significance Index: -2.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0260
    Cell Significance Index: -11.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0261
    Cell Significance Index: -19.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0325
    Cell Significance Index: -18.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0333
    Cell Significance Index: -20.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0370
    Cell Significance Index: -13.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0462
    Cell Significance Index: -5.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0508
    Cell Significance Index: -3.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0559
    Cell Significance Index: -7.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0570
    Cell Significance Index: -16.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0570
    Cell Significance Index: -2.8800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0774
    Cell Significance Index: -0.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0835
    Cell Significance Index: -1.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0871
    Cell Significance Index: -1.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0948
    Cell Significance Index: -11.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0974
    Cell Significance Index: -20.5100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1150
    Cell Significance Index: -0.7500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1321
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1341
    Cell Significance Index: -4.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1473
    Cell Significance Index: -2.0100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1584
    Cell Significance Index: -0.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1663
    Cell Significance Index: -17.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1773
    Cell Significance Index: -4.6600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1926
    Cell Significance Index: -1.0500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2162
    Cell Significance Index: -3.1100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2246
    Cell Significance Index: -1.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2486
    Cell Significance Index: -12.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2563
    Cell Significance Index: -20.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2598
    Cell Significance Index: -15.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2811
    Cell Significance Index: -18.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3036
    Cell Significance Index: -8.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3038
    Cell Significance Index: -18.6700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3051
    Cell Significance Index: -3.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3099
    Cell Significance Index: -19.5400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.3197
    Cell Significance Index: -3.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3216
    Cell Significance Index: -13.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3353
    Cell Significance Index: -18.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3588
    Cell Significance Index: -15.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RELB is a member of the NF-kB family of transcription factors, which are key regulators of immune responses and inflammation. Unlike other NF-kB family members, RELB is a constitutively active transcription factor that does not require the activation of NF-kB-inducing stimuli to induce gene expression. RELB is also unique in its ability to interact with various transcription factors and co-regulators, influencing the expression of genes involved in immune cell development, function, and cancer. **Pathways and Functions:** RELB is involved in multiple signaling pathways that control immune responses, inflammation, and cell survival. Some of the key pathways and functions of RELB include: 1. **Antigen processing and presentation:** RELB regulates the expression of genes involved in antigen processing and presentation, such as MHC class II and CD80/CD86. 2. **Cytokine signaling:** RELB interacts with cytokine receptors, influencing the expression of genes involved in cytokine signaling, such as IL-6 and TNF-α. 3. **Innate immune response:** RELB regulates the expression of genes involved in the innate immune response, such as pattern recognition receptors (PRRs) and Toll-like receptors (TLRs). 4. **Cellular response to stress:** RELB is involved in the regulation of genes involved in cellular response to stress, such as heat shock proteins and chaperones. 5. **Cancer:** RELB is overexpressed in various types of cancer, including breast, prostate, and lung cancer, where it promotes tumor growth, survival, and metastasis. **Clinical Significance:** RELB has been implicated in various immune-related disorders and cancers, including: 1. **Breast cancer:** RELB overexpression is associated with poor prognosis and increased metastasis in breast cancer patients. 2. **Prostate cancer:** RELB overexpression is associated with aggressive disease and poor survival in prostate cancer patients. 3. **Lupus:** RELB is overexpressed in lupus patients, where it promotes inflammation and immune dysregulation. 4. **Rheumatoid arthritis:** RELB is involved in the regulation of genes involved in inflammation and immune response in rheumatoid arthritis patients. In conclusion, RELB is a complex transcription factor that plays a critical role in regulating immune responses, inflammation, and cell survival. Its dysregulation has been implicated in various immune-related disorders and cancers, highlighting the need for further research into the mechanisms of RELB function and its potential as a therapeutic target.

Genular Protein ID: 4041142965

Symbol: RELB_HUMAN

Name: Transcription factor RelB

UniProtKB Accession Codes:

Q01201 Q6GTX7 Q9UEI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1577270

Title: I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.

PubMed ID: 1577270

DOI: 10.1101/gad.6.5.745

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1732739

Title: RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

PubMed ID: 1732739

DOI: 10.1128/mcb.12.2.674-684.1992

PubMed ID: 8441398

Title: Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.

PubMed ID: 8441398

DOI: 10.1128/mcb.13.3.1572-1582.1993

PubMed ID: 7925301

Title: Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

PubMed ID: 7925301

DOI: 10.1002/j.1460-2075.1994.tb06782.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22565310

Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

PubMed ID: 22565310

DOI: 10.1172/jci60144

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26385063

Title: The effects of RelB deficiency on lymphocyte development and function.

PubMed ID: 26385063

DOI: 10.1016/j.jaut.2015.09.001

Sequence Information:

  • Length: 579
  • Mass: 62134
  • Checksum: C2C61C2C8640513E
  • Sequence:
    • MLRSGPASGP SVPTGRAMPS RRVARPPAAP ELGALGSPDL SSLSLAVSRS TDELEIIDEY 
IKENGFGLDG GQPGPGEGLP RLVSRGAASL STVTLGPVAP PATPPPWGCP LGRLVSPAPG 
PGPQPHLVIT EQPKQRGMRF RYECEGRSAG SILGESSTEA SKTLPAIELR DCGGLREVEV 
TACLVWKDWP HRVHPHSLVG KDCTDGICRV RLRPHVSPRH SFNNLGIQCV RKKEIEAAIE 
RKIQLGIDPY NAGSLKNHQE VDMNVVRICF QASYRDQQGQ MRRMDPVLSE PVYDKKSTNT 
SELRICRINK ESGPCTGGEE LYLLCDKVQK EDISVVFSRA SWEGRADFSQ ADVHRQIAIV 
FKTPPYEDLE IVEPVTVNVF LQRLTDGVCS EPLPFTYLPR DHDSYGVDKK RKRGMPDVLG 
ELNSSDPHGI ESKRRKKKPA ILDHFLPNHG SGPFLPPSAL LPDPDFFSGT VSLPGLEPPG 
GPDLLDDGFA YDPTAPTLFT MLDLLPPAPP HASAVVCSGG AGAVVGETPG PEPLTLDSYQ 
APGPGDGGTA SLVGSNMFPN HYREAAFGGG LLSPGPEAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.