Details for: RELB
Gene ID: 5971
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RELB
Ensembl ID: ENSG00000104856
Description: RELB proto-oncogene, NF-kB subunit
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 14.27rCSI 21.92%PRS 60.72
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CSI 10.43rCSI 12.97%PRS 54.85
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CSI 9.31rCSI 15.92%PRS 72.45
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CSI 7.73rCSI 15.4%PRS 71.01
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CSI 6.03rCSI 5.57%PRS 73.04
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CSI 5.74rCSI 15.46%PRS 60.83
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CSI 5.68rCSI 4.89%PRS 59.76
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CSI 5.36rCSI 5.17%PRS 43.26
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CSI 5.07rCSI 3.54%PRS 55.16
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CSI 4.84rCSI 9.14%PRS 63.2
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CSI 4.16rCSI 6.85%PRS 58.16
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CSI 4.07rCSI 10.58%PRS 56.98
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CSI 4.04rCSI 14.62%PRS 72.49
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CSI 3.91rCSI 3.11%PRS 75.18
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CSI 3.84rCSI 8.42%PRS 61.7
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CSI 3.26rCSI 2.45%PRS 82.3
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CSI 3.13rCSI 3.28%PRS 49.58
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CSI 3.12rCSI 2.24%PRS 66.7
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CSI 3.09rCSI 4.13%PRS 76.66
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CSI 3.05rCSI 3.89%PRS 58.89
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CSI 2.92rCSI 2.6%PRS 51.18
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CSI 2.92rCSI 2.03%PRS 62.81
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CSI 2.8rCSI 3.87%PRS 55.72
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CSI 2.7rCSI 3.61%PRS 61.47
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CSI 2.69rCSI 4.2%PRS 78.77
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CSI 2.66rCSI 3%PRS 69.26
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CSI 2.65rCSI 26.02%PRS 74.06
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CSI 2.64rCSI 2.08%PRS 59.41
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CSI 2.6rCSI 5.83%PRS 71.52
-
CSI 2.59rCSI 4.48%PRS 42.94
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CSI 2.58rCSI 2.07%PRS 74.22
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CSI 2.56rCSI 2.68%PRS 78.44
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CSI 2.51rCSI 1.9%PRS 66.46
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CSI 2.5rCSI 6%PRS 66.06
-
CSI 2.47rCSI 1.88%PRS 65.24
-
CSI 2.47rCSI 7.04%PRS 66.35
-
CSI 2.45rCSI 1.83%PRS 70.39
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CSI 2.45rCSI 2.26%PRS 53.83
-
CSI 2.38rCSI 1.85%PRS 53.62
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CSI 2.38rCSI 2%PRS 70.56
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CSI 2.38rCSI 3.05%PRS 57.58
-
CSI 2.37rCSI 3.17%PRS 75.21
-
CSI 2.33rCSI 3.56%PRS 69.66
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CSI 2.29rCSI 4.33%PRS 73.44
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CSI 2.29rCSI 6.82%PRS 73.11
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CSI 2.27rCSI 2.24%PRS 81.1
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CSI 2.2rCSI 1.85%PRS 57.52
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CSI 2.18rCSI 8.16%PRS 45.07
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CSI 2.1rCSI 1.4%PRS 75.65
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CSI 2.1rCSI 5.48%PRS 51.92
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CSI 2.09rCSI 1.83%PRS 58.07
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CSI 2.07rCSI 1.4%PRS 64.83
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CSI 2.06rCSI 2.42%PRS 68.94
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CSI 2.05rCSI 32.93%PRS 80.96
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CSI 2.05rCSI 4.89%PRS 62.12
-
CSI 1.99rCSI 1.85%PRS 52.45
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CSI 1.94rCSI 1.7%PRS 62.81
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CSI 1.93rCSI 2.91%PRS 55.68
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CSI 1.87rCSI 1.62%PRS 63.27
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CSI 1.85rCSI 2.66%PRS 58.38
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CSI 1.81rCSI 1.36%PRS 57.21
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CSI 1.76rCSI 2.21%PRS 65.64
-
CSI 1.73rCSI 2.27%PRS 66.33
-
CSI 1.73rCSI 3.3%PRS 68.73
-
CSI 1.71rCSI 2.73%PRS 56.53
-
CSI 1.69rCSI 1.26%PRS 66.72
-
CSI 1.67rCSI 1.51%PRS 49.51
-
CSI 1.6rCSI 2.45%PRS 53.25
-
CSI 1.59rCSI 1.97%PRS 63.87
-
CSI 1.58rCSI 1.51%PRS 76.11
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CSI 1.57rCSI 3.59%PRS 52.11
-
CSI 1.57rCSI 1.61%PRS 69.56
-
CSI 1.56rCSI 3.25%PRS 50.01
-
CSI 1.51rCSI 4.23%PRS 66
-
CSI 1.49rCSI 1.12%PRS 68.14
-
CSI 1.49rCSI 1.15%PRS 52.12
-
CSI 1.42rCSI 1.31%PRS 61.13
-
CSI 1.41rCSI 1.39%PRS 77.17
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CSI 1.4rCSI 4.56%PRS 54.52
-
CSI 1.38rCSI 2.1%PRS 62.24
-
CSI 1.37rCSI 1.45%PRS 65.5
-
CSI 1.36rCSI 5.49%PRS 51.09
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CSI 1.35rCSI 3.9%PRS 67.87
-
CSI 1.28rCSI 3.68%PRS 72.08
-
CSI 1.23rCSI 2.23%PRS 68.76
-
CSI 1.2rCSI 1.45%PRS 61.07
-
CSI 1.16rCSI 1.35%PRS 42.63
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CSI 1.15rCSI 1.66%PRS 68.94
-
CSI 1.13rCSI 2.4%PRS 72.12
-
CSI 1.12rCSI 3.91%PRS 66.9
-
CSI 1.1rCSI 1.47%PRS 53.77
-
CSI 1.08rCSI 1.04%PRS 53.05
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CSI 1.03rCSI 2.12%PRS 56.59
-
CSI 0.94rCSI 1.83%PRS 55.16
-
CSI 0.91rCSI 1.25%PRS 55.08
-
CSI 0.88rCSI 2.34%PRS 44.53
-
CSI 0.84rCSI 2.97%PRS 63.7
-
CSI 0.77rCSI 0.93%PRS 43.94
-
CSI 0.75rCSI 3.47%PRS 73.27
-
CSI 0.75rCSI 3.92%PRS 59.37
-
CSI 0.2rCSI 3.9%PRS 74.7%
-
CSI 0.4rCSI 2.1%PRS 84.0%
-
CSI 0.5rCSI 2.0%PRS 67.5%
-
CSI 0.5rCSI 2.4%PRS 64.9%
-
CSI 0.5rCSI 2.4%PRS 64.3%
-
CSI 0.6rCSI 1.4%PRS 42.5%
-
CSI 0.6rCSI 0.9%PRS 59.8%
-
CSI 0.6rCSI 3.4%PRS 66.8%
-
CSI 0.7rCSI 0.9%PRS 58.3%
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CSI 0.7rCSI 2.9%PRS 51.8%
-
CSI 0.7rCSI 3.1%PRS 69.8%
-
CSI 0.8rCSI 3.9%PRS 59.4%
-
CSI 0.8rCSI 3.5%PRS 73.3%
-
CSI 0.8rCSI 0.9%PRS 43.9%
-
CSI 0.8rCSI 3.0%PRS 63.7%
-
CSI 0.9rCSI 2.3%PRS 44.5%
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CSI 0.9rCSI 1.3%PRS 55.1%
-
CSI 0.9rCSI 1.8%PRS 55.2%
-
CSI 1.0rCSI 2.1%PRS 56.6%
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CSI 1.1rCSI 1.0%PRS 53.1%
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CSI 1.1rCSI 1.5%PRS 53.8%
-
CSI 1.1rCSI 3.9%PRS 66.9%
-
CSI 1.1rCSI 2.4%PRS 72.1%
-
CSI 1.2rCSI 1.7%PRS 68.9%
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CSI 1.2rCSI 1.4%PRS 42.6%
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CSI 1.2rCSI 1.5%PRS 61.1%
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CSI 1.2rCSI 2.2%PRS 68.8%
-
CSI 1.3rCSI 3.7%PRS 72.1%
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CSI 1.4rCSI 3.9%PRS 67.9%
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CSI 1.4rCSI 5.5%PRS 51.1%
-
CSI 1.4rCSI 1.5%PRS 65.5%
-
CSI 1.4rCSI 2.1%PRS 62.2%
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CSI 1.4rCSI 4.6%PRS 54.5%
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CSI 1.4rCSI 1.4%PRS 77.2%
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CSI 1.4rCSI 1.3%PRS 61.1%
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CSI 1.5rCSI 1.2%PRS 52.1%
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CSI 1.5rCSI 1.1%PRS 68.1%
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CSI 1.5rCSI 4.2%PRS 66.0%
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CSI 1.6rCSI 3.3%PRS 50.0%
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CSI 1.6rCSI 1.6%PRS 69.6%
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CSI 1.6rCSI 3.6%PRS 52.1%
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CSI 1.6rCSI 1.5%PRS 76.1%
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CSI 1.6rCSI 2.0%PRS 63.9%
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CSI 1.6rCSI 2.5%PRS 53.3%
-
CSI 1.7rCSI 1.5%PRS 49.5%
-
CSI 1.7rCSI 1.3%PRS 66.7%
-
CSI 1.7rCSI 2.7%PRS 56.5%
-
CSI 1.7rCSI 3.3%PRS 68.7%
-
CSI 1.7rCSI 2.3%PRS 66.3%
-
CSI 1.8rCSI 2.2%PRS 65.6%
-
CSI 1.8rCSI 1.4%PRS 57.2%
-
CSI 1.9rCSI 2.7%PRS 58.4%
-
CSI 1.9rCSI 1.6%PRS 63.3%
-
CSI 1.9rCSI 2.9%PRS 55.7%
-
CSI 1.9rCSI 1.7%PRS 62.8%
-
CSI 2.0rCSI 1.9%PRS 52.5%
-
CSI 2.1rCSI 4.9%PRS 62.1%
-
CSI 2.1rCSI 32.9%PRS 81.0%
-
CSI 2.1rCSI 2.4%PRS 68.9%
-
CSI 2.1rCSI 1.4%PRS 64.8%
-
CSI 2.1rCSI 1.8%PRS 58.1%
-
CSI 2.1rCSI 5.5%PRS 51.9%
-
CSI 2.1rCSI 1.4%PRS 75.7%
-
CSI 2.2rCSI 8.2%PRS 45.1%
-
CSI 2.2rCSI 1.9%PRS 57.5%
-
CSI 2.3rCSI 2.2%PRS 81.1%
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CSI 2.3rCSI 6.8%PRS 73.1%
-
CSI 2.3rCSI 4.3%PRS 73.4%
-
CSI 2.3rCSI 3.6%PRS 69.7%
-
CSI 2.4rCSI 3.2%PRS 75.2%
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CSI 2.4rCSI 3.1%PRS 57.6%
-
CSI 2.4rCSI 2.0%PRS 70.6%
-
CSI 2.4rCSI 1.9%PRS 53.6%
-
CSI 2.5rCSI 2.3%PRS 53.8%
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CSI 2.5rCSI 1.8%PRS 70.4%
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CSI 2.5rCSI 7.0%PRS 66.4%
-
CSI 2.5rCSI 1.9%PRS 65.2%
-
CSI 2.5rCSI 6.0%PRS 66.1%
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CSI 2.5rCSI 1.9%PRS 66.5%
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CSI 2.6rCSI 2.7%PRS 78.4%
-
CSI 2.6rCSI 2.1%PRS 74.2%
-
CSI 2.6rCSI 4.5%PRS 42.9%
-
CSI 2.6rCSI 5.8%PRS 71.5%
-
CSI 2.6rCSI 2.1%PRS 59.4%
-
CSI 2.7rCSI 26.0%PRS 74.1%
-
CSI 2.7rCSI 3.0%PRS 69.3%
-
CSI 2.7rCSI 4.2%PRS 78.8%
-
CSI 2.7rCSI 3.6%PRS 61.5%
-
CSI 2.8rCSI 3.9%PRS 55.7%
-
CSI 2.9rCSI 2.0%PRS 62.8%
-
CSI 2.9rCSI 2.6%PRS 51.2%
-
CSI 3.1rCSI 3.9%PRS 58.9%
-
CSI 3.1rCSI 4.1%PRS 76.7%
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CSI 3.1rCSI 2.2%PRS 66.7%
-
CSI 3.1rCSI 3.3%PRS 49.6%
-
CSI 3.3rCSI 2.5%PRS 82.3%
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CSI 3.8rCSI 8.4%PRS 61.7%
-
CSI 3.9rCSI 3.1%PRS 75.2%
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CSI 4.0rCSI 14.6%PRS 72.5%
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CSI 4.1rCSI 10.6%PRS 57.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4041142965
Symbol: RELB_HUMAN
Name: Transcription factor RelB
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1577270
Title: I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.
PubMed ID: 1577270
DOI: 10.1101/gad.6.5.745
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1732739
Title: RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
PubMed ID: 1732739
PubMed ID: 8441398
Title: Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.
PubMed ID: 8441398
PubMed ID: 7925301
Title: Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.
PubMed ID: 7925301
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20873783
Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
PubMed ID: 20873783
DOI: 10.1021/pr100562w
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22565310
Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
PubMed ID: 22565310
DOI: 10.1172/jci60144
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 26385063
Title: The effects of RelB deficiency on lymphocyte development and function.
PubMed ID: 26385063
Sequence Information:
- Length: 579
- Mass: 62134
- Checksum: C2C61C2C8640513E
- Sequence:
MLRSGPASGP SVPTGRAMPS RRVARPPAAP ELGALGSPDL SSLSLAVSRS TDELEIIDEY IKENGFGLDG GQPGPGEGLP RLVSRGAASL STVTLGPVAP PATPPPWGCP LGRLVSPAPG PGPQPHLVIT EQPKQRGMRF RYECEGRSAG SILGESSTEA SKTLPAIELR DCGGLREVEV TACLVWKDWP HRVHPHSLVG KDCTDGICRV RLRPHVSPRH SFNNLGIQCV RKKEIEAAIE RKIQLGIDPY NAGSLKNHQE VDMNVVRICF QASYRDQQGQ MRRMDPVLSE PVYDKKSTNT SELRICRINK ESGPCTGGEE LYLLCDKVQK EDISVVFSRA SWEGRADFSQ ADVHRQIAIV FKTPPYEDLE IVEPVTVNVF LQRLTDGVCS EPLPFTYLPR DHDSYGVDKK RKRGMPDVLG ELNSSDPHGI ESKRRKKKPA ILDHFLPNHG SGPFLPPSAL LPDPDFFSGT VSLPGLEPPG GPDLLDDGFA YDPTAPTLFT MLDLLPPAPP HASAVVCSGG AGAVVGETPG PEPLTLDSYQ APGPGDGGTA SLVGSNMFPN HYREAAFGGG LLSPGPEAT