Details for: DPF2

Gene ID: 5977

Symbol: DPF2

Ensembl ID: ENSG00000133884

Description: double PHD fingers 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 188.8840
    Cell Significance Index: -29.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.2265
    Cell Significance Index: -26.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.8727
    Cell Significance Index: -31.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.0778
    Cell Significance Index: -29.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.6781
    Cell Significance Index: -31.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9072
    Cell Significance Index: -26.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2247
    Cell Significance Index: -32.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.5209
    Cell Significance Index: -23.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6106
    Cell Significance Index: 187.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3176
    Cell Significance Index: 1189.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1152
    Cell Significance Index: 110.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0462
    Cell Significance Index: 113.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9629
    Cell Significance Index: 277.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8523
    Cell Significance Index: 138.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7438
    Cell Significance Index: 149.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6156
    Cell Significance Index: 84.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5841
    Cell Significance Index: 105.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5708
    Cell Significance Index: 70.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5271
    Cell Significance Index: 36.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5002
    Cell Significance Index: 99.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4838
    Cell Significance Index: 30.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4461
    Cell Significance Index: 28.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4368
    Cell Significance Index: 156.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4283
    Cell Significance Index: 233.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4061
    Cell Significance Index: 8.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4039
    Cell Significance Index: 10.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3795
    Cell Significance Index: 4.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3442
    Cell Significance Index: 9.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3399
    Cell Significance Index: 40.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3373
    Cell Significance Index: 43.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3334
    Cell Significance Index: 25.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2706
    Cell Significance Index: 119.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2296
    Cell Significance Index: 7.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2207
    Cell Significance Index: 10.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2120
    Cell Significance Index: 11.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2111
    Cell Significance Index: 6.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1800
    Cell Significance Index: 4.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1687
    Cell Significance Index: 7.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1658
    Cell Significance Index: 10.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1270
    Cell Significance Index: 3.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0689
    Cell Significance Index: 3.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0470
    Cell Significance Index: 2.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0433
    Cell Significance Index: 7.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0423
    Cell Significance Index: 8.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0263
    Cell Significance Index: 0.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0238
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0205
    Cell Significance Index: 38.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0148
    Cell Significance Index: 0.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0098
    Cell Significance Index: 6.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0063
    Cell Significance Index: -3.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0076
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -16.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0132
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0223
    Cell Significance Index: -1.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0308
    Cell Significance Index: -0.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0389
    Cell Significance Index: -21.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0394
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0461
    Cell Significance Index: -4.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0481
    Cell Significance Index: -1.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0499
    Cell Significance Index: -1.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0587
    Cell Significance Index: -7.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0720
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0773
    Cell Significance Index: -16.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0937
    Cell Significance Index: -10.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1038
    Cell Significance Index: -2.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1103
    Cell Significance Index: -16.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1144
    Cell Significance Index: -5.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1237
    Cell Significance Index: -8.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1294
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1297
    Cell Significance Index: -14.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1415
    Cell Significance Index: -1.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1602
    Cell Significance Index: -5.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1824
    Cell Significance Index: -4.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2070
    Cell Significance Index: -7.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2382
    Cell Significance Index: -2.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2428
    Cell Significance Index: -2.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2908
    Cell Significance Index: -30.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3159
    Cell Significance Index: -25.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4045
    Cell Significance Index: -9.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4093
    Cell Significance Index: -13.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4179
    Cell Significance Index: -9.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4231
    Cell Significance Index: -25.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4467
    Cell Significance Index: -6.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4642
    Cell Significance Index: -8.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4645
    Cell Significance Index: -11.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4816
    Cell Significance Index: -9.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4833
    Cell Significance Index: -2.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5200
    Cell Significance Index: -4.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5225
    Cell Significance Index: -15.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5575
    Cell Significance Index: -12.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5863
    Cell Significance Index: -16.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6101
    Cell Significance Index: -19.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **PHD domains**: The DPF2 protein contains two PHD domains, which are involved in the recognition and modification of histones. 2. **Histone binding**: The PHD domains of DPF2 are capable of binding to histones, specifically acetylated histones (H3k9me3). 3. **Transcriptional regulation**: DPF2 acts as a transcriptional regulator, influencing the expression of genes involved in various cellular processes. 4. **Cell cycle regulation**: The protein is involved in the regulation of the cell cycle, specifically in the transition from G0 to G1 and from G1 to S phase. 5. **Apoptosis**: DPF2 is also implicated in the regulation of apoptosis, a process of programmed cell death. **Pathways and Functions** 1. **Apoptotic signaling pathway**: DPF2 is involved in the regulation of apoptosis, specifically in the negative regulation of myeloid progenitor cell differentiation. 2. **Centrosome and chromatin**: The protein interacts with centrosomes and chromatin, influencing the organization of the cell's genetic material. 3. **Chromatin remodeling**: DPF2 is involved in chromatin remodeling, a process that reorganizes chromatin structure to regulate gene expression. 4. **DNA repair**: The protein plays a role in the positive regulation of double-strand break repair, a process that maintains genome stability. 5. **Stem cell maintenance**: DPF2 is involved in the positive regulation of stem cell population maintenance, supporting the self-renewal of stem cells. **Clinical Significance** 1. **Cancer research**: The DPF2 gene and its protein product have been implicated in cancer research, particularly in the study of leukemia and lymphoma. 2. **Immunological disorders**: The protein's role in regulating immune cell differentiation and function makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases. 3. **Neurological disorders**: The involvement of DPF2 in nervous system development and function suggests its potential role in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive health**: The gene's expression in oogonial cells and male germ cells implies its potential role in reproductive health and fertility. In conclusion, the DPF2 gene is a complex transcriptional regulator that plays a critical role in various cellular processes, including apoptosis, cell cycle regulation, and DNA repair. Further research is needed to fully elucidate the functions and clinical significance of the DPF2 gene and its protein product.

Genular Protein ID: 2073468193

Symbol: REQU_HUMAN

Name: Zinc finger protein ubi-d4

UniProtKB Accession Codes:

Q92785 A8K7C9 B4DT58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9253601

Title: A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

PubMed ID: 9253601

DOI: 10.1101/gr.7.7.725

PubMed ID: 9680388

Title: Expression and chromosomal localization of the Requiem gene.

PubMed ID: 9680388

DOI: 10.1007/s003359900840

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8812431

Title: The d4 gene family in the human genome.

PubMed ID: 8812431

DOI: 10.1006/geno.1996.0440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20460684

Title: Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.

PubMed ID: 20460684

DOI: 10.1074/jbc.m109.087783

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29429572

Title: Mutations in the BAF-complex subunit DPF2 are associated with Coffin-Siris syndrome.

PubMed ID: 29429572

DOI: 10.1016/j.ajhg.2018.01.014

PubMed ID: 21888896

Title: Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.

PubMed ID: 21888896

DOI: 10.1016/j.bbrc.2011.08.043

PubMed ID: 27775714

Title: Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.

PubMed ID: 27775714

DOI: 10.1038/nchembio.2218

PubMed ID: 28533407

Title: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

PubMed ID: 28533407

DOI: 10.1073/pnas.1700328114

Sequence Information:

  • Length: 391
  • Mass: 44155
  • Checksum: 1044B4D3036075FC
  • Sequence:
    • MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR 
HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE 
ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN SRARKRILEP DDFLDDLDDE DYEEDTPKRR 
GKGKSKGKGV GSARKKLDAS ILEDRDKPYA CDICGKRYKN RPGLSYHYAH SHLAEEEGED 
KEDSQPPTPV SQRSEEQKSK KGPDGLALPN NYCDFCLGDS KINKKTGQPE ELVSCSDCGR 
SGHPSCLQFT PVMMAAVKTY RWQCIECKCC NICGTSENDD QLLFCDDCDR GYHMYCLTPS 
MSEPPEGSWS CHLCLDLLKE KASIYQNQNS S

Genular Protein ID: 525760308

Symbol: J3KMZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KMZ8

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 405
  • Mass: 45780
  • Checksum: EF4C5A781BAD84B8
  • Sequence:
    • MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR 
HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE 
ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN SRARKRILEP DDFLDDLDDE DYEEDTPKRR 
GKGKSKGKGV GSARKKLDAS ILEDRDKPYA CDNSFKQKHT SKAPQRVCGK RYKNRPGLSY 
HYAHSHLAEE EGEDKEDSQP PTPVSQRSEE QKSKKGPDGL ALPNNYCDFC LGDSKINKKT 
GQPEELVSCS DCGRSGHPSC LQFTPVMMAA VKTYRWQCIE CKCCNICGTS ENDDQLLFCD 
DCDRGYHMYC LTPSMSEPPE GSWSCHLCLD LLKEKASIYQ NQNSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.