Details for: DPF2
Gene ID: 5977
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DPF2
Ensembl ID: ENSG00000133884
Description: double PHD fingers 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 9.59rCSI 30.86%PRS 64.77
-
CSI 9.21rCSI 6.21%PRS 80.67
-
CSI 5.73rCSI 16.45%PRS 86.15
-
CSI 5.46rCSI 8.35%PRS 76.13
-
CSI 5.28rCSI 4.44%PRS 83.06
-
CSI 5.14rCSI 13.03%PRS 56.59
-
CSI 4.85rCSI 4.02%PRS 69.53
-
CSI 4.16rCSI 4.08%PRS 82.52
-
CSI 4.13rCSI 3.31%PRS 85.55
-
CSI 4.1rCSI 9.86%PRS 83.57
-
CSI 4.07rCSI 9.01%PRS 65.37
-
CSI 3.9rCSI 5.03%PRS 49.69
-
CSI 3.87rCSI 5.91%PRS 71.35
-
CSI 3.77rCSI 2.8%PRS 80.28
-
CSI 3.74rCSI 9.46%PRS 74.51
-
CSI 3.69rCSI 8.28%PRS 49.01
-
CSI 3.32rCSI 2.53%PRS 80.21
-
CSI 3.31rCSI 2.31%PRS 82.21
-
CSI 3.16rCSI 4.32%PRS 72.79
-
CSI 3.07rCSI 3.85%PRS 77.44
-
CSI 2.98rCSI 2.93%PRS 69.8
-
CSI 2.94rCSI 2.05%PRS 78.62
-
CSI 2.94rCSI 5.29%PRS 60.23
-
CSI 2.88rCSI 7.13%PRS 65.77
-
CSI 2.77rCSI 2.25%PRS 67.43
-
CSI 2.73rCSI 2.37%PRS 77.81
-
CSI 2.7rCSI 3.44%PRS 73.17
-
CSI 2.64rCSI 3.75%PRS 63.39
-
CSI 2.64rCSI 2.08%PRS 54.1
-
CSI 2.62rCSI 1.97%PRS 72.94
-
CSI 2.6rCSI 1.93%PRS 59.88
-
CSI 2.59rCSI 2.34%PRS 64.28
-
CSI 2.56rCSI 2.67%PRS 67.03
-
CSI 2.55rCSI 3.79%PRS 68
-
CSI 2.47rCSI 4.95%PRS 56.23
-
CSI 2.44rCSI 6.2%PRS 60.96
-
CSI 2.44rCSI 1.82%PRS 82.61
-
CSI 2.43rCSI 2.91%PRS 65.18
-
CSI 2.42rCSI 4.27%PRS 74.93
-
CSI 2.4rCSI 4.21%PRS 59.42
-
CSI 2.39rCSI 1.88%PRS 73.64
-
CSI 2.33rCSI 2.84%PRS 74.55
-
CSI 2.33rCSI 2.62%PRS 83.1
-
CSI 2.29rCSI 1.86%PRS 68.94
-
CSI 2.25rCSI 5.94%PRS 75.65
-
CSI 2.23rCSI 1.96%PRS 72.52
-
CSI 2.21rCSI 1.83%PRS 66.67
-
CSI 2.14rCSI 3.88%PRS 58.51
-
CSI 2.11rCSI 1.47%PRS 70
-
CSI 2.09rCSI 3.09%PRS 72.37
-
CSI 2.05rCSI 3.26%PRS 59.71
-
CSI 2.05rCSI 1.58%PRS 68.36
-
CSI 2.04rCSI 1.54%PRS 80.57
-
CSI 2rCSI 2.39%PRS 48.21
-
CSI 1.99rCSI 2.13%PRS 67.2
-
CSI 1.97rCSI 2.69%PRS 59.76
-
CSI 1.96rCSI 2.01%PRS 82.25
-
CSI 1.93rCSI 7.23%PRS 58.97
-
CSI 1.92rCSI 7.64%PRS 77.91
-
CSI 1.88rCSI 2.86%PRS 63.43
-
CSI 1.87rCSI 1.8%PRS 58.32
-
CSI 1.85rCSI 3.21%PRS 57.37
-
CSI 1.83rCSI 2.35%PRS 63.82
-
CSI 1.8rCSI 1.58%PRS 55
-
CSI 1.8rCSI 2.63%PRS 71.9
-
CSI 1.77rCSI 1.55%PRS 75.97
-
CSI 1.76rCSI 1.84%PRS 64.91
-
CSI 1.74rCSI 2.48%PRS 68.97
-
CSI 1.72rCSI 1.14%PRS 70.04
-
CSI 1.7rCSI 1.87%PRS 70.74
-
CSI 1.7rCSI 1.32%PRS 69.89
-
CSI 1.68rCSI 2.09%PRS 46.46
-
CSI 1.67rCSI 1.93%PRS 59.88
-
CSI 1.66rCSI 1.7%PRS 79.03
-
CSI 1.64rCSI 8.22%PRS 79.77
-
CSI 1.64rCSI 1.57%PRS 66.78
-
CSI 1.61rCSI 4.75%PRS 69.61
-
CSI 1.58rCSI 1.52%PRS 86.66
-
CSI 1.54rCSI 3.49%PRS 69.88
-
CSI 1.53rCSI 2.25%PRS 60.18
-
CSI 1.5rCSI 2.66%PRS 47.47
-
CSI 1.5rCSI 1.92%PRS 71.46
-
CSI 1.49rCSI 8.79%PRS 49.55
-
CSI 1.49rCSI 1.78%PRS 85.43
-
CSI 1.49rCSI 2.07%PRS 65.72
-
CSI 1.47rCSI 2.37%PRS 56.63
-
CSI 1.41rCSI 2.48%PRS 63.62
-
CSI 1.4rCSI 1.91%PRS 78.28
-
CSI 1.4rCSI 4.04%PRS 67.94
-
CSI 1.39rCSI 1.82%PRS 80.11
-
CSI 1.34rCSI 2.14%PRS 59.26
-
CSI 1.34rCSI 1.92%PRS 56.6
-
CSI 1.34rCSI 1.82%PRS 58.61
-
CSI 1.28rCSI 2.06%PRS 50.4
-
CSI 1.28rCSI 4.84%PRS 48.97
-
CSI 1.28rCSI 2.14%PRS 48.42
-
CSI 1.24rCSI 1.87%PRS 71.94
-
CSI 1.21rCSI 2.41%PRS 83.1
-
CSI 1.15rCSI 2.16%PRS 55.09
-
CSI 1.1rCSI 1.62%PRS 62.28
-
CSI 0.3rCSI 6.6%PRS 47.5%
-
CSI 0.3rCSI 1.6%PRS 75.2%
-
CSI 0.3rCSI 7.1%PRS 48.2%
-
CSI 0.4rCSI 1.6%PRS 46.6%
-
CSI 0.5rCSI 2.7%PRS 75.3%
-
CSI 0.5rCSI 1.6%PRS 50.1%
-
CSI 0.5rCSI 1.6%PRS 52.6%
-
CSI 0.7rCSI 3.3%PRS 56.8%
-
CSI 0.7rCSI 3.3%PRS 67.1%
-
CSI 0.8rCSI 2.2%PRS 56.5%
-
CSI 0.8rCSI 2.6%PRS 71.5%
-
CSI 0.8rCSI 2.0%PRS 46.8%
-
CSI 0.9rCSI 2.5%PRS 77.1%
-
CSI 0.9rCSI 1.7%PRS 70.1%
-
CSI 0.9rCSI 3.3%PRS 85.5%
-
CSI 0.9rCSI 1.1%PRS 57.7%
-
CSI 1.0rCSI 3.1%PRS 64.3%
-
CSI 1.0rCSI 6.2%PRS 58.8%
-
CSI 1.1rCSI 1.7%PRS 69.6%
-
CSI 1.1rCSI 1.6%PRS 62.3%
-
CSI 1.2rCSI 2.2%PRS 55.1%
-
CSI 1.2rCSI 2.4%PRS 83.1%
-
CSI 1.2rCSI 1.9%PRS 71.9%
-
CSI 1.3rCSI 2.1%PRS 48.4%
-
CSI 1.3rCSI 4.8%PRS 49.0%
-
CSI 1.3rCSI 2.1%PRS 50.4%
-
CSI 1.3rCSI 1.8%PRS 58.6%
-
CSI 1.3rCSI 1.9%PRS 56.6%
-
CSI 1.3rCSI 2.1%PRS 59.3%
-
CSI 1.4rCSI 1.8%PRS 80.1%
-
CSI 1.4rCSI 4.0%PRS 67.9%
-
CSI 1.4rCSI 1.9%PRS 78.3%
-
CSI 1.4rCSI 2.5%PRS 63.6%
-
CSI 1.5rCSI 2.4%PRS 56.6%
-
CSI 1.5rCSI 2.1%PRS 65.7%
-
CSI 1.5rCSI 1.8%PRS 85.4%
-
CSI 1.5rCSI 8.8%PRS 49.6%
-
CSI 1.5rCSI 1.9%PRS 71.5%
-
CSI 1.5rCSI 2.7%PRS 47.5%
-
CSI 1.5rCSI 2.3%PRS 60.2%
-
CSI 1.5rCSI 3.5%PRS 69.9%
-
CSI 1.6rCSI 1.5%PRS 86.7%
-
CSI 1.6rCSI 4.8%PRS 69.6%
-
CSI 1.6rCSI 1.6%PRS 66.8%
-
CSI 1.6rCSI 8.2%PRS 79.8%
-
CSI 1.7rCSI 1.7%PRS 79.0%
-
CSI 1.7rCSI 1.9%PRS 59.9%
-
CSI 1.7rCSI 2.1%PRS 46.5%
-
CSI 1.7rCSI 1.3%PRS 69.9%
-
CSI 1.7rCSI 1.9%PRS 70.7%
-
CSI 1.7rCSI 1.1%PRS 70.0%
-
CSI 1.7rCSI 2.5%PRS 69.0%
-
CSI 1.8rCSI 1.8%PRS 64.9%
-
CSI 1.8rCSI 1.6%PRS 76.0%
-
CSI 1.8rCSI 2.6%PRS 71.9%
-
CSI 1.8rCSI 1.6%PRS 55.0%
-
CSI 1.8rCSI 2.4%PRS 63.8%
-
CSI 1.9rCSI 3.2%PRS 57.4%
-
CSI 1.9rCSI 1.8%PRS 58.3%
-
CSI 1.9rCSI 2.9%PRS 63.4%
-
CSI 1.9rCSI 7.6%PRS 77.9%
-
CSI 1.9rCSI 7.2%PRS 59.0%
-
CSI 2.0rCSI 2.0%PRS 82.3%
-
CSI 2.0rCSI 2.7%PRS 59.8%
-
CSI 2.0rCSI 2.1%PRS 67.2%
-
CSI 2.0rCSI 2.4%PRS 48.2%
-
CSI 2.0rCSI 1.5%PRS 80.6%
-
CSI 2.1rCSI 1.6%PRS 68.4%
-
CSI 2.1rCSI 3.3%PRS 59.7%
-
CSI 2.1rCSI 3.1%PRS 72.4%
-
CSI 2.1rCSI 1.5%PRS 70.0%
-
CSI 2.1rCSI 3.9%PRS 58.5%
-
CSI 2.2rCSI 1.8%PRS 66.7%
-
CSI 2.2rCSI 2.0%PRS 72.5%
-
CSI 2.3rCSI 5.9%PRS 75.7%
-
CSI 2.3rCSI 1.9%PRS 68.9%
-
CSI 2.3rCSI 2.6%PRS 83.1%
-
CSI 2.3rCSI 2.8%PRS 74.6%
-
CSI 2.4rCSI 1.9%PRS 73.6%
-
CSI 2.4rCSI 4.2%PRS 59.4%
-
CSI 2.4rCSI 4.3%PRS 74.9%
-
CSI 2.4rCSI 2.9%PRS 65.2%
-
CSI 2.4rCSI 1.8%PRS 82.6%
-
CSI 2.4rCSI 6.2%PRS 61.0%
-
CSI 2.5rCSI 5.0%PRS 56.2%
-
CSI 2.6rCSI 3.8%PRS 68.0%
-
CSI 2.6rCSI 2.7%PRS 67.0%
-
CSI 2.6rCSI 2.3%PRS 64.3%
-
CSI 2.6rCSI 1.9%PRS 59.9%
-
CSI 2.6rCSI 2.0%PRS 72.9%
-
CSI 2.6rCSI 2.1%PRS 54.1%
-
CSI 2.6rCSI 3.8%PRS 63.4%
-
CSI 2.7rCSI 3.4%PRS 73.2%
-
CSI 2.7rCSI 2.4%PRS 77.8%
-
CSI 2.8rCSI 2.3%PRS 67.4%
-
CSI 2.9rCSI 7.1%PRS 65.8%
-
CSI 2.9rCSI 5.3%PRS 60.2%
-
CSI 2.9rCSI 2.1%PRS 78.6%
-
CSI 3.0rCSI 2.9%PRS 69.8%
-
CSI 3.1rCSI 3.9%PRS 77.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2073468193
Symbol: REQU_HUMAN
Name: Zinc finger protein ubi-d4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9253601
Title: A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.
PubMed ID: 9253601
DOI: 10.1101/gr.7.7.725
PubMed ID: 9680388
Title: Expression and chromosomal localization of the Requiem gene.
PubMed ID: 9680388
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8812431
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20460684
Title: Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.
PubMed ID: 20460684
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29429572
Title: Mutations in the BAF-complex subunit DPF2 are associated with Coffin-Siris syndrome.
PubMed ID: 29429572
PubMed ID: 21888896
Title: Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.
PubMed ID: 21888896
PubMed ID: 27775714
Title: Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.
PubMed ID: 27775714
PubMed ID: 28533407
Title: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.
PubMed ID: 28533407
Sequence Information:
- Length: 391
- Mass: 44155
- Checksum: 1044B4D3036075FC
- Sequence:
MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN SRARKRILEP DDFLDDLDDE DYEEDTPKRR GKGKSKGKGV GSARKKLDAS ILEDRDKPYA CDICGKRYKN RPGLSYHYAH SHLAEEEGED KEDSQPPTPV SQRSEEQKSK KGPDGLALPN NYCDFCLGDS KINKKTGQPE ELVSCSDCGR SGHPSCLQFT PVMMAAVKTY RWQCIECKCC NICGTSENDD QLLFCDDCDR GYHMYCLTPS MSEPPEGSWS CHLCLDLLKE KASIYQNQNS S
Genular Protein ID: 525760308
Symbol: J3KMZ8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 405
- Mass: 45780
- Checksum: EF4C5A781BAD84B8
- Sequence:
MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN SRARKRILEP DDFLDDLDDE DYEEDTPKRR GKGKSKGKGV GSARKKLDAS ILEDRDKPYA CDNSFKQKHT SKAPQRVCGK RYKNRPGLSY HYAHSHLAEE EGEDKEDSQP PTPVSQRSEE QKSKKGPDGL ALPNNYCDFC LGDSKINKKT GQPEELVSCS DCGRSGHPSC LQFTPVMMAA VKTYRWQCIE CKCCNICGTS ENDDQLLFCD DCDRGYHMYC LTPSMSEPPE GSWSCHLCLD LLKEKASIYQ NQNSS