REST | ENSG00000084093 | NCBI 5978

Details for: REST

Gene ID: 5978

Symbol: REST

Ensembl ID: ENSG00000084093

Description: RE1 silencing transcription factor

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Pip3 activates akt signaling
(R-HSA-1257604)
Potential therapeutics for sars
(R-HSA-9679191)
Pten regulation
(R-HSA-6807070)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 gene transcription
(R-HSA-9768777)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov infections
(R-HSA-9679506)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by npas4
(R-HSA-9634815)
Viral infection pathways
(R-HSA-9824446)
Auditory receptor cell stereocilium organization
(GO:0060088)
Cardiac muscle cell myoblast differentiation
(GO:0060379)
Cellular response to electrical stimulus
(GO:0071257)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to stress
(GO:0033554)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Detection of mechanical stimulus involved in sensory perception of sound
(GO:0050910)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Modification of synaptic structure
(GO:0099563)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of aldosterone biosynthetic process
(GO:0032348)
Negative regulation of amniotic stem cell differentiation
(GO:2000798)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cortisol biosynthetic process
(GO:2000065)
Negative regulation of dense core granule biogenesis
(GO:2000706)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of mesenchymal stem cell differentiation
(GO:2000740)
Negative regulation of mirna transcription
(GO:1902894)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system process
(GO:0050877)
Neuromuscular process controlling balance
(GO:0050885)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of programmed cell death
(GO:0043068)
Positive regulation of stem cell population maintenance
(GO:1902459)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of osteoblast differentiation
(GO:0045667)
Response to hypoxia
(GO:0001666)
Response to ischemia
(GO:0002931)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Somatic stem cell population maintenance
(GO:0035019)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription repressor complex
(GO:0017053)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 214.2785
Cell Significance Index: -33.3300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 111.3571
Cell Significance Index: -28.2500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 87.4869
Cell Significance Index: -36.0400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 82.0444
Cell Significance Index: -38.7400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 80.9832
Cell Significance Index: -32.9000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 72.3485
Cell Significance Index: -37.2200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 57.7626
Cell Significance Index: -38.7600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 34.9413
Cell Significance Index: -33.3600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 29.6442
Cell Significance Index: -36.5500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.9786
Cell Significance Index: -29.4100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.6697
Cell Significance Index: -29.7000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.5374
Cell Significance Index: -37.6400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.1599
Cell Significance Index: -15.6700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 3.6859
Cell Significance Index: 701.4500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.0853
Cell Significance Index: 339.1500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.8259
Cell Significance Index: 102.4600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.7046
Cell Significance Index: 21.8300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.5343
Cell Significance Index: 98.9900
Cell Name: germ cell (CL0000586)
Fold Change: 1.4800
Cell Significance Index: 11.1800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.4590
Cell Significance Index: 87.5900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3678
Cell Significance Index: 37.2300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.3183
Cell Significance Index: 45.8100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1434
Cell Significance Index: 157.0200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0913
Cell Significance Index: 134.1900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0777
Cell Significance Index: 194.2700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0654
Cell Significance Index: 211.4300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.9999
Cell Significance Index: 20.9300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9252
Cell Significance Index: 409.0600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8696
Cell Significance Index: 474.9100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7576
Cell Significance Index: 20.2300
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7557
Cell Significance Index: 19.8700
Cell Name: kidney cell (CL1000497)
Fold Change: 0.7076
Cell Significance Index: 5.6500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6845
Cell Significance Index: 35.6600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6836
Cell Significance Index: 617.2500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6228
Cell Significance Index: 44.0500
Cell Name: peg cell (CL4033014)
Fold Change: 0.5990
Cell Significance Index: 13.8400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5405
Cell Significance Index: 63.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5070
Cell Significance Index: 23.8300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4682
Cell Significance Index: 21.8300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3964
Cell Significance Index: 11.4200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3935
Cell Significance Index: 20.4400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3608
Cell Significance Index: 46.2500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3361
Cell Significance Index: 33.2500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2897
Cell Significance Index: 13.1300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2737
Cell Significance Index: 7.3400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.2732
Cell Significance Index: 2.9700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1864
Cell Significance Index: 4.6600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1819
Cell Significance Index: 13.9600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1700
Cell Significance Index: 19.4100
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.1441
Cell Significance Index: 1.2100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1423
Cell Significance Index: 24.3000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1163
Cell Significance Index: 5.8800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0885
Cell Significance Index: 2.6000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0806
Cell Significance Index: 6.0100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0771
Cell Significance Index: 2.7100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0625
Cell Significance Index: 117.7200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0454
Cell Significance Index: 0.7600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0390
Cell Significance Index: 28.6300
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0374
Cell Significance Index: 4.8300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0195
Cell Significance Index: 0.1800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0185
Cell Significance Index: 11.7800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0160
Cell Significance Index: 9.9900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0148
Cell Significance Index: 20.1900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0096
Cell Significance Index: 17.6400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0073
Cell Significance Index: 11.2200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0183
Cell Significance Index: -8.3200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0202
Cell Significance Index: -14.9500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0257
Cell Significance Index: -19.4800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0297
Cell Significance Index: -4.3100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0393
Cell Significance Index: -27.2000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0429
Cell Significance Index: -4.3800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0444
Cell Significance Index: -25.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0795
Cell Significance Index: -9.1100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0843
Cell Significance Index: -30.2300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0849
Cell Significance Index: -2.2700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1209
Cell Significance Index: -34.7900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1287
Cell Significance Index: -1.3300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1292
Cell Significance Index: -27.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1385
Cell Significance Index: -3.8700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1623
Cell Significance Index: -32.5600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1771
Cell Significance Index: -1.0700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1826
Cell Significance Index: -21.2800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1935
Cell Significance Index: -2.6400
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2049
Cell Significance Index: -4.0000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2105
Cell Significance Index: -13.2700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2188
Cell Significance Index: -5.5900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2496
Cell Significance Index: -15.3400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2517
Cell Significance Index: -3.5300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2534
Cell Significance Index: -7.2700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3046
Cell Significance Index: -3.4600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3145
Cell Significance Index: -32.7500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3159
Cell Significance Index: -25.0200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3409
Cell Significance Index: -6.3000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3428
Cell Significance Index: -10.9800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5312
Cell Significance Index: -32.5700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5758
Cell Significance Index: -38.7200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6049
Cell Significance Index: -8.9300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6275
Cell Significance Index: -7.4800
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.7183
Cell Significance Index: -6.1100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7329
Cell Significance Index: -18.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **DNA-binding transcription factor**: REST is a member of the E1A family of transcription factors, which are known for their ability to bind to specific DNA sequences. 2. **Transcriptional repressor**: REST is primarily a transcriptional repressor, which means it inhibits the expression of target genes. 3. **Chromatin remodeling**: REST interacts with chromatin-modifying enzymes to regulate chromatin structure and accessibility. 4. **Cellular differentiation**: REST is involved in various cellular differentiation processes, including cardiac muscle cell differentiation, neuronal differentiation, and stem cell maintenance. 5. **Regulation of gene expression**: REST modulates the expression of numerous genes, including those involved in immune responses, neuronal development, and cancer. **Pathways and Functions:** 1. **Cardiac muscle cell differentiation**: REST regulates the expression of cardiac muscle cell-specific genes, including those involved in cardiac muscle development and function. 2. **Cellular response to electrical stimulus**: REST is involved in the regulation of cellular responses to electrical stimuli, including those involved in cardiac muscle cell contraction and relaxation. 3. **Regulation of alternative mRNA splicing**: REST interacts with the spliceosome to regulate alternative mRNA splicing, which is essential for cellular differentiation and development. 4. **Immune responses**: REST modulates the expression of genes involved in immune responses, including those involved in inflammation and immune cell development. 5. **Neuronal development**: REST is involved in the regulation of neuronal development, including the expression of genes involved in neuronal differentiation and survival. **Clinical Significance:** 1. **Cancer**: Dysregulation of REST has been implicated in various cancers, including leukemia, lymphoma, and breast cancer. 2. **Neurological disorders**: REST dysregulation has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Infectious diseases**: REST modulates the expression of genes involved in immune responses, which is essential for combating infectious diseases. 4. **Cardiac muscle cell differentiation**: REST dysregulation has been implicated in cardiac muscle cell differentiation disorders, including dilated cardiomyopathy and heart failure. 5. **Stem cell maintenance**: REST is involved in the regulation of stem cell maintenance, which is essential for tissue repair and regeneration. In conclusion, REST is a critical regulator of gene expression and cellular differentiation, and its dysregulation has been implicated in various diseases. Further research is necessary to fully understand the mechanisms by which REST regulates gene expression and cellular differentiation, and to develop therapeutic strategies for targeting REST dysregulation in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RE1-silencing transcription factor
A0A1W2PQA1_HUMAN

Genular Protein ID: 987527687

Symbol: REST_HUMAN

Name: RE1-silencing transcription factor

UniProtKB Accession Codes:

Q13127 A2RUE0 B9EGJ0 Q12956 Q12957 Q13134 Q59ER1 Q8IWI3

Database IDs:

Citations:

PubMed ID: 7697725

Title: REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.

PubMed ID: 7697725

DOI: 10.1016/0092-8674(95)90298-8

PubMed ID: 7871435

Title: The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.

PubMed ID: 7871435

DOI: 10.1126/science.7871435

PubMed ID: 8568247

Title: A zinc finger protein that represses transcription of the human MHC class II gene, DPA.

PubMed ID: 8568247

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10521596

Title: Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat.

PubMed ID: 10521596

DOI: 10.1016/s0169-328x(99)00196-5

PubMed ID: 10449787

Title: CoREST: a functional corepressor required for regulation of neural-specific gene expression.

PubMed ID: 10449787

DOI: 10.1073/pnas.96.17.9873

PubMed ID: 10734093

Title: The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.

PubMed ID: 10734093

DOI: 10.1074/jbc.275.13.9461

PubMed ID: 11779185

Title: REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation.

PubMed ID: 11779185

DOI: 10.1006/bbrc.2001.6194

PubMed ID: 11741002

Title: RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressor.

PubMed ID: 11741002

DOI: 10.1016/s0197-0186(01)00091-2

PubMed ID: 12399542

Title: Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.

PubMed ID: 12399542

DOI: 10.1126/science.1076469

PubMed ID: 14645515

Title: REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor.

PubMed ID: 14645515

DOI: 10.1128/mcb.23.24.9025-9031.2003

PubMed ID: 16442230

Title: Characterization of the nuclear targeting signal of REST/NRSF.

PubMed ID: 16442230

DOI: 10.1016/j.neulet.2005.12.080

PubMed ID: 19061646

Title: CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

PubMed ID: 19061646

DOI: 10.1016/j.molcel.2008.10.025

PubMed ID: 18354482

Title: Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

PubMed ID: 18354482

DOI: 10.1038/nature06641

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21284946

Title: Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes.

PubMed ID: 21284946

DOI: 10.1016/j.yjmcc.2011.01.017

PubMed ID: 21258371

Title: Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.

PubMed ID: 21258371

DOI: 10.1038/ncb2153

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24670762

Title: REST and stress resistance in ageing and Alzheimer's disease.

PubMed ID: 24670762

DOI: 10.1038/nature13163

PubMed ID: 26053433

Title: Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness.

PubMed ID: 26053433

DOI: 10.1038/srep11207

PubMed ID: 27531581

Title: REST is a hypoxia-responsive transcriptional repressor.

PubMed ID: 27531581

DOI: 10.1038/srep31355

PubMed ID: 30684677

Title: Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients.

PubMed ID: 30684677

DOI: 10.1016/j.neulet.2019.01.042

PubMed ID: 16288918

Title: The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix.

PubMed ID: 16288918

DOI: 10.1016/j.jmb.2005.10.008

PubMed ID: 26551668

Title: Mutations in the transcriptional repressor REST predispose to Wilms tumor.

PubMed ID: 26551668

DOI: 10.1038/ng.3440

PubMed ID: 28686854

Title: REST final-exon-truncating mutations cause hereditary gingival fibromatosis.

PubMed ID: 28686854

DOI: 10.1016/j.ajhg.2017.06.006

PubMed ID: 29961578

Title: Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness.

PubMed ID: 29961578

DOI: 10.1016/j.cell.2018.06.004

Sequence Information:

Length: 1097
Mass: 121872
Checksum: EBC652EED19CA161
Sequence:

MATQVMGQSS GGGGLFTSSG NIGMALPNDM YDLHDLSKAE LAAPQLIMLA NVALTGEVNG 
SCCDYLVGEE RQMAELMPVG DNNFSDSEEG EGLEESADIK GEPHGLENME LRSLELSVVE 
PQPVFEASGA PDIYSSNKDL PPETPGAEDK GKSSKTKPFR CKPCQYEAES EEQFVHHIRV 
HSAKKFFVEE SAEKQAKARE SGSSTAEEGD FSKGPIRCDR CGYNTNRYDH YTAHLKHHTR 
AGDNERVYKC IICTYTTVSE YHWRKHLRNH FPRKVYTCGK CNYFSDRKNN YVQHVRTHTG 
ERPYKCELCP YSSSQKTHLT RHMRTHSGEK PFKCDQCSYV ASNQHEVTRH ARQVHNGPKP 
LNCPHCDYKT ADRSNFKKHV ELHVNPRQFN CPVCDYAASK KCNLQYHFKS KHPTCPNKTM 
DVSKVKLKKT KKREADLPDN ITNEKTEIEQ TKIKGDVAGK KNEKSVKAEK RDVSKEKKPS 
NNVSVIQVTT RTRKSVTEVK EMDVHTGSNS EKFSKTKKSK RKLEVDSHSL HGPVNDEESS 
TKKKKKVESK SKNNSQEVPK GDSKVEENKK QNTCMKKSTK KKTLKNKSSK KSSKPPQKEP 
VEKGSAQMDP PQMGPAPTEA VQKGPVQVEP PPPMEHAQME GAQIRPAPDE PVQMEVVQEG 
PAQKELLPPV EPAQMVGAQI VLAHMELPPP METAQTEVAQ MGPAPMEPAQ MEVAQVESAP 
MQVVQKEPVQ MELSPPMEVV QKEPVQIELS PPMEVVQKEP VKIELSPPIE VVQKEPVQME 
LSPPMGVVQK EPAQREPPPP REPPLHMEPI SKKPPLRKDK KEKSNMQSER ARKEQVLIEV 
GLVPVKDSWL LKESVSTEDL SPPSPPLPKE NLREEASGDQ KLLNTGEGNK EAPLQKVGAE 
EADESLPGLA ANINESTHIS SSGQNLNTPE GETLNGKHQT DSIVCEMKMD TDQNTRENLT 
GINSTVEEPV SPMLPPSAVE EREAVSKTAL ASPPATMAAN ESQEIDEDEG IHSHEGSDLS 
DNMSEGSDDS GLHGARPVPQ ESSRKNAKEA LAVKAAKGDF VCIFCDRSFR KGKDYSKHLN 
RHLVNVYYLE EAAQGQE

Genular Protein ID: 3144527305

Symbol: A0A1W2PQA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1W2PQA1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 1069
Mass: 118556
Checksum: 568728E013833893
Sequence:

MATQVMGQSS GGGGLFTSSG NIGMALPNDM YDLHDLSKAE LAAPQLIMLA NVALTGEVNG 
SCCDYLVGEE RQMAELMPVG DNNFSDSEEG EGLEESADIK GEPHGLENME LRSLELSVVE 
PQPVFEASGA PDIYSSNKDL PPETPGAEDK GKSSKTKPFR CKPCQYEAES EEQFVHHIRV 
HSAKKFFVEE SAEKQAKARE SGSSTAEEGD FSKGPIRCDR CGYNTNRYDH YTAHLKHHTR 
AGDNERVYKC IICTYTTVSE YHWRKHLRNH FPRKVYTCGK CNYFSDRKNN YVQHVRTHTG 
EKPFKCDQCS YVASNQHEVT RHARQVHNGP KPLNCPHCDY KTADRSNFKK HVELHVNPRQ 
FNCPVCDYAA SKKCNLQYHF KSKHPTCPNK TMDVSKVKLK KTKKREADLP DNITNEKTEI 
EQTKIKGDVA GKKNEKSVKA EKRDVSKEKK PSNNVSVIQV TTRTRKSVTE VKEMDVHTGS 
NSEKFSKTKK SKRKLEVDSH SLHGPVNDEE SSTKKKKKVE SKSKNNSQEV PKGDSKVEEN 
KKQNTCMKKS TKKKTLKNKS SKKSSKPPQK EPVEKGSAQM DPPQMGPAPT EAVQKGPVQV 
EPPPPMEHAQ MEGAQIRPAP DEPVQMEVVQ EGPAQKELLP PVEPAQMVGA QIVLAHMELP 
PPMETAQTEV AQMGPAPMEP AQMEVAQVES APMQVVQKEP VQMELSPPME VVQKEPVQIE 
LSPPMEVVQK EPVKIELSPP IEVVQKEPVQ MELSPPMGVV QKEPAQREPP PPREPPLHME 
PISKKPPLRK DKKEKSNMQS ERARKEQVLI EVGLVPVKDS WLLKESVSTE DLSPPSPPLP 
KENLREEASG DQKLLNTGEG NKEAPLQKVG AEEADESLPG LAANINESTH ISSSGQNLNT 
PEGETLNGKH QTDSIVCEMK MDTDQNTREN LTGINSTVEE PVSPMLPPSA VEEREAVSKT 
ALASPPATMA ANESQEIDED EGIHSHEGSD LSDNMSEGSD DSGLHGARPV PQESSRKNAK 
EALAVKAAKG DFVCIFCDRS FRKGKDYSKH LNRHLVNVYY LEEAAQGQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: REST

Associated with

Cells (max top 100)

Other Information

REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. PubMed ID: 7697725

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. PubMed ID: 7871435

A zinc finger protein that represses transcription of the human MHC class II gene, DPA. PubMed ID: 8568247

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. PubMed ID: 10521596

CoREST: a functional corepressor required for regulation of neural-specific gene expression. PubMed ID: 10449787

The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. PubMed ID: 10734093

REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation. PubMed ID: 11779185

RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressor. PubMed ID: 11741002

Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. PubMed ID: 12399542

REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. PubMed ID: 14645515

Characterization of the nuclear targeting signal of REST/NRSF. PubMed ID: 16442230

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. PubMed ID: 19061646

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. PubMed ID: 18354482

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. PubMed ID: 21284946

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. PubMed ID: 21258371

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

REST and stress resistance in ageing and Alzheimer's disease. PubMed ID: 24670762

Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness. PubMed ID: 26053433

REST is a hypoxia-responsive transcriptional repressor. PubMed ID: 27531581

Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients. PubMed ID: 30684677

The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. PubMed ID: 16288918

Mutations in the transcriptional repressor REST predispose to Wilms tumor. PubMed ID: 26551668

REST final-exon-truncating mutations cause hereditary gingival fibromatosis. PubMed ID: 28686854

Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness. PubMed ID: 29961578

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Database document:

PubMed ID: 7697725

PubMed ID: 7871435

PubMed ID: 8568247

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 10521596

PubMed ID: 10449787

PubMed ID: 10734093

PubMed ID: 11779185

PubMed ID: 11741002

PubMed ID: 12399542

PubMed ID: 14645515

PubMed ID: 16442230

PubMed ID: 19061646

PubMed ID: 18354482

PubMed ID: 19413330

PubMed ID: 20068231

PubMed ID: 21284946

PubMed ID: 21258371

PubMed ID: 23186163

PubMed ID: 24670762

PubMed ID: 26053433

PubMed ID: 27531581

PubMed ID: 30684677

PubMed ID: 16288918

PubMed ID: 26551668

PubMed ID: 28686854

PubMed ID: 29961578

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 15815621