REST | ENSG00000084093 | NCBI 5978

Details for: REST

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Pip3 activates akt signaling
(R-HSA-1257604)
Potential therapeutics for sars
(R-HSA-9679191)
Pten regulation
(R-HSA-6807070)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 gene transcription
(R-HSA-9768777)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov infections
(R-HSA-9679506)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by npas4
(R-HSA-9634815)
Viral infection pathways
(R-HSA-9824446)
Auditory receptor cell stereocilium organization
(GO:0060088)
Cardiac muscle cell myoblast differentiation
(GO:0060379)
Cellular response to electrical stimulus
(GO:0071257)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to stress
(GO:0033554)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Detection of mechanical stimulus involved in sensory perception of sound
(GO:0050910)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Modification of synaptic structure
(GO:0099563)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of aldosterone biosynthetic process
(GO:0032348)
Negative regulation of amniotic stem cell differentiation
(GO:2000798)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cortisol biosynthetic process
(GO:2000065)
Negative regulation of dense core granule biogenesis
(GO:2000706)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of mesenchymal stem cell differentiation
(GO:2000740)
Negative regulation of mirna transcription
(GO:1902894)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system process
(GO:0050877)
Neuromuscular process controlling balance
(GO:0050885)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of programmed cell death
(GO:0043068)
Positive regulation of stem cell population maintenance
(GO:1902459)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of osteoblast differentiation
(GO:0045667)
Response to hypoxia
(GO:0001666)
Response to ischemia
(GO:0002931)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Somatic stem cell population maintenance
(GO:0035019)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription repressor complex
(GO:0017053)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

fallopian tube secretory epithelial cell CL4030006

CSI 28.62

rCSI 27.55%

PRS 30.52
CD4-positive helper T cell CL0000492

CSI 18.14

rCSI 13.72%

PRS 39.86
double negative thymocyte CL0002489

CSI 10.79

rCSI 7.5%

PRS 35.76
common dendritic progenitor CL0001029

CSI 8.99

rCSI 11.28%

PRS 37.77
retinal rod cell CL0000604

CSI 8.57

rCSI 15.11%

PRS 28.87
epithelial cell CL0000066

CSI 8.12

rCSI 12.48%

PRS 36.07
activated CD4-positive, alpha-beta T cell CL0000896

CSI 7.5

rCSI 6.93%

PRS 49.15
astrocyte of the cerebral cortex CL0002605

CSI 7.31

rCSI 16.39%

PRS 19.08
epithelial cell of lower respiratory tract CL0002632

CSI 7.14

rCSI 5.54%

PRS 29.08
podocyte CL0000653

CSI 5.58

rCSI 24.78%

PRS 28.65
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 5.48

rCSI 7.46%

PRS 58.4
helper T cell CL0000912

CSI 5.12

rCSI 7.24%

PRS 39.49
regular ventricular cardiac myocyte CL0002131

CSI 4.99

rCSI 31.18%

PRS 24.07
lymphoid lineage restricted progenitor cell CL0000838

CSI 4.94

rCSI 19.22%

PRS 47.16
mesenchymal cell CL0008019

CSI 4.65

rCSI 11.82%

PRS 28.41
transit amplifying cell CL0009010

CSI 4.24

rCSI 6.49%

PRS 45.32
vascular associated smooth muscle cell CL0000359

CSI 4.08

rCSI 13.24%

PRS 34.03
luminal cell of prostate epithelium CL0002340

CSI 3.99

rCSI 21.46%

PRS 46.45
pro-B cell CL0000826

CSI 3.92

rCSI 3.25%

PRS 30.09
double-positive, alpha-beta thymocyte CL0000809

CSI 3.84

rCSI 3.91%

PRS 41.01
unswitched memory B cell CL0000970

CSI 3.76

rCSI 3.16%

PRS 44.82
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.57

rCSI 5.07%

PRS 27.61
hematopoietic precursor cell CL0008001

CSI 3.52

rCSI 3.62%

PRS 45.33
myelocyte CL0002193

CSI 3.46

rCSI 22.73%

PRS 67.59
goblet cell CL0000160

CSI 3.46

rCSI 3.27%

PRS 30.84
dendritic cell, human CL0001056

CSI 3.41

rCSI 5.23%

PRS 35.06
midzonal region hepatocyte CL0019028

CSI 3.39

rCSI 7.95%

PRS 39.98
plasmablast CL0000980

CSI 3.23

rCSI 2.54%

PRS 35.18
plasmacytoid dendritic cell, human CL0001058

CSI 3.17

rCSI 2.21%

PRS 31.21
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 3.09

rCSI 3.04%

PRS 43.54
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.02

rCSI 2.42%

PRS 49.33
hematopoietic stem cell CL0000037

CSI 2.96

rCSI 1.97%

PRS 34.02
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.91

rCSI 2.09%

PRS 39.98
myeloid lineage restricted progenitor cell CL0000839

CSI 2.86

rCSI 14.79%

PRS 52.53
acinar cell CL0000622

CSI 2.82

rCSI 4.13%

PRS 38.37
fibroblast of cardiac tissue CL0002548

CSI 2.79

rCSI 13.36%

PRS 26.9
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.79

rCSI 2.12%

PRS 38.61
lung macrophage CL1001603

CSI 2.7

rCSI 6.04%

PRS 34.52
alpha-beta T cell CL0000789

CSI 2.6

rCSI 3.05%

PRS 41.45
myeloid leukocyte CL0000766

CSI 2.55

rCSI 2.35%

PRS 30.7
renal alpha-intercalated cell CL0005011

CSI 2.51

rCSI 3.35%

PRS 36.77
skin fibroblast CL0002620

CSI 2.48

rCSI 2.14%

PRS 40.52
melanocyte CL0000148

CSI 2.47

rCSI 1.83%

PRS 25.51
class switched memory B cell CL0000972

CSI 2.46

rCSI 1.84%

PRS 46.78
immature B cell CL0000816

CSI 2.44

rCSI 1.81%

PRS 41.46
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.43

rCSI 6.33%

PRS 28.49
neuroblast (sensu Vertebrata) CL0000031

CSI 2.42

rCSI 3.11%

PRS 28.3
myofibroblast cell CL0000186

CSI 2.42

rCSI 3.36%

PRS 37.19
blood vessel endothelial cell CL0000071

CSI 2.38

rCSI 4.94%

PRS 29.03
glioblast CL0000030

CSI 2.35

rCSI 3.75%

PRS 25.3
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.33

rCSI 1.37%

PRS 41.18
hepatocyte CL0000182

CSI 2.32

rCSI 4.15%

PRS 27.81
T-helper 17 cell CL0000899

CSI 2.3

rCSI 1.83%

PRS 49.63
renal interstitial pericyte CL1001318

CSI 2.29

rCSI 6.31%

PRS 27.74
Bergmann glial cell CL0000644

CSI 2.25

rCSI 3.08%

PRS 28.61
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.23

rCSI 1.5%

PRS 36.93
nasal mucosa goblet cell CL0002480

CSI 2.23

rCSI 2.58%

PRS 40.5
Schwann cell CL0002573

CSI 2.23

rCSI 6.32%

PRS 31.49
mature T cell CL0002419

CSI 2.22

rCSI 1.73%

PRS 42.94
tracheobronchial smooth muscle cell CL0019019

CSI 2.2

rCSI 3.89%

PRS 37.27
Mueller cell CL0000636

CSI 2.19

rCSI 5%

PRS 25.48
fibroblast of lung CL0002553

CSI 2.18

rCSI 2.03%

PRS 29.64
vascular leptomeningeal cell CL4023051

CSI 2.17

rCSI 3.81%

PRS 23.65
keratinocyte CL0000312

CSI 2.16

rCSI 1.81%

PRS 34.47
brush cell of tracheobronchial tree CL0002075

CSI 2.16

rCSI 6.4%

PRS 39.61
precursor B cell CL0000817

CSI 2.12

rCSI 1.86%

PRS 38.2
choroid plexus epithelial cell CL0000706

CSI 2.12

rCSI 3.47%

PRS 23.14
mature B cell CL0000785

CSI 2.11

rCSI 1.83%

PRS 36.79
ciliated epithelial cell CL0000067

CSI 2.07

rCSI 1.82%

PRS 21.85
perivascular cell CL4033054

CSI 2.07

rCSI 2.83%

PRS 33.35
naive T cell CL0000898

CSI 2.07

rCSI 1.44%

PRS 40.6
secretory cell CL0000151

CSI 2.07

rCSI 2.16%

PRS 30.36
cerebral cortex endothelial cell CL1001602

CSI 2.06

rCSI 3.56%

PRS 22.88
pulmonary ionocyte CL0017000

CSI 2.05

rCSI 2.5%

PRS 36.21
interstitial cell of Cajal CL0002088

CSI 2.05

rCSI 2.61%

PRS 33.94
epithelial cell of lung CL0000082

CSI 2

rCSI 1.66%

PRS 28.27
tuft cell of colon CL0009041

CSI 1.96

rCSI 4.57%

PRS 50.49
duct epithelial cell CL0000068

CSI 1.95

rCSI 2.85%

PRS 31.55
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.94

rCSI 2.32%

PRS 48.11
radial glial cell CL0000681

CSI 1.91

rCSI 2.65%

PRS 29.83
ciliated cell CL0000064

CSI 1.89

rCSI 3.07%

PRS 29.38
Kupffer cell CL0000091

CSI 1.88

rCSI 4.3%

PRS 29.12
T follicular helper cell CL0002038

CSI 1.88

rCSI 1.4%

PRS 43.6
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.86

rCSI 2.15%

PRS 25.76
neural crest cell CL0011012

CSI 1.86

rCSI 1.47%

PRS 20.69
renal beta-intercalated cell CL0002201

CSI 1.86

rCSI 4.42%

PRS 32.68
stromal cell CL0000499

CSI 1.83

rCSI 5.15%

PRS 34.1
respiratory suprabasal cell CL4033048

CSI 1.79

rCSI 2.29%

PRS 34.02
small pre-B-II cell CL0000954

CSI 1.77

rCSI 1.7%

PRS 53.61
squamous epithelial cell CL0000076

CSI 1.76

rCSI 4.18%

PRS 35.47
hepatic stellate cell CL0000632

CSI 1.76

rCSI 6.6%

PRS 25.08
ependymal cell CL0000065

CSI 1.76

rCSI 3.57%

PRS 17
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.76

rCSI 1.6%

PRS 43.23
mature alpha-beta T cell CL0000791

CSI 1.75

rCSI 6.33%

PRS 47.14
CD14-low, CD16-positive monocyte CL0002396

CSI 1.7

rCSI 1.31%

PRS 28.03
colon epithelial cell CL0011108

CSI 1.7

rCSI 1.78%

PRS 27.67
myoepithelial cell CL0000185

CSI 1.68

rCSI 4.25%

PRS 36.19
basal cell CL0000646

CSI 1.67

rCSI 2.23%

PRS 31.73
conjunctival epithelial cell CL1000432

CSI 1.64

rCSI 2.5%

PRS 29.93
stem cell CL0000034

CSI 1.63

rCSI 1.57%

PRS 22.41

cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.8%

PRS 41.6%
mesenchymal stem cell CL0000134

CSI 0.2

rCSI 1.8%

PRS 47.5%
eosinophil CL0000771

CSI 0.2

rCSI 1.3%

PRS 62.6%
tracheal goblet cell CL1000329

CSI 0.3

rCSI 0.6%

PRS 50.9%
group 2 innate lymphoid cell CL0001069

CSI 0.3

rCSI 1.8%

PRS 70.4%
erythroid progenitor cell CL0000038

CSI 0.4

rCSI 2.1%

PRS 40.7%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.4

rCSI 0.5%

PRS 32.3%
pancreatic stellate cell CL0002410

CSI 0.4

rCSI 2.4%

PRS 41.1%
microcirculation associated smooth muscle cell CL0008035

CSI 0.5

rCSI 1.4%

PRS 32.6%
kidney connecting tubule epithelial cell CL1000768

CSI 0.5

rCSI 1.3%

PRS 23.0%
megakaryocyte CL0000556

CSI 0.5

rCSI 2.3%

PRS 46.1%
mucus secreting cell CL0000319

CSI 0.6

rCSI 0.9%

PRS 37.9%
parietal epithelial cell CL1000452

CSI 0.6

rCSI 1.6%

PRS 25.0%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.6

rCSI 1.7%

PRS 37.9%
endothelial cell of placenta CL0009092

CSI 0.6

rCSI 3.0%

PRS 39.1%
antibody secreting cell CL0000946

CSI 0.6

rCSI 2.8%

PRS 77.0%
late pro-B cell CL0002048

CSI 0.7

rCSI 1.6%

PRS 63.4%
promonocyte CL0000559

CSI 0.7

rCSI 1.1%

PRS 38.5%
endocardial cell CL0002350

CSI 0.7

rCSI 3.3%

PRS 33.7%
memory T cell CL0000813

CSI 0.7

rCSI 1.3%

PRS 59.4%
vein endothelial cell of respiratory system CL4033008

CSI 0.7

rCSI 4.7%

PRS 50.7%
cardiac muscle cell CL0000746

CSI 0.7

rCSI 1.0%

PRS 23.4%
cardiac neuron CL0010022

CSI 0.7

rCSI 2.3%

PRS 26.3%
primitive red blood cell CL0002355

CSI 0.7

rCSI 3.9%

PRS 45.2%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.7

rCSI 1.7%

PRS 29.7%
myeloid dendritic cell, human CL0001057

CSI 0.8

rCSI 4.2%

PRS 66.4%
large pre-B-II cell CL0000957

CSI 0.8

rCSI 2.2%

PRS 45.0%
mesangial cell CL0000650

CSI 0.8

rCSI 3.1%

PRS 40.7%
germinal center B cell CL0000844

CSI 0.8

rCSI 2.3%

PRS 55.2%
respiratory basal cell CL0002633

CSI 0.8

rCSI 0.8%

PRS 34.6%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.8

rCSI 2.0%

PRS 44.8%
corneal epithelial cell CL0000575

CSI 0.9

rCSI 2.4%

PRS 47.5%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.9

rCSI 1.8%

PRS 46.8%
pluripotent stem cell CL0002248

CSI 0.9

rCSI 27.0%

PRS 55.4%
forebrain radial glial cell CL0013000

CSI 0.9

rCSI 2.9%

PRS 38.8%
epithelial cell of proximal tubule CL0002306

CSI 0.9

rCSI 2.2%

PRS 28.2%
paneth cell CL0000510

CSI 0.9

rCSI 1.4%

PRS 44.5%
elicited macrophage CL0000861

CSI 0.9

rCSI 0.9%

PRS 35.2%
endothelial cell of uterus CL0009095

CSI 1.0

rCSI 6.9%

PRS 61.5%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.0

rCSI 1.3%

PRS 50.6%
retinal cone cell CL0000573

CSI 1.0

rCSI 1.6%

PRS 22.9%
club cell CL0000158

CSI 1.0

rCSI 1.4%

PRS 32.0%
extravillous trophoblast CL0008036

CSI 1.0

rCSI 1.2%

PRS 26.3%
Langerhans cell CL0000453

CSI 1.0

rCSI 1.5%

PRS 47.4%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.0

rCSI 2.9%

PRS 43.6%
enteric smooth muscle cell CL0002504

CSI 1.1

rCSI 1.5%

PRS 32.3%
pancreatic ductal cell CL0002079

CSI 1.1

rCSI 2.1%

PRS 30.6%
Hofbauer cell CL3000001

CSI 1.1

rCSI 2.0%

PRS 37.4%
stromal cell of ovary CL0002132

CSI 1.1

rCSI 2.9%

PRS 45.5%
lung ciliated cell CL1000271

CSI 1.1

rCSI 1.3%

PRS 22.2%
mesodermal cell CL0000222

CSI 1.1

rCSI 1.3%

PRS 28.6%
retinal pigment epithelial cell CL0002586

CSI 1.1

rCSI 2.2%

PRS 30.3%
lung secretory cell CL1000272

CSI 1.1

rCSI 2.8%

PRS 27.9%
thymocyte CL0000893

CSI 1.1

rCSI 4.0%

PRS 69.0%
promyelocyte CL0000836

CSI 1.2

rCSI 1.7%

PRS 39.2%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.2

rCSI 2.0%

PRS 50.9%
granulocyte CL0000094

CSI 1.2

rCSI 1.8%

PRS 37.4%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.2

rCSI 1.5%

PRS 40.9%
intestinal epithelial cell CL0002563

CSI 1.2

rCSI 1.2%

PRS 30.3%
activated type II NK T cell CL0000931

CSI 1.2

rCSI 1.3%

PRS 44.7%
intermediate monocyte CL0002393

CSI 1.2

rCSI 1.8%

PRS 30.5%
cardiac endothelial cell CL0010008

CSI 1.2

rCSI 4.9%

PRS 28.3%
placental villous trophoblast CL2000060

CSI 1.2

rCSI 1.9%

PRS 27.9%
glandular epithelial cell CL0000150

CSI 1.3

rCSI 3.3%

PRS 52.3%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.3

rCSI 1.5%

PRS 35.4%
kidney epithelial cell CL0002518

CSI 1.3

rCSI 2.4%

PRS 54.1%
early lymphoid progenitor CL0000936

CSI 1.3

rCSI 1.2%

PRS 33.7%
chondrocyte CL0000138

CSI 1.3

rCSI 2.1%

PRS 25.1%
muscle cell CL0000187

CSI 1.3

rCSI 2.7%

PRS 53.4%
transit amplifying cell of colon CL0009011

CSI 1.3

rCSI 1.6%

PRS 33.4%
alveolar adventitial fibroblast CL4028006

CSI 1.4

rCSI 2.1%

PRS 30.1%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.4

rCSI 6.9%

PRS 38.5%
bronchus fibroblast of lung CL2000093

CSI 1.4

rCSI 1.2%

PRS 30.7%
common lymphoid progenitor CL0000051

CSI 1.4

rCSI 1.9%

PRS 51.4%
fraction A pre-pro B cell CL0002045

CSI 1.5

rCSI 1.7%

PRS 52.7%
pancreatic acinar cell CL0002064

CSI 1.5

rCSI 2.0%

PRS 32.6%
ionocyte CL0005006

CSI 1.5

rCSI 1.6%

PRS 27.6%
adipocyte CL0000136

CSI 1.5

rCSI 1.9%

PRS 28.2%
group 3 innate lymphoid cell CL0001071

CSI 1.5

rCSI 1.1%

PRS 31.7%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.5

rCSI 3.9%

PRS 27.4%
intestinal tuft cell CL0019032

CSI 1.5

rCSI 2.4%

PRS 33.6%
common myeloid progenitor CL0000049

CSI 1.5

rCSI 1.3%

PRS 29.8%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.6

rCSI 1.4%

PRS 27.1%
multi-ciliated epithelial cell CL0005012

CSI 1.6

rCSI 1.6%

PRS 25.4%
BEST4+ enteroycte CL4030026

CSI 1.6

rCSI 1.9%

PRS 31.7%
respiratory hillock cell CL4030023

CSI 1.6

rCSI 2.8%

PRS 45.2%
innate lymphoid cell CL0001065

CSI 1.6

rCSI 3.3%

PRS 39.7%
small intestine goblet cell CL1000495

CSI 1.6

rCSI 3.5%

PRS 38.7%
IgG plasma cell CL0000985

CSI 1.6

rCSI 1.9%

PRS 47.7%
granulocyte monocyte progenitor cell CL0000557

CSI 1.6

rCSI 1.4%

PRS 32.9%
myeloid dendritic cell CL0000782

CSI 1.6

rCSI 2.3%

PRS 43.5%
stem cell CL0000034

CSI 1.6

rCSI 1.6%

PRS 22.4%
conjunctival epithelial cell CL1000432

CSI 1.6

rCSI 2.5%

PRS 29.9%
basal cell CL0000646

CSI 1.7

rCSI 2.2%

PRS 31.7%
myoepithelial cell CL0000185

CSI 1.7

rCSI 4.3%

PRS 36.2%
colon epithelial cell CL0011108

CSI 1.7

rCSI 1.8%

PRS 27.7%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.7

rCSI 1.3%

PRS 28.0%
mature alpha-beta T cell CL0000791

CSI 1.8

rCSI 6.3%

PRS 47.1%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.8

rCSI 1.6%

PRS 43.2%
ependymal cell CL0000065

CSI 1.8

rCSI 3.6%

PRS 17.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

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Pathway Categories (for ONTOLOGY source):

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Baseline Cell Context(s): Comma-separated if multiple.

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Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [REST](/details-gene/5978) (RE1 Silencing Transcription Factor) is a well-characterized transcriptional repressor that plays a critical role in vertebrate development by silencing neuron-specific gene expression in non-neuronal tissues. It achieves this by binding to the RE1/NRSE DNA element and recruiting a complex of corepressors and chromatin-modifying enzymes ([Link](https://doi.org/10.1016/0092-8674(95)90298-8), [Link](https://doi.org/10.1126/science.7871435)). While its canonical function is in neurogenesis, expression data reveals a broader role, with significant expression in diverse cell types including [fallopian tube secretory epithelial cell](/details-cell/CL4030006), various T lymphocyte populations, and progenitor cells. This suggests that [REST](/details-gene/5978) functions as a master regulator controlling cell fate and identity across multiple lineages. Its dysregulation is associated with human disease, as indicated by its clinical association ([153245](https://omim.org/entry/600571)). ## Cellular Roles and Expression Landscape The expression profile of [REST](/details-gene/5978) underscores its function as a pivotal regulator in a wide range of cellular contexts, extending far beyond its originally described role in neuronal gene silencing. **Overall**, the gene demonstrates its highest significance in highly specialized, non-neuronal cells, suggesting a crucial role in maintaining their specific phenotypes by repressing alternative gene programs. The most prominent expression is observed in the [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 28.62), indicating a potentially vital function in the reproductive system. A significant theme in its expression landscape is its role within the immune system, particularly in the T cell lineage. [REST](/details-gene/5978) shows high significance in [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 18.14), [double negative thymocyte](/details-cell/CL0002489) (CSI: 10.79), [activated CD4-positive, alpha-beta T cell](/details-cell/CL0000896) (CSI: 7.50), and [effector memory CD4-positive, alpha-beta T cell](/details-cell/CL0000905) (CSI: 5.48). This pattern is consistent with a role in regulating T cell development, differentiation, and activation state. Furthermore, [REST](/details-gene/5978) appears to be a key factor in progenitor and specialized differentiated cells from other lineages, including [common dendritic progenitor](/details-cell/CL0001029) (CSI: 8.99), [retinal rod cell](/details-cell/CL0000604) (CSI: 8.57), [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 7.31), and [podocyte](/details-cell/CL0000653) (CSI: 5.58). Its presence in these varied cell types suggests it is a master regulator that actively suppresses inappropriate gene expression to maintain cellular identity across ectodermal, mesodermal, and endodermal lineages. ## Pathways and Molecular Function The molecular function of [REST](/details-gene/5978) is primarily centered on its activity as a [DNA-binding transcription repressor activity, rna polymerase ii-specific](/details-cell/GO:0001227) ([GO:0001227](https://www.ebi.ac.uk/QuickGO/term/GO:0001227)). It operates by binding to specific DNA sequences and assembling a [transcription repressor complex](/details-cell/GO:0017053) ([GO:0017053](https://www.ebi.ac.uk/QuickGO/term/GO:0017053)) that includes histone deacetylases and other chromatin modifiers ([Link](https://doi.org/10.1073/pnas.96.17.9873)). This mechanism is reflected in its association with Reactome pathways such as [Gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160) ([R-HSA-74160](https://reactome.org/content/detail/R-HSA-74160)) and [Chromatin modifying enzymes](https://reactome.org/content/detail/R-HSA-3247509) ([R-HSA-3247509](https://reactome.org/content/detail/R-HSA-3247509)). The functional annotations from Gene Ontology (GO) confirm its established role in the [negative regulation of neurogenesis](/details-cell/GO:0050768) ([GO:0050768](https://www.ebi.ac.uk/QuickGO/term/GO:0050768)) and [negative regulation of neuron differentiation](/details-cell/GO:0045665) ([GO:0045665](https://www.ebi.ac.uk/QuickGO/term/GO:0045665)). However, the annotations also point to a much broader regulatory scope, including: * **Stem Cell and Progenitor Biology:** Involvement in [hematopoietic progenitor cell differentiation](/details-cell/GO:0002244) ([GO:0002244](https://www.ebi.ac.uk/QuickGO/term/GO:0002244)) and [neuronal stem cell population maintenance](/details-cell/GO:0097150) ([GO:0097150](https://www.ebi.ac.uk/QuickGO/term/GO:0097150)) aligns with its expression in progenitor cells and suggests a role in maintaining pluripotency and controlling lineage commitment. * **Cell Proliferation and Apoptosis:** [REST](/details-gene/5978) participates in the [negative regulation of cell population proliferation](/details-cell/GO:0008285) ([GO:0008285](https://www.ebi.ac.uk/QuickGO/term/GO:0008285)) and, paradoxically, the [positive regulation of apoptotic process](/details-cell/GO:0043065) ([GO:0043065](https://www.ebi.ac.uk/QuickGO/term/GO:0043065)). This dual functionality may be context-dependent and could be relevant to its roles in both development and cancer biology. * **Cellular Responses:** The factor is implicated in cellular responses to various stimuli, including [hypoxia](/details-cell/GO:0001666) ([GO:0001666](https://www.ebi.ac.uk/QuickGO/term/GO:0001666)), [glucocorticoid stimulus](/details-cell/GO:0071385) ([GO:0071385](https://www.ebi.ac.uk/QuickGO/term/GO:0071385)), and [stress](/details-cell/GO:0033554) ([GO:0033554](https://www.ebi.ac.uk/QuickGO/term/GO:0033554)), highlighting its role in cellular homeostasis and adaptation. ## Research Directions The broad and cell-type-specific expression profile of [REST](/details-gene/5978), combined with its function as a master transcriptional repressor, opens up several avenues for future investigation. **Testable Hypotheses:** 1. Given its exceptionally high significance in [fallopian tube secretory epithelial cell](/details-cell/CL4030006), [REST](/details-gene/5978) may be essential for maintaining the identity of this cell type by repressing genes associated with ciliated epithelial cells or other alternative fates within the fallopian tube. 2. The consistent high significance of [REST](/details-gene/5978) across multiple stages of T cell development suggests it acts as a critical checkpoint regulator. It may function by suppressing gene networks associated with other hematopoietic lineages (e.g., B cell or myeloid programs) during T cell commitment in the thymus. **Proposed Experimental Approach:** To test the second hypothesis regarding the role of [REST](/details-gene/5978) in T cell lineage commitment, a conditional knockout mouse model using a Lck-Cre or CD4-Cre driver could be employed to specifically delete [REST](/details-gene/5978) in the T cell lineage. Thymocytes and peripheral T cells from these knockout mice and control littermates could be analyzed using single-cell RNA sequencing (scRNA-seq) and ATAC-seq. This approach would allow for the identification of derepressed genes and changes in chromatin accessibility, revealing the specific transcriptional programs that [REST](/details-gene/5978) normally silences to ensure T cell fidelity. Functional assays, such as in vitro T cell differentiation and proliferation assays, would further clarify the phenotypic consequences of its deletion. **Therapeutic Potential:** As a master transcriptional regulator, [REST](/details-gene/5978) presents a complex but potentially valuable therapeutic target. Direct systemic inhibition could have widespread, unpredictable effects due to its role in numerous cell types. However, context-specific modulation of its activity is a promising strategy. For neurological disorders characterized by neuronal loss, targeted inhibition of [REST](/details-gene/5978) could potentially promote the expression of neuroprotective genes. Conversely, in certain cancers where [REST](/details-gene/5978) can act as a tumor suppressor, strategies to enhance its expression or repressive function might be beneficial. Therapeutic development will likely require sophisticated delivery systems (e.g., nanoparticle-based siRNA) or small molecules that disrupt specific protein-protein interactions within the REST co-repressor complex to achieve cell-type or pathway-specific effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RE1-silencing transcription factor
A0A1W2PQA1_HUMAN

Genular Protein ID: 987527687

Symbol: REST_HUMAN

Name: RE1-silencing transcription factor

UniProtKB Accession Codes:

Q13127 A2RUE0 B9EGJ0 Q12956 Q12957 Q13134 Q59ER1 Q8IWI3

Database IDs:

Citations:

PubMed ID: 7697725

Title: REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.

PubMed ID: 7697725

DOI: 10.1016/0092-8674(95)90298-8

PubMed ID: 7871435

Title: The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.

PubMed ID: 7871435

DOI: 10.1126/science.7871435

PubMed ID: 8568247

Title: A zinc finger protein that represses transcription of the human MHC class II gene, DPA.

PubMed ID: 8568247

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10521596

Title: Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat.

PubMed ID: 10521596

DOI: 10.1016/s0169-328x(99)00196-5

PubMed ID: 10449787

Title: CoREST: a functional corepressor required for regulation of neural-specific gene expression.

PubMed ID: 10449787

DOI: 10.1073/pnas.96.17.9873

PubMed ID: 10734093

Title: The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.

PubMed ID: 10734093

DOI: 10.1074/jbc.275.13.9461

PubMed ID: 11779185

Title: REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation.

PubMed ID: 11779185

DOI: 10.1006/bbrc.2001.6194

PubMed ID: 11741002

Title: RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressor.

PubMed ID: 11741002

DOI: 10.1016/s0197-0186(01)00091-2

PubMed ID: 12399542

Title: Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.

PubMed ID: 12399542

DOI: 10.1126/science.1076469

PubMed ID: 14645515

Title: REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor.

PubMed ID: 14645515

DOI: 10.1128/mcb.23.24.9025-9031.2003

PubMed ID: 16442230

Title: Characterization of the nuclear targeting signal of REST/NRSF.

PubMed ID: 16442230

DOI: 10.1016/j.neulet.2005.12.080

PubMed ID: 19061646

Title: CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

PubMed ID: 19061646

DOI: 10.1016/j.molcel.2008.10.025

PubMed ID: 18354482

Title: Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

PubMed ID: 18354482

DOI: 10.1038/nature06641

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21284946

Title: Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes.

PubMed ID: 21284946

DOI: 10.1016/j.yjmcc.2011.01.017

PubMed ID: 21258371

Title: Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.

PubMed ID: 21258371

DOI: 10.1038/ncb2153

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24670762

Title: REST and stress resistance in ageing and Alzheimer's disease.

PubMed ID: 24670762

DOI: 10.1038/nature13163

PubMed ID: 26053433

Title: Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness.

PubMed ID: 26053433

DOI: 10.1038/srep11207

PubMed ID: 27531581

Title: REST is a hypoxia-responsive transcriptional repressor.

PubMed ID: 27531581

DOI: 10.1038/srep31355

PubMed ID: 30684677

Title: Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients.

PubMed ID: 30684677

DOI: 10.1016/j.neulet.2019.01.042

PubMed ID: 16288918

Title: The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix.

PubMed ID: 16288918

DOI: 10.1016/j.jmb.2005.10.008

PubMed ID: 26551668

Title: Mutations in the transcriptional repressor REST predispose to Wilms tumor.

PubMed ID: 26551668

DOI: 10.1038/ng.3440

PubMed ID: 28686854

Title: REST final-exon-truncating mutations cause hereditary gingival fibromatosis.

PubMed ID: 28686854

DOI: 10.1016/j.ajhg.2017.06.006

PubMed ID: 29961578

Title: Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness.

PubMed ID: 29961578

DOI: 10.1016/j.cell.2018.06.004

Sequence Information:

Length: 1097
Mass: 121872
Checksum: EBC652EED19CA161
Sequence:

MATQVMGQSS GGGGLFTSSG NIGMALPNDM YDLHDLSKAE LAAPQLIMLA NVALTGEVNG 
SCCDYLVGEE RQMAELMPVG DNNFSDSEEG EGLEESADIK GEPHGLENME LRSLELSVVE 
PQPVFEASGA PDIYSSNKDL PPETPGAEDK GKSSKTKPFR CKPCQYEAES EEQFVHHIRV 
HSAKKFFVEE SAEKQAKARE SGSSTAEEGD FSKGPIRCDR CGYNTNRYDH YTAHLKHHTR 
AGDNERVYKC IICTYTTVSE YHWRKHLRNH FPRKVYTCGK CNYFSDRKNN YVQHVRTHTG 
ERPYKCELCP YSSSQKTHLT RHMRTHSGEK PFKCDQCSYV ASNQHEVTRH ARQVHNGPKP 
LNCPHCDYKT ADRSNFKKHV ELHVNPRQFN CPVCDYAASK KCNLQYHFKS KHPTCPNKTM 
DVSKVKLKKT KKREADLPDN ITNEKTEIEQ TKIKGDVAGK KNEKSVKAEK RDVSKEKKPS 
NNVSVIQVTT RTRKSVTEVK EMDVHTGSNS EKFSKTKKSK RKLEVDSHSL HGPVNDEESS 
TKKKKKVESK SKNNSQEVPK GDSKVEENKK QNTCMKKSTK KKTLKNKSSK KSSKPPQKEP 
VEKGSAQMDP PQMGPAPTEA VQKGPVQVEP PPPMEHAQME GAQIRPAPDE PVQMEVVQEG 
PAQKELLPPV EPAQMVGAQI VLAHMELPPP METAQTEVAQ MGPAPMEPAQ MEVAQVESAP 
MQVVQKEPVQ MELSPPMEVV QKEPVQIELS PPMEVVQKEP VKIELSPPIE VVQKEPVQME 
LSPPMGVVQK EPAQREPPPP REPPLHMEPI SKKPPLRKDK KEKSNMQSER ARKEQVLIEV 
GLVPVKDSWL LKESVSTEDL SPPSPPLPKE NLREEASGDQ KLLNTGEGNK EAPLQKVGAE 
EADESLPGLA ANINESTHIS SSGQNLNTPE GETLNGKHQT DSIVCEMKMD TDQNTRENLT 
GINSTVEEPV SPMLPPSAVE EREAVSKTAL ASPPATMAAN ESQEIDEDEG IHSHEGSDLS 
DNMSEGSDDS GLHGARPVPQ ESSRKNAKEA LAVKAAKGDF VCIFCDRSFR KGKDYSKHLN 
RHLVNVYYLE EAAQGQE

Genular Protein ID: 3144527305

Symbol: A0A1W2PQA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1W2PQA1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 1069
Mass: 118556
Checksum: 568728E013833893
Sequence:

MATQVMGQSS GGGGLFTSSG NIGMALPNDM YDLHDLSKAE LAAPQLIMLA NVALTGEVNG 
SCCDYLVGEE RQMAELMPVG DNNFSDSEEG EGLEESADIK GEPHGLENME LRSLELSVVE 
PQPVFEASGA PDIYSSNKDL PPETPGAEDK GKSSKTKPFR CKPCQYEAES EEQFVHHIRV 
HSAKKFFVEE SAEKQAKARE SGSSTAEEGD FSKGPIRCDR CGYNTNRYDH YTAHLKHHTR 
AGDNERVYKC IICTYTTVSE YHWRKHLRNH FPRKVYTCGK CNYFSDRKNN YVQHVRTHTG 
EKPFKCDQCS YVASNQHEVT RHARQVHNGP KPLNCPHCDY KTADRSNFKK HVELHVNPRQ 
FNCPVCDYAA SKKCNLQYHF KSKHPTCPNK TMDVSKVKLK KTKKREADLP DNITNEKTEI 
EQTKIKGDVA GKKNEKSVKA EKRDVSKEKK PSNNVSVIQV TTRTRKSVTE VKEMDVHTGS 
NSEKFSKTKK SKRKLEVDSH SLHGPVNDEE SSTKKKKKVE SKSKNNSQEV PKGDSKVEEN 
KKQNTCMKKS TKKKTLKNKS SKKSSKPPQK EPVEKGSAQM DPPQMGPAPT EAVQKGPVQV 
EPPPPMEHAQ MEGAQIRPAP DEPVQMEVVQ EGPAQKELLP PVEPAQMVGA QIVLAHMELP 
PPMETAQTEV AQMGPAPMEP AQMEVAQVES APMQVVQKEP VQMELSPPME VVQKEPVQIE 
LSPPMEVVQK EPVKIELSPP IEVVQKEPVQ MELSPPMGVV QKEPAQREPP PPREPPLHME 
PISKKPPLRK DKKEKSNMQS ERARKEQVLI EVGLVPVKDS WLLKESVSTE DLSPPSPPLP 
KENLREEASG DQKLLNTGEG NKEAPLQKVG AEEADESLPG LAANINESTH ISSSGQNLNT 
PEGETLNGKH QTDSIVCEMK MDTDQNTREN LTGINSTVEE PVSPMLPPSA VEEREAVSKT 
ALASPPATMA ANESQEIDED EGIHSHEGSD LSDNMSEGSD DSGLHGARPV PQESSRKNAK 
EALAVKAAKG DFVCIFCDRS FRKGKDYSKH LNRHLVNVYY LEEAAQGQE

	Overall overall
	Acute kidney failure MONDO0002492
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461

Details for: REST

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. PubMed ID: 7697725

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. PubMed ID: 7871435

A zinc finger protein that represses transcription of the human MHC class II gene, DPA. PubMed ID: 8568247

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. PubMed ID: 10521596

CoREST: a functional corepressor required for regulation of neural-specific gene expression. PubMed ID: 10449787

The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. PubMed ID: 10734093

REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation. PubMed ID: 11779185

RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressor. PubMed ID: 11741002

Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. PubMed ID: 12399542

REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. PubMed ID: 14645515

Characterization of the nuclear targeting signal of REST/NRSF. PubMed ID: 16442230

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. PubMed ID: 19061646

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. PubMed ID: 18354482

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. PubMed ID: 21284946

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. PubMed ID: 21258371

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

REST and stress resistance in ageing and Alzheimer's disease. PubMed ID: 24670762

Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness. PubMed ID: 26053433

REST is a hypoxia-responsive transcriptional repressor. PubMed ID: 27531581

Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients. PubMed ID: 30684677

The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. PubMed ID: 16288918

Mutations in the transcriptional repressor REST predispose to Wilms tumor. PubMed ID: 26551668

REST final-exon-truncating mutations cause hereditary gingival fibromatosis. PubMed ID: 28686854

Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness. PubMed ID: 29961578

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

PubMed ID: 7697725

PubMed ID: 7871435

PubMed ID: 8568247

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 10521596

PubMed ID: 10449787

PubMed ID: 10734093

PubMed ID: 11779185

PubMed ID: 11741002

PubMed ID: 12399542

PubMed ID: 14645515

PubMed ID: 16442230

PubMed ID: 19061646

PubMed ID: 18354482

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