Details for: REV3L

Gene ID: 5980

Symbol: REV3L

Ensembl ID: ENSG00000009413

Description: REV3 like, DNA directed polymerase zeta catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 626.5702
    Cell Significance Index: -97.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 386.6452
    Cell Significance Index: -98.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 212.6990
    Cell Significance Index: -100.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 190.0397
    Cell Significance Index: -77.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 81.4871
    Cell Significance Index: -100.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.3308
    Cell Significance Index: -77.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.9944
    Cell Significance Index: -93.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 31.8607
    Cell Significance Index: -69.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.4723
    Cell Significance Index: -84.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.8081
    Cell Significance Index: -101.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.0460
    Cell Significance Index: 118.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.8316
    Cell Significance Index: 1374.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.2389
    Cell Significance Index: 199.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.1852
    Cell Significance Index: 178.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5716
    Cell Significance Index: 510.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5544
    Cell Significance Index: 512.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3413
    Cell Significance Index: 231.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.2775
    Cell Significance Index: 54.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1599
    Cell Significance Index: 165.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1258
    Cell Significance Index: 1470.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9686
    Cell Significance Index: 1777.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.8523
    Cell Significance Index: 12.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7674
    Cell Significance Index: 118.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7414
    Cell Significance Index: 42.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.5907
    Cell Significance Index: 27.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.1781
    Cell Significance Index: 122.6700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0820
    Cell Significance Index: 8.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0038
    Cell Significance Index: 137.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9612
    Cell Significance Index: 42.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.9059
    Cell Significance Index: 411.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9036
    Cell Significance Index: 19.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8929
    Cell Significance Index: 33.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8730
    Cell Significance Index: 1643.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8369
    Cell Significance Index: 91.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8336
    Cell Significance Index: 97.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7981
    Cell Significance Index: 1228.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6886
    Cell Significance Index: 35.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6704
    Cell Significance Index: 1236.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6552
    Cell Significance Index: 357.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6369
    Cell Significance Index: 17.8000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.5363
    Cell Significance Index: 7.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4767
    Cell Significance Index: 302.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4464
    Cell Significance Index: 7.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4155
    Cell Significance Index: 74.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3328
    Cell Significance Index: 40.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3040
    Cell Significance Index: 8.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2540
    Cell Significance Index: 345.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1871
    Cell Significance Index: 8.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1548
    Cell Significance Index: 29.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1022
    Cell Significance Index: 45.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0634
    Cell Significance Index: 0.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0595
    Cell Significance Index: -37.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0712
    Cell Significance Index: -52.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0795
    Cell Significance Index: -58.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1012
    Cell Significance Index: -57.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1145
    Cell Significance Index: -2.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1202
    Cell Significance Index: -90.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2094
    Cell Significance Index: -26.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2193
    Cell Significance Index: -37.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2251
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2675
    Cell Significance Index: -56.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2779
    Cell Significance Index: -7.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2813
    Cell Significance Index: -18.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2860
    Cell Significance Index: -41.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3056
    Cell Significance Index: -87.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3353
    Cell Significance Index: -54.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4189
    Cell Significance Index: -49.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4230
    Cell Significance Index: -14.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4762
    Cell Significance Index: -22.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4823
    Cell Significance Index: -25.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5295
    Cell Significance Index: -36.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5923
    Cell Significance Index: -12.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.6031
    Cell Significance Index: -77.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6115
    Cell Significance Index: -62.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6465
    Cell Significance Index: -9.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6583
    Cell Significance Index: -41.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6838
    Cell Significance Index: -78.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8106
    Cell Significance Index: -16.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8240
    Cell Significance Index: -94.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.9261
    Cell Significance Index: -65.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9493
    Cell Significance Index: -44.2600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9570
    Cell Significance Index: -14.5600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.0435
    Cell Significance Index: -13.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.0616
    Cell Significance Index: -79.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0688
    Cell Significance Index: -84.6500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0786
    Cell Significance Index: -13.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.2155
    Cell Significance Index: -17.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2355
    Cell Significance Index: -24.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3539
    Cell Significance Index: -35.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3665
    Cell Significance Index: -70.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3776
    Cell Significance Index: -84.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3881
    Cell Significance Index: -35.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.4041
    Cell Significance Index: -32.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.4370
    Cell Significance Index: -28.8500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.4650
    Cell Significance Index: -18.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.4928
    Cell Significance Index: -21.4700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.5277
    Cell Significance Index: -24.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.5828
    Cell Significance Index: -55.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA Polymerase Activity:** REV3L is a DNA polymerase that exhibits error-prone translesion synthesis capabilities, allowing it to bypass DNA lesions and maintain genome integrity. 2. **Homologous Recombination:** REV3L is involved in the repair of double-strand breaks via homologous recombination, a critical process for maintaining genome stability. 3. **Translesion Synthesis:** The REV3L protein is capable of translesion synthesis, a process that enables the bypassing of DNA lesions, including those caused by oxidative stress, UV radiation, and chemical mutagens. 4. **Cellular Expression:** REV3L is highly expressed in various cell types, including skeletal muscle fibers, alveolar type 2 fibroblasts, and epithelial cells of the lower respiratory tract. **Pathways and Functions:** 1. **DNA Damage Response:** REV3L plays a critical role in the DNA damage response, facilitating the repair of DNA damage, including double-strand breaks, and maintaining genome stability. 2. **Translesion Synthesis:** REV3L is involved in translesion synthesis, a process that enables the bypassing of DNA lesions, allowing cells to maintain genome integrity in the presence of mutagens. 3. **Homologous Recombination:** REV3L is involved in the repair of double-strand breaks via homologous recombination, a critical process for maintaining genome stability. 4. **Cell Cycle Regulation:** REV3L may play a role in cell cycle regulation, as its expression is tightly regulated during the cell cycle, and its dysregulation has been implicated in various diseases. **Clinical Significance:** 1. **Cancer:** Dysregulation of REV3L has been implicated in various cancers, including breast, lung, and colon cancer, where it contributes to genomic instability and tumorigenesis. 2. **Neurodegenerative Diseases:** REV3L has been implicated in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it contributes to genomic instability and neuronal dysfunction. 3. **Genetic Disorders:** REV3L mutations have been associated with genetic disorders, including Fanconi anemia, a rare genetic disorder characterized by genomic instability and increased risk of cancer. 4. **Radiation Therapy:** REV3L may play a role in the response to radiation therapy, as its dysregulation has been implicated in radiation-induced genomic instability and increased risk of secondary cancers. In conclusion, the REV3L gene is a critical component in maintaining genomic stability, and its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and genetic disorders. Further research is needed to fully elucidate the role of REV3L in human disease and to develop targeted therapies for these conditions.

Genular Protein ID: 2657122083

Symbol: REV3L_HUMAN

Name: DNA polymerase zeta catalytic subunit

UniProtKB Accession Codes:

O60673 O43214 Q5TC33

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 3 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 3 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9618506

Title: A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta.

PubMed ID: 9618506

DOI: 10.1073/pnas.95.12.6876

PubMed ID: 10102035

Title: A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans.

PubMed ID: 10102035

DOI: 10.1016/s0921-8777(98)00065-2

PubMed ID: 9925914

Title: Alternative splicing, genomic structure, and fine chromosome localization of REV3L.

PubMed ID: 9925914

DOI: 10.1159/000015157

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 10660610

Title: A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2.

PubMed ID: 10660610

DOI: 10.1074/jbc.275.6.4391

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24449906

Title: Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol eta in cisplatin bypass.

PubMed ID: 24449906

DOI: 10.1073/pnas.1324001111

PubMed ID: 20164194

Title: Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1.

PubMed ID: 20164194

DOI: 10.1074/jbc.m109.092403

Sequence Information:

  • Length: 3130
  • Mass: 352776
  • Checksum: 4FBAA214639DF3C6
  • Sequence:
    • MFSVRIVTAD YYMASPLQGL DTCQSPLTQA PVKKVPVVRV FGATPAGQKT CLHLHGIFPY 
LYVPYDGYGQ QPESYLSQMA FSIDRALNVA LGNPSSTAQH VFKVSLVSGM PFYGYHEKER 
HFMKIYLYNP TMVKRICELL QSGAIMNKFY QPHEAHIPYL LQLFIDYNLY GMNLINLAAV 
KFRKARRKSN TLHATGSCKN HLSGNSLADT LFRWEQDEIP SSLILEGVEP QSTCELEVDA 
VAADILNRLD IEAQIGGNPG LQAIWEDEKQ RRRNRNETSQ MSQPESQDHR FVPATESEKK 
FQKRLQEILK QNDFSVTLSG SVDYSDGSQE FSAELTLHSE VLSPEMLQCT PANMVEVHKD 
KESSKGHTRH KVEEALINEE AILNLMENSQ TFQPLTQRLS ESPVFMDSSP DEALVHLLAG 
LESDGYRGER NRMPSPCRSF GNNKYPQNSD DEENEPQIEK EEMELSLVMS QRWDSNIEEH 
CAKKRSLCRN THRSSTEDDD SSSGEEMEWS DNSLLLASLS IPQLDGTADE NSDNPLNNEN 
SRTHSSVIAT SKLSVKPSIF HKDAATLEPS SSAKITFQCK HTSALSSHVL NKEDLIEDLS 
QTNKNTEKGL DNSVTSFTNE STYSMKYPGS LSSTVHSENS HKENSKKEIL PVSSCESSIF 
DYEEDIPSVT RQVPSRKYTN IRKIEKDSPF IHMHRHPNEN TLGKNSFNFS DLNHSKNKVS 
SEGNEKGNST ALSSLFPSSF TENCELLSCS GENRTMVHSL NSTADESGLN KLKIRYEEFQ 
EHKTEKPSLS QQAAHYMFFP SVVLSNCLTR PQKLSPVTYK LQPGNKPSRL KLNKRKLAGH 
QETSTKSSET GSTKDNFIQN NPCNSNPEKD NALASDLTKT TRGAFENKTP TDGFIDCHFG 
DGTLETEQSF GLYGNKYTLR AKRKVNYETE DSESSFVTHN SKISLPHPME IGESLDGTLK 
SRKRRKMSKK LPPVIIKYII INRFRGRKNM LVKLGKIDSK EKQVILTEEK MELYKKLAPL 
KDFWPKVPDS PATKYPIYPL TPKKSHRRKS KHKSAKKKTG KQQRTNNENI KRTLSFRKKR 
SHAILSPPSP SYNAETEDCD LNYSDVMSKL GFLSERSTSP INSSPPRCWS PTDPRAEEIM 
AAAEKEAMLF KGPNVYKKTV NSRIGKTSRA RAQIKKSKAK LANPSIVTKK RNKRNQTNKL 
VDDGKKKPRA KQKTNEKGTS RKHTTLKDEK IKSQSGAEVK FVLKHQNVSE FASSSGGSQL 
LFKQKDMPLM GSAVDHPLSA SLPTGINAQQ KLSGCFSSFL ESKKSVDLQT FPSSRDDLHP 
SVVCNSIGPG VSKINVQRPH NQSAMFTLKE STLIQKNIFD LSNHLSQVAQ NTQISSGMSS 
KIEDNANNIQ RNYLSSIGKL SEYRNSLESK LDQAYTPNFL HCKDSQQQIV CIAEQSKHSE 
TCSPGNTASE ESQMPNNCFV TSLRSPIKQI AWEQKQRGFI LDMSNFKPER VKPRSLSEAI 
SQTKALSQCK NRNVSTPSAF GEGQSGLAVL KELLQKRQQK AQNANTTQDP LSNKHQPNKN 
ISGSLEHNKA NKRTRSVTSP RKPRTPRSTK QKEKIPKLLK VDSLNLQNSS QLDNSVSDDS 
PIFFSDPGFE SCYSLEDSLS PEHNYNFDIN TIGQTGFCSF YSGSQFVPAD QNLPQKFLSD 
AVQDLFPGQA IEKNEFLSHD NQKCDEDKHH TTDSASWIRS GTLSPEIFEK STIDSNENRR 
HNQWKNSFHP LTTRSNSIMD SFCVQQAEDC LSEKSRLNRS SVSKEVFLSL PQPNNSDWIQ 
GHTRKEMGQS LDSANTSFTA ILSSPDGELV DVACEDLELY VSRNNDMLTP TPDSSPRSTS 
SPSQSKNGSF TPRTANILKP LMSPPSREEI MATLLDHDLS ETIYQEPFCS NPSDVPEKPR 
EIGGRLLMVE TRLANDLAEF EGDFSLEGLR LWKTAFSAMT QNPRPGSPLR SGQGVVNKGS 
SNSPKMVEDK KIVIMPCKCA PSRQLVQVWL QAKEEYERSK KLPKTKPTGV VKSAENFSSS 
VNPDDKPVVP PKMDVSPCIL PTTAHTKEDV DNSQIALQAP TTGCSQTASE SQMLPPVASA 
SDPEKDEDDD DNYYISYSSP DSPVIPPWQQ PISPDSKALN GDDRPSSPVE ELPSLAFENF 
LKPIKDGIQK SPCSEPQEPL VISPINTRAR TGKCESLCFH STPIIQRKLL ERLPEAPGLS 
PLSTEPKTQK LSNKKGSNTD TLRRVLLTQA KNQFAAVNTP QKETSQIDGP SLNNTYGFKV 
SIQNLQEAKA LHEIQNLTLI SVELHARTRR DLEPDPEFDP ICALFYCISS DTPLPDTEKT 
ELTGVIVIDK DKTVFSQDIR YQTPLLIRSG ITGLEVTYAA DEKALFHEIA NIIKRYDPDI 
LLGYEIQMHS WGYLLQRAAA LSIDLCRMIS RVPDDKIENR FAAERDEYGS YTMSEINIVG 
RITLNLWRIM RNEVALTNYT FENVSFHVLH QRFPLFTFRV LSDWFDNKTD LYRWKMVDHY 
VSRVRGNLQM LEQLDLIGKT SEMARLFGIQ FLHVLTRGSQ YRVESMMLRI AKPMNYIPVT 
PSVQQRSQMR APQCVPLIME PESRFYSNSV LVLDFQSLYP SIVIAYNYCF STCLGHVENL 
GKYDEFKFGC TSLRVPPDLL YQVRHDITVS PNGVAFVKPS VRKGVLPRML EEILKTRFMV 
KQSMKAYKQD RALSRMLDAR QLGLKLIANV TFGYTSANFS GRMPCIEVGD SIVHKARETL 
ERAIKLVNDT KKWGARVVYG DTDSMFVLLK GATKEQSFKI GQEIAEAVTA TNPKPVKLKF 
EKVYLPCVLQ TKKRYVGYMY ETLDQKDPVF DAKGIETVRR DSCPAVSKIL ERSLKLLFET 
RDISLIKQYV QRQCMKLLEG KASIQDFIFA KEYRGSFSYK PGACVPALEL TRKMLTYDRR 
SEPQVGERVP YVIIYGTPGV PLIQLVRRPV EVLQDPTLRL NATYYITKQI LPPLARIFSL 
IGIDVFSWYH ELPRIHKATS SSRSEPEGRK GTISQYFTTL HCPVCDDLTQ HGICSKCRSQ 
PQHVAVILNQ EIRELERQQE QLVKICKNCT GCFDRHIPCV SLNCPVLFKL SRVNRELSKA 
PYLRQLLDQF

Genular Protein ID: 1640975338

Symbol: Q9UG47_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UG47

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 Pfam 2 RefSeq 3 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 323
  • Mass: 37386
  • Checksum: 30A662AE83F6F68B
  • Sequence:
    • MTSSLPYFIF NPPSMFVLLK GATKEQSFKI GQEIAEAVTA TNPKPVKLKF EKVYLPCVLQ 
TKKRYVGYMY ETLDQKDPVF DAKGIETVRR DSCPAVSKIL ERSLKLLFET RDISLIKQYV 
QRQCMKLLEG KASIQDFIFA KEYRGSFSYK PGACVPALEL TRKMLTYDRR SEPQVGERVP 
YVIIYGTPGV PLIQLVRRPV EVLQDPTLRL NATYYITKQI LPPLARIFSL IGIDVFSWYH 
ELPRGFIAAL FTIAKTWNQP KCPSMIDWIK KMWHIYTMEY YAAIKKDEFM SFAGTWMKLE 
TIILSKLSQG QKTKHRLFSL IDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.