Details for: RFC4

Gene ID: 5984

Symbol: RFC4

Ensembl ID: ENSG00000163918

Description: replication factor C subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.8732
    Cell Significance Index: -12.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 42.7724
    Cell Significance Index: -17.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.1163
    Cell Significance Index: -13.8600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 30.9878
    Cell Significance Index: -4.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6636
    Cell Significance Index: -14.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9793
    Cell Significance Index: -14.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4501
    Cell Significance Index: -14.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1332
    Cell Significance Index: -16.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.6925
    Cell Significance Index: -8.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6797
    Cell Significance Index: 166.1600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.5590
    Cell Significance Index: 0.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1526
    Cell Significance Index: 12.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0544
    Cell Significance Index: 63.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9704
    Cell Significance Index: 16.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8730
    Cell Significance Index: 94.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7736
    Cell Significance Index: 125.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7106
    Cell Significance Index: 83.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6991
    Cell Significance Index: 24.3000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.4557
    Cell Significance Index: 2.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4543
    Cell Significance Index: 9.5100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4185
    Cell Significance Index: 3.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4065
    Cell Significance Index: 11.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3940
    Cell Significance Index: 10.5400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3575
    Cell Significance Index: 5.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3167
    Cell Significance Index: 19.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3087
    Cell Significance Index: 17.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3013
    Cell Significance Index: 59.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2761
    Cell Significance Index: 122.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2317
    Cell Significance Index: 126.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1845
    Cell Significance Index: 35.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1840
    Cell Significance Index: 12.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1789
    Cell Significance Index: 161.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1725
    Cell Significance Index: 34.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1670
    Cell Significance Index: 22.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1639
    Cell Significance Index: 5.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1590
    Cell Significance Index: 4.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1417
    Cell Significance Index: 10.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1341
    Cell Significance Index: 7.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1114
    Cell Significance Index: 7.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1006
    Cell Significance Index: 2.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0880
    Cell Significance Index: 10.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0868
    Cell Significance Index: 2.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0758
    Cell Significance Index: 13.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0710
    Cell Significance Index: 3.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0663
    Cell Significance Index: 45.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0574
    Cell Significance Index: 20.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0459
    Cell Significance Index: 2.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0437
    Cell Significance Index: 2.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0380
    Cell Significance Index: 4.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0160
    Cell Significance Index: 0.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0154
    Cell Significance Index: 0.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0037
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0095
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0111
    Cell Significance Index: -15.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0142
    Cell Significance Index: -0.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0153
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -11.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0193
    Cell Significance Index: -12.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0219
    Cell Significance Index: -16.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0261
    Cell Significance Index: -11.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0268
    Cell Significance Index: -0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0276
    Cell Significance Index: -15.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0279
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0294
    Cell Significance Index: -18.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0341
    Cell Significance Index: -5.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0452
    Cell Significance Index: -5.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0464
    Cell Significance Index: -13.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0504
    Cell Significance Index: -5.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0598
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0706
    Cell Significance Index: -8.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0729
    Cell Significance Index: -10.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0827
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0881
    Cell Significance Index: -18.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1109
    Cell Significance Index: -1.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1118
    Cell Significance Index: -1.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1225
    Cell Significance Index: -9.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1255
    Cell Significance Index: -9.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1490
    Cell Significance Index: -7.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1495
    Cell Significance Index: -15.5700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1518
    Cell Significance Index: -0.9500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1592
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1805
    Cell Significance Index: -2.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1858
    Cell Significance Index: -12.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1875
    Cell Significance Index: -14.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2082
    Cell Significance Index: -5.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2162
    Cell Significance Index: -13.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2350
    Cell Significance Index: -6.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2586
    Cell Significance Index: -11.4400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2797
    Cell Significance Index: -1.6600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3024
    Cell Significance Index: -2.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3219
    Cell Significance Index: -12.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3233
    Cell Significance Index: -7.4700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.3366
    Cell Significance Index: -3.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3631
    Cell Significance Index: -7.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3719
    Cell Significance Index: -5.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RFC4 is a subunit of the RFC complex, which is composed of four subunits (α, β, γ, and δ). The RFC complex is responsible for unwinding DNA during replication and repair processes. RFC4 is specifically involved in the unwinding of double-stranded DNA and the recruitment of DNA polymerases to the replication fork. The gene has been implicated in various DNA repair pathways, including base excision repair, nucleotide excision repair, and homologous recombination repair. RFC4 is also involved in the regulation of cell cycle checkpoints and the maintenance of genome stability. **Pathways and Functions:** RFC4 is involved in several key pathways and functions, including: 1. **DNA Replication:** RFC4 is essential for the unwinding of DNA during replication, allowing for the recruitment of DNA polymerases to the replication fork. 2. **DNA Repair:** RFC4 is involved in various DNA repair pathways, including base excision repair, nucleotide excision repair, and homologous recombination repair. 3. **Cell Cycle Regulation:** RFC4 plays a role in regulating cell cycle checkpoints and maintaining genome stability. 4. **Telomere Maintenance:** RFC4 is involved in the maintenance of telomeres, including the synthesis of telomeres on the lagging strand. 5. **Transcriptional Regulation:** RFC4 is involved in the regulation of transcriptional processes, including the regulation of TP53 activity and the transcription of genes involved in DNA repair. **Clinical Significance:** Dysregulation of RFC4 has been implicated in various diseases, including: 1. **Cancer:** RFC4 mutations have been linked to various types of cancer, including breast cancer and colon cancer. 2. **Genetic Disorders:** RFC4 mutations have been associated with genetic disorders, including BRCA2-related disorders. 3. **Genomic Instability:** RFC4 mutations can lead to genomic instability, which can result in the development of cancer and other diseases. In conclusion, RFC4 is a critical gene involved in various aspects of DNA replication, repair, and cell cycle regulation. Understanding the functions and pathways associated with RFC4 is essential for comprehending the mechanisms of DNA replication, repair, and cell cycle regulation, which are critical for maintaining genome stability and preventing diseases.

Genular Protein ID: 2691558886

Symbol: RFC4_HUMAN

Name: Replication factor C subunit 4

UniProtKB Accession Codes:

P35249 B4DM41 D3DNV2 Q6FHX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 13 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 21 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1351677

Title: Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells.

PubMed ID: 1351677

DOI: 10.1073/pnas.89.12.5211

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11572977

Title: Purification and characterization of human DNA damage checkpoint Rad complexes.

PubMed ID: 11572977

DOI: 10.1073/pnas.201373498

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 363
  • Mass: 39682
  • Checksum: 6FEAB3794379F3E0
  • Sequence:
    • MQAFLKGTSI STKPPLTKDR GVAASAGSSG ENKKAKPVPW VEKYRPKCVD EVAFQEEVVA 
VLKKSLEGAD LPNLLFYGPP GTGKTSTILA AARELFGPEL FRLRVLELNA SDERGIQVVR 
EKVKNFAQLT VSGSRSDGKP CPPFKIVILD EADSMTSAAQ AALRRTMEKE SKTTRFCLIC 
NYVSRIIEPL TSRCSKFRFK PLSDKIQQQR LLDIAKKENV KISDEGIAYL VKVSEGDLRK 
AITFLQSATR LTGGKEITEK VITDIAGVIP AEKIDGVFAA CQSGSFDKLE AVVKDLIDEG 
HAATQLVNQL HDVVVENNLS DKQKSIITEK LAEVDKCLAD GADEHLQLIS LCATVMQQLS 
QNC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.