Details for: RPL11

Gene ID: 6135

Symbol: RPL11

Ensembl ID: ENSG00000142676

Description: ribosomal protein L11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 805.2480
    Cell Significance Index: -331.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 679.9716
    Cell Significance Index: -321.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 650.0381
    Cell Significance Index: -334.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 480.4461
    Cell Significance Index: -322.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.7063
    Cell Significance Index: -101.0100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 19.5821
    Cell Significance Index: 297.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 18.7734
    Cell Significance Index: 479.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.9610
    Cell Significance Index: 1732.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.7650
    Cell Significance Index: 394.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.7690
    Cell Significance Index: 647.1300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 13.7072
    Cell Significance Index: 80.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 12.6150
    Cell Significance Index: 331.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.2143
    Cell Significance Index: 350.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.4163
    Cell Significance Index: 146.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 10.6303
    Cell Significance Index: 369.4000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.6288
    Cell Significance Index: 187.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.1383
    Cell Significance Index: 1309.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.8429
    Cell Significance Index: 111.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.4244
    Cell Significance Index: 1294.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.1853
    Cell Significance Index: 1655.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.1496
    Cell Significance Index: 1125.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.0956
    Cell Significance Index: 643.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.7835
    Cell Significance Index: 654.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.7299
    Cell Significance Index: 201.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.6736
    Cell Significance Index: 3834.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.4418
    Cell Significance Index: 176.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.3463
    Cell Significance Index: 4558.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.9535
    Cell Significance Index: 937.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.6893
    Cell Significance Index: 985.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.1273
    Cell Significance Index: 459.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.8609
    Cell Significance Index: 201.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.4187
    Cell Significance Index: 69.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.1063
    Cell Significance Index: 112.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.6866
    Cell Significance Index: 265.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0560
    Cell Significance Index: 137.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.5844
    Cell Significance Index: 782.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.5471
    Cell Significance Index: 3441.7700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.4522
    Cell Significance Index: 27.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7982
    Cell Significance Index: 199.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0458
    Cell Significance Index: 28.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.8085
    Cell Significance Index: 74.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7732
    Cell Significance Index: 550.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0721
    Cell Significance Index: 1870.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.6887
    Cell Significance Index: 1238.1200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.6234
    Cell Significance Index: 13.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0331
    Cell Significance Index: 196.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.9876
    Cell Significance Index: 78.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3402
    Cell Significance Index: 33.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0323
    Cell Significance Index: -1.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0412
    Cell Significance Index: -2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0464
    Cell Significance Index: -87.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1145
    Cell Significance Index: -22.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1321
    Cell Significance Index: -97.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1358
    Cell Significance Index: -250.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1665
    Cell Significance Index: -256.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2419
    Cell Significance Index: -328.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2543
    Cell Significance Index: -2.0300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2594
    Cell Significance Index: -5.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2924
    Cell Significance Index: -164.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2986
    Cell Significance Index: -186.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3450
    Cell Significance Index: -123.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3703
    Cell Significance Index: -235.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6332
    Cell Significance Index: -287.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.6822
    Cell Significance Index: -196.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6868
    Cell Significance Index: -144.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.8531
    Cell Significance Index: -138.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2214
    Cell Significance Index: -68.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3845
    Cell Significance Index: -62.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4192
    Cell Significance Index: -162.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.6550
    Cell Significance Index: -188.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.7205
    Cell Significance Index: -29.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8999
    Cell Significance Index: -276.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.0682
    Cell Significance Index: -66.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1323
    Cell Significance Index: -134.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.4277
    Cell Significance Index: -40.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.5495
    Cell Significance Index: -153.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.6613
    Cell Significance Index: -93.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.0886
    Cell Significance Index: -321.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.2330
    Cell Significance Index: -223.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.2996
    Cell Significance Index: -82.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.3553
    Cell Significance Index: -57.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.4634
    Cell Significance Index: -20.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.9469
    Cell Significance Index: -302.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.4231
    Cell Significance Index: -297.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.5520
    Cell Significance Index: -279.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.7977
    Cell Significance Index: -103.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.8431
    Cell Significance Index: -72.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.4025
    Cell Significance Index: -73.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.0552
    Cell Significance Index: -118.1800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.3673
    Cell Significance Index: -34.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.5512
    Cell Significance Index: -192.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.8463
    Cell Significance Index: -197.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.8524
    Cell Significance Index: -303.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -7.1150
    Cell Significance Index: -84.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -7.6517
    Cell Significance Index: -205.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -8.1012
    Cell Significance Index: -297.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -8.3270
    Cell Significance Index: -315.3200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -8.7607
    Cell Significance Index: -112.8200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -8.8134
    Cell Significance Index: -23.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -8.8988
    Cell Significance Index: -134.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein L11**: RPL11 is a 60S ribosomal protein that forms a heterodimer with RPL10 to form the 60S large ribosomal subunit. 2. **Expression**: RPL11 is highly expressed in various cell types, including epithelial cells, immune cells, and cancerous cells. 3. **Structural organization**: RPL11 is composed of 144 amino acids, with a molecular weight of approximately 16 kDa. 4. **Post-translational modifications**: RPL11 undergoes various post-translational modifications, including phosphorylation, ubiquitination, and sumoylation. **Pathways and Functions:** 1. **Translation initiation**: RPL11 plays a critical role in the initiation of translation, interacting with eIF2α and eIF3 to facilitate the recruitment of the small ribosomal subunit to the mRNA. 2. **Translation elongation**: RPL11 is involved in the elongation phase of translation, interacting with eEF2 and eEF3 to facilitate the translocation of the ribosome along the mRNA. 3. **Cell signaling**: RPL11 has been implicated in various signaling pathways, including the NF-κB and MAPK pathways, which regulate inflammation and cell survival. 4. **Stress response**: RPL11 has been shown to play a role in the cellular response to stress, including hypoxia, starvation, and heat shock. 5. **Regulation of gene expression**: RPL11 has been shown to regulate the expression of various genes, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Cancer**: RPL11 has been implicated in various types of cancer, including breast, lung, and colon cancer, where it is often overexpressed. 2. **Infectious diseases**: RPL11 has been shown to play a role in the replication and translation of viral RNAs, including influenza virus. 3. **Neurological disorders**: RPL11 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immune system disorders**: RPL11 has been shown to play a role in the regulation of immune responses, including the activation of T cells and B cells. In conclusion, RPL11 is a multifaceted gene that plays a critical role in various cellular processes, including translation, cell signaling, and stress response. Its dysregulation has been implicated in various human diseases, including cancer, infectious diseases, and neurological disorders. Further research is needed to fully elucidate the functions and significance of RPL11 in human health and disease.

Genular Protein ID: 2539289735

Symbol: RL11_HUMAN

Name: 60S ribosomal protein L11

UniProtKB Accession Codes:

P62913 P25121 P39026 Q8TDH2 Q9Y674

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 EMDB 70 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 86 PDBsum 86 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7748210

Title: Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11.

PubMed ID: 7748210

PubMed ID: 12815950

Title: Structural and functional analysis of the human ribosomal protein L11 gene.

PubMed ID: 12815950

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19061985

Title: Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients.

PubMed ID: 19061985

DOI: 10.1016/j.ajhg.2008.11.004

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24120868

Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

PubMed ID: 24120868

DOI: 10.1016/j.celrep.2013.08.049

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24556985

Title: GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

PubMed ID: 24556985

DOI: 10.1073/pnas.1400705111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27829214

Title: PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.

PubMed ID: 27829214

DOI: 10.18632/oncotarget.13082

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 19191325

Title: Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia.

PubMed ID: 19191325

DOI: 10.1002/humu.20874

Sequence Information:

  • Length: 178
  • Mass: 20252
  • Checksum: 26EC965C9239774E
  • Sequence:
    • MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF SKARYTVRSF 
GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS DTGNFGFGIQ EHIDLGIKYD 
PSIGIYGLDF YVVLGRPGFS IADKKRRTGC IGAKHRISKE EAMRWFQQKY DGIILPGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.