Details for: RPL24

Gene ID: 6152

Symbol: RPL24

Ensembl ID: ENSG00000114391

Description: ribosomal protein L24

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.55
    Marker Score: 5127
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.15
    Marker Score: 30234
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 6.13
    Marker Score: 1796
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5.84
    Marker Score: 3290
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.36
    Marker Score: 72029
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 5.35
    Marker Score: 22226
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.32
    Marker Score: 11155
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.24
    Marker Score: 51897
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.2
    Marker Score: 8008.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.16
    Marker Score: 3641
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.05
    Marker Score: 171754
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.95
    Marker Score: 8496
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.9
    Marker Score: 6377
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.88
    Marker Score: 14257
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.85
    Marker Score: 1787
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.83
    Marker Score: 3460.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.82
    Marker Score: 2925
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.8
    Marker Score: 15147
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.76
    Marker Score: 2444.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.73
    Marker Score: 3571
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.72
    Marker Score: 3426
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.71
    Marker Score: 249049.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.69
    Marker Score: 2502.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.66
    Marker Score: 4156.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.6
    Marker Score: 2375
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.55
    Marker Score: 23894
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.48
    Marker Score: 59089
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.31
    Marker Score: 241068
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.3
    Marker Score: 50024
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.25
    Marker Score: 2583
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.24
    Marker Score: 11355.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.24
    Marker Score: 25741
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.21
    Marker Score: 2709
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.2
    Marker Score: 11769.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.19
    Marker Score: 4657.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.17
    Marker Score: 11529.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.17
    Marker Score: 9505
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.15
    Marker Score: 3532
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.14
    Marker Score: 10101.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.13
    Marker Score: 2935
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.13
    Marker Score: 1341
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.11
    Marker Score: 3492
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.09
    Marker Score: 3484.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17514
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.08
    Marker Score: 3943.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.08
    Marker Score: 14476
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.04
    Marker Score: 4319
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4
    Marker Score: 3937.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4
    Marker Score: 26051
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.99
    Marker Score: 9730
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.97
    Marker Score: 3116
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.97
    Marker Score: 4790
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.96
    Marker Score: 7445
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.96
    Marker Score: 5831
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.95
    Marker Score: 6280
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.93
    Marker Score: 9996.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.92
    Marker Score: 1684
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.89
    Marker Score: 28923
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.87
    Marker Score: 3653
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.84
    Marker Score: 917
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.8
    Marker Score: 3576
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.77
    Marker Score: 3315
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.76
    Marker Score: 1236.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.74
    Marker Score: 2463
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.73
    Marker Score: 24259.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.73
    Marker Score: 3888
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.72
    Marker Score: 3306
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.71
    Marker Score: 2495
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.7
    Marker Score: 2044
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.68
    Marker Score: 2052
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.64
    Marker Score: 9185
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.63
    Marker Score: 2972
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.63
    Marker Score: 4370
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.61
    Marker Score: 2729
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.61
    Marker Score: 3216
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.61
    Marker Score: 3987.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.59
    Marker Score: 4108.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.58
    Marker Score: 3081
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.56
    Marker Score: 2050
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.56
    Marker Score: 2994
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.56
    Marker Score: 2356
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.54
    Marker Score: 3807
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.54
    Marker Score: 2496
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.53
    Marker Score: 1614.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.53
    Marker Score: 5792.5
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.51
    Marker Score: 2919
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.51
    Marker Score: 2059
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.51
    Marker Score: 3563
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.49
    Marker Score: 1807
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.48
    Marker Score: 20661
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.48
    Marker Score: 7903
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.48
    Marker Score: 4107
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.47
    Marker Score: 2506
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.47
    Marker Score: 5748
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.45
    Marker Score: 1437
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.44
    Marker Score: 6873
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.44
    Marker Score: 3217
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.44
    Marker Score: 8996
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 3.44
    Marker Score: 1235
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.42
    Marker Score: 3019

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Other Information

**Key characteristics:** * RPL24 is a large protein with a molecular weight of approximately 100 kDa. * It is encoded by the RPL24 gene. * RPL24 is a member of the ribosomal protein L24 family. * It is expressed in a variety of cell types, including thyroid follicular cell, myoepithelial cell of mammary gland, tracheobronchial smooth muscle cell, epithelial cell of exocrine pancreas, malignant cell, classical monocyte, CD38-negative naive B cell, mature T cell, and mesenchymal stem cell. **Pathways and functions:** * RPL24 is involved in the initiation, elongation, and termination of protein translation. * It is a key regulator of axonal guidance, as it is expressed in neurons and is required for the proper development of the nervous system. * It is also involved in the regulation of cellular responses to stimuli, as it is expressed in cells that are exposed to a variety of environmental cues. * RPL24 is also involved in cellular responses to stress, as it is expressed in cells that are exposed to stress factors such as heat, cold, and oxidative stress. * It is involved in developmental biology, as it is expressed in cells during embryonic development and in tissues that are responsible for tissue repair and growth. **Clinical significance:** RPL24 is a promising target for cancer therapy, as it is expressed in a variety of cancer cells. Inhibition of RPL24 has been shown to inhibit cancer cell growth and metastasis, suggesting that it could be used as a therapeutic agent for cancer. **Additional information:** * RPL24 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a member of the RNase P superfamily, which are enzymes that are involved in the processing of RNA molecules. * RPL24 is a substrate for the protein kinase CK2, which is involved in a variety of cellular processes, including cell cycle regulation and growth.

Genular Protein ID: 2599948767

Symbol: RL24_HUMAN

Name: 60S ribosomal protein L24

UniProtKB Accession Codes:

P83731 B2R4Y3 P38663 Q6IBS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 EMDB 30 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 43 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8428672

Title: Characterization of cDNA clones encoding the human homologue of Saccharomyces cerevisiae ribosomal protein L30.

PubMed ID: 8428672

DOI: 10.1016/0378-1119(93)90139-t

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34314702

Title: Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

PubMed ID: 34314702

DOI: 10.1016/j.cell.2021.07.005

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 157
  • Mass: 17779
  • Checksum: 1D48EEB7C0652574
  • Sequence:
    • MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN WTVLYRRKHK 
KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV RKAQREQAIR AAKEAKKAKQ 
ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA PRVGGKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.