RPL24 | ENSG00000114391 | NCBI 6152

Details for: RPL24

Gene ID: 6152

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPL24

Ensembl ID: ENSG00000114391

Description: ribosomal protein L24

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cadherin binding
(GO:0045296)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Endoplasmic reticulum
(GO:0005783)
Exit from mitosis
(GO:0010458)
Extracellular exosome
(GO:0070062)
Membrane
(GO:0016020)
Mrna binding
(GO:0003729)
Optic nerve development
(GO:0021554)
Protein binding
(GO:0005515)
Retina development in camera-type eye
(GO:0060041)
Retinal ganglion cell axon guidance
(GO:0031290)
Ribosomal large subunit assembly
(GO:0000027)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 154.62

rCSI 91.31%

PRS 0.81
hematopoietic stem cell CL0000037

CSI 148.34

rCSI 98.6%

PRS 0.69
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 140.13

rCSI 94.41%

PRS 0.7
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 133.48

rCSI 93.74%

PRS 1.77
epithelial cell of lower respiratory tract CL0002632

CSI 132.37

rCSI 100%

PRS 0.53
plasmacytoid dendritic cell, human CL0001058

CSI 131.92

rCSI 92.11%

PRS 0.61
CD4-positive helper T cell CL0000492

CSI 131.29

rCSI 99.32%

PRS 0.81
double negative thymocyte CL0002489

CSI 131.15

rCSI 91.18%

PRS 0.68
T follicular helper cell CL0002038

CSI 127.48

rCSI 95.4%

PRS 0.95
naive T cell CL0000898

CSI 125.78

rCSI 87.53%

PRS 0.85
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 124.16

rCSI 82.75%

PRS 1.65
common myeloid progenitor CL0000049

CSI 123.68

rCSI 100%

PRS 0.57
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 123.26

rCSI 92.43%

PRS 1.75
immature B cell CL0000816

CSI 122.08

rCSI 90.7%

PRS 0.86
neural crest cell CL0011012

CSI 121.7

rCSI 96.19%

PRS 0.4
CD4-positive, alpha-beta thymocyte CL0000810

CSI 119.24

rCSI 95.52%

PRS 1.09
epithelial cell of lung CL0000082

CSI 118.94

rCSI 98.6%

PRS 0.54
T-helper 17 cell CL0000899

CSI 118.36

rCSI 93.98%

PRS 1.03
keratinocyte CL0000312

CSI 117.6

rCSI 98.58%

PRS 0.7
mature T cell CL0002419

CSI 117.01

rCSI 91.01%

PRS 0.82
group 3 innate lymphoid cell CL0001071

CSI 115.47

rCSI 86.76%

PRS 0.6
melanocyte CL0000148

CSI 114.84

rCSI 85.05%

PRS 0.55
CD14-low, CD16-positive monocyte CL0002396

CSI 114.33

rCSI 88.09%

PRS 0.52
granulocyte monocyte progenitor cell CL0000557

CSI 113.82

rCSI 98.56%

PRS 0.65
bronchus fibroblast of lung CL2000093

CSI 112.69

rCSI 91.57%

PRS 0.6
plasmablast CL0000980

CSI 110.68

rCSI 87.07%

PRS 0.69
effector CD8-positive, alpha-beta T cell CL0001050

CSI 109.53

rCSI 83.31%

PRS 0.77
mature B cell CL0000785

CSI 109.06

rCSI 94.81%

PRS 0.71
unswitched memory B cell CL0000970

CSI 109.03

rCSI 91.74%

PRS 0.98
mucosal invariant T cell CL0000940

CSI 108.07

rCSI 87.32%

PRS 1.52
naive B cell CL0000788

CSI 107.45

rCSI 92.16%

PRS 1.89
megakaryocyte-erythroid progenitor cell CL0000050

CSI 107.21

rCSI 96.81%

PRS 0.51
early lymphoid progenitor CL0000936

CSI 106.85

rCSI 93.84%

PRS 0.65
skin fibroblast CL0002620

CSI 105.58

rCSI 91.01%

PRS 0.97
fibroblast of lung CL0002553

CSI 104.6

rCSI 97.35%

PRS 0.58
CD4-positive, alpha-beta memory T cell CL0000897

CSI 104.2

rCSI 74.8%

PRS 0.79
ciliated epithelial cell CL0000067

CSI 104

rCSI 91.46%

PRS 0.43
pro-B cell CL0000826

CSI 103.11

rCSI 85.39%

PRS 0.58
class switched memory B cell CL0000972

CSI 99.48

rCSI 74.27%

PRS 0.98
fallopian tube secretory epithelial cell CL4030006

CSI 99.27

rCSI 95.56%

PRS 0.6
pancreatic D cell CL0000173

CSI 98.11

rCSI 96.5%

PRS 0.64
intestine goblet cell CL0019031

CSI 97.64

rCSI 86.66%

PRS 0.58
double-positive, alpha-beta thymocyte CL0000809

CSI 95.9

rCSI 97.74%

PRS 0.84
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 95.89

rCSI 87.33%

PRS 0.91
activated CD4-positive, alpha-beta T cell CL0000896

CSI 94.8

rCSI 87.64%

PRS 1.06
memory B cell CL0000787

CSI 93.1

rCSI 91.93%

PRS 2.57
respiratory basal cell CL0002633

CSI 89.8

rCSI 93.02%

PRS 0.68
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 88.82

rCSI 87.22%

PRS 0.93
pancreatic A cell CL0000171

CSI 87.06

rCSI 91.21%

PRS 0.63
hematopoietic precursor cell CL0008001

CSI 86.98

rCSI 89.48%

PRS 0.76
small pre-B-II cell CL0000954

CSI 86.61

rCSI 83.29%

PRS 1.27
precursor B cell CL0000817

CSI 86.1

rCSI 75.42%

PRS 0.78
intestinal epithelial cell CL0002563

CSI 83.68

rCSI 87.46%

PRS 0.62
transit amplifying cell of colon CL0009011

CSI 83.01

rCSI 97.49%

PRS 0.71
multi-ciliated epithelial cell CL0005012

CSI 82.26

rCSI 82.1%

PRS 0.49
fraction A pre-pro B cell CL0002045

CSI 80.15

rCSI 91.75%

PRS 1.21
goblet cell CL0000160

CSI 79.54

rCSI 75.16%

PRS 0.61
CD8-positive, alpha-beta memory T cell CL0000909

CSI 79.26

rCSI 82.78%

PRS 1.87
mesodermal cell CL0000222

CSI 79.04

rCSI 94.88%

PRS 0.58
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 77.34

rCSI 89.32%

PRS 0.54
gamma-delta T cell CL0000798

CSI 76.99

rCSI 90.42%

PRS 5.9
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 76.86

rCSI 96.58%

PRS 3.2
common dendritic progenitor CL0001029

CSI 76.58

rCSI 96.11%

PRS 0.73
mature NK T cell CL0000814

CSI 76.24

rCSI 97.51%

PRS 2.7
elicited macrophage CL0000861

CSI 76.07

rCSI 69.84%

PRS 0.64
activated type II NK T cell CL0000931

CSI 75.58

rCSI 85.06%

PRS 0.98
IgA plasma cell CL0000987

CSI 74.97

rCSI 76.74%

PRS 1.1
CD1c-positive myeloid dendritic cell CL0002399

CSI 74.19

rCSI 89.61%

PRS 0.67
renal alpha-intercalated cell CL0005011

CSI 73.42

rCSI 98.15%

PRS 0.79
respiratory suprabasal cell CL4033048

CSI 72.92

rCSI 93.52%

PRS 0.67
CD4-positive, alpha-beta T cell CL0000624

CSI 72.66

rCSI 92.99%

PRS 12.92
neuroblast (sensu Vertebrata) CL0000031

CSI 72.58

rCSI 93.15%

PRS 0.58
perivascular cell CL4033054

CSI 71.42

rCSI 97.64%

PRS 0.67
B cell CL0000236

CSI 70.67

rCSI 94.56%

PRS 3.57
enteroendocrine cell CL0000164

CSI 69.89

rCSI 95.5%

PRS 0.64
radial glial cell CL0000681

CSI 69.72

rCSI 96.86%

PRS 0.62
peripheral nervous system neuron CL2000032

CSI 69.19

rCSI 94.28%

PRS 0.53
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 68.34

rCSI 81.59%

PRS 1.01
common lymphoid progenitor CL0000051

CSI 68.34

rCSI 91.32%

PRS 1.11
mucous neck cell CL0000651

CSI 68.27

rCSI 98.39%

PRS 0.94
enteric smooth muscle cell CL0002504

CSI 68.21

rCSI 97.34%

PRS 0.66
pancreatic acinar cell CL0002064

CSI 68.2

rCSI 90.65%

PRS 0.64
lung ciliated cell CL1000271

CSI 67.95

rCSI 78.58%

PRS 0.42
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 67.72

rCSI 93.04%

PRS 1.25
pulmonary alveolar type 2 cell CL0002063

CSI 67.7

rCSI 100%

PRS 0.92
promyelocyte CL0000836

CSI 67.31

rCSI 97.08%

PRS 0.8
placental villous trophoblast CL2000060

CSI 67.19

rCSI 100%

PRS 0.55
alveolar type 1 fibroblast cell CL4028004

CSI 66.53

rCSI 72.87%

PRS 0.67
M cell of gut CL0000682

CSI 66.27

rCSI 70.42%

PRS 1.06
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 65.73

rCSI 89.54%

PRS 1.46
endothelial cell of artery CL1000413

CSI 65.46

rCSI 95.91%

PRS 3.58
conventional dendritic cell CL0000990

CSI 65.06

rCSI 54.31%

PRS 2.21
interstitial cell of Cajal CL0002088

CSI 64.47

rCSI 82.07%

PRS 0.68
classical monocyte CL0000860

CSI 63.83

rCSI 94.63%

PRS 6.95
extravillous trophoblast CL0008036

CSI 63.79

rCSI 78.91%

PRS 0.51
myeloid dendritic cell CL0000782

CSI 62.84

rCSI 91.03%

PRS 0.85
acinar cell CL0000622

CSI 62.15

rCSI 91.14%

PRS 0.77
myofibroblast cell CL0000186

CSI 61.63

rCSI 85.36%

PRS 0.84
epithelial cell CL0000066

CSI 61.23

rCSI 94.08%

PRS 0.84
activated CD8-positive, alpha-beta T cell CL0000906

CSI 61.01

rCSI 59.97%

PRS 1.74

inhibitory interneuron CL0000498

CSI -31.4

rCSI -72.5%

PRS 0.6%
kidney interstitial alternatively activated macrophage CL1000695

CSI -30.7

rCSI -80.1%

PRS 0.7%
sncg GABAergic cortical interneuron CL4023015

CSI -27.5

rCSI -44.2%

PRS 0.5%
lamp5 GABAergic cortical interneuron CL4023011

CSI -25.2

rCSI -42.2%

PRS 0.4%
adipocyte CL0000136

CSI -24.8

rCSI -31.8%

PRS 0.8%
GABAergic neuron CL0000617

CSI -21.6

rCSI -72.3%

PRS 0.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -20.1

rCSI -48.8%

PRS 0.4%
astrocyte of the cerebral cortex CL0002605

CSI -19.2

rCSI -42.9%

PRS 0.4%
neural cell CL0002319

CSI -18.4

rCSI -69.3%

PRS 1.4%
vascular leptomeningeal cell CL4023051

CSI -17.9

rCSI -31.4%

PRS 0.5%
L6b glutamatergic cortical neuron CL4023038

CSI -17.8

rCSI -55.6%

PRS 0.4%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -15.3

rCSI -47.8%

PRS 0.5%
professional antigen presenting cell CL0000145

CSI -14.6

rCSI -50.3%

PRS 2.3%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -13.8

rCSI -100.0%

PRS 11.9%
near-projecting glutamatergic cortical neuron CL4023012

CSI -13.3

rCSI -50.2%

PRS 0.4%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -13.0

rCSI -46.8%

PRS 0.4%
kidney collecting duct principal cell CL1001431

CSI -12.9

rCSI -64.7%

PRS 4.1%
pvalb GABAergic cortical interneuron CL4023018

CSI -11.6

rCSI -14.4%

PRS 0.3%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -11.2

rCSI -20.4%

PRS 0.7%
midzonal region hepatocyte CL0019028

CSI -11.1

rCSI -26.0%

PRS 1.1%
retinal bipolar neuron CL0000748

CSI -10.8

rCSI -20.3%

PRS 0.5%
cerebral cortex neuron CL0010012

CSI -10.6

rCSI -43.0%

PRS 0.8%
cerebral cortex endothelial cell CL1001602

CSI -10.3

rCSI -17.9%

PRS 0.5%
invaginating midget bipolar cell CL4033034

CSI -9.9

rCSI -58.3%

PRS 1.8%
OFFx cell CL4033036

CSI -9.7

rCSI -45.5%

PRS 2.1%
exhausted T cell CL0011025

CSI -9.0

rCSI -100.0%

PRS 3.5%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -9.0

rCSI -52.9%

PRS 0.5%
melanocyte of skin CL1000458

CSI -8.5

rCSI -11.6%

PRS 0.6%
periportal region hepatocyte CL0019026

CSI -8.4

rCSI -32.6%

PRS 1.0%
VIP GABAergic cortical interneuron CL4023016

CSI -8.1

rCSI -9.7%

PRS 0.4%
erythroid lineage cell CL0000764

CSI -8.1

rCSI -51.8%

PRS 1.7%
diffuse bipolar 1 cell CL4033027

CSI -7.8

rCSI -58.2%

PRS 2.1%
glutamatergic neuron CL0000679

CSI -7.7

rCSI -15.8%

PRS 0.7%
glycinergic amacrine cell CL4030028

CSI -7.3

rCSI -18.9%

PRS 1.0%
diffuse bipolar 6 cell CL4033032

CSI -7.1

rCSI -37.1%

PRS 2.2%
hepatic stellate cell CL0000632

CSI -6.8

rCSI -25.4%

PRS 0.5%
rod bipolar cell CL0000751

CSI -6.6

rCSI -11.8%

PRS 0.5%
cell of skeletal muscle CL0000188

CSI -6.5

rCSI -70.4%

PRS 3.4%
starburst amacrine cell CL0004232

CSI -6.2

rCSI -52.3%

PRS 2.2%
kidney collecting duct intercalated cell CL1001432

CSI -5.9

rCSI -42.4%

PRS 2.7%
regular ventricular cardiac myocyte CL0002131

CSI -5.9

rCSI -36.8%

PRS 0.5%
kidney granular cell CL0000648

CSI -5.5

rCSI -80.1%

PRS 8.8%
flat midget bipolar cell CL4033033

CSI -5.5

rCSI -39.5%

PRS 1.9%
platelet CL0000233

CSI -5.3

rCSI -22.0%

PRS 1.8%
renal interstitial pericyte CL1001318

CSI -5.3

rCSI -14.5%

PRS 0.5%
cardiac blood vessel endothelial cell CL0010006

CSI -5.1

rCSI -35.7%

PRS 2.4%
diffuse bipolar 4 cell CL4033031

CSI -5.0

rCSI -56.7%

PRS 2.8%
S cone cell CL0003050

CSI -4.7

rCSI -20.8%

PRS 1.2%
central nervous system neuron CL2000029

CSI -4.7

rCSI -34.3%

PRS 0.4%
sst GABAergic cortical interneuron CL4023017

CSI -3.8

rCSI -4.9%

PRS 0.4%
epicardial adipocyte CL1000309

CSI -3.3

rCSI -10.7%

PRS 1.2%
endocrine cell CL0000163

CSI -3.1

rCSI -15.7%

PRS 2.3%
fast muscle cell CL0000190

CSI -2.9

rCSI -11.1%

PRS 4.0%
cardiac endothelial cell CL0010008

CSI -2.7

rCSI -11.0%

PRS 0.7%
cord blood hematopoietic stem cell CL2000095

CSI -2.5

rCSI -48.5%

PRS 4.0%
diffuse bipolar 2 cell CL4033028

CSI -2.1

rCSI -16.5%

PRS 1.9%
ON midget ganglion cell CL4033046

CSI -2.0

rCSI -41.2%

PRS 0.8%
OFF midget ganglion cell CL4033047

CSI -1.9

rCSI -39.3%

PRS 0.9%
squamous epithelial cell CL0000076

CSI -1.8

rCSI -4.1%

PRS 0.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI -0.9

rCSI -1.7%

PRS 0.4%
kidney resident macrophage CL1000698

CSI -0.8

rCSI -15.0%

PRS 15.5%
alpha-beta T cell CL0000789

CSI -0.7

rCSI -0.9%

PRS 1.0%
H1 horizontal cell CL0004217

CSI -0.5

rCSI -2.1%

PRS 1.8%
diffuse bipolar 3b cell CL4033030

CSI -0.4

rCSI -2.5%

PRS 1.7%
diffuse bipolar 3a cell CL4033029

CSI -0.4

rCSI -2.4%

PRS 1.6%
direct pathway medium spiny neuron CL4023026

CSI -0.3

rCSI -7.8%

PRS 0.4%
pulmonary capillary endothelial cell CL4028001

CSI -0.1

rCSI -0.1%

PRS 0.9%
endothelial cell of vascular tree CL0002139

CSI 0.2

rCSI 1.1%

PRS 1.7%
renal intercalated cell CL0005010

CSI 0.4

rCSI 3.3%

PRS 4.8%
endocardial cell CL0002350

CSI 0.4

rCSI 1.8%

PRS 1.1%
tracheobronchial goblet cell CL0019003

CSI 0.6

rCSI 10.4%

PRS 14.9%
immature innate lymphoid cell CL0001082

CSI 0.8

rCSI 25.4%

PRS 11.5%
basal cell of epidermis CL0002187

CSI 0.9

rCSI 1.5%

PRS 0.9%
macula densa epithelial cell CL1000850

CSI 0.9

rCSI 13.5%

PRS 11.8%
indirect pathway medium spiny neuron CL4023029

CSI 1.0

rCSI 24.9%

PRS 0.5%
neutrophil CL0000775

CSI 1.2

rCSI 6.5%

PRS 2.4%
neuron CL0000540

CSI 1.2

rCSI 3.3%

PRS 1.1%
GABAergic amacrine cell CL4030027

CSI 1.3

rCSI 4.3%

PRS 0.9%
serous secreting cell CL0000313

CSI 1.8

rCSI 9.1%

PRS 3.0%
hepatic pit cell CL2000054

CSI 1.8

rCSI 25.2%

PRS 8.2%
amacrine cell CL0000561

CSI 2.2

rCSI 6.4%

PRS 0.6%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 2.2

rCSI 10.2%

PRS 2.4%
H2 horizontal cell CL0004218

CSI 2.4

rCSI 11.9%

PRS 1.3%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 2.5

rCSI 21.9%

PRS 1.7%
Bergmann glial cell CL0000644

CSI 2.7

rCSI 3.6%

PRS 0.7%
slow muscle cell CL0000189

CSI 2.7

rCSI 35.9%

PRS 9.3%
kidney loop of Henle epithelial cell CL1000909

CSI 2.9

rCSI 60.3%

PRS 4.9%
cerebellar granule cell CL0001031

CSI 3.0

rCSI 4.4%

PRS 0.6%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 3.0

rCSI 92.2%

PRS 8.7%
B-1 B cell CL0000819

CSI 3.0

rCSI 77.6%

PRS 3.5%
group 3 innate lymphoid cell, human CL0001078

CSI 3.1

rCSI 64.9%

PRS 11.7%
retinal ganglion cell CL0000740

CSI 3.1

rCSI 6.9%

PRS 0.4%
uterine smooth muscle cell CL0002601

CSI 3.2

rCSI 21.3%

PRS 4.7%
pluripotent stem cell CL0002248

CSI 3.4

rCSI 100.0%

PRS 1.5%
microglial cell CL0000129

CSI 3.5

rCSI 14.0%

PRS 2.9%
forebrain neuroblast CL1000042

CSI 3.5

rCSI 38.1%

PRS 9.6%
odontoblast CL0000060

CSI 3.6

rCSI 82.0%

PRS 3.5%
kidney connecting tubule principal cell CL4030018

CSI 3.7

rCSI 26.8%

PRS 9.3%
B-2 B cell CL0000822

CSI 3.7

rCSI 78.7%

PRS 3.9%
cardiac muscle cell CL0000746

CSI 3.7

rCSI 5.4%

PRS 0.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPL24](/details-gene/6152) (Ribosomal Protein L24) is a protein-coding gene located on chromosome 3q12.3. As its name suggests, it encodes a core structural component of the 60S large subunit of the ribosome. Its fundamental role in protein synthesis is reflected in its high expression in metabolically active and highly proliferative cell types. **Overall**, expression data shows [RPL24](/details-gene/6152) is a gene of high significance in progenitor populations, including [hematopoietic stem cells](/details-cell/CL0000037), and in various lymphocyte lineages such as [central memory CD4-positive, alpha-beta T cells](/details-cell/CL0000904) and [central memory CD8-positive, alpha-beta T cells](/details-cell/CL0000907). This expression pattern underscores its essential function in supporting cell growth, differentiation, and effector functions within the immune system and during development. ## Cellular Roles and Expression Landscape The expression profile of [RPL24](/details-gene/6152) highlights its critical role in cellular proliferation and protein production. **Overall**, the gene exhibits its highest significance in hematopoietic and immune cell populations. Top-ranking cell types include progenitor cells like [hematopoietic stem cells](/details-cell/CL0000037) and [common myeloid progenitors](/details-cell/CL0000049), as well as various developmental and mature stages of T lymphocytes, such as [naive thymus-derived CD8-positive, alpha-beta T cells](/details-cell/CL0000900) and [CD4-positive helper T cells](/details-cell/CL0000492). High significance is also observed in other key immune players like [plasmacytoid dendritic cells, human](/details-cell/CL0001058), and natural killer cells, consistent with the high translational demands of immune surveillance and response. The notable presence of [neural crest cells](/details-cell/CL0011012) among the top cell types suggests an important role during embryonic development. Conversely, [RPL24](/details-gene/6152) shows significantly low expression in terminally differentiated, post-mitotic cell types, particularly within the central nervous system. It is a strong anti-marker for various neuronal subtypes, including [inhibitory interneurons](/details-cell/CL0000498), [GABAergic neurons](/details-cell/CL0000617), and multiple glutamatergic neuron populations. This marked absence in mature neural cells, contrasted with its high significance in progenitor and immune cells, strongly suggests that its primary role is tied to the machinery of cell growth, division, and high-volume protein export rather than specialized functions of quiescent cells. ## Pathways and Molecular Function The functional annotations for [RPL24](/details-gene/6152) confirm its canonical role as an integral part of the translational machinery. It is a [structural constituent of the ribosome (GO:0003735)](https://www.ebi.ac.uk/QuickGO/term/GO:0003735) involved in [cytoplasmic translation (GO:0002181)](https://www.ebi.ac.uk/QuickGO/term/GO:0002181), [ribosomal large subunit assembly (GO:0000027)](https://www.ebi.ac.uk/QuickGO/term/GO:0000027), and [mRNA binding (GO:0003729)](https://www.ebi.ac.uk/QuickGO/term/GO:0003729). Reactome pathways further detail its involvement in all major phases of protein synthesis, including [eukaryotic translation initiation (R-HSA-72613)](https://reactome.org/content/detail/R-HSA-72613), [elongation (R-HSA-156842)](https://reactome.org/content/detail/R-HSA-156842), and [termination (R-HSA-72764)](https://reactome.org/content/detail/R-HSA-72764). Intriguingly, annotations also suggest potential extra-ribosomal functions or specialized roles for translation in specific contexts. The gene is implicated in processes like [axon guidance (R-HSA-422475)](https://reactome.org/content/detail/R-HSA-422475), [optic nerve development (GO:0021554)](https://www.ebi.ac.uk/QuickGO/term/GO:0021554), and [retinal ganglion cell axon guidance (GO:0031290)](https://www.ebi.ac.uk/QuickGO/term/GO:0031290). These annotations align with its high significance in [neural crest cells](/details-cell/CL0011012) and point towards a requirement for robust, perhaps localized, protein synthesis during nervous system development. Furthermore, its annotated function in [cadherin binding (GO:0045296)](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) raises the possibility of roles in cell-cell adhesion, potentially linking translational machinery to structural cell components. ## Research Directions The widespread and essential nature of [RPL24](/details-gene/6152) as a ribosomal protein makes it a challenging therapeutic target, but its expression patterns and non-canonical functional annotations provide avenues for further research. **Proposed Hypotheses:** 1. **Extra-ribosomal role in neural development:** Based on its links to [axon guidance (R-HSA-422475)](https://reactome.org/content/detail/R-HSA-422475) and [cadherin binding (GO:0045296)](https://www.ebi.ac.uk/QuickGO/term/GO:0045296), [RPL24](/details-gene/6152) may have a moonlighting function independent of the ribosome. It could act as an RNA-binding protein that localizes specific transcripts to the growth cone of developing neurons or to sites of cell-cell adhesion, thereby facilitating localized protein synthesis required for these processes. 2. **Specialized role in T cell activation:** The high significance of [RPL24](/details-gene/6152) in multiple T cell subsets suggests it may be a rate-limiting component for the rapid translational upregulation required for T cell activation and differentiation. Depletion of [RPL24](/details-gene/6152) may disproportionately impact the synthesis of key cytokines and effector molecules compared to housekeeping proteins, revealing a specialized role in orchestrating the T cell effector program. **Experimental Approach:** To test the hypothesis of an extra-ribosomal role in neural development, a multi-pronged approach could be employed in a relevant model system, such as differentiating human neural crest cells or a neuroblastoma cell line. Proximity-dependent biotinylation (e.g., BioID) using an RPL24-BioID2 fusion protein could identify its non-ribosomal protein interactors. Concurrently, RNA immunoprecipitation followed by sequencing (RIP-Seq) would reveal the specific mRNA transcripts that [RPL24](/details-gene/6152) binds to outside of the fully assembled ribosome, potentially identifying cargoes critical for axon guidance or cell adhesion. **Therapeutic Potential:** As a core component of the ribosome, direct targeting of [RPL24](/details-gene/6152) would likely cause unacceptable systemic toxicity. However, its high expression in proliferative cells, including many cancer types that exhibit "ribosome addiction," makes the pathway it represents a compelling therapeutic vulnerability. Rather than targeting [RPL24](/details-gene/6152) itself, therapies aimed at inhibiting ribosome biogenesis or function could be particularly effective in cancers that overexpress this and other ribosomal proteins. Therefore, its expression level could serve as a biomarker for sensitivity to ribosome-targeting agents, where inhibition would be the therapeutic strategy.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L24

Genular Protein ID: 2599948767

Symbol: RL24_HUMAN

Name: 60S ribosomal protein L24

UniProtKB Accession Codes:

P83731 B2R4Y3 P38663 Q6IBS3

Database IDs:

Citations:

PubMed ID: 8428672

Title: Characterization of cDNA clones encoding the human homologue of Saccharomyces cerevisiae ribosomal protein L30.

PubMed ID: 8428672

DOI: 10.1016/0378-1119(93)90139-t

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34314702

Title: Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

PubMed ID: 34314702

DOI: 10.1016/j.cell.2021.07.005

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 157
Mass: 17779
Checksum: 1D48EEB7C0652574
Sequence:

MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN WTVLYRRKHK 
KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV RKAQREQAIR AAKEAKKAKQ 
ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA PRVGGKR

Details for: RPL24

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Characterization of cDNA clones encoding the human homologue of Saccharomyces cerevisiae ribosomal protein L30. PubMed ID: 8428672

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. PubMed ID: 34314702

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547