Details for: RPL24

Gene ID: 6152

Symbol: RPL24

Ensembl ID: ENSG00000114391

Description: ribosomal protein L24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 629.8495
    Cell Significance Index: -259.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 566.3162
    Cell Significance Index: -230.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 512.4728
    Cell Significance Index: -241.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 492.9185
    Cell Significance Index: -253.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 362.8643
    Cell Significance Index: -243.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 241.3320
    Cell Significance Index: -230.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 48.5729
    Cell Significance Index: -130.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 15.0736
    Cell Significance Index: 385.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 13.1080
    Cell Significance Index: 350.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.9803
    Cell Significance Index: 372.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 12.6259
    Cell Significance Index: 1289.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.6914
    Cell Significance Index: 549.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.4069
    Cell Significance Index: 146.0900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.1753
    Cell Significance Index: 59.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.8436
    Cell Significance Index: 1214.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.6758
    Cell Significance Index: 200.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.5498
    Cell Significance Index: 151.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.2832
    Cell Significance Index: 386.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 8.2563
    Cell Significance Index: 217.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.2205
    Cell Significance Index: 285.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.1833
    Cell Significance Index: 171.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.7492
    Cell Significance Index: 1001.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.7453
    Cell Significance Index: 87.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.6037
    Cell Significance Index: 934.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.5895
    Cell Significance Index: 536.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.4882
    Cell Significance Index: 4089.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.4803
    Cell Significance Index: 1348.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.7773
    Cell Significance Index: 2996.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.7254
    Cell Significance Index: 501.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.6734
    Cell Significance Index: 181.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.1198
    Cell Significance Index: 66.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.1166
    Cell Significance Index: 721.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.0492
    Cell Significance Index: 390.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.4251
    Cell Significance Index: 100.2700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.3102
    Cell Significance Index: 32.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.2351
    Cell Significance Index: 153.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.0097
    Cell Significance Index: 642.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.1556
    Cell Significance Index: 709.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.0820
    Cell Significance Index: 214.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.8241
    Cell Significance Index: 35.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.6310
    Cell Significance Index: 164.5800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.3519
    Cell Significance Index: 20.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.1856
    Cell Significance Index: 1654.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0190
    Cell Significance Index: 16.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4850
    Cell Significance Index: 77.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3037
    Cell Significance Index: 34.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.0289
    Cell Significance Index: 754.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8534
    Cell Significance Index: 162.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8286
    Cell Significance Index: 748.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5903
    Cell Significance Index: 117.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4549
    Cell Significance Index: 27.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.4097
    Cell Significance Index: 32.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3591
    Cell Significance Index: 72.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0179
    Cell Significance Index: -33.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -18.0000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0945
    Cell Significance Index: -1.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1269
    Cell Significance Index: -234.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1503
    Cell Significance Index: -231.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1552
    Cell Significance Index: -55.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1904
    Cell Significance Index: -107.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2124
    Cell Significance Index: -288.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2414
    Cell Significance Index: -153.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2723
    Cell Significance Index: -170.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3013
    Cell Significance Index: -29.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4322
    Cell Significance Index: -196.1600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4402
    Cell Significance Index: -2.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4578
    Cell Significance Index: -25.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4672
    Cell Significance Index: -98.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5350
    Cell Significance Index: -15.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5833
    Cell Significance Index: -40.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6372
    Cell Significance Index: -3.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.7197
    Cell Significance Index: -207.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7692
    Cell Significance Index: -48.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9193
    Cell Significance Index: -105.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1715
    Cell Significance Index: -37.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.2369
    Cell Significance Index: -201.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.3903
    Cell Significance Index: -202.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4813
    Cell Significance Index: -24.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.5175
    Cell Significance Index: -173.2200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5796
    Cell Significance Index: -27.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.1156
    Cell Significance Index: -74.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.2931
    Cell Significance Index: -238.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.5226
    Cell Significance Index: -151.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.5953
    Cell Significance Index: -35.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.6834
    Cell Significance Index: -45.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.8526
    Cell Significance Index: -218.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.3702
    Cell Significance Index: -50.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.4084
    Cell Significance Index: -229.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.4085
    Cell Significance Index: -208.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.8372
    Cell Significance Index: -95.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -4.1650
    Cell Significance Index: -216.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.6264
    Cell Significance Index: -100.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.6564
    Cell Significance Index: -137.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -4.7028
    Cell Significance Index: -56.0600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -4.9071
    Cell Significance Index: -30.4900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.1808
    Cell Significance Index: -28.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.2464
    Cell Significance Index: -232.0600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -5.6088
    Cell Significance Index: -72.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.6918
    Cell Significance Index: -208.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.9632
    Cell Significance Index: -50.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein L24**: RPL24 is a 60S ribosomal protein, which is a subunit of the large ribosomal subunit responsible for protein synthesis. 2. **Highly expressed**: RPL24 is significantly expressed in various cell types, including thyroid follicular cells, myoepithelial cells, malignant cells, and immune cells. 3. **Multiple pathways**: RPL24 is involved in various cellular pathways, including axon guidance, cap-dependent translation initiation, cellular responses to stimuli, and cytoplasmic translation. 4. **Cellular localization**: RPL24 is primarily localized to the cytosol, where it plays a crucial role in protein synthesis and translation. **Pathways and Functions:** 1. **Translation initiation**: RPL24 is involved in the initiation of translation, where it helps to recruit the small ribosomal subunit to the mRNA. 2. **Protein synthesis**: RPL24 plays a crucial role in protein synthesis, where it interacts with other ribosomal proteins to form the 60S ribosomal subunit. 3. **Response to stress**: RPL24 is involved in the response to cellular stress, where it helps to regulate the expression of genes involved in stress response. 4. **Axon guidance**: RPL24 is involved in axon guidance, where it helps to regulate the migration of axons during neuronal development. 5. **Nonsense-mediated decay**: RPL24 is involved in nonsense-mediated decay (NMD), a process that regulates the expression of genes with premature stop codons. **Clinical Significance:** 1. **Disease association**: RPL24 has been associated with various diseases, including cancer, where it is often overexpressed. 2. **Thyroid disease**: RPL24 has been implicated in thyroid disease, where it is involved in the regulation of thyroid hormone synthesis. 3. **Immune cell function**: RPL24 is involved in the regulation of immune cell function, where it helps to regulate the expression of genes involved in immune responses. 4. **Neurological disorders**: RPL24 has been implicated in neurological disorders, where it is involved in the regulation of axon guidance and neuronal development. **Conclusion:** In conclusion, RPL24 is a crucial protein involved in various cellular processes, including protein synthesis, translation initiation, and response to stress. Its high expression in various cell types and involvement in multiple pathways make it an important target for the development of novel therapeutic strategies for various diseases. Further research is needed to fully elucidate the role of RPL24 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2599948767

Symbol: RL24_HUMAN

Name: 60S ribosomal protein L24

UniProtKB Accession Codes:

P83731 B2R4Y3 P38663 Q6IBS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 EMDB 42 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 57 PDBsum 57 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8428672

Title: Characterization of cDNA clones encoding the human homologue of Saccharomyces cerevisiae ribosomal protein L30.

PubMed ID: 8428672

DOI: 10.1016/0378-1119(93)90139-t

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34314702

Title: Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

PubMed ID: 34314702

DOI: 10.1016/j.cell.2021.07.005

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 157
  • Mass: 17779
  • Checksum: 1D48EEB7C0652574
  • Sequence:
    • MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN WTVLYRRKHK 
KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV RKAQREQAIR AAKEAKKAKQ 
ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA PRVGGKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.