RPL26 | ENSG00000161970 | NCBI 6154

Details for: RPL26

Gene ID: 6154

Symbol: RPL26

Ensembl ID: ENSG00000161970

Description: ribosomal protein L26

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to uv
(GO:0034644)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Extracellular exosome
(GO:0070062)
Membrane
(GO:0016020)
Mrna 5'-utr binding
(GO:0048027)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
(GO:1902164)
Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:1902167)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Regulation of translation involved in cellular response to uv
(GO:1904803)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal large subunit biogenesis
(GO:0042273)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 714.5083
Cell Significance Index: -294.3400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 684.1234
Cell Significance Index: -277.9300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 606.6432
Cell Significance Index: -286.4100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 572.1393
Cell Significance Index: -294.3000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 428.3465
Cell Significance Index: -287.4300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 291.7644
Cell Significance Index: -278.5600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 37.7586
Cell Significance Index: -101.1500
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 24.2284
Cell Significance Index: 64.9100
Cell Name: theca cell (CL0000503)
Fold Change: 21.9795
Cell Significance Index: 129.1300
Cell Name: pro-T cell (CL0000827)
Fold Change: 17.7389
Cell Significance Index: 453.1700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 16.5686
Cell Significance Index: 443.2000
Cell Name: abnormal cell (CL0001061)
Fold Change: 15.5348
Cell Significance Index: 1586.8700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 13.3687
Cell Significance Index: 628.3200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 12.7284
Cell Significance Index: 144.6000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 12.5449
Cell Significance Index: 221.6900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 12.2798
Cell Significance Index: 352.0100
Cell Name: peg cell (CL4033014)
Fold Change: 11.1163
Cell Significance Index: 256.8300
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 11.0044
Cell Significance Index: 116.9200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 10.5596
Cell Significance Index: 221.0300
Cell Name: lactocyte (CL0002325)
Fold Change: 10.3442
Cell Significance Index: 1336.3900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 10.2436
Cell Significance Index: 355.9600
Cell Name: granulosa cell (CL0000501)
Fold Change: 9.9196
Cell Significance Index: 260.8400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 9.4116
Cell Significance Index: 665.6300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 9.4042
Cell Significance Index: 1156.3300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 9.3923
Cell Significance Index: 1693.1400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.3293
Cell Significance Index: 1281.1700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 9.2253
Cell Significance Index: 687.5500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 8.7174
Cell Significance Index: 94.7700
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 8.3325
Cell Significance Index: 51.2800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 8.0940
Cell Significance Index: 3578.5600
Cell Name: cell in vitro (CL0001034)
Fold Change: 7.2183
Cell Significance Index: 3942.1000
Cell Name: odontoblast (CL0000060)
Fold Change: 7.0740
Cell Significance Index: 906.8400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 6.8122
Cell Significance Index: 200.0700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 6.7731
Cell Significance Index: 798.7600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.6888
Cell Significance Index: 61.6000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.4834
Cell Significance Index: 418.2800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.9855
Cell Significance Index: 261.7600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.5671
Cell Significance Index: 58.4900
Cell Name: kidney cell (CL1000497)
Fold Change: 4.4437
Cell Significance Index: 35.4800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.1996
Cell Significance Index: 114.3100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.7651
Cell Significance Index: 642.9200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.6845
Cell Significance Index: 68.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 3.5912
Cell Significance Index: 2718.2700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 3.2154
Cell Significance Index: 27.6300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.2922
Cell Significance Index: 2069.7000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.7343
Cell Significance Index: 80.8600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6284
Cell Significance Index: 161.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.4702
Cell Significance Index: 168.4300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.4558
Cell Significance Index: 1067.4100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.3937
Cell Significance Index: 110.3800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0830
Cell Significance Index: 206.1100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5019
Cell Significance Index: 30.8500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4940
Cell Significance Index: 13.1900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2208
Cell Significance Index: 44.3000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1119
Cell Significance Index: -210.6600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1129
Cell Significance Index: -83.6100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1723
Cell Significance Index: -317.7700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2084
Cell Significance Index: -320.8000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2435
Cell Significance Index: -137.3300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2513
Cell Significance Index: -156.9400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2517
Cell Significance Index: -10.3100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2559
Cell Significance Index: -347.9200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2955
Cell Significance Index: -14.9300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.3253
Cell Significance Index: -22.5000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.3460
Cell Significance Index: -124.1200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3942
Cell Significance Index: -20.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.4162
Cell Significance Index: -264.3600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5841
Cell Significance Index: -123.0200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.6167
Cell Significance Index: -279.9200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8011
Cell Significance Index: -4.8400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.8103
Cell Significance Index: -233.1600
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.1712
Cell Significance Index: -20.1900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1939
Cell Significance Index: -38.2400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.2435
Cell Significance Index: -141.9400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.3508
Cell Significance Index: -75.8000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -1.4208
Cell Significance Index: -231.0800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -1.4381
Cell Significance Index: -285.3900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.6488
Cell Significance Index: -103.9200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.9503
Cell Significance Index: -32.6400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.9506
Cell Significance Index: -283.5400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.2646
Cell Significance Index: -56.6100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -2.5994
Cell Significance Index: -117.8200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.7514
Cell Significance Index: -286.4900
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -3.0438
Cell Significance Index: -63.4800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -3.0886
Cell Significance Index: -185.4200
Cell Name: perivascular cell (CL4033054)
Fold Change: -3.3115
Cell Significance Index: -15.2900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.4803
Cell Significance Index: -267.0800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.9200
Cell Significance Index: -240.3300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -4.2078
Cell Significance Index: -63.0500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.4598
Cell Significance Index: -96.6200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.4736
Cell Significance Index: -300.8100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -4.5659
Cell Significance Index: -160.4400
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -4.7675
Cell Significance Index: -34.2400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -5.1376
Cell Significance Index: -267.6100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -5.6598
Cell Significance Index: -163.0700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.8640
Cell Significance Index: -172.7200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -5.8760
Cell Significance Index: -259.9100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -5.9115
Cell Significance Index: -80.6600
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -6.2461
Cell Significance Index: -38.8100
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -6.7543
Cell Significance Index: -36.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RPL26 is a 19-kDa protein that belongs to the ribosomal protein L26 family. It is a structural component of the large subunit of the ribosome, where it interacts with other ribosomal proteins to form the 60S subunit. RPL26 has a unique ability to bind to the 5' untranslated region (UTR) of mRNAs, regulating their translation and stability. Additionally, RPL26 has been implicated in various signaling pathways, including those involved in cellular responses to stress, DNA damage, and viral infections. **Pathways and Functions** RPL26 is involved in various cellular processes, including: 1. **Translation Initiation**: RPL26 plays a crucial role in the initiation of protein synthesis by binding to the 5' UTR of mRNAs and recruiting translation initiation factors. 2. **Translation Elongation**: RPL26 is involved in the elongation phase of protein synthesis, where it interacts with other ribosomal proteins to facilitate peptide chain elongation. 3. **Translation Termination**: RPL26 has been implicated in the termination of protein synthesis, where it interacts with other ribosomal proteins to release the completed polypeptide chain. 4. **Stress Response**: RPL26 is involved in the cellular response to stress, including heat shock, oxidative stress, and DNA damage, where it helps to regulate the expression of stress-related genes. 5. **DNA Damage Response**: RPL26 has been implicated in the DNA damage response pathway, where it helps to regulate the expression of genes involved in DNA repair and cell cycle arrest. 6. **Viral Infections**: RPL26 has been shown to interact with viral RNA and facilitate the translation of viral mRNAs, highlighting its importance in viral infections. **Clinical Significance** RPL26 has been implicated in various diseases, including: 1. **Cancer**: RPL26 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumorigenesis and cancer progression. 2. **Neurological Disorders**: RPL26 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where it may contribute to protein synthesis dysregulation and neuronal degeneration. 3. **Infectious Diseases**: RPL26 has been shown to interact with viral RNA and facilitate the translation of viral mRNAs, highlighting its importance in viral infections, such as influenza and HIV. In conclusion, RPL26 is a crucial component of the ribosome, involved in various cellular processes, including translation initiation, elongation, and termination, as well as response to stress, DNA damage, and viral infections. Its dysregulation has been implicated in various diseases, highlighting the importance of RPL26 in maintaining cellular homeostasis and integrity.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L26

Genular Protein ID: 2123035423

Symbol: RL26_HUMAN

Name: 60S ribosomal protein L26

UniProtKB Accession Codes:

P61254 B2R4F0 D3DTR8 Q02877 Q6IPY2

Database IDs:

Citations:

PubMed ID: 8479925

Title: Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6.

PubMed ID: 8479925

DOI: 10.1093/nar/21.7.1673

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22431104

Title: Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.

PubMed ID: 22431104

DOI: 10.1002/humu.22081

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26100019

Title: The DHX33 RNA Helicase Promotes mRNA Translation Initiation.

PubMed ID: 26100019

DOI: 10.1128/mcb.00315-15

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 145
Mass: 17258
Checksum: 049D53AB4E3F46B6
Sequence:

MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG 
HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH PSKVVITRLK LDKDRKKILE 
RKAKSRQVGK EKGKYKEETI EKMQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPL26

Associated with

Cells (max top 100)

Other Information

Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. PubMed ID: 8479925

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. PubMed ID: 22431104

A new system for naming ribosomal proteins. PubMed ID: 24524803

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

The DHX33 RNA Helicase Promotes mRNA Translation Initiation. PubMed ID: 26100019

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation. PubMed ID: 32160526

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547