Gene RPL26 - ENSG00000161970 | NCBI Gene ID: 6154

Details for: RPL26

Gene ID: 6154

Symbol: RPL26

Ensembl ID: ENSG00000161970

Description: ribosomal protein L26

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to uv
(GO:0034644)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Extracellular exosome
(GO:0070062)
Membrane
(GO:0016020)
Mrna 5'-utr binding
(GO:0048027)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
(GO:1902164)
Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:1902167)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Regulation of translation involved in cellular response to uv
(GO:1904803)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal large subunit biogenesis
(GO:0042273)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 6.21
Marker Score: 1821.5
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.19
Marker Score: 30386.5
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 5.83
Marker Score: 3287
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.45
Marker Score: 4267.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.41
Marker Score: 3927
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.36
Marker Score: 2755
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.33
Marker Score: 15555
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.31
Marker Score: 6922
Cell Name: mature T cell (CL0002419)
Fold Change: 5.3
Marker Score: 52486
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.27
Marker Score: 3715.5
Cell Name: malignant cell (CL0001064)
Fold Change: 5.16
Marker Score: 69291
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.12
Marker Score: 8786
Cell Name: theca cell (CL0000503)
Fold Change: 5.11
Marker Score: 3660
Cell Name: classical monocyte (CL0000860)
Fold Change: 5.07
Marker Score: 21067
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.05
Marker Score: 171846
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.96
Marker Score: 2559
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.87
Marker Score: 2954
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.85
Marker Score: 10166
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.79
Marker Score: 15121
Cell Name: radial glial cell (CL0000681)
Fold Change: 4.79
Marker Score: 1765
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.71
Marker Score: 7256.5
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.71
Marker Score: 3552
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.69
Marker Score: 247800
Cell Name: Kupffer cell (CL0000091)
Fold Change: 4.66
Marker Score: 4662
Cell Name: naive B cell (CL0000788)
Fold Change: 4.64
Marker Score: 4145.5
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.55
Marker Score: 2427
Cell Name: memory T cell (CL0000813)
Fold Change: 4.5
Marker Score: 1933
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.48
Marker Score: 1456
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.43
Marker Score: 4925
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.43
Marker Score: 3774
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.41
Marker Score: 58232
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.41
Marker Score: 11207.5
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.35
Marker Score: 2644
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.31
Marker Score: 11900.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.29
Marker Score: 239961
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.27
Marker Score: 25965
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.26
Marker Score: 22414
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.26
Marker Score: 11960.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.2
Marker Score: 10250
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.12
Marker Score: 10035.5
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.11
Marker Score: 6048
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.1
Marker Score: 3498
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.1
Marker Score: 17567
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.09
Marker Score: 4934
Cell Name: supporting cell (CL0000630)
Fold Change: 4.08
Marker Score: 7670
Cell Name: naive T cell (CL0000898)
Fold Change: 4.07
Marker Score: 2622
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.07
Marker Score: 2894
Cell Name: blood cell (CL0000081)
Fold Change: 4.05
Marker Score: 47036
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.04
Marker Score: 10822.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.04
Marker Score: 4312
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4.01
Marker Score: 3954
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.97
Marker Score: 6312
Cell Name: hepatocyte (CL0000182)
Fold Change: 3.97
Marker Score: 2708
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.96
Marker Score: 3362
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.94
Marker Score: 3093
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.93
Marker Score: 29279.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.87
Marker Score: 3649
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.86
Marker Score: 8798
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.86
Marker Score: 13704
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.83
Marker Score: 3604.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.79
Marker Score: 1248
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.76
Marker Score: 4154
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.75
Marker Score: 895.5
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.75
Marker Score: 3907
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.73
Marker Score: 3603
Cell Name: microglial cell (CL0000129)
Fold Change: 3.72
Marker Score: 6766.5
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.72
Marker Score: 2499
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 3.68
Marker Score: 2051
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.67
Marker Score: 3010
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.67
Marker Score: 3727
Cell Name: papillary tips cell (CL1000597)
Fold Change: 3.67
Marker Score: 740.5
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.66
Marker Score: 23802
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.65
Marker Score: 2101
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.65
Marker Score: 8285.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.64
Marker Score: 3237
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.63
Marker Score: 4157
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.63
Marker Score: 3188.5
Cell Name: reticular cell (CL0000432)
Fold Change: 3.61
Marker Score: 1316
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.61
Marker Score: 23504.5
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.6
Marker Score: 3212.5
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.6
Marker Score: 1985
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.59
Marker Score: 2363
Cell Name: memory B cell (CL0000787)
Fold Change: 3.58
Marker Score: 2712
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.57
Marker Score: 22770
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.55
Marker Score: 2949
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.54
Marker Score: 2979
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.53
Marker Score: 7058.5
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.53
Marker Score: 2671
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 3.52
Marker Score: 935
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.52
Marker Score: 1606
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.52
Marker Score: 1212
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.51
Marker Score: 27382
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.5
Marker Score: 1504
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.5
Marker Score: 2048
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.49
Marker Score: 1807
Cell Name: immature B cell (CL0000816)
Fold Change: 3.47
Marker Score: 2299
Cell Name: paneth cell (CL0000510)
Fold Change: 3.47
Marker Score: 2414
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.46
Marker Score: 3723
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.46
Marker Score: 2127
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.45
Marker Score: 1437

Hover over a box to see details here...

**Key characteristics:** * RPL26 is a large protein with a molecular weight of approximately 70 kDa. * It is a member of the ribosomal protein L26 family. * RPL26 is required for the initiation of translation of mRNA in all eukaryotes. * It is involved in the processing of mRNA and the formation of the ribosome. * It is a key regulator of protein synthesis. **Pathways and functions:** * RPL26 is involved in the initiation of translation of mRNA in all eukaryotes. * It is a key component of the ribosome, which is responsible for protein synthesis. * It is involved in the processing of mRNA and the formation of the ribosome. * It is a key regulator of protein synthesis. **Clinical significance:** * Mutations in RPL26 have been linked to a number of human diseases, including cancer, neurodegenerative diseases, and metabolic disorders. * RPL26 is a promising target for the development of novel therapies for these diseases. **Additional information:** * RPL26 is a highly conserved protein across different species. * It is expressed in high levels in cells that are actively synthesizing proteins. * It is a target for a variety of drugs, including siRNAs and antibodies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L26

Genular Protein ID: 2123035423

Symbol: RL26_HUMAN

Name: 60S ribosomal protein L26

UniProtKB Accession Codes:

P61254 B2R4F0 D3DTR8 Q02877 Q6IPY2

Database IDs:

Citations:

PubMed ID: 8479925

Title: Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6.

PubMed ID: 8479925

DOI: 10.1093/nar/21.7.1673

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22431104

Title: Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.

PubMed ID: 22431104

DOI: 10.1002/humu.22081

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26100019

Title: The DHX33 RNA Helicase Promotes mRNA Translation Initiation.

PubMed ID: 26100019

DOI: 10.1128/mcb.00315-15

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 145
Mass: 17258
Checksum: 049D53AB4E3F46B6
Sequence:

MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG 
HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH PSKVVITRLK LDKDRKKILE 
RKAKSRQVGK EKGKYKEETI EKMQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPL26

Associated with

Cells (max top 100)

Other Information

Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. PubMed ID: 8479925

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. PubMed ID: 22431104

A new system for naming ribosomal proteins. PubMed ID: 24524803

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

The DHX33 RNA Helicase Promotes mRNA Translation Initiation. PubMed ID: 26100019

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation. PubMed ID: 32160526

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547