Details for: RPL30

Gene ID: 6156

Symbol: RPL30

Ensembl ID: ENSG00000156482

Description: ribosomal protein L30

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 795.9265
    Cell Significance Index: -327.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 729.8334
    Cell Significance Index: -296.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 661.4383
    Cell Significance Index: -312.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 640.8232
    Cell Significance Index: -329.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 467.5852
    Cell Significance Index: -313.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 316.6926
    Cell Significance Index: -302.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 58.8422
    Cell Significance Index: -157.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 20.0424
    Cell Significance Index: 304.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.7557
    Cell Significance Index: 1507.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 14.5052
    Cell Significance Index: 370.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.0657
    Cell Significance Index: 376.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 13.5242
    Cell Significance Index: 173.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.4429
    Cell Significance Index: 584.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.1340
    Cell Significance Index: 347.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 11.8598
    Cell Significance Index: 219.2000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.5529
    Cell Significance Index: 28.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.8861
    Cell Significance Index: 112.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.2047
    Cell Significance Index: 1264.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.8775
    Cell Significance Index: 1091.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.8420
    Cell Significance Index: 625.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.7219
    Cell Significance Index: 1126.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.7162
    Cell Significance Index: 1571.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.3843
    Cell Significance Index: 3706.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.2003
    Cell Significance Index: 189.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.0516
    Cell Significance Index: 949.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.7775
    Cell Significance Index: 204.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.5285
    Cell Significance Index: 4111.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.2547
    Cell Significance Index: 128.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.1925
    Cell Significance Index: 150.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.9385
    Cell Significance Index: 517.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.6913
    Cell Significance Index: 431.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.4499
    Cell Significance Index: 224.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.2180
    Cell Significance Index: 797.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.7350
    Cell Significance Index: 168.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.4392
    Cell Significance Index: 148.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2809
    Cell Significance Index: 246.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.9644
    Cell Significance Index: 53.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.3693
    Cell Significance Index: 227.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.0805
    Cell Significance Index: 696.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.9446
    Cell Significance Index: 36.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.9437
    Cell Significance Index: 291.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.4534
    Cell Significance Index: 1857.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3421
    Cell Significance Index: 464.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2126
    Cell Significance Index: 59.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2021
    Cell Significance Index: 99.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8110
    Cell Significance Index: 1635.2200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1928
    Cell Significance Index: 10.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.0311
    Cell Significance Index: 756.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8785
    Cell Significance Index: 167.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2287
    Cell Significance Index: 12.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2108
    Cell Significance Index: 10.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0428
    Cell Significance Index: -80.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1019
    Cell Significance Index: -20.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1236
    Cell Significance Index: -91.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1325
    Cell Significance Index: -244.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1651
    Cell Significance Index: -254.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2102
    Cell Significance Index: -118.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2439
    Cell Significance Index: -331.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2760
    Cell Significance Index: -99.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3072
    Cell Significance Index: -191.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3731
    Cell Significance Index: -236.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4510
    Cell Significance Index: -27.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6000
    Cell Significance Index: -47.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6327
    Cell Significance Index: -287.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6350
    Cell Significance Index: -103.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6910
    Cell Significance Index: -145.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8886
    Cell Significance Index: -255.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4751
    Cell Significance Index: -169.0000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.5957
    Cell Significance Index: -9.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6049
    Cell Significance Index: -90.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8866
    Cell Significance Index: -274.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.8922
    Cell Significance Index: -32.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.0037
    Cell Significance Index: -228.7200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -2.0051
    Cell Significance Index: -11.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.1194
    Cell Significance Index: -146.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2981
    Cell Significance Index: -38.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.7505
    Cell Significance Index: -173.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.9554
    Cell Significance Index: -307.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.0011
    Cell Significance Index: -96.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.1696
    Cell Significance Index: -19.1500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.4020
    Cell Significance Index: -70.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.4088
    Cell Significance Index: -85.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.8656
    Cell Significance Index: -232.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.0100
    Cell Significance Index: -307.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.1266
    Cell Significance Index: -277.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.2447
    Cell Significance Index: -91.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.3506
    Cell Significance Index: -266.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -4.3831
    Cell Significance Index: -154.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.6659
    Cell Significance Index: -63.6600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.0818
    Cell Significance Index: -27.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.3871
    Cell Significance Index: -80.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.1220
    Cell Significance Index: -164.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -6.1809
    Cell Significance Index: -49.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.5817
    Cell Significance Index: -193.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.6983
    Cell Significance Index: -114.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.0788
    Cell Significance Index: -313.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.5820
    Cell Significance Index: -278.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -7.8651
    Cell Significance Index: -226.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -7.9298
    Cell Significance Index: -102.1200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -8.3795
    Cell Significance Index: -38.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL30 is a 23-kDa protein that belongs to the ribosomal protein family. It is encoded by the RPL30 gene, located on chromosome 10q24.3 in humans. The protein is highly conserved across species and is involved in the translation elongation phase, where it interacts with the 40S ribosomal subunit to facilitate the assembly of the 80S ribosome. RPL30 is also known to be involved in the regulation of protein synthesis, particularly in response to amino acid availability and stress. **Pathways and Functions:** RPL30 is involved in various cellular processes, including: 1. **Antimicrobial Humoral Immune Response:** RPL30 has been shown to be involved in the production of antimicrobial peptides, such as defensins, which play a crucial role in defending against bacterial infections. 2. **Axon Guidance:** RPL30 has been implicated in axon guidance, a process essential for the development and maintenance of the nervous system. 3. **Cap-dependent Translation Initiation:** RPL30 is involved in the initiation of translation of mRNAs capped at the 5' end, which is essential for the synthesis of proteins involved in various cellular processes. 4. **Cellular Responses to Stimuli:** RPL30 has been shown to be involved in the regulation of protein synthesis in response to various stimuli, including stress and amino acid availability. 5. **Cytoplasmic Translation:** RPL30 is involved in the translation of mRNAs in the cytoplasm, where it interacts with the 40S ribosomal subunit to facilitate protein synthesis. **Clinical Significance:** RPL30 has been implicated in various diseases, including: 1. **Cancer:** Dysregulation of RPL30 has been linked to the development and progression of various cancers, including breast, lung, and colorectal cancer. 2. **Infectious Diseases:** RPL30 has been shown to play a crucial role in the immune response against bacterial infections, such as influenza and tuberculosis. 3. **Neurological Disorders:** RPL30 has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RPL30 is a crucial protein involved in various cellular processes, including protein synthesis, antimicrobial responses, and axon guidance. Its dysregulation has been linked to various diseases, highlighting the importance of RPL30 in maintaining cellular homeostasis and immune function. Further research is needed to fully elucidate the role of RPL30 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2249015836

Symbol: RL30_HUMAN

Name: 60S ribosomal protein L30

UniProtKB Accession Codes:

P62888 B2R591 P04645 Q502Z6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 70 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 86 PDBsum 86 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22139155

Title: Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e.

PubMed ID: 22139155

DOI: 10.1107/s1744309111045131

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 115
  • Mass: 12784
  • Checksum: 95186B081E39748C
  • Sequence:
    • MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN NCPALRKSEI 
EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG DSDIIRSMPE QTGEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.