Details for: RPL28

Gene ID: 6158

Symbol: RPL28

Ensembl ID: ENSG00000108107

Description: ribosomal protein L28

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 792.7222
    Cell Significance Index: -326.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 753.2422
    Cell Significance Index: -306.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 653.9402
    Cell Significance Index: -308.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 649.0126
    Cell Significance Index: -333.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 322.0815
    Cell Significance Index: -307.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 45.4148
    Cell Significance Index: -121.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 19.0155
    Cell Significance Index: 485.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 17.0885
    Cell Significance Index: 315.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 17.0748
    Cell Significance Index: 456.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.0623
    Cell Significance Index: 1538.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.6392
    Cell Significance Index: 594.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.0466
    Cell Significance Index: 154.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 10.2748
    Cell Significance Index: 1211.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 10.0586
    Cell Significance Index: 1813.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.9241
    Cell Significance Index: 1220.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.7943
    Cell Significance Index: 280.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.5787
    Cell Significance Index: 251.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.5759
    Cell Significance Index: 221.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.4270
    Cell Significance Index: 666.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.3066
    Cell Significance Index: 1278.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.8579
    Cell Significance Index: 100.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.7973
    Cell Significance Index: 4804.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.6414
    Cell Significance Index: 1116.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.6137
    Cell Significance Index: 252.9800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.1822
    Cell Significance Index: 70.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.1147
    Cell Significance Index: 3587.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.4952
    Cell Significance Index: 483.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.3394
    Cell Significance Index: 153.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 7.1085
    Cell Significance Index: 65.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.7696
    Cell Significance Index: 504.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.5427
    Cell Significance Index: 838.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.2183
    Cell Significance Index: 289.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.6368
    Cell Significance Index: 99.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.1177
    Cell Significance Index: 139.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.8541
    Cell Significance Index: 220.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.8495
    Cell Significance Index: 52.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.8151
    Cell Significance Index: 3644.6800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.7949
    Cell Significance Index: 12.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.5698
    Cell Significance Index: 158.8000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.9932
    Cell Significance Index: 24.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.0620
    Cell Significance Index: 81.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.6940
    Cell Significance Index: 2432.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.6435
    Cell Significance Index: 451.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.5271
    Cell Significance Index: 132.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1623
    Cell Significance Index: 429.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3300
    Cell Significance Index: 69.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1351
    Cell Significance Index: 216.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.1228
    Cell Significance Index: 823.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9879
    Cell Significance Index: 97.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3224
    Cell Significance Index: 115.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2547
    Cell Significance Index: 51.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0486
    Cell Significance Index: -35.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0544
    Cell Significance Index: -102.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1645
    Cell Significance Index: -303.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1994
    Cell Significance Index: -306.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2495
    Cell Significance Index: -339.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3094
    Cell Significance Index: -174.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4085
    Cell Significance Index: -259.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.4216
    Cell Significance Index: -263.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6086
    Cell Significance Index: -276.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6578
    Cell Significance Index: -52.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.7304
    Cell Significance Index: -118.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8460
    Cell Significance Index: -52.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8642
    Cell Significance Index: -248.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -1.0768
    Cell Significance Index: -226.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.3177
    Cell Significance Index: -150.9700
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.4851
    Cell Significance Index: -8.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.6480
    Cell Significance Index: -28.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8521
    Cell Significance Index: -11.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8781
    Cell Significance Index: -273.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.0635
    Cell Significance Index: -66.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0759
    Cell Significance Index: -130.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.2946
    Cell Significance Index: -128.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.4929
    Cell Significance Index: -284.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.6046
    Cell Significance Index: -43.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.8667
    Cell Significance Index: -298.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.5287
    Cell Significance Index: -244.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.6893
    Cell Significance Index: -55.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.8148
    Cell Significance Index: -256.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.9941
    Cell Significance Index: -306.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.0070
    Cell Significance Index: -54.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.1261
    Cell Significance Index: -89.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.3057
    Cell Significance Index: -263.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -4.6868
    Cell Significance Index: -244.1300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.8323
    Cell Significance Index: -26.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -5.1132
    Cell Significance Index: -127.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -5.4175
    Cell Significance Index: -43.2600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -5.5707
    Cell Significance Index: -116.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -6.1339
    Cell Significance Index: -215.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.2957
    Cell Significance Index: -107.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.4982
    Cell Significance Index: -191.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -7.4153
    Cell Significance Index: -198.7000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -7.5397
    Cell Significance Index: -56.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.5851
    Cell Significance Index: -335.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.7784
    Cell Significance Index: -285.5400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -7.9162
    Cell Significance Index: -101.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -8.0874
    Cell Significance Index: -83.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -8.2085
    Cell Significance Index: -97.8500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -8.3253
    Cell Significance Index: -38.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -8.3401
    Cell Significance Index: -240.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL28 is a highly conserved gene, with high sequence identity across different species. It is a member of the 28S ribosomal protein family and is involved in the assembly and function of the large ribosomal subunit. The protein has a unique structure, consisting of a β-barrel domain and a C-terminal domain that interacts with other ribosomal proteins. RPL28 is also known to be involved in the regulation of translation initiation and elongation, as well as the response to amino acid deficiency. **Pathways and Functions** RPL28 is involved in various cellular pathways, including: 1. **Translation**: RPL28 is a crucial component of the large ribosomal subunit, which is essential for protein synthesis. It plays a key role in the assembly and function of the ribosome, and its dysregulation can lead to defects in protein synthesis. 2. **Stress Response**: RPL28 is involved in the cellular response to stress, including amino acid deficiency and viral infection. It regulates the expression of genes involved in stress response and is also involved in the regulation of the unfolded protein response (UPR). 3. **Viral Infection**: RPL28 is involved in the replication of influenza virus and other RNA viruses. It plays a key role in the translation of viral mRNA and the regulation of viral gene expression. 4. **Cellular Responses**: RPL28 is involved in the regulation of cellular responses to stimuli, including the response to amino acid deficiency and the regulation of the UPR. **Clinical Significance** Dysregulation of RPL28 has been implicated in various diseases, including: 1. **Cancer**: RPL28 is overexpressed in various types of cancer, including breast cancer and lung cancer. Its overexpression is associated with poor prognosis and reduced survival rates. 2. **Neurological Disorders**: RPL28 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. Its dysregulation is associated with defects in protein synthesis and the regulation of protein homeostasis. 3. **Infectious Diseases**: RPL28 is involved in the replication of various viruses, including influenza and HIV. Its dysregulation can lead to defects in viral replication and the regulation of viral gene expression. In conclusion, RPL28 is a crucial gene that plays a pivotal role in eukaryotic translation and beyond. Its dysregulation can lead to defects in protein synthesis, the regulation of stress response, and the replication of viruses. Further research is needed to fully understand the mechanisms of RPL28 and its role in various diseases. **Recommendations** 1. **Further Research**: Further research is needed to fully understand the mechanisms of RPL28 and its role in various diseases. 2. **Therapeutic Targeting**: RPL28 could be a potential therapeutic target for the treatment of various diseases, including cancer and neurological disorders. 3. **Diagnostic Biomarkers**: RPL28 could be used as a diagnostic biomarker for various diseases, including cancer and infectious diseases.

Genular Protein ID: 4239235428

Symbol: RL28_HUMAN

Name: 60S ribosomal protein L28

UniProtKB Accession Codes:

P46779 B2R4A6 B4DEP9 C9JB50 E9PB24 G5E9L2 Q6IAY0 Q96FX1 Q9BWQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 EMBL 12 EMDB 76 Ensembl 6 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 91 PDBsum 91 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 13 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 137
  • Mass: 15748
  • Checksum: 44DCDE45473D7C7B
  • Sequence:
    • MSAHLQWMVV RNCSSFLIKR NKQTYSTEPN NLKARNSFRY NGLIHRKTVG VEPAADGKGV 
VVVIKRRSGQ RKPATSYVRT TINKNARATL SSIRHMIRKN KYRPDLRMAA IRRASAILRS 
QKPVMVKRKR TRPTKSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.