Details for: RPL28

Gene ID: 6158

Symbol: RPL28

Ensembl ID: ENSG00000108107

Description: ribosomal protein L28

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.18
    Marker Score: 30371.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.8
    Marker Score: 12149.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.71
    Marker Score: 4139.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.51
    Marker Score: 2829
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.48
    Marker Score: 73574
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.41
    Marker Score: 15786.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 5.4
    Marker Score: 3810
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.36
    Marker Score: 8249
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.32
    Marker Score: 1963
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.27
    Marker Score: 52144
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.23
    Marker Score: 2697
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.21
    Marker Score: 8934
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.07
    Marker Score: 2865
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.05
    Marker Score: 171981
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 5.04
    Marker Score: 4496
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.87
    Marker Score: 15375
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 4.84
    Marker Score: 2728
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.79
    Marker Score: 253044
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.77
    Marker Score: 25090
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.75
    Marker Score: 3405
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.74
    Marker Score: 2037
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.69
    Marker Score: 11922
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.67
    Marker Score: 3975
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.65
    Marker Score: 1110.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.62
    Marker Score: 3486
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.61
    Marker Score: 257522
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.56
    Marker Score: 12232
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.56
    Marker Score: 19011
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.55
    Marker Score: 5923.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.54
    Marker Score: 5047
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.5
    Marker Score: 1461.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.48
    Marker Score: 59066
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.45
    Marker Score: 27010.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.43
    Marker Score: 15725
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.4
    Marker Score: 51184
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.39
    Marker Score: 2673
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.37
    Marker Score: 3774
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.32
    Marker Score: 2782
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.31
    Marker Score: 11900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.28
    Marker Score: 1926
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.26
    Marker Score: 11937
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.25
    Marker Score: 4109
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.25
    Marker Score: 27104
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.23
    Marker Score: 4937.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.23
    Marker Score: 10328
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.21
    Marker Score: 2466
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.19
    Marker Score: 31175
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.18
    Marker Score: 3181
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.17
    Marker Score: 5153
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.15
    Marker Score: 2950
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.14
    Marker Score: 3247
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.13
    Marker Score: 10074.5
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.13
    Marker Score: 946.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.12
    Marker Score: 9384
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.11
    Marker Score: 10367
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.1
    Marker Score: 3676
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.1
    Marker Score: 3105
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.1
    Marker Score: 6032
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.09
    Marker Score: 17545
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.09
    Marker Score: 3487
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 4.06
    Marker Score: 10102
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.02
    Marker Score: 26214
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.01
    Marker Score: 3951.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.96
    Marker Score: 3247
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.96
    Marker Score: 1042.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.93
    Marker Score: 3449
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.92
    Marker Score: 3460
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.91
    Marker Score: 1102.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.9
    Marker Score: 2715
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.9
    Marker Score: 4195
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.89
    Marker Score: 4158
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.89
    Marker Score: 2615
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.88
    Marker Score: 1417
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.87
    Marker Score: 4531
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.86
    Marker Score: 3629
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.86
    Marker Score: 4264
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.85
    Marker Score: 1994
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.85
    Marker Score: 3909
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.85
    Marker Score: 1099
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.84
    Marker Score: 4627
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.83
    Marker Score: 3410
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.83
    Marker Score: 3181
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.82
    Marker Score: 1085.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.82
    Marker Score: 1980
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.81
    Marker Score: 7163
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.8
    Marker Score: 3674
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.8
    Marker Score: 2025
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.79
    Marker Score: 4341.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.79
    Marker Score: 2183
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.79
    Marker Score: 1005
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.79
    Marker Score: 3578
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.79
    Marker Score: 882.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.78
    Marker Score: 1320
  • Cell Name: glial cell (CL0000125)
    Fold Change: 3.78
    Marker Score: 4157
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.78
    Marker Score: 1243.5
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.77
    Marker Score: 938.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.77
    Marker Score: 2497
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.77
    Marker Score: 1114
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.77
    Marker Score: 2851
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 3.76
    Marker Score: 1061

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Other Information

**Key characteristics:** * RPL28 is a large protein with a molecular weight of approximately 110 kDa. * It is a key component of the ribosome, which is responsible for protein synthesis. * RPL28 is involved in the initiation and elongation of protein translation. * It is a target for nonsense-mediated decay (nmd), a process that removes damaged or incomplete proteins from the ribosome. **Pathways and functions:** * RPL28 is involved in the initiation of protein translation by interacting with the initiator complex of the ribosome. * It is also involved in the elongation of protein translation by interacting with the elongation complex of the ribosome. * RPL28 is also involved in the regulation of protein translation by binding to the 5' cap of mRNA and facilitating its release from the ribosome. **Clinical significance:** * Mutations in RPL28 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * RPL28 is a potential target for the development of new drugs for these diseases. **Additional notes:** * RPL28 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a well-characterized protein that has been extensively studied in model systems.

Genular Protein ID: 4239235428

Symbol: RL28_HUMAN

Name: 60S ribosomal protein L28

UniProtKB Accession Codes:

P46779 B2R4A6 B4DEP9 C9JB50 E9PB24 G5E9L2 Q6IAY0 Q96FX1 Q9BWQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 EMBL 12 EMDB 64 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 81 PDBsum 77 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 13 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 137
  • Mass: 15748
  • Checksum: 44DCDE45473D7C7B
  • Sequence:
    • MSAHLQWMVV RNCSSFLIKR NKQTYSTEPN NLKARNSFRY NGLIHRKTVG VEPAADGKGV 
VVVIKRRSGQ RKPATSYVRT TINKNARATL SSIRHMIRKN KYRPDLRMAA IRRASAILRS 
QKPVMVKRKR TRPTKSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.