Details for: RPL36AL

Gene ID: 6166

Symbol: RPL36AL

Ensembl ID: ENSG00000165502

Description: ribosomal protein L36a like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 389.5884
    Cell Significance Index: -160.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 363.3906
    Cell Significance Index: -147.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 329.3424
    Cell Significance Index: -155.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 314.9391
    Cell Significance Index: -162.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 232.7643
    Cell Significance Index: -156.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 156.8485
    Cell Significance Index: -149.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.1400
    Cell Significance Index: -59.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 9.7592
    Cell Significance Index: 996.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.3482
    Cell Significance Index: 210.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.0174
    Cell Significance Index: 329.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 6.9017
    Cell Significance Index: 176.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.3750
    Cell Significance Index: 297.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.1108
    Cell Significance Index: 166.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.9381
    Cell Significance Index: 137.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.9294
    Cell Significance Index: 104.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.3949
    Cell Significance Index: 402.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.1649
    Cell Significance Index: 709.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.9566
    Cell Significance Index: 145.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.9197
    Cell Significance Index: 635.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.6385
    Cell Significance Index: 570.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.5975
    Cell Significance Index: 52.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.4810
    Cell Significance Index: 2447.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.4696
    Cell Significance Index: 82.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.4021
    Cell Significance Index: 793.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 4.3618
    Cell Significance Index: 65.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.1546
    Cell Significance Index: 489.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.5170
    Cell Significance Index: 600.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.4754
    Cell Significance Index: 1536.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.2755
    Cell Significance Index: 231.6600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.0890
    Cell Significance Index: 19.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.0188
    Cell Significance Index: 194.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9595
    Cell Significance Index: 77.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.7110
    Cell Significance Index: 24.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3072
    Cell Significance Index: 119.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2992
    Cell Significance Index: 294.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0790
    Cell Significance Index: 109.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0396
    Cell Significance Index: 1841.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4790
    Cell Significance Index: 88.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.9075
    Cell Significance Index: 686.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8945
    Cell Significance Index: 177.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8586
    Cell Significance Index: 84.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8314
    Cell Significance Index: 22.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7007
    Cell Significance Index: 24.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5088
    Cell Significance Index: 10.6500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.4408
    Cell Significance Index: 2.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3984
    Cell Significance Index: 75.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3378
    Cell Significance Index: 54.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2876
    Cell Significance Index: 210.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.2437
    Cell Significance Index: 1.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0200
    Cell Significance Index: 0.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0160
    Cell Significance Index: 3.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0502
    Cell Significance Index: -37.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0566
    Cell Significance Index: -106.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0820
    Cell Significance Index: -46.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0821
    Cell Significance Index: -51.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0924
    Cell Significance Index: -170.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1114
    Cell Significance Index: -171.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1230
    Cell Significance Index: -167.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2131
    Cell Significance Index: -135.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2187
    Cell Significance Index: -23.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2400
    Cell Significance Index: -86.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2843
    Cell Significance Index: -59.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3209
    Cell Significance Index: -145.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3842
    Cell Significance Index: -110.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3991
    Cell Significance Index: -45.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5339
    Cell Significance Index: -61.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5528
    Cell Significance Index: -9.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6869
    Cell Significance Index: -4.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7021
    Cell Significance Index: -55.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7750
    Cell Significance Index: -22.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8661
    Cell Significance Index: -54.5900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.9161
    Cell Significance Index: -4.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9433
    Cell Significance Index: -12.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0180
    Cell Significance Index: -147.9800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.0590
    Cell Significance Index: -9.1000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.2227
    Cell Significance Index: -25.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.2233
    Cell Significance Index: -18.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.2315
    Cell Significance Index: -20.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3088
    Cell Significance Index: -41.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3621
    Cell Significance Index: -29.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3997
    Cell Significance Index: -72.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.4092
    Cell Significance Index: -15.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.4972
    Cell Significance Index: -155.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.0025
    Cell Significance Index: -153.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.0388
    Cell Significance Index: -137.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.0574
    Cell Significance Index: -28.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.2977
    Cell Significance Index: -140.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.3010
    Cell Significance Index: -129.1200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.6738
    Cell Significance Index: -14.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -2.6840
    Cell Significance Index: -21.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.7027
    Cell Significance Index: -166.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.8917
    Cell Significance Index: -77.3500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.9977
    Cell Significance Index: -25.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.0766
    Cell Significance Index: -36.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.1585
    Cell Significance Index: -93.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.3123
    Cell Significance Index: -88.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.6335
    Cell Significance Index: -160.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.6612
    Cell Significance Index: -134.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.8194
    Cell Significance Index: -95.4800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -4.3182
    Cell Significance Index: -55.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The RPL36AL gene is a member of the ribosomal protein family, which is essential for protein synthesis and cell growth. The protein encoded by this gene is a 60S ribosomal protein, which is a component of the large ribosomal subunit responsible for translation elongation. The RPL36AL protein is highly conserved across species, suggesting its critical role in fundamental cellular processes. **Pathways and Functions** The RPL36AL gene is involved in various cellular pathways, including: 1. **Translation**: The RPL36AL protein is essential for translation elongation, which is the process by which the ribosome reads the mRNA sequence and assembles the amino acid chain. 2. **Cell growth and differentiation**: The RPL36AL protein is involved in the regulation of cell growth and differentiation, particularly in the context of T cell development and thyroid follicular cell differentiation. 3. **Response to stress**: The RPL36AL protein is involved in the cellular response to stress, including amino acid deficiency and viral infections. 4. **RNA processing**: The RPL36AL protein is involved in the regulation of RNA processing, particularly in the context of nonsense-mediated decay (NMD). **Functions** The RPL36AL protein has several functions, including: 1. **Translation elongation**: The RPL36AL protein is essential for translation elongation, which is the process by which the ribosome reads the mRNA sequence and assembles the amino acid chain. 2. **Protein synthesis regulation**: The RPL36AL protein regulates protein synthesis by controlling the rate of translation elongation. 3. **Cell growth regulation**: The RPL36AL protein regulates cell growth by controlling the rate of protein synthesis. 4. **Response to stress**: The RPL36AL protein regulates the cellular response to stress, including amino acid deficiency and viral infections. **Clinical Significance** Dysregulation of the RPL36AL gene has been implicated in various diseases, including: 1. **Cancer**: The RPL36AL gene is overexpressed in several types of cancer, including breast cancer and leukemia. 2. **Infectious diseases**: The RPL36AL gene is involved in the regulation of protein synthesis in response to viral infections, such as influenza. 3. **Neurological disorders**: The RPL36AL gene is involved in the regulation of protein synthesis in the nervous system, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease. In conclusion, the RPL36AL gene is a crucial component of the 60S ribosomal subunit, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the role of the RPL36AL gene in cellular processes and its potential as a therapeutic target for disease treatment.

Genular Protein ID: 656281534

Symbol: RL36L_HUMAN

Name: 60S ribosomal protein L36a-like

UniProtKB Accession Codes:

Q969Q0 Q3B7A5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 7 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3542712

Title: Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein.

PubMed ID: 3542712

DOI: 10.1016/0378-1119(86)90253-2

PubMed ID: 12490704

Title: Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.

PubMed ID: 12490704

DOI: 10.1093/nar/gkf696

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 106
  • Mass: 12469
  • Checksum: 9C0E08264A578D31
  • Sequence:
    • MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGRRR YDRKQSGYGG QTKPIFRKKA 
KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK GQVIQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.