RPL38 | ENSG00000172809 | NCBI 6169

Details for: RPL38

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
90s preribosome assembly
(GO:0034463)
Axial mesoderm development
(GO:0048318)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Eukaryotic 80s initiation complex
(GO:0033291)
Focal adhesion
(GO:0005925)
Middle ear morphogenesis
(GO:0042474)
Ossification
(GO:0001503)
Postsynaptic density
(GO:0014069)
Protein-rna complex assembly
(GO:0022618)
Protein binding
(GO:0005515)
Regulation of translation
(GO:0006417)
Rna binding
(GO:0003723)
Sensory perception of sound
(GO:0007605)
Skeletal system development
(GO:0001501)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 142.82

rCSI 94.93%

PRS 1.28
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 121.39

rCSI 81.78%

PRS 1.3
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 120.91

rCSI 84.92%

PRS 3.29
common myeloid progenitor CL0000049

CSI 109.82

rCSI 88.8%

PRS 1.05
CD4-positive helper T cell CL0000492

CSI 108.23

rCSI 81.87%

PRS 1.51
keratinocyte CL0000312

CSI 107.37

rCSI 90.01%

PRS 1.3
epithelial cell of lung CL0000082

CSI 104.52

rCSI 86.64%

PRS 1
granulocyte monocyte progenitor cell CL0000557

CSI 103.79

rCSI 89.86%

PRS 1.2
megakaryocyte-erythroid progenitor cell CL0000050

CSI 99.64

rCSI 89.98%

PRS 0.95
mature B cell CL0000785

CSI 99.57

rCSI 86.56%

PRS 1.32
ciliated epithelial cell CL0000067

CSI 96.95

rCSI 85.25%

PRS 0.79
epithelial cell of lower respiratory tract CL0002632

CSI 96.33

rCSI 74.68%

PRS 1.01
intestinal epithelial cell CL0002563

CSI 94.6

rCSI 98.88%

PRS 1.15
T-helper 17 cell CL0000899

CSI 93.47

rCSI 74.22%

PRS 1.92
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 92.74

rCSI 61.81%

PRS 3.06
fallopian tube secretory epithelial cell CL4030006

CSI 92.64

rCSI 89.18%

PRS 1.12
neural crest cell CL0011012

CSI 90.44

rCSI 71.48%

PRS 0.75
naive B cell CL0000788

CSI 88.44

rCSI 75.86%

PRS 3.5
intestine goblet cell CL0019031

CSI 88.1

rCSI 78.2%

PRS 1.08
class switched memory B cell CL0000972

CSI 87.45

rCSI 65.28%

PRS 1.82
pancreatic D cell CL0000173

CSI 86.84

rCSI 85.41%

PRS 1.19
early lymphoid progenitor CL0000936

CSI 86.28

rCSI 75.78%

PRS 1.2
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 85.47

rCSI 64.09%

PRS 3.25
group 3 innate lymphoid cell CL0001071

CSI 85.3

rCSI 64.09%

PRS 1.11
memory B cell CL0000787

CSI 84.32

rCSI 83.27%

PRS 4.78
plasmacytoid dendritic cell, human CL0001058

CSI 83.66

rCSI 58.41%

PRS 1.13
CD4-positive, alpha-beta thymocyte CL0000810

CSI 82.93

rCSI 66.43%

PRS 2.02
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 82.37

rCSI 48.64%

PRS 1.5
T follicular helper cell CL0002038

CSI 81.76

rCSI 61.19%

PRS 1.77
pancreatic A cell CL0000171

CSI 81.56

rCSI 85.44%

PRS 1.16
double-positive, alpha-beta thymocyte CL0000809

CSI 79.33

rCSI 80.85%

PRS 1.57
unswitched memory B cell CL0000970

CSI 77.89

rCSI 65.54%

PRS 1.81
CD14-low, CD16-positive monocyte CL0002396

CSI 77.64

rCSI 59.82%

PRS 0.97
immature B cell CL0000816

CSI 77.27

rCSI 57.41%

PRS 1.61
extravillous trophoblast CL0008036

CSI 75.5

rCSI 93.4%

PRS 0.95
common dendritic progenitor CL0001029

CSI 75.46

rCSI 94.7%

PRS 1.36
transit amplifying cell of colon CL0009011

CSI 75.22

rCSI 88.34%

PRS 1.32
pancreatic acinar cell CL0002064

CSI 74.75

rCSI 99.36%

PRS 1.18
plasmablast CL0000980

CSI 74.28

rCSI 58.43%

PRS 1.28
mature T cell CL0002419

CSI 74.22

rCSI 57.73%

PRS 1.54
mucosal invariant T cell CL0000940

CSI 72.06

rCSI 58.23%

PRS 2.83
elicited macrophage CL0000861

CSI 71.25

rCSI 65.42%

PRS 1.21
skin fibroblast CL0002620

CSI 70.68

rCSI 60.93%

PRS 1.8
fraction A pre-pro B cell CL0002045

CSI 69.34

rCSI 79.37%

PRS 2.24
multi-ciliated epithelial cell CL0005012

CSI 68.87

rCSI 68.74%

PRS 0.9
peripheral nervous system neuron CL2000032

CSI 68.11

rCSI 92.8%

PRS 0.99
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 67.8

rCSI 85.19%

PRS 5.94
activated CD4-positive, alpha-beta T cell CL0000896

CSI 67.67

rCSI 62.56%

PRS 1.98
CD4-positive, alpha-beta memory T cell CL0000897

CSI 66.03

rCSI 47.4%

PRS 1.47
CD1c-positive myeloid dendritic cell CL0002399

CSI 65.96

rCSI 79.67%

PRS 1.24
double negative thymocyte CL0002489

CSI 65.51

rCSI 45.54%

PRS 1.26
pro-B cell CL0000826

CSI 64.24

rCSI 53.2%

PRS 1.08
naive T cell CL0000898

CSI 63.99

rCSI 44.53%

PRS 1.57
mesodermal cell CL0000222

CSI 62.5

rCSI 75.02%

PRS 1.08
promyelocyte CL0000836

CSI 61.01

rCSI 88%

PRS 1.49
enteroendocrine cell CL0000164

CSI 59.61

rCSI 81.45%

PRS 1.19
mucous neck cell CL0000651

CSI 59.53

rCSI 85.81%

PRS 1.75
placental villous trophoblast CL2000060

CSI 59.27

rCSI 91.59%

PRS 1.02
hematopoietic precursor cell CL0008001

CSI 58.47

rCSI 60.15%

PRS 1.61
bronchus fibroblast of lung CL2000093

CSI 57.57

rCSI 46.77%

PRS 1.12
CD4-positive, alpha-beta T cell CL0000624

CSI 56.67

rCSI 72.52%

PRS 23.62
conventional dendritic cell CL0000990

CSI 56.07

rCSI 46.81%

PRS 3.8
CD8-positive, alpha-beta memory T cell CL0000909

CSI 55.93

rCSI 58.41%

PRS 3.48
common lymphoid progenitor CL0000051

CSI 53.29

rCSI 71.21%

PRS 2.06
gamma-delta T cell CL0000798

CSI 53.04

rCSI 62.3%

PRS 10.96
T-helper 1 cell CL0000545

CSI 52.98

rCSI 95.63%

PRS 3.42
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 52.68

rCSI 71.76%

PRS 2.7
perivascular cell CL4033054

CSI 51.57

rCSI 70.49%

PRS 1.24
mature NK T cell CL0000814

CSI 51.18

rCSI 65.46%

PRS 5.02
epithelial cell CL0000066

CSI 50.99

rCSI 78.36%

PRS 1.57
renal alpha-intercalated cell CL0005011

CSI 50.49

rCSI 67.51%

PRS 1.47
M cell of gut CL0000682

CSI 50.37

rCSI 53.52%

PRS 1.97
activated type II NK T cell CL0000931

CSI 50.32

rCSI 56.64%

PRS 1.81
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 50.24

rCSI 85.95%

PRS 2.47
promonocyte CL0000559

CSI 49.87

rCSI 85.44%

PRS 1.44
enteric smooth muscle cell CL0002504

CSI 49.44

rCSI 70.55%

PRS 1.23
myeloid leukocyte CL0000766

CSI 49.37

rCSI 45.55%

PRS 1.09
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 49.32

rCSI 48.44%

PRS 1.72
colon epithelial cell CL0011108

CSI 48.93

rCSI 51.25%

PRS 1
secretory cell CL0000151

CSI 48.4

rCSI 50.5%

PRS 1.1
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 47.85

rCSI 55.26%

PRS 1.01
lung ciliated cell CL1000271

CSI 47.73

rCSI 55.19%

PRS 0.78
neuroblast (sensu Vertebrata) CL0000031

CSI 47.07

rCSI 60.4%

PRS 1.09
colonocyte CL1000347

CSI 46.91

rCSI 67.24%

PRS 1.51
goblet cell CL0000160

CSI 46.66

rCSI 44.09%

PRS 1.12
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 46.55

rCSI 56.4%

PRS 1.8
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 46.39

rCSI 92.47%

PRS 1.93
classical monocyte CL0000860

CSI 46.34

rCSI 68.7%

PRS 13.09
respiratory basal cell CL0002633

CSI 46.28

rCSI 47.94%

PRS 1.26
myeloid dendritic cell CL0000782

CSI 45.84

rCSI 66.41%

PRS 1.58
endothelial cell of artery CL1000413

CSI 45.77

rCSI 67.05%

PRS 6.65
enterocyte CL0000584

CSI 45.38

rCSI 73.18%

PRS 1.75
intermediate monocyte CL0002393

CSI 44.47

rCSI 67.1%

PRS 1.05
acinar cell CL0000622

CSI 44.18

rCSI 64.78%

PRS 1.43
effector CD8-positive, alpha-beta T cell CL0001050

CSI 44.1

rCSI 33.55%

PRS 1.43
precursor B cell CL0000817

CSI 43.67

rCSI 38.25%

PRS 1.45
B cell CL0000236

CSI 42.95

rCSI 57.47%

PRS 6.63
melanocyte CL0000148

CSI 42.8

rCSI 31.7%

PRS 1.03
dendritic cell, human CL0001056

CSI 42.71

rCSI 65.6%

PRS 1.25
dendritic cell CL0000451

CSI 42.53

rCSI 52.41%

PRS 3.58

pulmonary capillary endothelial cell CL4028001

CSI -35.2

rCSI -67.2%

PRS 1.7%
astrocyte of the cerebral cortex CL0002605

CSI -27.9

rCSI -62.5%

PRS 0.7%
squamous epithelial cell CL0000076

CSI -27.1

rCSI -64.4%

PRS 1.5%
vascular leptomeningeal cell CL4023051

CSI -27.0

rCSI -47.3%

PRS 0.9%
sncg GABAergic cortical interneuron CL4023015

CSI -25.9

rCSI -41.6%

PRS 0.9%
kidney interstitial alternatively activated macrophage CL1000695

CSI -22.9

rCSI -59.7%

PRS 1.4%
inhibitory interneuron CL0000498

CSI -21.7

rCSI -50.0%

PRS 1.1%
pvalb GABAergic cortical interneuron CL4023018

CSI -20.3

rCSI -25.3%

PRS 0.6%
cerebral cortex endothelial cell CL1001602

CSI -20.0

rCSI -34.7%

PRS 0.8%
kidney interstitial fibroblast CL1000692

CSI -19.9

rCSI -100.0%

PRS 10.2%
mature astrocyte CL0002627

CSI -17.0

rCSI -72.4%

PRS 3.1%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -16.1

rCSI -39.1%

PRS 0.7%
kidney collecting duct principal cell CL1001431

CSI -15.6

rCSI -78.3%

PRS 7.7%
neural cell CL0002319

CSI -15.5

rCSI -58.5%

PRS 2.6%
mature microglial cell CL0002629

CSI -14.7

rCSI -61.2%

PRS 4.1%
epicardial adipocyte CL1000309

CSI -14.5

rCSI -47.0%

PRS 2.1%
GABAergic neuron CL0000617

CSI -13.9

rCSI -46.6%

PRS 1.2%
adipocyte CL0000136

CSI -13.9

rCSI -17.8%

PRS 1.4%
renal interstitial pericyte CL1001318

CSI -12.9

rCSI -35.5%

PRS 1.1%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -12.4

rCSI -100.0%

PRS 21.5%
endocrine cell CL0000163

CSI -11.3

rCSI -58.0%

PRS 4.9%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -10.7

rCSI -63.2%

PRS 0.8%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -10.4

rCSI -18.9%

PRS 1.3%
cerebral cortex neuron CL0010012

CSI -10.3

rCSI -41.9%

PRS 1.6%
Schwann cell CL0002573

CSI -10.0

rCSI -28.3%

PRS 1.5%
erythroid lineage cell CL0000764

CSI -9.8

rCSI -63.1%

PRS 3.1%
diffuse bipolar 3b cell CL4033030

CSI -9.1

rCSI -60.5%

PRS 3.0%
retinal bipolar neuron CL0000748

CSI -8.4

rCSI -15.7%

PRS 0.9%
professional antigen presenting cell CL0000145

CSI -8.0

rCSI -27.5%

PRS 4.7%
H2 horizontal cell CL0004218

CSI -7.7

rCSI -38.5%

PRS 2.3%
platelet CL0000233

CSI -7.6

rCSI -31.4%

PRS 3.4%
VIP GABAergic cortical interneuron CL4023016

CSI -7.5

rCSI -8.9%

PRS 0.7%
periportal region hepatocyte CL0019026

CSI -6.9

rCSI -26.8%

PRS 1.9%
near-projecting glutamatergic cortical neuron CL4023012

CSI -6.8

rCSI -25.7%

PRS 0.8%
exhausted T cell CL0011025

CSI -6.8

rCSI -100.0%

PRS 6.4%
diffuse bipolar 3a cell CL4033029

CSI -6.4

rCSI -43.4%

PRS 2.9%
glutamatergic neuron CL0000679

CSI -5.8

rCSI -11.8%

PRS 1.3%
cell of skeletal muscle CL0000188

CSI -5.5

rCSI -60.3%

PRS 7.3%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -4.4

rCSI -13.7%

PRS 0.9%
hepatic stellate cell CL0000632

CSI -4.4

rCSI -16.4%

PRS 0.9%
H1 horizontal cell CL0004217

CSI -4.0

rCSI -16.0%

PRS 3.2%
ON midget ganglion cell CL4033046

CSI -4.0

rCSI -81.9%

PRS 1.5%
cord blood hematopoietic stem cell CL2000095

CSI -4.0

rCSI -77.0%

PRS 9.0%
kidney collecting duct intercalated cell CL1001432

CSI -4.0

rCSI -28.2%

PRS 5.0%
cardiac blood vessel endothelial cell CL0010006

CSI -3.7

rCSI -26.1%

PRS 4.1%
rod bipolar cell CL0000751

CSI -2.9

rCSI -5.1%

PRS 1.0%
lamp5 GABAergic cortical interneuron CL4023011

CSI -2.8

rCSI -4.7%

PRS 0.7%
lung pericyte CL0009089

CSI -2.5

rCSI -6.6%

PRS 1.3%
kidney granular cell CL0000648

CSI -2.4

rCSI -34.0%

PRS 15.9%
Bergmann glial cell CL0000644

CSI -1.2

rCSI -1.6%

PRS 1.2%
glycinergic amacrine cell CL4030028

CSI -0.5

rCSI -1.4%

PRS 1.7%
endocardial cell CL0002350

CSI -0.4

rCSI -2.1%

PRS 2.0%
L6b glutamatergic cortical neuron CL4023038

CSI -0.4

rCSI -1.1%

PRS 0.7%
GABAergic amacrine cell CL4030027

CSI -0.3

rCSI -1.1%

PRS 1.6%
immature innate lymphoid cell CL0001082

CSI -0.2

rCSI -6.4%

PRS 20.7%
sst GABAergic cortical interneuron CL4023017

CSI 0.2

rCSI 0.3%

PRS 0.7%
primordial germ cell CL0000670

CSI 0.3

rCSI 1.3%

PRS 8.3%
direct pathway medium spiny neuron CL4023026

CSI 0.4

rCSI 10.4%

PRS 0.7%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.5

rCSI 0.9%

PRS 0.7%
kidney resident macrophage CL1000698

CSI 0.5

rCSI 10.8%

PRS 28.8%
choroid plexus epithelial cell CL0000706

CSI 0.5

rCSI 0.9%

PRS 0.9%
cardiac endothelial cell CL0010008

CSI 0.7

rCSI 2.6%

PRS 1.3%
group 3 innate lymphoid cell, human CL0001078

CSI 0.7

rCSI 14.4%

PRS 21.4%
Purkinje cell CL0000121

CSI 0.9

rCSI 12.4%

PRS 12.0%
retinal ganglion cell CL0000740

CSI 1.0

rCSI 2.1%

PRS 0.8%
airway submucosal gland duct basal cell CL4033024

CSI 1.1

rCSI 6.9%

PRS 5.7%
hepatic pit cell CL2000054

CSI 1.1

rCSI 15.1%

PRS 14.7%
cholangiocyte CL1000488

CSI 1.2

rCSI 7.3%

PRS 2.5%
renal intercalated cell CL0005010

CSI 1.3

rCSI 11.2%

PRS 10.1%
indirect pathway medium spiny neuron CL4023029

CSI 1.3

rCSI 31.1%

PRS 0.9%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI 1.3

rCSI 12.8%

PRS 14.7%
neutrophil CL0000775

CSI 1.5

rCSI 8.6%

PRS 4.4%
immature alpha-beta T cell CL0000790

CSI 1.6

rCSI 23.3%

PRS 17.9%
parietal epithelial cell CL1000452

CSI 2.0

rCSI 5.2%

PRS 1.1%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.0

rCSI 61.1%

PRS 15.8%
neural progenitor cell CL0011020

CSI 2.0

rCSI 8.8%

PRS 1.2%
cardiac muscle cell CL0000746

CSI 2.0

rCSI 2.9%

PRS 1.0%
epithelial cell of proximal tubule segment 3 CL4030011

CSI 2.0

rCSI 16.2%

PRS 14.2%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 2.5

rCSI 21.7%

PRS 3.1%
amacrine cell CL0000561

CSI 2.6

rCSI 7.7%

PRS 1.0%
uterine smooth muscle cell CL0002601

CSI 2.7

rCSI 17.6%

PRS 8.7%
lung interstitial macrophage CL4033043

CSI 2.7

rCSI 6.1%

PRS 2.8%
slow muscle cell CL0000189

CSI 2.7

rCSI 36.3%

PRS 16.1%
forebrain neuroblast CL1000042

CSI 2.8

rCSI 29.7%

PRS 17.5%
eye photoreceptor cell CL0000287

CSI 2.8

rCSI 31.1%

PRS 4.9%
cone retinal bipolar cell CL0000752

CSI 2.9

rCSI 37.2%

PRS 7.8%
alpha-beta T cell CL0000789

CSI 2.9

rCSI 3.5%

PRS 1.8%
lung microvascular endothelial cell CL2000016

CSI 3.0

rCSI 57.8%

PRS 4.0%
follicular dendritic cell CL0000442

CSI 3.0

rCSI 48.1%

PRS 6.7%
mesenchymal lymphangioblast CL0005021

CSI 3.0

rCSI 79.4%

PRS 6.3%
pluripotent stem cell CL0002248

CSI 3.1

rCSI 93.7%

PRS 2.7%
odontoblast CL0000060

CSI 3.2

rCSI 71.6%

PRS 6.7%
fast muscle cell CL0000190

CSI 3.2

rCSI 12.4%

PRS 7.1%
kidney loop of Henle epithelial cell CL1000909

CSI 3.2

rCSI 68.4%

PRS 10.8%
retinal pigment epithelial cell CL0002586

CSI 3.3

rCSI 6.6%

PRS 1.2%
metallothionein-positive alveolar macrophage CL4033042

CSI 3.3

rCSI 36.1%

PRS 5.4%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 3.4

rCSI 15.5%

PRS 4.5%
decidual natural killer cell, human CL0002343

CSI 3.4

rCSI 34.5%

PRS 10.4%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 3.4

rCSI 36.1%

PRS 1.9%
osteoblast CL0000062

CSI 3.5

rCSI 86.8%

PRS 10.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPL38](/details-gene/6169) (ribosomal protein L38) is a protein-coding gene located on chromosome 17q25.1. It encodes a component of the 60S large subunit of the eukaryotic ribosome. As a fundamental part of the translational machinery, [RPL38](/details-gene/6169) plays an essential role in protein synthesis. Its expression profile reflects this core function, with high significance observed in highly proliferative and metabolically active cell populations. **Overall**, it is a prominent marker in hematopoietic stem and progenitor cells, various subsets of T and B lymphocytes, and rapidly dividing epithelial cells, underscoring its critical role in immune system development and tissue maintenance. ## Cellular Roles and Expression Landscape The expression pattern of [RPL38](/details-gene/6169) highlights its role as a key workhorse protein essential for cellular growth and function. **Overall**, it shows the highest significance in cell types characterized by high rates of protein synthesis, including immune cells and progenitor populations. The most significant expression is found in [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 142.82), followed by lymphoid lineages such as [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 121.39) and [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) (CSI: 120.91). High significance is also noted in myeloid progenitors, including [common myeloid progenitor](/details-cell/CL0000049) (CSI: 109.82) and [granulocyte monocyte progenitor cell](/details-cell/CL0000557) (CSI: 103.79), as well as in mature lymphocyte populations like [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 108.23) and [mature B cell](/details-cell/CL0000785) (CSI: 99.57). This widespread importance across the hematopoietic system is consistent with the high demand for protein production during immune cell development, differentiation, and effector function. Beyond the immune system, [RPL38](/details-gene/6169) is also highly significant in epithelial tissues with high turnover rates, such as [keratinocyte](/details-cell/CL0000312) (CSI: 107.37) and [epithelial cell of lung](/details-cell/CL0000082) (CSI: 104.52). Conversely, [RPL38](/details-gene/6169) expression is markedly low in terminally differentiated and less proliferative cell types. The lowest significance scores are observed in various [neural cell](/details-cell/CL0002319) populations, including [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: -27.86) and multiple subtypes of interneurons, as well as in specific stromal and endothelial cells like [pulmonary capillary endothelial cell](/details-cell/CL4028001) (CSI: -35.22). This pattern suggests that while [RPL38](/details-gene/6169) is universally required, its expression levels are tightly correlated with the translational demands of a given cell, being less critical in quiescent or terminally differentiated states. ## Pathways and Molecular Function Functionally, [RPL38](/details-gene/6169) is annotated as a [structural constituent of ribosome](/details-cell/GO:0003735) that participates centrally in [translation](/details-cell/GO:0006412) and [cytoplasmic translation](/details-cell/GO:0002181). Its involvement is integral to all phases of protein synthesis, as evidenced by its association with Reactome pathways for [Eukaryotic translation initiation](/details-cell/R-HSA-72613), [Peptide chain elongation](/details-cell/R-HSA-156902), and [Eukaryotic translation termination](/details-cell/R-HSA-72764). The gene product is a key component of the [cytosolic large ribosomal subunit](/details-cell/GO:0022625) and contributes to the assembly of the functional 80S ribosome. Beyond its canonical role in global protein synthesis, Gene Ontology annotations suggest more specialized functions. [RPL38](/details-gene/6169) is implicated in specific developmental processes, including [skeletal system development](/details-cell/GO:0001501), [ossification](/details-cell/GO:0001503), and [sensory perception of sound](/details-cell/GO:0007605). These associations may indicate that certain developmental programs are exquisitely sensitive to the precise stoichiometry of ribosomal components or that [RPL38](/details-gene/6169) participates in specialized ribosomes that regulate the translation of specific mRNA transcripts critical for these processes. Furthermore, its connection to pathways like [cellular responses to stress](/details-cell/R-HSA-2262752) and [viral mRNA translation](/details-cell/R-HSA-192823) points to its role in cellular adaptation and host-pathogen interactions. ## Research Directions The ubiquitous nature of [RPL38](/details-gene/6169) as a ribosomal component complicates its study, yet its high expression in specific cellular contexts provides avenues for investigation into diseases of proliferation and development. ### Proposed Testable Hypotheses 1. Given its high significance in hematopoietic stem and progenitor cells, haploinsufficiency of [RPL38](/details-gene/6169) may lead to a Diamond-Blackfan anemia-like phenotype, disproportionately affecting the development of specific hematopoietic lineages that have high translational demands, such as erythroid or lymphoid progenitors. 2. The association of [RPL38](/details-gene/6169) with [skeletal system development](/details-cell/GO:0001501) and [sensory perception of sound](/details-cell/GO:0007605) suggests a role in specialized translation. It can be hypothesized that [RPL38](/details-gene/6169) is required for the efficient translation of a specific subset of mRNAs essential for chondrocyte differentiation or inner ear hair cell function, and its deficiency could lead to specific skeletal or hearing defects independent of global translation inhibition. ### Suggested Key Experiment To test the hypothesis regarding hematopoietic development (Hypothesis 1), a conditional knockout mouse model could be generated (e.g., *Rpl38*^fl/fl; *Vav1-iCre*). Hematopoietic-specific deletion of *Rpl38* would allow for a detailed characterization of hematopoietic stem cell function, lineage output, and red blood cell production. Bone marrow from these mice could be competitively transplanted into irradiated wild-type recipients to assess the cell-intrinsic role of [RPL38](/details-gene/6169) in hematopoietic reconstitution. Subsequent ribosome profiling (Ribo-seq) on sorted progenitor populations could identify specific mRNAs whose translation is impaired upon [RPL38](/details-gene/6169) loss. ### Therapeutic Potential As a core component of the ribosome, [RPL38](/details-gene/6169) is a poor candidate for direct therapeutic inhibition due to the high likelihood of systemic toxicity. Targeting a fundamental process like protein synthesis would affect all cells, particularly those with high proliferation rates like gut epithelia and hematopoietic progenitors. However, many cancers are characterized by an elevated demand for protein synthesis and can be sensitive to perturbations in the translational machinery. Therefore, while direct targeting of [RPL38](/details-gene/6169) is unlikely, understanding how its expression is regulated in cancer cells or whether it contributes to the preferential translation of oncogenic transcripts could reveal indirect vulnerabilities. Modulating pathways that control ribosome biogenesis, rather than inhibiting core components, may represent a more viable therapeutic strategy.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L38

Genular Protein ID: 11967601

Symbol: RL38_HUMAN

Name: 60S ribosomal protein L38

UniProtKB Accession Codes:

P63173 B2R5A8 P23411

Database IDs:

Citations:

PubMed ID: 9375793

Title: Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene.

PubMed ID: 9375793

DOI: 10.1016/s0167-4781(97)00124-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 70
Mass: 8218
Checksum: FDD9A107BC98DBBA
Sequence:

MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL 
PPGLAVKELK

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Breast cancer UBERON0002107_MONDO0007254
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Healthy UBERON0000029_PATO0000461
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Rectum UBERON0001052
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	Transverse colon UBERON0001157
	\|— Transverse colon Healthy UBERON0001157_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: RPL38

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene. PubMed ID: 9375793

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547