Details for: RPL38

Gene ID: 6169

Symbol: RPL38

Ensembl ID: ENSG00000172809

Description: ribosomal protein L38

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 577.2821
    Cell Significance Index: -237.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 514.7110
    Cell Significance Index: -209.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 474.3259
    Cell Significance Index: -223.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 447.4856
    Cell Significance Index: -230.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 335.1007
    Cell Significance Index: -224.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 221.7037
    Cell Significance Index: -211.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 58.9878
    Cell Significance Index: -158.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 16.0695
    Cell Significance Index: 244.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 13.2870
    Cell Significance Index: 1357.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 10.4507
    Cell Significance Index: 266.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 9.9374
    Cell Significance Index: 265.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.5842
    Cell Significance Index: 403.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.1530
    Cell Significance Index: 233.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.9682
    Cell Significance Index: 1094.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.6856
    Cell Significance Index: 945.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.5393
    Cell Significance Index: 85.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.3685
    Cell Significance Index: 130.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.2244
    Cell Significance Index: 1302.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.0193
    Cell Significance Index: 906.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 6.9852
    Cell Significance Index: 494.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.4883
    Cell Significance Index: 2868.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.2763
    Cell Significance Index: 292.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.7650
    Cell Significance Index: 151.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.6990
    Cell Significance Index: 3112.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.6292
    Cell Significance Index: 419.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.4690
    Cell Significance Index: 701.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.3868
    Cell Significance Index: 112.7600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.3524
    Cell Significance Index: 32.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.3238
    Cell Significance Index: 117.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.0327
    Cell Significance Index: 475.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0027
    Cell Significance Index: 258.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.6960
    Cell Significance Index: 365.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.5902
    Cell Significance Index: 39.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.5267
    Cell Significance Index: 602.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4430
    Cell Significance Index: 27.4900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.4214
    Cell Significance Index: 29.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.3913
    Cell Significance Index: 62.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2817
    Cell Significance Index: 30.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.7552
    Cell Significance Index: 35.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.6550
    Cell Significance Index: 61.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.6265
    Cell Significance Index: 91.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4353
    Cell Significance Index: 2198.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0675
    Cell Significance Index: 108.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.8799
    Cell Significance Index: 1422.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8714
    Cell Significance Index: 54.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6322
    Cell Significance Index: 323.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5115
    Cell Significance Index: 43.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1659
    Cell Significance Index: 31.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0410
    Cell Significance Index: 198.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8267
    Cell Significance Index: 37.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8034
    Cell Significance Index: 4.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4379
    Cell Significance Index: 22.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2135
    Cell Significance Index: 156.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0462
    Cell Significance Index: -9.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0651
    Cell Significance Index: -3.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0706
    Cell Significance Index: -132.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1203
    Cell Significance Index: -221.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1279
    Cell Significance Index: -79.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1350
    Cell Significance Index: -76.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1467
    Cell Significance Index: -225.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1762
    Cell Significance Index: -63.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1994
    Cell Significance Index: -271.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2706
    Cell Significance Index: -16.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2964
    Cell Significance Index: -188.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4526
    Cell Significance Index: -205.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4587
    Cell Significance Index: -74.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4771
    Cell Significance Index: -100.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.6720
    Cell Significance Index: -193.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8649
    Cell Significance Index: -99.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9035
    Cell Significance Index: -103.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9751
    Cell Significance Index: -61.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9856
    Cell Significance Index: -78.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0650
    Cell Significance Index: -18.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2951
    Cell Significance Index: -41.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.3092
    Cell Significance Index: -46.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.4447
    Cell Significance Index: -210.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4813
    Cell Significance Index: -24.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.5854
    Cell Significance Index: -172.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.6104
    Cell Significance Index: -9.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6294
    Cell Significance Index: -91.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7425
    Cell Significance Index: -26.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8902
    Cell Significance Index: -47.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.1425
    Cell Significance Index: -223.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.2636
    Cell Significance Index: -49.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.9658
    Cell Significance Index: -227.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.0495
    Cell Significance Index: -186.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.0861
    Cell Significance Index: -207.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.5130
    Cell Significance Index: -47.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -4.1672
    Cell Significance Index: -32.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.2318
    Cell Significance Index: -72.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.5124
    Cell Significance Index: -132.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -4.8850
    Cell Significance Index: -130.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.9950
    Cell Significance Index: -220.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.2504
    Cell Significance Index: -192.7400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.3623
    Cell Significance Index: -29.2400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -5.7859
    Cell Significance Index: -26.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -5.8064
    Cell Significance Index: -113.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -5.8709
    Cell Significance Index: -60.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.1866
    Cell Significance Index: -234.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL38 is a 38-kDa protein that is composed of 154 amino acids. It is highly conserved across species, with high sequence identity to other ribosomal proteins. RPL38 is a member of the L38 family of ribosomal proteins, which are essential for the assembly of the 60S subunit. The protein is characterized by a high degree of structural similarity to other ribosomal proteins, including L11 and L17. **Pathways and Functions** RPL38 is involved in several key cellular pathways, including: 1. **Translation Initiation**: RPL38 plays a critical role in the initiation of translation, which involves the binding of mRNA to the ribosome and the recruitment of initiation factors. 2. **Cell Growth and Development**: RPL38 is involved in the regulation of cell growth and development, including the regulation of protein synthesis and cell proliferation. 3. **Immunological Regulation**: RPL38 is expressed in immune cells and plays a role in the regulation of immune responses, including the regulation of cytokine production and T-cell activation. 4. **Cancer Development**: Mutations in RPL38 have been associated with various cancers, including leukemia and lymphoma. **Clinical Significance** RPL38 has significant clinical implications, particularly in the context of cancer and immunodeficiency disorders. Mutations in RPL38 have been associated with: 1. **Cancer Development**: RPL38 mutations have been identified in various cancers, including leukemia and lymphoma. 2. **Immunodeficiency Disorders**: RPL38 mutations have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID). 3. **Neurological Disorders**: RPL38 mutations have been associated with neurological disorders, including autism and schizophrenia. In conclusion, RPL38 is a critical component of the ribosomal machinery that plays a key role in various cellular processes, including translation, cell growth, and development. Mutations in RPL38 have significant clinical implications, particularly in the context of cancer and immunodeficiency disorders. Further research is needed to fully understand the role of RPL38 in human disease and to develop therapeutic strategies to target this protein in the treatment of various diseases.

Genular Protein ID: 11967601

Symbol: RL38_HUMAN

Name: 60S ribosomal protein L38

UniProtKB Accession Codes:

P63173 B2R5A8 P23411

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 70 Ensembl 3 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 85 PDBsum 85 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9375793

Title: Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene.

PubMed ID: 9375793

DOI: 10.1016/s0167-4781(97)00124-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 70
  • Mass: 8218
  • Checksum: FDD9A107BC98DBBA
  • Sequence:
    • MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL 
PPGLAVKELK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.