RPL39 | ENSG00000198918 | NCBI 6170

Details for: RPL39

Gene ID: 6170

Symbol: RPL39

Ensembl ID: ENSG00000198918

Description: ribosomal protein L39

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Antibacterial humoral response
(GO:0019731)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular space
(GO:0005615)
Innate immune response in mucosa
(GO:0002227)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 712.6149
Cell Significance Index: -293.5600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 648.4317
Cell Significance Index: -263.4300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 570.0300
Cell Significance Index: -293.2200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 568.0092
Cell Significance Index: -268.1700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 281.0600
Cell Significance Index: -268.3400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 90.5385
Cell Significance Index: -242.5400
Cell Name: theca cell (CL0000503)
Fold Change: 24.1991
Cell Significance Index: 142.1700
Cell Name: pro-T cell (CL0000827)
Fold Change: 18.3670
Cell Significance Index: 469.2200
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 16.1602
Cell Significance Index: 171.7000
Cell Name: abnormal cell (CL0001061)
Fold Change: 16.1588
Cell Significance Index: 1650.6200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 16.1346
Cell Significance Index: 298.2100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 15.9202
Cell Significance Index: 425.8600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 15.1473
Cell Significance Index: 711.9100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 14.8091
Cell Significance Index: 189.6600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 14.6480
Cell Significance Index: 419.9000
Cell Name: granulosa cell (CL0000501)
Fold Change: 14.3606
Cell Significance Index: 377.6100
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 13.6525
Cell Significance Index: 84.0200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 12.5730
Cell Significance Index: 108.0400
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 12.4250
Cell Significance Index: 33.2900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 11.2805
Cell Significance Index: 236.1200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 11.2218
Cell Significance Index: 127.4900
Cell Name: lactocyte (CL0002325)
Fold Change: 10.2711
Cell Significance Index: 1326.9500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 10.1860
Cell Significance Index: 180.0000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 10.1525
Cell Significance Index: 718.0300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.6344
Cell Significance Index: 1323.0800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 9.3208
Cell Significance Index: 1146.0800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 9.2263
Cell Significance Index: 1663.2100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 8.9961
Cell Significance Index: 97.8000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.9498
Cell Significance Index: 1055.4600
Cell Name: peg cell (CL4033014)
Fold Change: 8.8598
Cell Significance Index: 204.6900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 8.5397
Cell Significance Index: 3775.6100
Cell Name: cell in vitro (CL0001034)
Fold Change: 8.2440
Cell Significance Index: 4502.2700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.1163
Cell Significance Index: 604.9000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 7.5379
Cell Significance Index: 486.3100
Cell Name: odontoblast (CL0000060)
Fold Change: 7.1681
Cell Significance Index: 918.9100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 6.7647
Cell Significance Index: 235.0700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 6.3363
Cell Significance Index: 186.0900
Cell Name: kidney cell (CL1000497)
Fold Change: 6.1859
Cell Significance Index: 49.3900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 5.2336
Cell Significance Index: 48.2000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.9926
Cell Significance Index: 232.7800
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 4.7090
Cell Significance Index: 98.2100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.5894
Cell Significance Index: 124.9200
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 4.5656
Cell Significance Index: 32.7900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 4.1821
Cell Significance Index: 3165.4800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.8235
Cell Significance Index: 652.8800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.2913
Cell Significance Index: 2068.9100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.2429
Cell Significance Index: 117.7600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.9561
Cell Significance Index: 101.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.7486
Cell Significance Index: 79.2600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.3162
Cell Significance Index: 91.0300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2172
Cell Significance Index: 231.6400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.9074
Cell Significance Index: 665.3300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8062
Cell Significance Index: 79.7500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1769
Cell Significance Index: 9.1900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0637
Cell Significance Index: 1.7000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1034
Cell Significance Index: -76.5700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1336
Cell Significance Index: -251.5700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1747
Cell Significance Index: -322.2000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2092
Cell Significance Index: -321.9900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2296
Cell Significance Index: -129.4700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2420
Cell Significance Index: -329.1200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2804
Cell Significance Index: -175.0900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.3872
Cell Significance Index: -138.8700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.4321
Cell Significance Index: -274.4100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4905
Cell Significance Index: -38.8500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.5282
Cell Significance Index: -151.9900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.5300
Cell Significance Index: -106.3100
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.5807
Cell Significance Index: -10.0100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5943
Cell Significance Index: -125.1800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.6371
Cell Significance Index: -289.1700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -1.0251
Cell Significance Index: -166.7300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -1.0760
Cell Significance Index: -213.5400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.1307
Cell Significance Index: -129.5400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.5220
Cell Significance Index: -173.7300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.6802
Cell Significance Index: -28.1200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.8578
Cell Significance Index: -104.2500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.8641
Cell Significance Index: -59.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.9383
Cell Significance Index: -281.7600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.0122
Cell Significance Index: -126.8200
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -2.0521
Cell Significance Index: -11.1900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.1438
Cell Significance Index: -53.5900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.4776
Cell Significance Index: -71.3900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.6412
Cell Significance Index: -275.0100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.9284
Cell Significance Index: -43.8800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.4508
Cell Significance Index: -264.8100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -3.5484
Cell Significance Index: -218.1000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -3.6926
Cell Significance Index: -186.6100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.7074
Cell Significance Index: -80.3200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.7246
Cell Significance Index: -228.3500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -3.9405
Cell Significance Index: -138.4700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -3.9778
Cell Significance Index: -162.9900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -4.1809
Cell Significance Index: -251.0000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.4098
Cell Significance Index: -296.5200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.3371
Cell Significance Index: -157.2000
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -6.3997
Cell Significance Index: -82.4200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -6.4813
Cell Significance Index: -237.9300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -6.6250
Cell Significance Index: -293.0400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -6.6514
Cell Significance Index: -90.7500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -6.9704
Cell Significance Index: -58.5500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -7.5915
Cell Significance Index: -248.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RPL39 is a small, acidic protein that belongs to the 60S ribosomal protein family. It is composed of 39 amino acids and is highly conserved across species. RPL39 is specifically localized to the 60S ribosomal subunit, where it interacts with other ribosomal proteins to facilitate protein synthesis. The protein is also involved in the regulation of translation initiation and elongation, and its dysregulation can lead to changes in protein synthesis rates. **Pathways and Functions** RPL39 is involved in several cellular pathways, including: 1. **Antibacterial humoral response**: RPL39 is expressed in immune cells, such as activated CD8+ T cells and natural T-regulatory cells, where it plays a role in the production of antimicrobial peptides. 2. **Cap-dependent translation initiation**: RPL39 is involved in the initiation of translation in eukaryotic cells, where it interacts with other ribosomal proteins to facilitate the binding of mRNA to the ribosome. 3. **Influenza infection**: RPL39 is expressed in cells infected with influenza virus, where it plays a role in the regulation of viral RNA transcription and replication. 4. **Selenocysteine synthesis**: RPL39 is involved in the synthesis of selenocysteine, a critical amino acid for the production of selenoproteins. **Clinical Significance** Dysregulation of RPL39 has been linked to various diseases, including: 1. **Cancer**: Overexpression of RPL39 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Infectious diseases**: RPL39 is involved in the regulation of the innate immune response, and its dysregulation can lead to increased susceptibility to infectious diseases. 3. **Neurological disorders**: RPL39 has been implicated in the regulation of neuronal function and development, and its dysregulation can contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RPL39 is a critical component of the 60S ribosomal subunit, playing a vital role in the regulation of protein synthesis and cell growth. Its dysregulation has been linked to various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully understand the mechanisms by which RPL39 regulates cellular processes and to explore its therapeutic potential in the treatment of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L39

Genular Protein ID: 911914704

Symbol: RL39_HUMAN

Name: 60S ribosomal protein L39

UniProtKB Accession Codes:

P62891 P02404 P39025 Q9BYF2

Database IDs:

Citations:

PubMed ID: 8908372

Title: Primary structures and sequence analysis of human ribosomal proteins L39 and S27.

PubMed ID: 8908372

DOI: 10.1080/15216549600201203

PubMed ID: 8764829

Title: Molecular cloning of a cDNA encoding human ribosomal protein L39.

PubMed ID: 8764829

DOI: 10.1016/0167-4781(96)00106-6

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11401437

Title: A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.

PubMed ID: 11401437

DOI: 10.1006/geno.2000.6470

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 51
Mass: 6407
Checksum: 2023CA8590C7752C
Sequence:

MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPL39

Associated with

Cells (max top 100)

Other Information

Primary structures and sequence analysis of human ribosomal proteins L39 and S27. PubMed ID: 8908372

Molecular cloning of a cDNA encoding human ribosomal protein L39. PubMed ID: 8764829

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. PubMed ID: 11401437

A new system for naming ribosomal proteins. PubMed ID: 24524803

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547