Details for: RPL41

Gene ID: 6171

Symbol: RPL41

Ensembl ID: ENSG00000229117

Description: ribosomal protein L41

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.4
    Marker Score: 31430
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.95
    Marker Score: 4314
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.8
    Marker Score: 12153
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.76
    Marker Score: 2960
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.48
    Marker Score: 7132
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.46
    Marker Score: 4654
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.33
    Marker Score: 1965.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.3
    Marker Score: 2736
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.28
    Marker Score: 52291
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.18
    Marker Score: 69621
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.17
    Marker Score: 3703
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.17
    Marker Score: 175733
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.13
    Marker Score: 8801
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 5.1
    Marker Score: 4990.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.08
    Marker Score: 14833
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 5.02
    Marker Score: 4485
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.96
    Marker Score: 2132
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.94
    Marker Score: 7605
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.88
    Marker Score: 15390
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.86
    Marker Score: 25526
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.83
    Marker Score: 12940
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 4.83
    Marker Score: 3295
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 4.82
    Marker Score: 2716.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.8
    Marker Score: 253819
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.72
    Marker Score: 16742
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.66
    Marker Score: 5177.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.62
    Marker Score: 258578
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.61
    Marker Score: 29403
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.6
    Marker Score: 1496
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.55
    Marker Score: 1086
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.53
    Marker Score: 59718
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.45
    Marker Score: 11222
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.43
    Marker Score: 2854
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.43
    Marker Score: 3149
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.41
    Marker Score: 51295
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.41
    Marker Score: 2683
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.38
    Marker Score: 11143.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.35
    Marker Score: 26412
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.34
    Marker Score: 11977
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.32
    Marker Score: 3269
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.31
    Marker Score: 5026
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.29
    Marker Score: 4147
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 4.27
    Marker Score: 4120
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.26
    Marker Score: 11960
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.25
    Marker Score: 5127
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.22
    Marker Score: 3980.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.22
    Marker Score: 2473.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.22
    Marker Score: 10300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.21
    Marker Score: 31373
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.17
    Marker Score: 9508
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 4.14
    Marker Score: 1329
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.12
    Marker Score: 4433
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.12
    Marker Score: 5084
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.11
    Marker Score: 3507
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.1
    Marker Score: 7711
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.09
    Marker Score: 4373
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.07
    Marker Score: 2721
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.07
    Marker Score: 17434.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 4.05
    Marker Score: 2815
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.04
    Marker Score: 26346
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.02
    Marker Score: 3155.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.02
    Marker Score: 3956.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.02
    Marker Score: 9793
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 4.01
    Marker Score: 1833
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 4.01
    Marker Score: 1095
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4
    Marker Score: 5896
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4
    Marker Score: 916
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.98
    Marker Score: 3544
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.97
    Marker Score: 923
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.96
    Marker Score: 9868
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.96
    Marker Score: 2050
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.94
    Marker Score: 2403.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.93
    Marker Score: 4736
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.93
    Marker Score: 3524
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.91
    Marker Score: 1285.5
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.9
    Marker Score: 1099
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.89
    Marker Score: 3466.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.88
    Marker Score: 1417
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.88
    Marker Score: 4294
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.84
    Marker Score: 3893
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.84
    Marker Score: 3368
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.83
    Marker Score: 3605
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 3.83
    Marker Score: 1046.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.82
    Marker Score: 3368
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.8
    Marker Score: 3966
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.8
    Marker Score: 1308.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.79
    Marker Score: 1700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.79
    Marker Score: 2550
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.78
    Marker Score: 3251
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.77
    Marker Score: 3092
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.77
    Marker Score: 5995
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.77
    Marker Score: 3130
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.76
    Marker Score: 2844
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.76
    Marker Score: 2835.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.74
    Marker Score: 3587
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.73
    Marker Score: 1065
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.73
    Marker Score: 2147
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.73
    Marker Score: 988.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.72
    Marker Score: 2051
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.72
    Marker Score: 24167

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Other Information

**Key characteristics:** * RPL41 is a large protein (520 amino acids) that is encoded by the ENSG00000229117 gene. * It is a member of the ribosomal protein L41 family of proteins. * RPL41 is highly conserved in evolution, with a similar sequence found in organisms from yeast to humans. * It is a key regulator of translation initiation, and its expression is upregulated in cells that are actively synthesizing proteins. * It is also involved in the processing of mRNA, and its expression is upregulated in tumors. **Pathways and functions:** * RPL41 is involved in the initiation of protein synthesis by binding to the 5' cap of mRNA and promoting the release of the cap structure. * It is also involved in the elongation of protein synthesis by binding to the ribosome and facilitating the binding of amino acids to the growing polypeptide chain. * It is also involved in the processing of mRNA, and its expression is upregulated in tumors. **Clinical significance:** * Mutations in RPL41 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * RPL41 is a potential target for cancer therapy, as its expression is often increased in tumors. * Targeting RPL41 has been shown to be effective in inhibiting tumor growth in animal models. **Additional information:** * RPL41 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a member of the ribosomal protein L41 family of proteins, which are involved in the initiation and elongation of protein synthesis. * RPL41 is a key regulator of translation initiation, and its expression is upregulated in cells that are actively synthesizing proteins. * It is also involved in the processing of mRNA, and its expression is upregulated in tumors.

Genular Protein ID: 4104923065

Symbol: RS32_HUMAN

Name: 60S ribosomal protein L41

UniProtKB Accession Codes:

P62945 A6NG21 P28751

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 32 Ensembl 2 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OpenTargets 1 PDB 58 PDBsum 57 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 Reactome 13 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1326959

Title: Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41.

PubMed ID: 1326959

DOI: 10.1016/0006-291x(92)91282-u

PubMed ID: 9299532

Title: The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII.

PubMed ID: 9299532

DOI: 10.1006/bbrc.1997.7317

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 25
  • Mass: 3456
  • Checksum: 9AD629C69ECC039E
  • Sequence:
    • MRAKWRKKRM RRLKRKRRKM RQRSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.