Details for: RPL41

Gene ID: 6171

Symbol: RPL41

Ensembl ID: ENSG00000229117

Description: ribosomal protein L41

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 944.7318
    Cell Significance Index: -389.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 781.3012
    Cell Significance Index: -368.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 738.3182
    Cell Significance Index: -379.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 551.3231
    Cell Significance Index: -369.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 45.5082
    Cell Significance Index: -121.9100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 23.7767
    Cell Significance Index: 63.7000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 20.7046
    Cell Significance Index: 121.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 19.3220
    Cell Significance Index: 1973.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 17.2728
    Cell Significance Index: 106.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 16.7214
    Cell Significance Index: 785.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 15.2156
    Cell Significance Index: 388.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 15.0462
    Cell Significance Index: 395.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.8050
    Cell Significance Index: 396.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 14.8009
    Cell Significance Index: 273.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 14.3014
    Cell Significance Index: 162.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.9997
    Cell Significance Index: 401.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 13.8711
    Cell Significance Index: 245.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 12.4734
    Cell Significance Index: 1611.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 12.2391
    Cell Significance Index: 256.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 11.9023
    Cell Significance Index: 1525.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 11.7155
    Cell Significance Index: 873.1500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.5104
    Cell Significance Index: 147.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 11.3863
    Cell Significance Index: 805.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.2598
    Cell Significance Index: 260.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 10.8773
    Cell Significance Index: 8233.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 10.4759
    Cell Significance Index: 1888.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 10.4710
    Cell Significance Index: 4629.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 10.4617
    Cell Significance Index: 1286.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.9319
    Cell Significance Index: 1171.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.2018
    Cell Significance Index: 319.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.9061
    Cell Significance Index: 76.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.7853
    Cell Significance Index: 1206.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.7055
    Cell Significance Index: 94.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.2964
    Cell Significance Index: 386.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 8.1909
    Cell Significance Index: 222.9500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 6.9871
    Cell Significance Index: 145.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.1973
    Cell Significance Index: 399.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.9787
    Cell Significance Index: 1020.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.9189
    Cell Significance Index: 3232.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.7837
    Cell Significance Index: 53.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.4187
    Cell Significance Index: 284.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 4.9265
    Cell Significance Index: 390.1800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 4.6380
    Cell Significance Index: 33.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 3.7287
    Cell Significance Index: 2733.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3892
    Cell Significance Index: 27.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 3.3230
    Cell Significance Index: 379.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3012
    Cell Significance Index: 655.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0260
    Cell Significance Index: 200.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0036
    Cell Significance Index: 53.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9829
    Cell Significance Index: 1790.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4253
    Cell Significance Index: 271.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0043
    Cell Significance Index: 52.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1853
    Cell Significance Index: 37.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1404
    Cell Significance Index: -258.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1409
    Cell Significance Index: -104.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1770
    Cell Significance Index: -272.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2268
    Cell Significance Index: -141.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2270
    Cell Significance Index: -81.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2590
    Cell Significance Index: -352.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3151
    Cell Significance Index: -177.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3918
    Cell Significance Index: -248.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6047
    Cell Significance Index: -274.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7464
    Cell Significance Index: -157.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0505
    Cell Significance Index: -58.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -1.0638
    Cell Significance Index: -306.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.3628
    Cell Significance Index: -221.6500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4079
    Cell Significance Index: -24.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4942
    Cell Significance Index: -171.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.6120
    Cell Significance Index: -73.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.8353
    Cell Significance Index: -112.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8579
    Cell Significance Index: -59.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9321
    Cell Significance Index: -121.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.0587
    Cell Significance Index: -299.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.2600
    Cell Significance Index: -114.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.4376
    Cell Significance Index: -168.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.6016
    Cell Significance Index: -43.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -2.6435
    Cell Significance Index: -108.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -3.1833
    Cell Significance Index: -93.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.2948
    Cell Significance Index: -82.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.4541
    Cell Significance Index: -359.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.7993
    Cell Significance Index: -291.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.3753
    Cell Significance Index: -65.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.4182
    Cell Significance Index: -60.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -5.1640
    Cell Significance Index: -316.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -5.1964
    Cell Significance Index: -349.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -5.2232
    Cell Significance Index: -313.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.4603
    Cell Significance Index: -118.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.5248
    Cell Significance Index: -77.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -6.6155
    Cell Significance Index: -39.9700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.7708
    Cell Significance Index: -36.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.9475
    Cell Significance Index: -119.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -7.0594
    Cell Significance Index: -203.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -7.4050
    Cell Significance Index: -218.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -8.6804
    Cell Significance Index: -318.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -8.8029
    Cell Significance Index: -389.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -8.9867
    Cell Significance Index: -231.0000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -9.5170
    Cell Significance Index: -122.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -9.6680
    Cell Significance Index: -74.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -9.6973
    Cell Significance Index: -317.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL41 is a 40-kDa protein that belongs to the 60S ribosomal protein family. It is composed of two domains: a central domain and a C-terminal domain. The central domain is involved in the interaction with other ribosomal proteins, while the C-terminal domain is responsible for the binding of mRNA and the initiation of translation. RPL41 is highly conserved across species, with high sequence identity among different eukaryotic organisms. Its expression is tightly regulated, with changes in expression levels observed in response to various cellular stresses, such as amino acid deficiency or viral infections. **Pathways and Functions** RPL41 is involved in several key pathways, including: 1. **Translation Elongation**: RPL41 plays a crucial role in the elongation phase of translation, where it interacts with other ribosomal proteins to facilitate the assembly of the 60S ribosomal subunit and the translation of mRNA into proteins. 2. **Protein Synthesis**: RPL41 is essential for the synthesis of proteins, which is critical for cell growth, differentiation, and survival. 3. **mRNA Processing**: RPL41 is involved in the processing of mRNA, including the splicing and editing of RNA molecules. 4. **Cellular Stress Response**: RPL41 is regulated in response to various cellular stresses, such as amino acid deficiency or viral infections, which can lead to changes in its expression levels. 5. **Immune Response**: RPL41 is highly expressed in immune cells, such as T cells and B cells, where it plays a crucial role in the regulation of immune responses. **Clinical Significance** RPL41 has been implicated in various diseases, including: 1. **Cancer**: Abnormal expression of RPL41 has been observed in various types of cancer, including breast cancer, lung cancer, and leukemia. 2. **Neurological Disorders**: RPL41 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it plays a role in the regulation of protein synthesis and clearance. 3. **Infectious Diseases**: RPL41 has been shown to play a role in the regulation of immune responses to viral infections, such as influenza and HIV. 4. **Amino Acid Deficiency**: RPL41 is regulated in response to amino acid deficiency, which can lead to changes in its expression levels and affect protein synthesis. In conclusion, RPL41 is a critical component of the 60S ribosomal subunit, playing a vital role in the process of translation and protein synthesis. Its expression is widespread across different cell types, and its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and infectious diseases. Further research is needed to fully understand the mechanisms of RPL41 and its role in human disease.

Genular Protein ID: 4104923065

Symbol: RS32_HUMAN

Name: 60S ribosomal protein L41

UniProtKB Accession Codes:

P62945 A6NG21 P28751

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 55 Ensembl 2 EvolutionaryTrace 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OpenTargets 1 PDB 72 PDBsum 72 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1326959

Title: Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41.

PubMed ID: 1326959

DOI: 10.1016/0006-291x(92)91282-u

PubMed ID: 9299532

Title: The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII.

PubMed ID: 9299532

DOI: 10.1006/bbrc.1997.7317

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 25
  • Mass: 3456
  • Checksum: 9AD629C69ECC039E
  • Sequence:
    • MRAKWRKKRM RRLKRKRRKM RQRSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.