Details for: RPS3

Gene ID: 6188

Symbol: RPS3

Ensembl ID: ENSG00000149273

Description: ribosomal protein S3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 748.0320
    Cell Significance Index: -308.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 704.5169
    Cell Significance Index: -286.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 621.0886
    Cell Significance Index: -293.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 603.2055
    Cell Significance Index: -310.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 438.3164
    Cell Significance Index: -294.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 304.3568
    Cell Significance Index: -290.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 22.6041
    Cell Significance Index: 577.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.9632
    Cell Significance Index: -56.1600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 19.6901
    Cell Significance Index: 115.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 16.6875
    Cell Significance Index: 446.3800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 15.0510
    Cell Significance Index: 40.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.8058
    Cell Significance Index: 1512.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 14.7519
    Cell Significance Index: 387.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 14.4226
    Cell Significance Index: 184.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.9231
    Cell Significance Index: 654.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.8424
    Cell Significance Index: 339.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.2269
    Cell Significance Index: 390.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.8317
    Cell Significance Index: 191.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.3961
    Cell Significance Index: 1343.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.6094
    Cell Significance Index: 201.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.4353
    Cell Significance Index: 1295.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.1523
    Cell Significance Index: 211.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.9984
    Cell Significance Index: 670.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.9572
    Cell Significance Index: 633.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.9345
    Cell Significance Index: 101.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.7232
    Cell Significance Index: 256.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.5923
    Cell Significance Index: 1056.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.3333
    Cell Significance Index: 1502.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.1569
    Cell Significance Index: 4454.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.0027
    Cell Significance Index: 3538.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.9889
    Cell Significance Index: 86.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.9270
    Cell Significance Index: 934.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.8889
    Cell Significance Index: 48.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.3472
    Cell Significance Index: 474.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.2312
    Cell Significance Index: 798.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.2454
    Cell Significance Index: 142.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.7899
    Cell Significance Index: 88.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7550
    Cell Significance Index: 221.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.3312
    Cell Significance Index: 3278.3700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.1790
    Cell Significance Index: 35.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.0211
    Cell Significance Index: 686.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.9331
    Cell Significance Index: 105.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.8429
    Cell Significance Index: 201.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.5223
    Cell Significance Index: 183.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3300
    Cell Significance Index: 660.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4220
    Cell Significance Index: 2186.9300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3885
    Cell Significance Index: 19.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0291
    Cell Significance Index: 18.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3516
    Cell Significance Index: 257.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.0003
    Cell Significance Index: 733.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5531
    Cell Significance Index: 54.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3525
    Cell Significance Index: 70.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1295
    Cell Significance Index: 6.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0486
    Cell Significance Index: 17.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0504
    Cell Significance Index: -94.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1171
    Cell Significance Index: -86.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1548
    Cell Significance Index: -285.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1856
    Cell Significance Index: -285.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2467
    Cell Significance Index: -335.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2514
    Cell Significance Index: -141.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2981
    Cell Significance Index: -186.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3913
    Cell Significance Index: -248.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4907
    Cell Significance Index: -79.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5398
    Cell Significance Index: -30.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5856
    Cell Significance Index: -265.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5939
    Cell Significance Index: -47.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6048
    Cell Significance Index: -127.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7146
    Cell Significance Index: -43.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8748
    Cell Significance Index: -28.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.9018
    Cell Significance Index: -259.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1592
    Cell Significance Index: -132.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2054
    Cell Significance Index: -20.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.5025
    Cell Significance Index: -68.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5060
    Cell Significance Index: -104.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.6998
    Cell Significance Index: -10.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8105
    Cell Significance Index: -263.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.8873
    Cell Significance Index: -31.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.0493
    Cell Significance Index: -233.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1738
    Cell Significance Index: -137.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.6531
    Cell Significance Index: -159.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7513
    Cell Significance Index: -286.4800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.2624
    Cell Significance Index: -68.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.6790
    Cell Significance Index: -282.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.7776
    Cell Significance Index: -254.0100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -3.9337
    Cell Significance Index: -21.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.1242
    Cell Significance Index: -252.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.4000
    Cell Significance Index: -65.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.0171
    Cell Significance Index: -108.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.2149
    Cell Significance Index: -71.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -5.4200
    Cell Significance Index: -190.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.5727
    Cell Significance Index: -95.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.7605
    Cell Significance Index: -169.6700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -5.8628
    Cell Significance Index: -27.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.0095
    Cell Significance Index: -161.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.0819
    Cell Significance Index: -72.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.2669
    Cell Significance Index: -277.2000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.9910
    Cell Significance Index: -90.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.2200
    Cell Significance Index: -265.0400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -7.3365
    Cell Significance Index: -45.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -7.4716
    Cell Significance Index: -282.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Ribosomal protein S3 (RPS3) is a small subunit ribosomal protein that is essential for the translation of mRNAs into proteins. It is part of the 40S ribosomal subunit, which is responsible for the initiation and elongation of protein synthesis. RPS3 has several key characteristics that distinguish it from other ribosomal proteins: 1. **Structural role**: RPS3 is a structural component of the 40S ribosomal subunit, interacting with other ribosomal proteins to form the ribosomal complex. 2. **Translation initiation**: RPS3 plays a crucial role in the initiation of translation, binding to the mRNA cap-binding complex and eIFs to facilitate the recruitment of the 40S subunit to the mRNA. 3. **Apoptosis regulation**: RPS3 has been implicated in the regulation of apoptosis, with its expression and activity modulated in response to cellular stress and damage. 4. **Response to stress**: RPS3 is responsive to various forms of cellular stress, including oxidative stress, starvation, and hypoxia. **Pathways and Functions** The RPS3 gene is involved in several key pathways and processes, including: 1. **Translation initiation**: RPS3 plays a critical role in the initiation of translation, binding to the mRNA cap-binding complex and eIFs to facilitate the recruitment of the 40S subunit to the mRNA. 2. **Apoptosis regulation**: RPS3 is involved in the regulation of apoptosis, with its expression and activity modulated in response to cellular stress and damage. 3. **Response to stress**: RPS3 is responsive to various forms of cellular stress, including oxidative stress, starvation, and hypoxia. 4. **DNA damage response**: RPS3 has been implicated in the response to DNA damage, with its expression and activity modulated in response to DNA damage and repair. **Clinical Significance** The RPS3 gene has significant clinical implications, particularly in the context of: 1. **Cancer**: RPS3 has been implicated in the regulation of apoptosis and response to stress in cancer cells, making it a potential target for cancer therapy. 2. **Infectious diseases**: RPS3 has been shown to play a role in the translation machinery of viruses, including influenza and SARS-CoV-2, making it a potential target for antiviral therapy. 3. **Neurological disorders**: RPS3 has been implicated in the regulation of protein synthesis and apoptosis in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunological disorders**: RPS3 has been shown to play a role in the regulation of immune cell function and response to stress, making it a potential target for immunotherapy. In conclusion, the RPS3 gene plays a critical role in various cellular processes, including protein synthesis, apoptosis, and response to stress. Its clinical significance is evident in its involvement in cancer, infectious diseases, neurological disorders, and immunological disorders, making it a potential target for therapeutic intervention.

Genular Protein ID: 628908447

Symbol: RS3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2129557

Title: Isolation of a cDNA encoding human 40S ribosomal protein s3.

PubMed ID: 2129557

DOI: 10.1093/nar/18.22.6689

PubMed ID: 1712897

Title: Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein.

PubMed ID: 1712897

DOI: 10.1128/mcb.11.8.3842-3849.1991

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8319909

Title: A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3.

PubMed ID: 8319909

DOI: 10.1101/gad.7.7a.1176

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 7775413

Title: Implication of mammalian ribosomal protein S3 in the processing of DNA damage.

PubMed ID: 7775413

DOI: 10.1074/jbc.270.23.13620

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15518571

Title: Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1.

PubMed ID: 15518571

DOI: 10.1021/bi049234b

PubMed ID: 14706345

Title: Characterization of human ribosomal protein S3 binding to 7,8-dihydro-8-oxoguanine and abasic sites by surface plasmon resonance.

PubMed ID: 14706345

DOI: 10.1016/j.dnarep.2003.10.004

PubMed ID: 14988002

Title: RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis.

PubMed ID: 14988002

DOI: 10.1016/s0014-5793(04)00074-2

PubMed ID: 15707971

Title: Characterization of a wide range base-damage-endonuclease activity of mammalian rpS3.

PubMed ID: 15707971

DOI: 10.1016/j.bbrc.2005.01.045

PubMed ID: 15950189

Title: Erk phosphorylates threonine 42 residue of ribosomal protein S3.

PubMed ID: 15950189

DOI: 10.1016/j.bbrc.2005.05.079

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16737853

Title: The high binding affinity of human ribosomal protein S3 to 7,8-dihydro-8-oxoguanine is abrogated by a single amino acid change.

PubMed ID: 16737853

DOI: 10.1016/j.dnarep.2006.04.001

PubMed ID: 16314389

Title: Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation.

PubMed ID: 16314389

DOI: 10.1091/mbc.e05-08-0713

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 18045535

Title: Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.

PubMed ID: 18045535

DOI: 10.1016/j.cell.2007.10.009

PubMed ID: 17049931

Title: Knockdown of ribosomal protein S3 protects human cells from genotoxic stress.

PubMed ID: 17049931

DOI: 10.1016/j.dnarep.2006.09.004

PubMed ID: 17560175

Title: Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress.

PubMed ID: 17560175

DOI: 10.1016/j.dnarep.2007.04.009

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18610840

Title: Interactions of human ribosomal protein S3 with undamaged and damaged DNA.

PubMed ID: 18610840

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18973764

Title: Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA glycosylase (hUNG) and stimulates its glycosylase activity.

PubMed ID: 18973764

DOI: 10.1016/j.mrfmmm.2008.09.013

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19460357

Title: Arginine methylation of ribosomal protein S3 affects ribosome assembly.

PubMed ID: 19460357

DOI: 10.1016/j.bbrc.2009.05.055

PubMed ID: 19059439

Title: PKCdelta-dependent functional switch of rpS3 between translation and DNA repair.

PubMed ID: 19059439

DOI: 10.1016/j.bbamcr.2008.10.017

PubMed ID: 19656744

Title: Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain.

PubMed ID: 19656744

DOI: 10.1016/j.dnarep.2009.07.003

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20041225

Title: Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function.

PubMed ID: 20041225

DOI: 10.1371/journal.ppat.1000708

PubMed ID: 19541769

Title: IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR.

PubMed ID: 19541769

DOI: 10.1261/rna.1578409

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20605787

Title: Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair.

PubMed ID: 20605787

DOI: 10.1074/jbc.m110.131367

PubMed ID: 20217897

Title: RpS3 translation is repressed by interaction with its own mRNA.

PubMed ID: 20217897

DOI: 10.1002/jcb.22537

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21968017

Title: Ribosomal protein S3 is stabilized by sumoylation.

PubMed ID: 21968017

DOI: 10.1016/j.bbrc.2011.09.099

PubMed ID: 21871177

Title: Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase.

PubMed ID: 21871177

DOI: 10.5483/bmbrep.2011.44.8.529

PubMed ID: 21399639

Title: IKKbeta phosphorylation regulates RPS3 nuclear translocation and NF-kappaB function during infection with Escherichia coli strain O157:H7.

PubMed ID: 21399639

DOI: 10.1038/ni.2007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22510408

Title: Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation.

PubMed ID: 22510408

DOI: 10.1016/j.bbrc.2012.04.020

PubMed ID: 23131551

Title: Ribosomal protein S3 localizes on the mitotic spindle and functions as a microtubule associated protein in mitosis.

PubMed ID: 23131551

DOI: 10.1016/j.bbrc.2012.10.093

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23911537

Title: Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial DNA damage surveillance.

PubMed ID: 23911537

DOI: 10.1016/j.bbamcr.2013.07.015

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24457201

Title: Ribosomal protein S3 interacts with the NF-kappaB inhibitor IkappaBalpha.

PubMed ID: 24457201

DOI: 10.1016/j.febslet.2013.12.034

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24423872

Title: AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.

PubMed ID: 24423872

DOI: 10.1093/nar/gkt1379

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28065601

Title: Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.

PubMed ID: 28065601

DOI: 10.1016/j.molcel.2016.11.039

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28757607

Title: Ubiquitination of stalled ribosome triggers ribosome-associated quality control.

PubMed ID: 28757607

DOI: 10.1038/s41467-017-00188-1

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 31981475

Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

PubMed ID: 31981475

DOI: 10.1016/j.molcel.2019.12.024

PubMed ID: 34348161

Title: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.

PubMed ID: 34348161

DOI: 10.1016/j.celrep.2021.109468

PubMed ID: 34469731

Title: iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.

PubMed ID: 34469731

DOI: 10.1016/j.celrep.2021.109642

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 243
  • Mass: 26688
  • Checksum: 6ECBB34A8EE04AAF
  • Sequence:
  • MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG 
    EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY 
    GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG 
    VLGIKVKIML PWDPTGKIGP KKPLPDHVSI VEPKDEILPT TPISEQKGGK PEPPAMPQPV 
    PTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.