RPS6 | ENSG00000137154 | NCBI 6194

Details for: RPS6

Gene ID: 6194

Symbol: RPS6

Ensembl ID: ENSG00000137154

Description: ribosomal protein S6

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mtorc1-mediated signalling
(R-HSA-166208)
Mtor signalling
(R-HSA-165159)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Peptide chain elongation
(R-HSA-156902)
Post-translational protein modification
(R-HSA-597592)
Protein hydroxylation
(R-HSA-9629569)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna modification in the nucleus and cytosol
(R-HSA-6790901)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by robo receptors
(R-HSA-376176)
Signal transduction
(R-HSA-162582)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Activation-induced cell death of t cells
(GO:0006924)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Erythrocyte development
(GO:0048821)
G1/s transition of mitotic cell cycle
(GO:0000082)
Gastrulation
(GO:0007369)
Glucose homeostasis
(GO:0042593)
Mammalian oogenesis stage
(GO:0022605)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Placenta development
(GO:0001890)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Ribosomal small subunit biogenesis
(GO:0042274)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
T cell differentiation in thymus
(GO:0033077)
T cell proliferation involved in immune response
(GO:0002309)
Tor signaling
(GO:0031929)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 774.6373
Cell Significance Index: -319.1100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 655.0205
Cell Significance Index: -309.2500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 623.4432
Cell Significance Index: -320.6900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 463.0101
Cell Significance Index: -310.6900
Cell Name: theca cell (CL0000503)
Fold Change: 24.1242
Cell Significance Index: 141.7300
Cell Name: pro-T cell (CL0000827)
Fold Change: 21.2370
Cell Significance Index: 542.5400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.2176
Cell Significance Index: -54.1600
Cell Name: abnormal cell (CL0001061)
Fold Change: 18.0033
Cell Significance Index: 1839.0400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 16.9606
Cell Significance Index: 453.6900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 14.2082
Cell Significance Index: 667.7700
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 13.3952
Cell Significance Index: 236.7100
Cell Name: granulosa cell (CL0000501)
Fold Change: 13.2335
Cell Significance Index: 347.9800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 12.9058
Cell Significance Index: 448.4700
Cell Name: lactocyte (CL0002325)
Fold Change: 11.6885
Cell Significance Index: 1510.0700
Cell Name: peg cell (CL4033014)
Fold Change: 11.3468
Cell Significance Index: 262.1500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 10.8609
Cell Significance Index: 66.8400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 10.7639
Cell Significance Index: 1940.3900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 10.5183
Cell Significance Index: 96.8600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 10.0947
Cell Significance Index: 752.3500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 9.9502
Cell Significance Index: 1223.4700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 9.6980
Cell Significance Index: 685.8800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 9.5489
Cell Significance Index: 108.4800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.2721
Cell Significance Index: 1273.3200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 9.2559
Cell Significance Index: 193.7400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 8.8392
Cell Significance Index: 3908.0400
Cell Name: cell in vitro (CL0001034)
Fold Change: 8.5284
Cell Significance Index: 4657.5700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.1682
Cell Significance Index: 963.2800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 8.1495
Cell Significance Index: 233.6100
Cell Name: odontoblast (CL0000060)
Fold Change: 7.7144
Cell Significance Index: 988.9400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 7.5679
Cell Significance Index: 96.9200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 7.4020
Cell Significance Index: 80.4700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 7.2049
Cell Significance Index: 464.8300
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 6.9242
Cell Significance Index: 59.5000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 6.6659
Cell Significance Index: 181.4400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.5503
Cell Significance Index: 305.4100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 5.7793
Cell Significance Index: 4374.4600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 5.7105
Cell Significance Index: 167.7100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 5.0088
Cell Significance Index: 855.2800
Cell Name: kidney cell (CL1000497)
Fold Change: 4.3886
Cell Significance Index: 35.0400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 3.7447
Cell Significance Index: 370.4300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.6667
Cell Significance Index: 3310.7900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.1181
Cell Significance Index: 163.7100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.8527
Cell Significance Index: 566.1300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.6668
Cell Significance Index: 49.2900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.5789
Cell Significance Index: 68.8600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.9372
Cell Significance Index: 100.6300
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.9034
Cell Significance Index: 13.6700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.7275
Cell Significance Index: 136.8200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.6454
Cell Significance Index: 1206.4100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2127
Cell Significance Index: 230.7800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1458
Cell Significance Index: 51.9400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 1.0327
Cell Significance Index: 117.8800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.4921
Cell Significance Index: 141.6100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0629
Cell Significance Index: -118.4600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0937
Cell Significance Index: -15.2500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1162
Cell Significance Index: -86.0400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1418
Cell Significance Index: -261.4900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1722
Cell Significance Index: -107.5100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1788
Cell Significance Index: -275.2400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1792
Cell Significance Index: -101.0500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2413
Cell Significance Index: -328.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3675
Cell Significance Index: -233.4100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.4079
Cell Significance Index: -81.8300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.4977
Cell Significance Index: -178.5300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5414
Cell Significance Index: -30.3800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.5855
Cell Significance Index: -265.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.6067
Cell Significance Index: -127.7900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7031
Cell Significance Index: -48.6200
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.9838
Cell Significance Index: -16.9600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.1596
Cell Significance Index: -132.8500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.8135
Cell Significance Index: -263.6100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.9157
Cell Significance Index: -120.7400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.9445
Cell Significance Index: -62.2800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.9470
Cell Significance Index: -119.6700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.1039
Cell Significance Index: -35.2100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.4839
Cell Significance Index: -62.0900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.9047
Cell Significance Index: -302.4500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.9503
Cell Significance Index: -17.8300
Cell Name: hepatic pit cell (CL2000054)
Fold Change: -3.4492
Cell Significance Index: -9.2400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.7419
Cell Significance Index: -287.1500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -3.9696
Cell Significance Index: -54.1600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -4.1511
Cell Significance Index: -249.2100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.1845
Cell Significance Index: -256.5500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.3589
Cell Significance Index: -293.1000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -4.8358
Cell Significance Index: -72.4600
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -5.1329
Cell Significance Index: -107.0500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -5.2188
Cell Significance Index: -150.3700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.6026
Cell Significance Index: -165.0200
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -5.9400
Cell Significance Index: -32.3900
Cell Name: preadipocyte (CL0002334)
Fold Change: -6.0613
Cell Significance Index: -118.3000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -6.1487
Cell Significance Index: -133.2100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -6.1551
Cell Significance Index: -105.4800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -6.4036
Cell Significance Index: -76.3400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -6.8047
Cell Significance Index: -182.3400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -6.8889
Cell Significance Index: -242.0700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -6.9025
Cell Significance Index: -57.9800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -6.9829
Cell Significance Index: -308.8700
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -7.2198
Cell Significance Index: -44.8600
Cell Name: perivascular cell (CL4033054)
Fold Change: -7.2381
Cell Significance Index: -33.4200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -7.2679
Cell Significance Index: -266.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** RPS6 is a phosphoprotein, with a molecular weight of approximately 33 kDa. It is highly conserved across species, with high sequence identity among different organisms. RPS6 is a component of the 40S ribosomal subunit, which is responsible for the initiation of protein synthesis. The protein is also involved in various post-translational modifications, including phosphorylation, ubiquitination, and sumoylation. **Pathways and Functions:** RPS6 is involved in multiple cellular pathways, including: 1. **Translation initiation**: RPS6 plays a crucial role in the initiation of protein synthesis, binding to mRNA and facilitating the recruitment of the 60S ribosomal subunit. 2. **Cell growth and proliferation**: RPS6 is a key regulator of cell growth and proliferation, influencing the translation of mRNAs involved in these processes. 3. **Metabolic regulation**: RPS6 is involved in the regulation of metabolic pathways, including glucose homeostasis and amino acid metabolism. 4. **Stress response**: RPS6 is activated in response to stress, including hypoxia, starvation, and viral infections. 5. **Signaling pathways**: RPS6 interacts with various signaling molecules, including mTOR, AKT, and MAPK, influencing cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of RPS6 has been implicated in various diseases, including: 1. **Cancer**: RPS6 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Metabolic disorders**: RPS6 is involved in the regulation of glucose homeostasis and amino acid metabolism, and its dysregulation has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 3. **Infectious diseases**: RPS6 is involved in the translation of viral mRNAs, and its dysregulation has been implicated in viral infections, such as influenza and SARS-CoV-2. 4. **Neurological disorders**: RPS6 is involved in the regulation of neuronal function and survival, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RPS6 is a critical protein involved in various cellular processes, including translation initiation, cell growth, and metabolic regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of RPS6 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which RPS6 regulates cellular processes and to develop novel therapeutic strategies targeting this protein.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Phosphoprotein NP33

Genular Protein ID: 3470706467

Symbol: RS6_HUMAN

Name: Phosphoprotein NP33

UniProtKB Accession Codes:

P62753 P08227 P10660 Q4VBY7 Q8N6Z7

Database IDs:

Citations:

PubMed ID: 2840355

Title: Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6.

PubMed ID: 2840355

DOI: 10.1016/0378-1119(88)90414-3

PubMed ID: 3279029

Title: The primary structure of the human ribosomal protein S6 derived from a cloned cDNA.

PubMed ID: 3279029

DOI: 10.1016/s0021-9258(18)68900-8

PubMed ID: 1301164

Title: The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21.

PubMed ID: 1301164

DOI: 10.1093/hmg/1.8.565

PubMed ID: 1446836

Title: The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9.

PubMed ID: 1446836

DOI: 10.1016/0378-1119(92)90149-j

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17360704

Title: RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.

PubMed ID: 17360704

DOI: 10.1074/jbc.m700906200

PubMed ID: 17220279

Title: hDREF regulates cell proliferation and expression of ribosomal protein genes.

PubMed ID: 17220279

DOI: 10.1128/mcb.01462-06

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18974095

Title: Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.

PubMed ID: 18974095

DOI: 10.1074/jbc.m805165200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21418524

Title: Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN.

PubMed ID: 21418524

DOI: 10.1111/j.1742-4658.2011.08100.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29563586

Title: JMJD5 is a human L-arginyl C-3 hydroxylase.

PubMed ID: 29563586

DOI: 10.1038/s41467-018-03410-w

PubMed ID: 34314702

Title: Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

PubMed ID: 34314702

DOI: 10.1016/j.cell.2021.07.005

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 249
Mass: 28681
Checksum: A61E435884E636AE
Sequence:

MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG 
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD 
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV 
TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS 
TSKSESSQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS6

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6. PubMed ID: 2840355

The primary structure of the human ribosomal protein S6 derived from a cloned cDNA. PubMed ID: 3279029

The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21. PubMed ID: 1301164

The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9. PubMed ID: 1446836

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. PubMed ID: 17360704

hDREF regulates cell proliferation and expression of ribosomal protein genes. PubMed ID: 17220279

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. PubMed ID: 18974095

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. PubMed ID: 21418524

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

JMJD5 is a human L-arginyl C-3 hydroxylase. PubMed ID: 29563586

Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. PubMed ID: 34314702

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797