Details for: RPS8

Gene ID: 6202

Symbol: RPS8

Ensembl ID: ENSG00000142937

Description: ribosomal protein S8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 835.1305
    Cell Significance Index: -344.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 769.7465
    Cell Significance Index: -312.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 696.1538
    Cell Significance Index: -328.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 668.6234
    Cell Significance Index: -343.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 491.9957
    Cell Significance Index: -330.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 333.2101
    Cell Significance Index: -318.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 58.2076
    Cell Significance Index: -155.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 18.0935
    Cell Significance Index: 462.2300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 17.4195
    Cell Significance Index: 102.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 16.7167
    Cell Significance Index: 214.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 16.5445
    Cell Significance Index: 442.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.8713
    Cell Significance Index: 1621.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.3764
    Cell Significance Index: 628.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 12.9947
    Cell Significance Index: 341.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.3862
    Cell Significance Index: 355.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.8571
    Cell Significance Index: 273.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 11.7090
    Cell Significance Index: 133.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.0488
    Cell Significance Index: 383.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 10.3359
    Cell Significance Index: 1419.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 10.3092
    Cell Significance Index: 1267.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 10.2483
    Cell Significance Index: 724.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.1845
    Cell Significance Index: 1315.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.9614
    Cell Significance Index: 1795.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.7183
    Cell Significance Index: 203.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 9.4614
    Cell Significance Index: 5167.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 9.1969
    Cell Significance Index: 4066.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.1593
    Cell Significance Index: 1080.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.1507
    Cell Significance Index: 161.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.4253
    Cell Significance Index: 627.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.6679
    Cell Significance Index: 83.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.4381
    Cell Significance Index: 218.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.6774
    Cell Significance Index: 430.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.0591
    Cell Significance Index: 776.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.4476
    Cell Significance Index: 148.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.1777
    Cell Significance Index: 269.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.0374
    Cell Significance Index: 93.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.1844
    Cell Significance Index: 714.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.1660
    Cell Significance Index: 194.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.0753
    Cell Significance Index: 25.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.4801
    Cell Significance Index: 182.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.3497
    Cell Significance Index: 2535.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.0377
    Cell Significance Index: 2742.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.0275
    Cell Significance Index: 80.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9689
    Cell Significance Index: 27.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3982
    Cell Significance Index: 475.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9384
    Cell Significance Index: 191.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.5299
    Cell Significance Index: 1121.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0663
    Cell Significance Index: 202.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7817
    Cell Significance Index: 224.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.4962
    Cell Significance Index: 39.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0252
    Cell Significance Index: 5.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0857
    Cell Significance Index: -161.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1379
    Cell Significance Index: -102.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1601
    Cell Significance Index: -295.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1950
    Cell Significance Index: -69.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1964
    Cell Significance Index: -302.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2686
    Cell Significance Index: -365.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2976
    Cell Significance Index: -167.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3082
    Cell Significance Index: -192.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3613
    Cell Significance Index: -2.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4473
    Cell Significance Index: -284.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5019
    Cell Significance Index: -26.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5884
    Cell Significance Index: -33.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6729
    Cell Significance Index: -305.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7244
    Cell Significance Index: -152.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8947
    Cell Significance Index: -54.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0478
    Cell Significance Index: -119.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.5264
    Cell Significance Index: -174.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.6990
    Cell Significance Index: -77.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7962
    Cell Significance Index: -57.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.1480
    Cell Significance Index: -312.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.1481
    Cell Significance Index: -35.9500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.2507
    Cell Significance Index: -38.8000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.4171
    Cell Significance Index: -20.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.4728
    Cell Significance Index: -14.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.8886
    Cell Significance Index: -182.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.1450
    Cell Significance Index: -327.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.2559
    Cell Significance Index: -225.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.1928
    Cell Significance Index: -321.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -4.2129
    Cell Significance Index: -105.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.4992
    Cell Significance Index: -302.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.5200
    Cell Significance Index: -277.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.6770
    Cell Significance Index: -70.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -5.2810
    Cell Significance Index: -317.0400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -5.6282
    Cell Significance Index: -117.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.6429
    Cell Significance Index: -76.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -5.9632
    Cell Significance Index: -159.7900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -6.4433
    Cell Significance Index: -29.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.5711
    Cell Significance Index: -112.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -6.6726
    Cell Significance Index: -144.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.8656
    Cell Significance Index: -202.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.9867
    Cell Significance Index: -309.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -7.4517
    Cell Significance Index: -145.4400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -7.7409
    Cell Significance Index: -42.2100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -7.7597
    Cell Significance Index: -65.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -8.1102
    Cell Significance Index: -297.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -8.3903
    Cell Significance Index: -241.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -8.4005
    Cell Significance Index: -318.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -8.5537
    Cell Significance Index: -110.1600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -9.1785
    Cell Significance Index: -97.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPS8 is a highly conserved protein, with high sequence identity across species. It is a small, acidic protein that binds to the 18S rRNA of the 40S subunit, forming a ternary complex with eIF2 and eIF3. This binding is essential for the recruitment of the 40S subunit to the mRNA and the initiation of translation. RPS8 also interacts with other ribosomal proteins, such as RPS14, to form the 40S small subunit processome. **Pathways and Functions** RPS8 is involved in several key pathways, including: 1. **Translation Initiation**: RPS8 binds to the 40S subunit, facilitating the recruitment of the mRNA and the initiation of translation. 2. **Stress Response**: RPS8 plays a role in the response to amino acid starvation, with RPS14-mediated translational silencing of ceruloplasmin expression. 3. **Viral Infections**: RPS8 is essential for the translation of viral RNAs, including influenza viral RNA transcription and replication. 4. **Cellular Response to Stimuli**: RPS8 is involved in the regulation of expression of Slits and Robos, influencing cell signaling and development. 5. **Metabolic Processes**: RPS8 is involved in the metabolism of amino acids and derivatives, with RPS14-mediated regulation of protein synthesis. **Clinical Significance** RPS8 has been implicated in various diseases, including: 1. **Influenza**: RPS8 is essential for the translation of influenza viral RNAs, making it a potential target for therapeutic interventions. 2. **Cancer**: RPS8 is overexpressed in malignant cells, suggesting its role in tumorigenesis. 3. **Neurological Disorders**: RPS8 has been linked to neurological disorders, such as SARS-CoV-2 infection, highlighting its role in viral infections and host translation machinery modulation. 4. **Metabolic Disorders**: RPS8 is involved in the regulation of protein synthesis, which is critical for metabolic processes, including amino acid metabolism and selenocysteine synthesis. In conclusion, RPS8 is a critical component of the 40S ribosomal subunit, playing a vital role in translation initiation, stress response, and viral infections. Its dysregulation has been implicated in various diseases, highlighting the importance of RPS8 in maintaining cellular homeostasis. Further research is necessary to elucidate the mechanisms underlying RPS8's role in disease and to explore its therapeutic potential.

Genular Protein ID: 4032500914

Symbol: RS8_HUMAN

Name: 40S ribosomal protein S8

UniProtKB Accession Codes:

P62241 P09058 Q6IRL7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 3 EMDB 82 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 95 PDBsum 95 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8432552

Title: The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1.

PubMed ID: 8432552

DOI: 10.1006/geno.1993.1011

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 208
  • Mass: 24205
  • Checksum: 407FDF59171F7422
  • Sequence:
    • MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL 
DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP 
LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS LLEEQFQQGK LLACIASRPG 
QCGRADGYVL EGKELEFYLR KIKARKGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.