Gene RPS13 - ENSG00000110700 | NCBI Gene ID: 6207

Details for: RPS13

Gene ID: 6207

Symbol: RPS13

Ensembl ID: ENSG00000110700

Description: ribosomal protein S13

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Mrna 5'-utr binding
(GO:0048027)
Mrna binding
(GO:0003729)
Negative regulation of rna splicing
(GO:0033119)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Small-subunit processome
(GO:0032040)
Small ribosomal subunit rrna binding
(GO:0070181)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 6.63
Marker Score: 3739
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.84
Marker Score: 28691
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.76
Marker Score: 12075
Cell Name: malignant cell (CL0001064)
Fold Change: 5.61
Marker Score: 75428
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.59
Marker Score: 4373
Cell Name: mature T cell (CL0002419)
Fold Change: 5.32
Marker Score: 52698
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 5.31
Marker Score: 2741.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.25
Marker Score: 6840
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.25
Marker Score: 15309
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.19
Marker Score: 3767
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.18
Marker Score: 2662
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.17
Marker Score: 1905
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.14
Marker Score: 8822
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.07
Marker Score: 7802
Cell Name: theca cell (CL0000503)
Fold Change: 5
Marker Score: 3580
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.98
Marker Score: 169273
Cell Name: naive T cell (CL0000898)
Fold Change: 4.97
Marker Score: 3202
Cell Name: naive B cell (CL0000788)
Fold Change: 4.86
Marker Score: 4341
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.86
Marker Score: 15328.5
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.78
Marker Score: 3604
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.76
Marker Score: 251550
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.54
Marker Score: 3871
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.54
Marker Score: 23845
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.52
Marker Score: 252758
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.48
Marker Score: 59080
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.47
Marker Score: 11374
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.4
Marker Score: 4895
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.4
Marker Score: 26724
Cell Name: blood cell (CL0000081)
Fold Change: 4.4
Marker Score: 51099.5
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.38
Marker Score: 1425
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.35
Marker Score: 2646
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.33
Marker Score: 1035
Cell Name: memory T cell (CL0000813)
Fold Change: 4.26
Marker Score: 1830
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.23
Marker Score: 11685
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.23
Marker Score: 10322.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.23
Marker Score: 11854
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.19
Marker Score: 4054
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.17
Marker Score: 31070
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.17
Marker Score: 11175
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.12
Marker Score: 2929
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.11
Marker Score: 9372
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.11
Marker Score: 10020
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.11
Marker Score: 2408
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 4.1
Marker Score: 14572
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.1
Marker Score: 2187.5
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.09
Marker Score: 3487
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.09
Marker Score: 17532
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.08
Marker Score: 6015
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.05
Marker Score: 3182
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.04
Marker Score: 4316
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.04
Marker Score: 26326.5
Cell Name: supporting cell (CL0000630)
Fold Change: 4.03
Marker Score: 7579
Cell Name: club cell (CL0000158)
Fold Change: 4.01
Marker Score: 4682
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4
Marker Score: 3944
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.99
Marker Score: 4820
Cell Name: granulocyte (CL0000094)
Fold Change: 3.98
Marker Score: 1782
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.96
Marker Score: 3740
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.92
Marker Score: 4213
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.89
Marker Score: 1779
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.84
Marker Score: 3608
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.83
Marker Score: 3360.5
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.83
Marker Score: 3133.5
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.81
Marker Score: 2561
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.81
Marker Score: 1253
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.78
Marker Score: 4672
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.77
Marker Score: 865
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.77
Marker Score: 3377
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.77
Marker Score: 3242.5
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.76
Marker Score: 4158
Cell Name: reticular cell (CL0000432)
Fold Change: 3.75
Marker Score: 1370
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.75
Marker Score: 4292
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.75
Marker Score: 3345
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.75
Marker Score: 3332
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.73
Marker Score: 3095
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.72
Marker Score: 24213
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.72
Marker Score: 22076
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.72
Marker Score: 9376
Cell Name: memory B cell (CL0000787)
Fold Change: 3.72
Marker Score: 2813
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.7
Marker Score: 1041
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.68
Marker Score: 969
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.67
Marker Score: 3237
Cell Name: immature B cell (CL0000816)
Fold Change: 3.67
Marker Score: 2432
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.66
Marker Score: 1896
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.65
Marker Score: 5808
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.65
Marker Score: 9087.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.65
Marker Score: 3698
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.64
Marker Score: 2093
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.63
Marker Score: 1032
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.63
Marker Score: 23184
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.63
Marker Score: 844
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.62
Marker Score: 2383
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.61
Marker Score: 2118
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.61
Marker Score: 1994
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.61
Marker Score: 8717
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.6
Marker Score: 5910
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.6
Marker Score: 8169
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.59
Marker Score: 1618
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.59
Marker Score: 3023
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.58
Marker Score: 4222
Cell Name: fibroblast (CL0000057)
Fold Change: 3.57
Marker Score: 3447

Hover over a box to see details here...

**Key characteristics:** * RS13 is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of protein synthesis. * It is involved in the initiation of translation at the start codon of mRNA. * It is also involved in the elongation of protein synthesis. **Pathways and functions:** * RS13 is involved in a variety of cellular processes, including: * Protein synthesis * Cell migration * Cell differentiation * Apoptosis * Immune responses * It is involved in the initiation of translation at the start codon of mRNA. * It is also involved in the elongation of protein synthesis. **Clinical significance:** * Mutations in the RPS13 gene have been linked to a number of human diseases, including: * Cancer * Diabetes * Cardiovascular disease * Renal disease * RS13 is a promising target for cancer therapy. * Small molecule inhibitors of RS13 have been shown to be effective in inhibiting cancer growth in vitro and in vivo. **Additional information:** * The RPS13 gene is located on chromosome 15q21.1. * It is a member of the RPS13 family of ribosomal proteins. * It is a highly conserved protein that is found in organisms from yeast to humans.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S13

Genular Protein ID: 2267300521

Symbol: RS13_HUMAN

Name: 40S ribosomal protein S13

UniProtKB Accession Codes:

P62277 B2R549 P19116 Q02546 Q29200 Q498Y0

Database IDs:

Citations:

PubMed ID: 8332508

Title: Cloning and analysis of the human S13 ribosomal protein cDNA.

PubMed ID: 8332508

DOI: 10.1093/nar/21.12.2945

PubMed ID: 8920921

Title: U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene.

PubMed ID: 8920921

DOI: 10.1006/bbrc.1996.1668

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 151
Mass: 17222
Checksum: 23F94D38F87B8D53
Sequence:

MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI GVILRDSHGV 
AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK HLERNRKDKD AKFRLILIES 
RIHRLARYYK TKRVLPPNWK YESSTASALV A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS13

Associated with

Cells (max top 100)

Other Information

Cloning and analysis of the human S13 ribosomal protein cDNA. PubMed ID: 8332508

U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene. PubMed ID: 8920921

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797