RPS13 | ENSG00000110700 | NCBI 6207

Details for: RPS13

Gene ID: 6207

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPS13

Ensembl ID: ENSG00000110700

Description: ribosomal protein S13

Cell Significance Landscape

Display Count:

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Mrna 5'-utr binding
(GO:0048027)
Mrna binding
(GO:0003729)
Negative regulation of rna splicing
(GO:0033119)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Small-subunit processome
(GO:0032040)
Small ribosomal subunit rrna binding
(GO:0070181)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 160.9

rCSI 95.02%

PRS 2.48
hematopoietic stem cell CL0000037

CSI 146.96

rCSI 97.68%

PRS 2.11
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 142.42

rCSI 95.95%

PRS 2.14
plasmacytoid dendritic cell, human CL0001058

CSI 142.34

rCSI 99.38%

PRS 1.87
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 136.49

rCSI 90.97%

PRS 5.03
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 135.61

rCSI 95.24%

PRS 5.42
double negative thymocyte CL0002489

CSI 133.13

rCSI 92.55%

PRS 2.07
immature B cell CL0000816

CSI 132.57

rCSI 98.49%

PRS 2.64
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 131.46

rCSI 98.58%

PRS 5.35
CD4-positive, alpha-beta memory T cell CL0000897

CSI 129.45

rCSI 92.93%

PRS 2.41
T follicular helper cell CL0002038

CSI 128.46

rCSI 96.14%

PRS 2.91
group 3 innate lymphoid cell CL0001071

CSI 128.38

rCSI 96.46%

PRS 1.82
naive T cell CL0000898

CSI 125.03

rCSI 87.01%

PRS 2.59
class switched memory B cell CL0000972

CSI 123.62

rCSI 92.28%

PRS 3
epithelial cell of lower respiratory tract CL0002632

CSI 122.51

rCSI 94.97%

PRS 1.69
pro-B cell CL0000826

CSI 122.07

rCSI 100%

PRS 1.77
common myeloid progenitor CL0000049

CSI 119.98

rCSI 97.01%

PRS 1.74
CD14-low, CD16-positive monocyte CL0002396

CSI 119.62

rCSI 92.17%

PRS 1.6
CD4-positive helper T cell CL0000492

CSI 119.45

rCSI 90.36%

PRS 2.48
mucosal invariant T cell CL0000940

CSI 119.06

rCSI 96.2%

PRS 4.65
bronchus fibroblast of lung CL2000093

CSI 117.37

rCSI 95.37%

PRS 1.85
unswitched memory B cell CL0000970

CSI 116.67

rCSI 98.16%

PRS 2.99
plasmablast CL0000980

CSI 115.48

rCSI 90.84%

PRS 2.11
epithelial cell of lung CL0000082

CSI 115.06

rCSI 95.39%

PRS 1.65
keratinocyte CL0000312

CSI 114.67

rCSI 96.13%

PRS 2.13
T-helper 17 cell CL0000899

CSI 114.36

rCSI 90.8%

PRS 3.15
granulocyte monocyte progenitor cell CL0000557

CSI 114.18

rCSI 98.87%

PRS 1.98
naive B cell CL0000788

CSI 114.16

rCSI 97.92%

PRS 5.77
mature B cell CL0000785

CSI 113.48

rCSI 98.65%

PRS 2.18
skin fibroblast CL0002620

CSI 112.77

rCSI 97.21%

PRS 2.97
mature T cell CL0002419

CSI 112.76

rCSI 87.71%

PRS 2.55
neural crest cell CL0011012

CSI 112.68

rCSI 89.07%

PRS 1.23
early lymphoid progenitor CL0000936

CSI 111.15

rCSI 97.62%

PRS 1.98
CD4-positive, alpha-beta thymocyte CL0000810

CSI 109.61

rCSI 87.8%

PRS 3.32
precursor B cell CL0000817

CSI 107.88

rCSI 94.5%

PRS 2.39
melanocyte CL0000148

CSI 105.85

rCSI 78.4%

PRS 1.69
megakaryocyte-erythroid progenitor cell CL0000050

CSI 104.99

rCSI 94.81%

PRS 1.56
small pre-B-II cell CL0000954

CSI 102.56

rCSI 98.63%

PRS 3.88
fibroblast of lung CL0002553

CSI 100.81

rCSI 93.82%

PRS 1.77
goblet cell CL0000160

CSI 100.71

rCSI 95.16%

PRS 1.85
double-positive, alpha-beta thymocyte CL0000809

CSI 98.09

rCSI 99.97%

PRS 2.58
activated CD4-positive, alpha-beta T cell CL0000896

CSI 97.88

rCSI 90.49%

PRS 3.25
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 97.68

rCSI 88.97%

PRS 2.77
memory B cell CL0000787

CSI 97.47

rCSI 96.26%

PRS 7.87
effector CD8-positive, alpha-beta T cell CL0001050

CSI 95.98

rCSI 73%

PRS 2.35
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 93.37

rCSI 91.69%

PRS 2.83
fallopian tube secretory epithelial cell CL4030006

CSI 91.79

rCSI 88.36%

PRS 1.85
respiratory basal cell CL0002633

CSI 91.11

rCSI 94.38%

PRS 2.07
intestine goblet cell CL0019031

CSI 90.12

rCSI 80%

PRS 1.78
hematopoietic precursor cell CL0008001

CSI 89.81

rCSI 92.39%

PRS 2.85
ciliated epithelial cell CL0000067

CSI 89.49

rCSI 78.69%

PRS 1.29
intestinal epithelial cell CL0002563

CSI 88.84

rCSI 92.85%

PRS 1.91
elicited macrophage CL0000861

CSI 87.44

rCSI 80.28%

PRS 2.02
CD8-positive, alpha-beta memory T cell CL0000909

CSI 86.92

rCSI 90.78%

PRS 5.73
fraction A pre-pro B cell CL0002045

CSI 85.49

rCSI 97.87%

PRS 3.69
pancreatic D cell CL0000173

CSI 85.48

rCSI 84.08%

PRS 1.96
activated CD8-positive, alpha-beta T cell CL0000906

CSI 84.22

rCSI 82.78%

PRS 5.31
activated type II NK T cell CL0000931

CSI 79.29

rCSI 89.24%

PRS 2.98
alveolar type 1 fibroblast cell CL4028004

CSI 79.28

rCSI 86.83%

PRS 2.08
common dendritic progenitor CL0001029

CSI 78.89

rCSI 99.01%

PRS 2.25
CD1c-positive myeloid dendritic cell CL0002399

CSI 77.83

rCSI 94%

PRS 2.03
gamma-delta T cell CL0000798

CSI 77.83

rCSI 91.41%

PRS 18.04
transit amplifying cell of colon CL0009011

CSI 77.82

rCSI 91.39%

PRS 2.17
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 75.95

rCSI 90.67%

PRS 3.09
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 75.67

rCSI 95.09%

PRS 9.78
respiratory suprabasal cell CL4033048

CSI 74.55

rCSI 95.61%

PRS 2.05
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 74.04

rCSI 85.5%

PRS 1.66
conventional dendritic cell CL0000990

CSI 74.02

rCSI 61.79%

PRS 5.87
IgA plasma cell CL0000987

CSI 73.27

rCSI 75%

PRS 3.35
extravillous trophoblast CL0008036

CSI 72.7

rCSI 89.93%

PRS 1.57
pancreatic A cell CL0000171

CSI 72.46

rCSI 75.91%

PRS 1.91
mature NK T cell CL0000814

CSI 72.01

rCSI 92.11%

PRS 8.26
M cell of gut CL0000682

CSI 71.74

rCSI 76.22%

PRS 3.21
B cell CL0000236

CSI 71.54

rCSI 95.72%

PRS 10.91
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 71.51

rCSI 97.42%

PRS 4.45
mesodermal cell CL0000222

CSI 71.15

rCSI 85.4%

PRS 1.77
CD4-positive, alpha-beta T cell CL0000624

CSI 70.64

rCSI 90.4%

PRS 38.75
multi-ciliated epithelial cell CL0005012

CSI 69.38

rCSI 69.24%

PRS 1.49
secretory cell CL0000151

CSI 69.29

rCSI 72.3%

PRS 1.81
CD14-positive monocyte CL0001054

CSI 68.3

rCSI 85.07%

PRS 2.62
common lymphoid progenitor CL0000051

CSI 68.29

rCSI 91.26%

PRS 3.39
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 68.08

rCSI 93.54%

PRS 3.81
promyelocyte CL0000836

CSI 67.55

rCSI 97.42%

PRS 2.46
myofibroblast cell CL0000186

CSI 67.32

rCSI 93.24%

PRS 2.56
renal alpha-intercalated cell CL0005011

CSI 67.07

rCSI 89.67%

PRS 2.42
perivascular cell CL4033054

CSI 66.62

rCSI 91.08%

PRS 2.03
mucous neck cell CL0000651

CSI 65.73

rCSI 94.74%

PRS 2.89
lung ciliated cell CL1000271

CSI 65.7

rCSI 75.97%

PRS 1.28
colon epithelial cell CL0011108

CSI 65.63

rCSI 68.75%

PRS 1.65
enteric smooth muscle cell CL0002504

CSI 65.07

rCSI 92.87%

PRS 2.03
enteroendocrine cell CL0000164

CSI 64.12

rCSI 87.62%

PRS 1.96
placental villous trophoblast CL2000060

CSI 64.03

rCSI 98.94%

PRS 1.68
endothelial cell of artery CL1000413

CSI 63.4

rCSI 92.89%

PRS 10.95
club cell CL0000158

CSI 63.25

rCSI 92.65%

PRS 2.1
myeloid dendritic cell CL0000782

CSI 63.06

rCSI 91.35%

PRS 2.6
radial glial cell CL0000681

CSI 62.51

rCSI 86.84%

PRS 1.91
myeloid leukocyte CL0000766

CSI 62.38

rCSI 57.55%

PRS 1.79
neuroblast (sensu Vertebrata) CL0000031

CSI 61.91

rCSI 79.46%

PRS 1.79
plasmacytoid dendritic cell CL0000784

CSI 61.76

rCSI 62.56%

PRS 11.89
dendritic cell CL0000451

CSI 61.73

rCSI 76.05%

PRS 5.89

lamp5 GABAergic cortical interneuron CL4023011

CSI -38.6

rCSI -64.8%

PRS 1.2%
inhibitory interneuron CL0000498

CSI -34.3

rCSI -79.2%

PRS 1.8%
vascular leptomeningeal cell CL4023051

CSI -33.0

rCSI -57.9%

PRS 1.5%
sncg GABAergic cortical interneuron CL4023015

CSI -30.2

rCSI -48.6%

PRS 1.4%
VIP GABAergic cortical interneuron CL4023016

CSI -30.0

rCSI -35.9%

PRS 1.2%
adipocyte CL0000136

CSI -20.9

rCSI -26.9%

PRS 2.4%
kidney interstitial fibroblast CL1000692

CSI -19.8

rCSI -100.0%

PRS 13.6%
kidney interstitial alternatively activated macrophage CL1000695

CSI -18.6

rCSI -48.5%

PRS 2.2%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI -17.9

rCSI -31.7%

PRS 1.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -17.7

rCSI -55.3%

PRS 1.4%
astrocyte of the cerebral cortex CL0002605

CSI -17.6

rCSI -39.4%

PRS 1.2%
GABAergic neuron CL0000617

CSI -17.2

rCSI -57.6%

PRS 1.9%
retinal bipolar neuron CL0000748

CSI -15.0

rCSI -28.1%

PRS 1.5%
kidney collecting duct principal cell CL1001431

CSI -14.6

rCSI -73.5%

PRS 12.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI -14.6

rCSI -55.0%

PRS 1.3%
cardiac endothelial cell CL0010008

CSI -14.6

rCSI -58.7%

PRS 2.2%
erythroid lineage cell CL0000764

CSI -13.6

rCSI -87.6%

PRS 5.1%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -13.5

rCSI -24.5%

PRS 2.1%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -13.0

rCSI -31.6%

PRS 1.1%
epicardial adipocyte CL1000309

CSI -12.5

rCSI -40.8%

PRS 3.3%
neural cell CL0002319

CSI -11.4

rCSI -42.9%

PRS 4.2%
glutamatergic neuron CL0000679

CSI -10.3

rCSI -21.2%

PRS 2.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -10.3

rCSI -60.4%

PRS 1.4%
rod bipolar cell CL0000751

CSI -10.1

rCSI -18.1%

PRS 1.6%
OFFx cell CL4033036

CSI -10.0

rCSI -47.3%

PRS 5.2%
cell of skeletal muscle CL0000188

CSI -9.5

rCSI -100.0%

PRS 12.8%
pvalb GABAergic cortical interneuron CL4023018

CSI -9.1

rCSI -11.3%

PRS 1.1%
Bergmann glial cell CL0000644

CSI -8.5

rCSI -11.6%

PRS 2.0%
starburst amacrine cell CL0004232

CSI -7.9

rCSI -66.6%

PRS 4.9%
kidney collecting duct intercalated cell CL1001432

CSI -7.7

rCSI -54.9%

PRS 8.3%
diffuse bipolar 1 cell CL4033027

CSI -7.7

rCSI -57.8%

PRS 4.4%
regular ventricular cardiac myocyte CL0002131

CSI -7.4

rCSI -46.3%

PRS 1.5%
pulmonary capillary endothelial cell CL4028001

CSI -7.1

rCSI -13.6%

PRS 2.9%
renal interstitial pericyte CL1001318

CSI -7.1

rCSI -19.6%

PRS 2.0%
GABAergic amacrine cell CL4030027

CSI -6.8

rCSI -23.3%

PRS 2.6%
invaginating midget bipolar cell CL4033034

CSI -6.7

rCSI -39.5%

PRS 4.5%
exhausted T cell CL0011025

CSI -6.1

rCSI -100.0%

PRS 10.3%
flat midget bipolar cell CL4033033

CSI -6.0

rCSI -43.0%

PRS 4.6%
cerebral cortex neuron CL0010012

CSI -5.7

rCSI -23.3%

PRS 2.5%
squamous epithelial cell CL0000076

CSI -5.6

rCSI -13.3%

PRS 2.4%
diffuse bipolar 6 cell CL4033032

CSI -5.3

rCSI -28.0%

PRS 5.5%
cardiac blood vessel endothelial cell CL0010006

CSI -5.0

rCSI -35.3%

PRS 6.0%
diffuse bipolar 4 cell CL4033031

CSI -4.0

rCSI -45.3%

PRS 5.6%
H1 horizontal cell CL0004217

CSI -3.8

rCSI -14.8%

PRS 5.1%
cerebral cortex endothelial cell CL1001602

CSI -3.4

rCSI -5.8%

PRS 1.4%
diffuse bipolar 2 cell CL4033028

CSI -3.2

rCSI -25.1%

PRS 5.1%
endothelial cell of vascular tree CL0002139

CSI -3.1

rCSI -17.2%

PRS 4.8%
kidney granular cell CL0000648

CSI -2.7

rCSI -39.1%

PRS 22.8%
ON midget ganglion cell CL4033046

CSI -2.5

rCSI -51.7%

PRS 2.3%
cord blood hematopoietic stem cell CL2000095

CSI -2.2

rCSI -41.3%

PRS 15.7%
amacrine cell CL0000561

CSI -2.1

rCSI -6.0%

PRS 1.7%
OFF midget ganglion cell CL4033047

CSI -1.9

rCSI -39.0%

PRS 2.5%
direct pathway medium spiny neuron CL4023026

CSI -1.5

rCSI -36.0%

PRS 1.0%
platelet CL0000233

CSI -1.4

rCSI -5.8%

PRS 5.6%
diffuse bipolar 3b cell CL4033030

CSI -1.2

rCSI -8.0%

PRS 4.7%
endocardial cell CL0002350

CSI -0.5

rCSI -2.2%

PRS 3.2%
indirect pathway medium spiny neuron CL4023029

CSI -0.4

rCSI -10.4%

PRS 1.4%
L6b glutamatergic cortical neuron CL4023038

CSI -0.1

rCSI -0.3%

PRS 1.2%
H2 horizontal cell CL0004218

CSI 0.4

rCSI 2.0%

PRS 3.6%
diffuse bipolar 3a cell CL4033029

CSI 0.6

rCSI 3.7%

PRS 4.4%
kidney resident macrophage CL1000698

CSI 0.6

rCSI 11.3%

PRS 46.1%
glycinergic amacrine cell CL4030028

CSI 0.7

rCSI 1.8%

PRS 2.9%
immature innate lymphoid cell CL0001082

CSI 0.8

rCSI 23.3%

PRS 32.8%
cholangiocyte CL1000488

CSI 1.4

rCSI 8.2%

PRS 4.3%
fast muscle cell CL0000190

CSI 1.5

rCSI 5.7%

PRS 11.2%
cerebellar granule cell CL0001031

CSI 1.5

rCSI 2.3%

PRS 2.0%
Schwann cell CL0002573

CSI 1.6

rCSI 4.4%

PRS 2.5%
enterocyte of epithelium of large intestine CL0002071

CSI 1.6

rCSI 8.3%

PRS 3.8%
tracheobronchial goblet cell CL0019003

CSI 1.7

rCSI 27.8%

PRS 44.1%
group 3 innate lymphoid cell, human CL0001078

CSI 1.8

rCSI 37.2%

PRS 35.8%
retinal rod cell CL0000604

CSI 1.8

rCSI 3.2%

PRS 2.1%
endocrine cell CL0000163

CSI 2.0

rCSI 10.4%

PRS 8.5%
macula densa epithelial cell CL1000850

CSI 2.1

rCSI 30.5%

PRS 28.1%
sst GABAergic cortical interneuron CL4023017

CSI 2.2

rCSI 2.8%

PRS 1.2%
renal intercalated cell CL0005010

CSI 2.3

rCSI 20.1%

PRS 17.6%
forebrain neuroblast CL1000042

CSI 2.3

rCSI 24.6%

PRS 27.4%
macroglial cell CL0000126

CSI 2.3

rCSI 6.0%

PRS 3.4%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.9

rCSI 90.8%

PRS 25.3%
retinal ganglion cell CL0000740

CSI 2.9

rCSI 6.5%

PRS 1.4%
odontoblast CL0000060

CSI 3.0

rCSI 67.6%

PRS 10.8%
pluripotent stem cell CL0002248

CSI 3.2

rCSI 97.2%

PRS 4.6%
slow muscle cell CL0000189

CSI 3.4

rCSI 44.7%

PRS 24.8%
basal cell of epidermis CL0002187

CSI 3.4

rCSI 6.1%

PRS 2.5%
B-2 B cell CL0000822

CSI 3.6

rCSI 76.7%

PRS 11.8%
kidney connecting tubule principal cell CL4030018

CSI 3.6

rCSI 26.3%

PRS 27.1%
cone retinal bipolar cell CL0000752

CSI 3.7

rCSI 47.6%

PRS 12.8%
mesenchymal lymphangioblast CL0005021

CSI 3.7

rCSI 96.8%

PRS 10.4%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 3.7

rCSI 32.3%

PRS 5.0%
B-1 B cell CL0000819

CSI 3.8

rCSI 97.7%

PRS 11.2%
epithelial cell of urethra CL1000296

CSI 3.8

rCSI 96.6%

PRS 6.4%
osteoblast CL0000062

CSI 3.9

rCSI 95.8%

PRS 17.7%
kidney loop of Henle epithelial cell CL1000909

CSI 3.9

rCSI 81.6%

PRS 17.0%
Merkel cell CL0000242

CSI 3.9

rCSI 90.7%

PRS 13.3%
lung microvascular endothelial cell CL2000016

CSI 4.0

rCSI 76.9%

PRS 6.6%
prostate gland microvascular endothelial cell CL2000059

CSI 4.1

rCSI 97.2%

PRS 6.8%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 4.1

rCSI 23.2%

PRS 11.1%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 4.2

rCSI 44.6%

PRS 3.2%
double negative T regulatory cell CL0011024

CSI 4.4

rCSI 84.6%

PRS 16.3%
uterine smooth muscle cell CL0002601

CSI 4.5

rCSI 29.6%

PRS 14.0%
enteric neuron CL0007011

CSI 4.5

rCSI 66.7%

PRS 5.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPS13](/details-gene/6207) encodes ribosomal protein S13, an essential structural component of the 40S small ribosomal subunit. Its primary function is integral to the process of protein synthesis, participating in mRNA binding and the overall mechanics of translation. Consistent with this fundamental "housekeeping" role, [RPS13](/details-gene/6207) shows significant expression in metabolically active cells, particularly those of the hematopoietic and immune systems, including T cells, hematopoietic stem cells, and dendritic cells. Its widespread and critical function in ribosome biogenesis and translation makes it a key player in cellular growth, proliferation, and response to stimuli. The gene is associated with Diamond-Blackfan anemia-1 ([180476](https://omim.org/entry/180476)), a ribosomopathy. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [RPS13](/details-gene/6207) underscores its critical importance in highly proliferative and protein-synthesizing cell populations. The gene exhibits its highest significance scores in a broad range of immune cells, suggesting it is a crucial workhorse for immune system development and function. Top cell types with high significance for [RPS13](/details-gene/6207) include key players in both innate and adaptive immunity. These include lymphocytes such as [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), and [immature B cell](/details-cell/CL0000816), as well as progenitor cells like the [hematopoietic stem cell](/details-cell/CL0000037). High expression is also noted in antigen-presenting cells like the [plasmacytoid dendritic cell, human](/details-cell/CL0001058) and cytotoxic cells like the [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939). This pattern is consistent with the high demand for protein synthesis required for immune cell activation, differentiation, cytokine production, and clonal expansion. Conversely, [RPS13](/details-gene/6207) shows significantly low expression in several terminally differentiated, non-proliferative cell types, particularly within the central nervous system. These include various neuronal subtypes such as [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011), [inhibitory interneuron](/details-cell/CL0000498), and [astrocyte of the cerebral cortex](/details-cell/CL0002605). Low significance is also observed in structural cells like [adipocyte](/details-cell/CL0000136) and [kidney interstitial fibroblast](/details-cell/CL1000692). This expression pattern reinforces its primary role in facilitating high rates of translation in dynamic cell populations rather than in structurally-focused or metabolically quiescent cells. ## Pathways and Molecular Function The functional annotations for [RPS13](/details-gene/6207) confirm its identity as a core component of the translational machinery. As a structural constituent of the ribosome ([GO:0003735](https://www.ebi.ac.uk/QuickGO/term/GO:0003735)), it is centrally involved in biological processes such as [cytoplasmic translation](/details-go/GO:0002181), [ribosomal small subunit biogenesis](/details-go/GO:0042274), and general [translation](/details-go/GO:0006412). Its molecular functions include direct binding to RNA ([GO:0003723](https://www.ebi.ac.uk/QuickGO/term/GO:0003723)) and specifically to mRNA ([GO:0003729](https://www.ebi.ac.uk/QuickGO/term/GO:0003729)), highlighting its role in positioning the mRNA template for decoding. Reactome pathway analysis further details its involvement in nearly every stage of protein synthesis. [RPS13](/details-gene/6207) is a participant in [Eukaryotic translation initiation](/details-pathway/R-HSA-72613), [Peptide chain elongation](/details-pathway/R-HSA-156902), and [Eukaryotic translation termination](/details-pathway/R-HSA-72764). Its importance is consistent with its high expression in immune cells, which rely on these pathways for rapid responses. Notably, the data also implicate [RPS13](/details-gene/6207) in pathways related to [Infectious disease](/details-pathway/R-HSA-5663205), including [Influenza infection](/details-pathway/R-HSA-168255) and [Sars-cov-2 infection](/details-pathway/R-HSA-9694516). This suggests that viruses may hijack ribosomes containing [RPS13](/details-gene/6207) to facilitate the translation of viral proteins ([Viral mrna translation](/details-pathway/R-HSA-192823)), making it a key host factor in viral pathogenesis. ## Research Directions The ubiquitous and fundamental role of [RPS13](/details-gene/6207) in translation provides a foundation for several research avenues, particularly concerning its role in disease. While its "housekeeping" nature makes it a challenging therapeutic target, its context-specific importance can be exploited. ### Proposed Hypotheses: 1. **Hypothesis 1:** Given its high significance in [hematopoietic stem cell](/details-cell/CL0000037) and various lymphoid progenitors, subtle haploinsufficiency or mutations in [RPS13](/details-gene/6207) may lead to cell-type-specific defects in hematopoiesis. This could result in specific cytopenias or immunodeficiencies by impairing the translational capacity required for proper differentiation and lineage commitment, contributing to the pathology of ribosomopathies like Diamond-Blackfan anemia. 2. **Hypothesis 2:** [RPS13](/details-gene/6207) may act as a critical host dependency factor for viral replication. Its involvement in pathways like [Sars-cov-2 modulates host translation machinery](/details-pathway/R-HSA-9754678) suggests that certain viruses have evolved mechanisms to preferentially utilize or interact with [RPS13](/details-gene/6207)-containing ribosomes to maximize the production of viral proteins. ### Experimental Approach: To test the second hypothesis regarding its role as a viral host factor, a functional genomics approach could be employed. * **Experiment:** Utilize CRISPR-Cas9 to generate a partial knockdown or a conditional knockout of [RPS13](/details-gene/6207) in a susceptible human cell line, such as Calu-3 cells for SARS-CoV-2. Following infection, viral replication efficiency would be quantified via plaque assays and RT-qPCR for viral RNA. Simultaneously, ribosomal profiling (Ribo-seq) could be performed to determine if the loss of [RPS13](/details-gene/6207) disproportionately affects the translation of viral mRNAs compared to host mRNAs. ### Therapeutic Potential: Directly targeting a core ribosomal protein like [RPS13](/details-gene/6207) for inhibition is likely to cause significant systemic toxicity due to its essential role in all cells. However, this perspective may change in specific pathological contexts. In cancers characterized by an elevated demand for protein synthesis, cells may become hyper-dependent on the efficiency of the translational machinery, a phenomenon known as "translation addiction." In such cases, a narrow therapeutic window might exist for inhibitors that partially disrupt ribosome function. Similarly, if [RPS13](/details-gene/6207) is proven to be a key factor for a specific virus, developing small molecules that disrupt its interaction with viral components could offer a viable antiviral strategy with a better toxicity profile than general translation inhibition. Any therapeutic strategy would likely focus on inhibition and require highly targeted delivery to diseased cells to be feasible.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S13

Genular Protein ID: 2267300521

Symbol: RS13_HUMAN

Name: 40S ribosomal protein S13

UniProtKB Accession Codes:

P62277 B2R549 P19116 Q02546 Q29200 Q498Y0

Database IDs:

Citations:

PubMed ID: 8332508

Title: Cloning and analysis of the human S13 ribosomal protein cDNA.

PubMed ID: 8332508

DOI: 10.1093/nar/21.12.2945

PubMed ID: 8920921

Title: U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene.

PubMed ID: 8920921

DOI: 10.1006/bbrc.1996.1668

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 151
Mass: 17222
Checksum: 23F94D38F87B8D53
Sequence:

MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI GVILRDSHGV 
AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK HLERNRKDKD AKFRLILIES 
RIHRLARYYK TKRVLPPNWK YESSTASALV A

Details for: RPS13

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning and analysis of the human S13 ribosomal protein cDNA. PubMed ID: 8332508

U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene. PubMed ID: 8920921

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797