Details for: RPS23

Gene ID: 6228

Symbol: RPS23

Ensembl ID: ENSG00000186468

Description: ribosomal protein S23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 771.2631
    Cell Significance Index: -317.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 727.7165
    Cell Significance Index: -295.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 650.9537
    Cell Significance Index: -307.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 628.7117
    Cell Significance Index: -323.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 459.9997
    Cell Significance Index: -308.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 315.8442
    Cell Significance Index: -301.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 51.8616
    Cell Significance Index: -138.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 21.1195
    Cell Significance Index: 539.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 19.1814
    Cell Significance Index: 1959.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 18.1342
    Cell Significance Index: 485.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 14.8157
    Cell Significance Index: 189.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 14.1016
    Cell Significance Index: 662.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.5024
    Cell Significance Index: 358.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.9086
    Cell Significance Index: 275.1300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.4927
    Cell Significance Index: 67.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.2862
    Cell Significance Index: 296.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.5172
    Cell Significance Index: 119.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 10.0567
    Cell Significance Index: 349.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.8994
    Cell Significance Index: 174.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.8384
    Cell Significance Index: 1271.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.6476
    Cell Significance Index: 1324.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.0909
    Cell Significance Index: 1117.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.9632
    Cell Significance Index: 1057.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.9392
    Cell Significance Index: 632.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.8148
    Cell Significance Index: 1589.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.4862
    Cell Significance Index: 177.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.3997
    Cell Significance Index: 3713.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.3175
    Cell Significance Index: 4542.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.0020
    Cell Significance Index: 596.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.8803
    Cell Significance Index: 508.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.3062
    Cell Significance Index: 936.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.9090
    Cell Significance Index: 75.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.2154
    Cell Significance Index: 182.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.8389
    Cell Significance Index: 304.1400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 5.5662
    Cell Significance Index: 47.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.7459
    Cell Significance Index: 129.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.1271
    Cell Significance Index: 76.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7150
    Cell Significance Index: 195.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.6848
    Cell Significance Index: 629.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5691
    Cell Significance Index: 166.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.5354
    Cell Significance Index: 2675.9900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.4594
    Cell Significance Index: 21.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1041
    Cell Significance Index: 28.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.0072
    Cell Significance Index: 2715.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9434
    Cell Significance Index: 584.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.8661
    Cell Significance Index: 76.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.9881
    Cell Significance Index: 1457.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.7913
    Cell Significance Index: 141.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2054
    Cell Significance Index: 229.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5310
    Cell Significance Index: 4.2400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.2538
    Cell Significance Index: 0.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1489
    Cell Significance Index: 42.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1066
    Cell Significance Index: 6.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0482
    Cell Significance Index: -90.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1239
    Cell Significance Index: -91.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1499
    Cell Significance Index: -276.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1855
    Cell Significance Index: -285.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2422
    Cell Significance Index: -329.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2626
    Cell Significance Index: -148.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2763
    Cell Significance Index: -172.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3136
    Cell Significance Index: -62.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3152
    Cell Significance Index: -113.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3698
    Cell Significance Index: -234.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4275
    Cell Significance Index: -48.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4883
    Cell Significance Index: -79.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5233
    Cell Significance Index: -27.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.5371
    Cell Significance Index: -53.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5526
    Cell Significance Index: -31.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5910
    Cell Significance Index: -268.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6298
    Cell Significance Index: -132.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.2618
    Cell Significance Index: -144.5700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.3680
    Cell Significance Index: -28.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4390
    Cell Significance Index: -46.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.4786
    Cell Significance Index: -67.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9105
    Cell Significance Index: -277.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.9605
    Cell Significance Index: -32.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9967
    Cell Significance Index: -34.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.2087
    Cell Significance Index: -152.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.2575
    Cell Significance Index: -142.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.4810
    Cell Significance Index: -14.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.4843
    Cell Significance Index: -62.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.9323
    Cell Significance Index: -305.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.6625
    Cell Significance Index: -128.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.7598
    Cell Significance Index: -288.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.0622
    Cell Significance Index: -243.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.0714
    Cell Significance Index: -273.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.2692
    Cell Significance Index: -261.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.3661
    Cell Significance Index: -94.5900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -5.1424
    Cell Significance Index: -72.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.1777
    Cell Significance Index: -88.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.4560
    Cell Significance Index: -74.4400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -5.4730
    Cell Significance Index: -25.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.5252
    Cell Significance Index: -82.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.7094
    Cell Significance Index: -68.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.0465
    Cell Significance Index: -174.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.1505
    Cell Significance Index: -272.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.2283
    Cell Significance Index: -183.4500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.4113
    Cell Significance Index: -34.9600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -6.7294
    Cell Significance Index: -48.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.1170
    Cell Significance Index: -261.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPS23 is a highly conserved protein, with high sequence identity among species. It is a component of the 40S ribosomal subunit, which is responsible for decoding messenger RNA (mRNA) during translation. RPS23 is also involved in the formation of the ternary complex, which is a crucial step in the initiation of translation. Additionally, RPS23 is involved in the regulation of protein synthesis, particularly in response to stress and starvation. **Pathways and Functions** RPS23 is involved in various cellular processes, including: 1. **Translation Initiation**: RPS23 plays a crucial role in the initiation of translation, particularly in the recognition of the start codon and the recruitment of the 40S ribosomal subunit. 2. **Ribosome Biogenesis**: RPS23 is involved in the formation of the 40S ribosomal subunit, which is essential for protein synthesis. 3. **Stress Response**: RPS23 is involved in the regulation of protein synthesis in response to stress and starvation, particularly through the activation of the eIF2α kinases. 4. **Viral Infection**: RPS23 has been shown to be involved in the translation of viral mRNAs, particularly in the case of influenza virus. 5. **Cellular Response to Stimuli**: RPS23 is involved in the regulation of protein synthesis in response to various cellular stimuli, including growth factors and cytokines. **Clinical Significance** RPS23 has been implicated in various diseases, including: 1. **Influenza**: RPS23 has been shown to be involved in the translation of influenza virus mRNAs, making it a potential target for antiviral therapy. 2. **Cancer**: RPS23 has been implicated in the regulation of protein synthesis in cancer cells, particularly in the case of epithelial-to-mesenchymal transition (EMT). 3. **Neurological Disorders**: RPS23 has been implicated in the regulation of protein synthesis in neurological disorders, particularly in the case of Alzheimer's disease and Parkinson's disease. 4. **Immune System Disorders**: RPS23 has been implicated in the regulation of protein synthesis in immune system disorders, particularly in the case of autoimmune diseases. In conclusion, RPS23 is a crucial component of the eukaryotic ribosome, playing a vital role in the translation process. Its involvement in various cellular processes, including translation initiation, ribosome biogenesis, stress response, and viral infection, makes it a potential target for therapeutic intervention in various diseases. **Recommendations** 1. **Antiviral Therapy**: RPS23 could be a potential target for antiviral therapy in the treatment of influenza virus infections. 2. **Cancer Therapy**: RPS23 could be a potential target for cancer therapy, particularly in the case of epithelial-to-mesenchymal transition (EMT). 3. **Neurological Disorder Therapy**: RPS23 could be a potential target for therapeutic intervention in neurological disorders, particularly in the case of Alzheimer's disease and Parkinson's disease. 4. **Immune System Disorder Therapy**: RPS23 could be a potential target for therapeutic intervention in immune system disorders, particularly in the case of autoimmune diseases. In summary, RPS23 is a crucial component of the eukaryotic ribosome, playing a vital role in the translation process. Its involvement in various cellular processes makes it a potential target for therapeutic intervention in various diseases.

Genular Protein ID: 2163095543

Symbol: RS23_HUMAN

Name: 40S ribosomal protein S23

UniProtKB Accession Codes:

P62266 P39028 Q6IB08

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 77 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 93 PDBsum 93 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 19 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8415000

Title: A cDNA sequence of human ribosomal protein, homologue of yeast S28.

PubMed ID: 8415000

DOI: 10.1093/nar/21.18.4394

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24550462

Title: Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.

PubMed ID: 24550462

DOI: 10.1073/pnas.1311750111

PubMed ID: 24550447

Title: OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.

PubMed ID: 24550447

DOI: 10.1073/pnas.1314482111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28257692

Title: A ribosomopathy reveals decoding defective ribosomes driving human dysmorphism.

PubMed ID: 28257692

DOI: 10.1016/j.ajhg.2017.01.034

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 143
  • Mass: 15808
  • Checksum: 8417A48B8CF0A8E5
  • Sequence:
    • MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI VLEKVGVEAK 
QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV LVAGFGRKGH AVGDIPGVRF 
KVVKVANVSL LALYKGKKER PRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.